ライフサイエンスコーパス: C-tail

1 phobic C-terminal transmembrane helices (or 'C-tails').

2 uires a signal (TLS1) in its cytosolic tail (C-tail).

3 of Smo carboxyl-terminal intracellular tail (C-tail).

4 ore-lining helix and proximal portion of the C-tail.

5 d by PKA/CK1-mediated phosphorylation of Smo C-tail.

6 promotes dimerization/oligomerization of Smo C-tail.

7 extension of the kinase domain known as the C-tail.

8 n (AR) and a C-terminal extension termed the C-tail.

9 volving both the intracellular loops and the C-tail.

10 btype being regulated by determinants in its C-tail.

11 th Costal2 (Cos2) and Fused (Fu) through its C-tail.

12 EGF-like1, CUB3, EGF-like2, CUB4, CUB5, and C-tail.

13 ubdomain, substrate-binding site, and kinase C-tail.

14 ation of a second signal (TLS2) in the Kex2p C-tail.

15 e GRK4alpha, including Ser-485 in the kinase C-tail.

16 of Pacsin 2 via a coiled-coil domain in its C-tail.

17 Gga2p VHS domain binds a site in the Vps10p C-tail.

18 is required for efficient export of the Cox2 C-tail.

19 ks of E. coli TatC involving both its N- and C-tails.

20 ical, segments (TMSs) and cytoplasmic N- and C-tails.

21 le substitutions of tyrosine residues in the C-tail affected neither phenotype.

22 Moreover, the C-tail alone is sufficient to mediate ssDNA binding.

23 Surprisingly, removal of the C-tail alone or mutation of highly conserved residues wi

24 tyrosine-containing endocytic motifs of the C-tail also impaired internalization.

25 The CXCR4 C-terminal domain (C-tail) also has a binding site for the actin-binding pr

26 ns of HHV-8 ORF74 was carried out to provide C-tail-altered proteins for functional analyses.

27 The APH proximal C-tail, although still accessible to Cys-directed reagen

28 We present evidence that U24 is a C-tail-anchored protein that is dependent for its functi

29 gested a direct interaction between the PTEN C-tail and a segment in the N-terminal region of the cat

30 tion with hydrophobic elements in arrestin's C-tail and alpha-helix I as well as its active state by

31 the involvement of receptor residues in the C-tail and beta-arrestin binding using site-directed mut

32 nase A (PKA)-mediated phosphorylation of Smo C-tail and depends on cell surface localization of both

33 decision is dictated specifically by the MOR C-tail and occurs irrespectively of the presence or abse

34 several tyrosine-containing sequences in the C-tail and seventh transmembrane domain.

35 (VHS) domains both bind a site in the Kex2p C-tail and that the Gga2p VHS domain binds a site in the

36 ng an intramolecular interaction between its C-tail and the C2 domain.

37 een the kinked hydrophobic fragment in hKOPR C-tail and the curved hydrophobic surface in GEC1 around

38 I-C modifications consist in the loss of the C-tail and the fusion with ectopic sequences.

39 y labeled arrestin with one nitroxide in the C-tail and the other in the N-domain.

40 recognized association between the cytosolic C-tail and the TM 4,5-loop was demonstrated using GST pu

41 s of the delta- and mu-opioid receptors, the C-tail and third intracellular domain of the delta-opioi

42 'reads' the message in the receptor phospho-C-tails and distinct phospho-interaction patterns are re

43 Fusions between the identified transmembrane C-tails and the exclusively Tat-dependent reporter prote

44 erminals in the caudate (Cd), especially the Cd tail and the adjacent ventral posterior Pu.

45 uirement for the first 62 amino acids of the C-tail, and the binding of calmodulin to this region did

46 o dissociate from each other and bind to the C-tail, and the DEP domain also binds to the third loop,

47 C tails are as abundant as G tails and are generated by

48 ere structural elements of the kinase domain C-tail are aligned to form novel interactions to the nuc

49 all of the serine/threonine residues in the C-tail are converted to alanine or to aspartate/glutamat

50 Therefore, Val477 and other residues in the C-tail are expected to play a role in the activation of

51 PVI transmembrane arginine and intracellular C-tail are necessary for coupling to Fc Rgamma and for s

52 ating that regulatory sequences on the GluR2 C-tail are required for the accumulation of synaptic AMP

53 Truncation of the C-tail at residues 324, 342, and 354 reduced internaliza

54 tion by phosphorylating Smo C-terminal tail (C-tail) at Ser741/Thr742, which is facilitated by PKA an

55 DPDPE moved the receptor C-tail away from the Gbetagamma dimer, resulting in beta

56 onist stimulation based on the source of its C-tail; beta 1AR with a beta 2AR C-tail underwent down-r

57 uggests that Cox18 not only translocates the C-tail, but also must deliver it in a distinct state com

58 GST-hKOR C-tail, but not GST, bound HA-NHERF-1/EBP50 transfected

59 to an agonist, but replacement of the GHSR1a C-tail by the tail of the vasopressin 2 receptor greatly

60 Aa and chimeric motors containing the Kif5Aa C-tail can rescue deficits.

61 16 protomers via its carboxy tail, but such C-tail clustering only occurred in stimulated membranes.

62 membrane domain directed octamers as well as C-tail clusters require Tha4's transmembrane glutamate r

63 ding reduction of FGF14(V160A) to the Nav1.6 C-tail compared with FGF14(K74A/I76A) Altogether these s

64 In contrast, overexpression of a PC1 C-tail construct increased intracellular calcium and sel

65 The PAR2 cytoplasmic tail (C-tail) contains multiple sites of phosphorylation and m

66 The GST fusion of the M3R C-tail could not bind to wild-type Gbeta(5)-RGS7 but cou

67 ferred from BPV1 E1 to HPV11 E1, that of the C-tail could not.

68 ds, and the orientation of their hydrophobic C-tails could be responsible for the resistance of rats

69 dentified role of a pair of cysteines in the C-tail (Cys-2610 and Cys-2613), a pair of highly conserv

70 PKC phosphorylation sites within the CysLT1R C-tail (CysLT1RS(313-316)A) reduced receptor internaliza

71 is basally palmitoylated at highly conserved C-tail cysteines.

72 to the 14-3-3 interaction motif in the hKOPR C-tail decreased interaction of coatomer protein I (COPI

73 The C-tail-deleted and phosphorylation-deficient receptors w

74 Analysis of various C-tail deletion mutants revealed that a region between r

75 wever, both variants, wild-type vGPCR, and a C-tail deletion version of the receptor were equally abl

76 phorylation-deficient, and cytoplasmic tail (C-tail) deletion mutants of both receptors were expresse

77 d pair, serine 861 and 864, is the principal C-tail determinant that mediates LGR5 constitutive inter

78 ation, but the chimeric beta2AR with beta1AR C-tail did not.

79 that both transmembrane domain directed- and C-tail directed oligomerization occur in the translocase

80 is in a partially open conformation with the C-tail disordered.

81 mbrane-adjacent CRAC4 and the long cytosolic C tail domain with several other CRAC motifs, which are

82 Cbv1 proteins is mediated by their cytosolic C tail domain, where we identified seven cholesterol rec

83 of the lamin A/C gene, and one in the lamin C tail domain.

84 does promote some translocation of the Cox2 C-tail domain across the inner membrane and causes incre

85 The Cox2 C-tail domain is exported post-translationally by the hi

86 Our data suggest that the C-tail domain is recognized posttranslationally by a spe

87 T and mGluR1 seven-transmembrane domain plus C-tail domain retained good response to [Ca(2+)](o) whet

88 lacking proteins required for export of the C-tail domain, Cox18 and Mss2.

89 truncation of the last 40 residues from the C-tail domain, indicating that sequence and/or structura

90 ne-based motif localized within the receptor C-tail domain.

91 or sites of phosphorylation occur within the C-tail domain.

92 ed for post-translational export of the Cox2 C-tail domain.

93 ndently of beta-arrestins and the receptor's C-tail domain.

94 motif localized within the C-terminal tail (C-tail) domain.

95 N domain can be modulated by the acidic and C-tail domains.

96 ndicate that combined deletion of the AR and C-tail drastically reduces DNA replication, by 85%, and

97 Association of NHERF-1/EBP50 with hKOR C-tail enhanced oligomerization of NHERF-1/EBP50.

98 e rhodopsin C terminus with Arg29 controls a C-tail exchange mechanism in which the C tail of arresti

99 dered region (IDR) at the carboxyl-terminus (C-tail) executes its functions.

100 gnificantly, the amphipathic helix (APH) and C-tail exhibited substantial changes in accessibility wh

101 igated the distinct mechanisms of N-tail and C-tail export by analysis of epitope-tagged Cox2 variant

102 C-tail export was blocked by truncation of the last 40 r

103 of cytochrome oxidase activity because Cox2p C-tail export was not blocked in mitochondria lacking Co

104 mportant roles in leader peptide processing, C-tail export, and stabilization of Cox2.

105 KlCox2p that appears to be due to a block of C-tail export.

106 ted for antinociceptive activity (55 degrees C tail flick) in mice.

107 d a partial agonist effect in the 55 degrees C tail-flick assay and a full agonist effect in the acet

108 e formalin test, and the thermal (49 degrees C) tail-flick and increasing-temperature (3 degrees C/mi

109 A warm-water (50 degrees C) tail-flick assay revealed a significant decrease in m

110 t, in addition to interacting with the CXCR4 C-tail, FLNA interacted with a region in the receptor th

111 e minimum necessary requirement of the GluA1 C-tail for LTP in mouse CA1 hippocampal pyramidal neuron

112 model, we found no requirement of the GluA1 C-tail for LTP.

113 ion of chimeric proteins in which the AR and C-tail from HPV11 E1 were replaced by those of BPV1 indi

114 Surprisingly, removal of the C-tail from intact-Ac45 caused cellular phenotypes also

115 , GST-GEC1 interacted directly with the hKOR C-tail, full-length hKOR, and tubulin.

116 g selective interactions with the alpha1D-AR C-tail fusion protein.

117 M1 (GAT) and glutathione S-transferase-Kex2p C-tail fusions show that Gga2p binds directly to the Kex

118 Proteolysis of the C-tail generated a trypsin-resistant core that was a mix

119 e, and the protein kinase A, G, and C kinase C-tail greatly impaired receptor phosphorylation.

120 llular loop PKA site Ser262 and the putative C-tail GRK sites Ser355, Ser356 of the human beta2AR ove

121 h beta 2AR C-tail > beta 2AR with a beta 1AR C-tail > beta 1AR.

122 rder being beta 2AR > beta 1AR with beta 2AR C-tail > beta 2AR with a beta 1AR C-tail > beta 1AR.

123 The C-tails had a corresponding effect on agonist-stimulated

124 hibits an inter-domain twist and a displaced C-tail, hallmarks of active arrestin.

125 ) is inactive, whereas membrane-tethered Smo C-tail has constitutive albeit low levels of Hh signalin

126 in vivo and suggest that the function of the C-tail has evolved in a PV type-specific manner.

127 tional rearrangements of the alpha1C subunit C-tail have been implicated in Ca2+ signal transduction.

128 hese data argue that both the alpha1C N- and C-tails have important but different roles in the voltag

129 of serine and threonine residues in the PAR2 C-tail hinder constitutive internalization through a non

130 nsfection of 293 cells with EGFR lacking the C-tail, i.e. Y974DeltaEGFR or Y992DeltaEGFR, led to EGF-

131 olecular recognition features present in the C-tail IDR enhance PTEN's protein-protein interactions t

132 ctions emanate from and are nucleated by the C-tail IDR, which form pliable network-hubs.

133 iple IDP-IDP interactions facilitated by its C-tail IDR.

134 Deletion of the last four amino acids of the C-tail (IIGV) eliminated these export signals and preven

135 amino acid region of the DHHC5 intracellular C-tail immediately after the fourth transmembrane domain

136 mum possible effect, %MPE) in the 52 degrees C tail-immersion test after a 72-h infusion from implant

137 e375, Phe377, Phe380, and Arg382) anchor the C tail in a position that blocks binding of the receptor

138 ngle-transmembrane (TM) topology placing the C tail in the ER lumen, and to bind vIL-6 via these sequ

139 Mss2p plays a role in recognizing the Cox2p C tail in the matrix and promoting its export.

140 Here we investigated the role of the C tail in Tie2 activation, signaling, and function both

141 , Gprk2 forms a dimer/oligomer and binds Smo C-tail in a kinase activity-independent manner to stabil

142 e catalytic core may have coevolved with the C-tail in AGC kinases.

143 xtensive literature on the role of the GluA1 C-tail in AMPAR trafficking, there is no effect of overe

144 ific, differential regulatory effects of the C-tail in gyrases from different organisms.

145 To examine the role of the EGFR C-tail in signal transducer and activator of transcripti

146 t transient anchoring of the alpha1C subunit C-tail in the plasma membrane inhibits Ca2+-dependent an

147 Viral-mediated delivery of the GluA2 C-tail in vivo blocked these synaptic changes, indicatin

148 G(i) and the other involving events at Smo's C-tail independent of G(i).

149 entire 11-transmembrane spanning region plus C-tail induced NFAT-green fluorescent protein nuclear tr

150 rease in channel conductance; thus, the TARP C-tail influences ion permeation.

151 The hKOPR C-tail interacted with 14-3-3zeta in rat brain extracts

152 ow that glutathione S-transferase (GST)-hKOR C-tail interacted with purified NHERF-1/EBP50, whereas G

153 However, none of the mutations in the C-tail interfered with this interaction or altered the a

154 ded for catalytic activity suggests that the C-tail is a cis-acting regulatory module that can also s

155 The C-tail is a hallmark of AGC functional divergence inasmu

156 ere that, in contrast to E. coli gyrase, the C-tail is a very moderate negative regulator of Bacillus

157 Ser(780) in the Kex2p C-tail is crucial for binding: an Ala substitution block

158 A large-scale movement of the C-tail is demonstrated by direct distance measurements u

159 le on the background of 3A mutant, where the C-tail is detached from the body of the molecule by trip

160 e observations, along with the fact that the C-tail is needed for catalytic activity suggests that th

161 ction of the AR is transferable, that of the C-tail is not.

162 tro, AMPA receptor trafficking via the GluA2 C-tail is required for the delayed increase in postsynap

163 ynaptic incorporation of this isolated GluR1 C-tail is sufficient to permit spine enlargement even wh

164 found that Smo lacking its C-terminal tail (C-tail) is inactive, whereas membrane-tethered Smo C-tai

165 how that the presence of a cytoplasmic tail (c-tail) is indispensible, and identified two domains in

166 Rs revealed a highly conserved region in the C tail, just distal to the seventh transmembrane domain.

167 r of gelsolin was open when we truncated the C-tail latch from this protein.

168 g the length of the intrinsically disordered C-tail linker modifies the interfilament spacing.

169 We report here characterization of a C-tail loss-of-function mutant, CF327A, and a related su

170 mine block, whereas complete deletion of the C-tail markedly enhanced the TARP-induced increase in ch

171 polar FtsZ protofilaments through their the C-tails may facilitate the coherent treadmilling dynamic

172 We have reported that a histone C tail modification, ubiquitylation of H2B, is required

173 It is interesting that PAR2 C-tail mutants lost the capacity to stably associate wit

174 ion, utilizing intracellular second loop and C-tail mutants of GHSR1a.

175 The inability of internalized PAR2 C-tail mutants to stably associate with arrestins also r

176 nel conductance, we examined various gamma-2 C-tail mutants.

177 ols a C-tail exchange mechanism in which the C tail of arrestin is released and exposes several charg

178 interactions in the polar core and along the C tail of arrestin.

179 6 weeks, group B) or short (+12 weeks, group C) tail of Peg-IFN-alpha/RBV treatment, and RGT with 12

180 ract strongly with the cytoplasmic carboxyl (C)-tail of hIKCa1 in a yeast two-hybrid system.

181 region of AKT2 and the catalytic domain and C-tail of AKT1 prevented strain activation of GSK-3beta,

182 region of AKT1 and the catalytic domain and C-tail of AKT2 did not.

183 ealed that clathrin binding increases as the C-tail of arrestin2 is shortened while site-directed mut

184 Thus, the palmitoylated C-tail of CCR5 is the major determinant of its raft asso

185 that its activity is required to export the C-tail of Cox2p bearing a short C-terminal epitope tag.

186 When the C-tail of CXCR4 was exchanged for that of CCR5, the resu

187 a beta-turn confirmation in the cytoplasmic C-tail of each transporter.

188 Residues in the C-tail of GRK2, although not ordered in the crystal stru

189 The C-tail of hSKCa3, a human neuronal small conductance cha

190 The data thus indicate that the C-tail of Mgm101, likely displayed on the ring surface,

191 he structure reported by Bunting et al., the C-tail of Pol IV contacts a hydrophobic cleft on the cla

192 pe Kex2p and a fusion protein containing the C-tail of Ste13p, and also caused missorting of carboxyp

193 nance, we identified a tribasic motif in the C-tail of the 5-HT(1A)R on which Yif1B binds directly wi

194 endent on type I PSD-95/DLG/ZO1 (PDZ) in the C-tail of the beta1-AR and on protein kinase A (PKA) act

195 orm (38-117) of GEC1 that interacts with the C-tail of the human kappa opioid receptor (hKOR) by yeas

196 GEC1-(38-117) did not interact with the C-tail of the mu or delta opioid receptors.

197 NHERF1 interacts with the C-tail of the P2Y(12)R and unlike many other GPCRs, NHER

198 city, it is the physical interactions of the C-tail of the receptor that mediate the long-term stabil

199 d intracellular loop but instead require the C-tail of the receptor.

200 eous mutation of two dileucine motifs in the C-tail of TXA2Rbeta did not affect agonist-promoted inte

201 ion of alpha-helix I, beta-strand I, and the C-tail of visual arrestin-1, facilitating its transition

202 R chimera with type I PDZ sequences from the C-tails of aquaporin-2 or GluR1 recycled in a SAP97- and

203 verexpression of arrestin-3, identifying the C-tails of both receptors as necessary in arrestin-3 int

204 se data indicate that phosphorylation of the C-tails of CXCR1 and CXCR2 are required for arrestin tra

205 h purified NHERF-1/EBP50, whereas GST or GST-C-tails of micro or delta opioid receptors did not.

206 We found that the C-tails of the two polypeptide chains of the rat Abeta(1

207 The C-terminal tail (C-tail) of AGC kinase domains is a highly conserved feat

208 opsin, and the flexible C-terminal sequence (C-tail) of arrestin becomes dynamically disordered in bo

209 a recombinant cytosolic C-terminal fragment (C-tail) of GluR1 is driven to the postsynaptic density a

210 LTP requires the cytoplasmic carboxyl tail (C-tail) of the AMPA (alpha-amino-3-hydroxy-5-methyl-4-is

211 of the non-conserved acidic C-terminal tail (C-tail) of the CTDs has been reported.

212 binds to the intracellular C-terminal tail (C-tail) of the receptor for parathyroid hormone and para

213 Kex2p chimera containing the cytosolic tail (C-tail) of the vacuolar protein sorting receptor, Vps10p

214 ucine sorting motifs in the cytosolic tails (C-tails) of intracellular receptors.

215 ng, there is no effect of overexpressing the C-tail on basal transmission.

216 onstrated that PC1 constructs containing the C-tail only or the entire 11-transmembrane spanning regi

217 Deletion of the C-tail or mutation of both C-tail tyrosine residues of F

218 proteins that interact with the polycystin-1 C-tail (P1CT), this segment was used as bait in a yeast

219 niformly into the membrane interface and the C-tails pack closer together in a mesh-like network.

220 LTP, synaptic scaling is blocked by a GluR2 C-tail peptide but not by a GluR1 C-tail peptide.

221 Attempts at using a purified C-tail peptide to rescue the activity loss of the trunca

222 by a GluR2 C-tail peptide but not by a GluR1 C-tail peptide.

223 These findings demonstrate that the Tie2 C tail performs a novel negative regulatory role in Tie2

224 Systematic evaluation of the PTEN C-tail phospho-cluster showed autoinhibition, and confor

225 R1 internalization via recognition of distal C-tail phosphorylation sites rather than the canonical t

226 teraction motif (354)RQSTS(358) in the hKOPR C-tail reduced interaction of the hKOPR with 14-3-3zeta

227 The C-tail reduces the degree of DNA bending by the CTDs but

228 Removal of the acidic region and the C-tail region convert the chimera from a strong activato

229 tubule binding region, and 392IVYK395 in the C-tail region of the protein.

230 usly thought, but also recruits its flanking C-tail region to the kinase core, thereby concertedly po

231 e whether residues in the TARP intracellular C-tail regulate polyamine block and channel conductance,

232 lomavirus 1 (BPV1) E1 showed that the AR and C-tail regulate the oligomerization of the protein into

233 herefore offer clues to how the EGF receptor C-tail regulates STAT activity.

234 Thus, the PAR2 C-tail regulates the stability of arrestin interaction a

235 , FGF14 binds directly to the Nav1.6 channel C-tail, regulating channel gating and expression, proper

236 f the receptor in the complex as well as the C-tail release upon receptor binding.

237 ytic domain of Pm, and the functions of this C-tail remain elusive.

238 notypes also found for cleaved-Ac45, whereas C-tail removal from cleaved-Ac45 still allowed its trans

239 interaction between these channels via their C-tails renders them capable of coordinating their gatin

240 contrast to the absolute requirement for the C-tail reported for BPV1 E1 in vitro and confirmed here

241 ues 314-322) in the context of a full-length C-tail resulted in severe reduction in surface expressio

242 ons out of 20, all within or adjacent to the C-tail, resulted in significant deficiencies in the abil

243 A fully ordered kinase C-tail reveals interactions linking the C-tail with impo

244 Antibodies against the Kex2p and Vps10p C-tails selectively block transport of Kex2p and the Kex

245 membrane, and the need for accessibility of C-tail sequences argue that the TGN-PVC transport reacti

246 re conserved residues that interact with the C-tail strikingly diverge from the canonical residues ob

247 ther MAPK members by virtue of a unique long C-tail, suggesting specific mechanisms of regulation.

248 icking aspartic acid residue at T1736 in the C-tail suggests that phosphorylation of this residue reg

249 that GEC1 had stronger association with KOPR-C-tail than GABARAP.

250 spensible, and identified two domains in the c-tail that are necessary for NLGN function at inhibitor

251 vealed multiple tyrosine residues within the C-tail that can act as the docking sites for both Stat1

252 cation across the inner membrane of the COX2 C-tail that contains the apo-CuA site.

253 an acidic region (AR) and a C-terminal tail (C-tail) that have been shown to regulate the oligomeriza

254 ns and three regions of the C-terminal tail (C-tail): the N-lobe tether (NLT), the active-site tether

255 is interaction or altered the ability of the C-tail to assemble into dimers.

256 PAR2 C-tail truncation mutants displayed normal agonist-induc

257 cription (STAT) activation, a series of EGFR C-tail truncations were constructed.

258 lysosomes via AP-3 interaction with a second C-tail tyrosine motif proximal to the transmembrane doma

259 Deletion of the C-tail or mutation of both C-tail tyrosine residues of FGFR1 to phenylalanine aboli

260 control adaptor protein recognition of PAR1 C-tail tyrosine-based motifs are not known.

261 urce of its C-tail; beta 1AR with a beta 2AR C-tail underwent down-regulation, and beta 2AR with a be

262 switched, the chimeric beta1AR with beta2AR C-tail underwent ubiquitination and down-regulation, but

263 own-regulation, and beta 2AR with a beta 1AR C-tail underwent up-regulation.

264 urate termination by RNA polymerase III on a C-tailed VA1 template.

265 The C-tail was required for endoplasmic reticulum export and

266 t in which all serines and threonines in the C-tail were converted to alanines and designated it PAR2

267 ed by a 231-residue-long COOH-terminal tail (C-tail), which contains multiple tyrosine residues.

268 Pulldown assay of GST-KOPR-C-tail with HA-GEC1 or HA-GABARAP revealed that GEC1 had

269 nase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, i

270 show that Gga2p binds directly to the Kex2p C-tail, with relative affinities Asp(780) > Ser(780) > A