ライフサイエンスコーパス: C-terminal

1 folds in a step-wise fashion mainly from the C terminal.

2 minal intermembrane space (IMS) domain and a C-terminal 16-stranded beta-barrel domain.

3 s of an autoinhibitor domain upstream of the C-terminal 33 residues and an anti-autoinhibitor domain

4 tylates PEX5 at K464 by interacting with its C-terminal 51 amino acids (CT51), which is required for

5 no acid substitution mutations within a PMS2 C-terminal (721)QRLIAP motif attenuate or abolish human

6 ith the two associating in cells through the C-terminal 77 amino acids of the light chain protease.

7 d a small 80-residue N-terminal domain and a C-terminal 8-bladed beta-propeller domain that are both

8 of p53 residence times on chromatin requires C-terminal acetylation-a classical mark for transcriptio

9 duction in WT M2 is due to W41 inhibition of C-terminal acid activation by H37.

10 the DNA binding domain with the 9 amino acid C-terminal acidic tip that is involved in SSB binding to

11 We found that melanophilin, specifically its C-terminal actin-binding domain (ABD), is a target of PK

12 ylcobalamin (AdoB12)-dependent photoreceptor C-terminal adenosylcobalamin binding domain (CarHC) prot

13 50A, whereas Cep68 interacts with the distal C-terminal AKAP350A region.

14 (PpMS) was abrogated by the deletion of 107 C-terminal amino acids or the R742A mutation.

15 aluate the mechanism by which this synthetic C-terminal amphiphilic peptide (LumC13), binds to ALK5.

16 ence that a physical interaction between the C-terminal and catalytic domains mediates ARTEMIS autoin

17 to an unexpected allosteric site between the C-terminal and the N-terminal helicase cassettes, while

18 tions in trans Except for the binding of the C-terminal angiopoietin domains to the Tie2 ligand-bindi

19 An Ala mutation of the distal C-terminal Arg-354 or Ser-357, which forms a consensus p

20 ytic cleavage of pro-EGF first occurs at the C-terminal arginyl residue of the EGF domain, and that p

21 Binding of the intrinsically disordered C-terminal arm of CcdA to the toxin CcdB prevents CcdB f

22 cked' together is stabilized via a conserved C-terminal arm, which may interact with the portal prote

23 We identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbe

24 rom the axonemes of C. reinhardtii, that the C-terminal beta-propeller but not the N-terminal domain

25 ions suggested that detachment of the short, C-terminal beta-strand from the soluble fold exposes key

26 contracts, resulting in a shortening of the C-terminal beta-strand.

27 pression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1 and 2) occurs

28 ranscriptional repressors via recruitment of C-terminal Binding Proteins.

29 oxidation potentials between internal versus C-terminal carboxylates can be exploited towards obtaini

30 Previous structural studies showed that the C-terminal catalytic domain of human A3B has a tightly c

31 ete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven

32 Moreover, two C-terminal charges impact CRY2 homo-oligomerization, wit

33 By engineering C-terminal charges, we develop CRY2high and CRY2low with

34 proteolytic-resistant alpha1C Prevention of C-terminal cleavage did not alter beta-adrenergic stimul

35 n melting temperatures possibly arising from C-terminal conformational changes.

36 ly disordered C-terminal linker (CTL), and a C-terminal conserved peptide (CTC).

37 nal modification of RAB GTPases that contain C-terminal CXC motifs.

38 s an unanticipated architecture in which the C-terminal cysteine-rich domain partially occludes the e

39 hosts a redox-active [2Fe-2S] cluster in its C-terminal cytosolic region.

40 , we showed that an amphipathic helix in the C-terminal cytosolic tail of RHD3 has a membrane anchori

41 The design of the peptides is based on the C-terminal D4 domain of the Escherichia coli polysacchar

42 Lon recognizes HspQ via a C-terminal degron, whose precise presentation, in synerg

43 e critical determinant, Ser5 mutants bearing C-terminal deletions were created.

44 l DHH domain linked to the substrate binding C-terminal DHHA1 domain via an extended linker.

45 rough its interaction with RNA Polymerase II C-terminal domain (CTD) and affecting the expression lev

46 ranslational modifications on the RNA pol II C-terminal domain (CTD) and the chromatin template.

47 The H1 C-terminal domain (CTD) localizes primarily to a single

48 r connecting the N-terminal domain (NTD) and C-terminal domain (CTD) of AhpF suggests that the enzyme

49 Many of these proteins bind the C-terminal domain (CTD) of FtsZ, which serves as a hub f

50 lves the catalytic core domain (CCD) and the C-terminal domain (CTD) of the integrase.

51 h the post-translational modification of the C-terminal domain (CTD) of the largest subunit of RNA po

52 topo II-targeted drugs is influenced by the C-terminal domain (CTD) of the topo II isoforms and by a

53 The Ska1 C-terminal domain (CTD) recruits protein phosphatase 1 (

54 Hfq possesses an intrinsically disordered C-terminal domain (CTD) that may tune the function of th

55 d two decavanadate-binding sites, one in the C-terminal domain and another in the intersubunit MHR in

56 a potential oligomerization interface in the C-terminal domain as well as a conserved oligomerization

57 RapZ at 3.40 A and 3.25 A, and its isolated C-terminal domain at 1.17 A resolution.

58 of RapZ possesses a kinase fold, whereas the C-terminal domain bears closest homology to a subdomain

59 In the absence of coiled-coil formation, the C-terminal domain bound liposomes and ProP concentrated

60 n lipoxygenases, the topologically conserved C-terminal domain catalyzes the oxidation of polyunsatur

61 pendent, and phosphomimetic mutations in the C-terminal domain did not result in unmasking of the cat

62 ring (SAXS) data revealed that the protein's C-terminal domain has a PG-binding-competent conformatio

63 rate liposomes, the overall structure of the C-terminal domain is in good agreement with crystallogra

64 ed on the face of the beta-helix whereas the C-terminal domain is likely involved in carbohydrates bi

65 The C-terminal domain is relatively unstructured in the mono

66 cessed by CO2 in a manner dependent on a key C-terminal domain located in its transactivation domain.

67 monstrates that two basic loops in the mVP40 C-terminal domain make important contributions to anioni

68 The positively charged C-terminal domain of ArfA anchors in the mRNA entry chan

69 induce a conformational rearrangement in the C-terminal domain of ExoU.

70 We show that the rotated C-terminal domain of FIN219 alters ATP binding and the c

71 ependent conformational rearrangement of the C-terminal domain of heme binding protein (PhuS) is requ

72 sion and that CHMP7 can bind directly to the C-terminal domain of LEM2 in vitro.

73 The C-terminal domain of nsp5 was shown to be required for t

74 A polymerase (RNAP), also interacts with the C-terminal domain of PigR, thus anchoring the (MglA-SspA

75 structural model of DnaB complexed with the C-terminal domain of primase, we found that Ile-85 is lo

76 this inhibitory effect required the globular C-terminal domain of PrP(C), which has not been previous

77 nse variants identified in the intracellular C-terminal domain of the GluN2B NMDAR subunit.

78 The C-terminal domain of the human Ino80 subunit (Ino80CTD)

79 that MB-10 binds to a specific pocket in the C-terminal domain of Tim44 of the protein-associated mot

80 polar spindle formation in vivo requires the C-terminal domain of TPX2.

81 n is the active part of the protein, and the C-terminal domain regulates the activity.

82 Our data show that, in the intermediate, the C-terminal domain retains a folded conformation that is

83 rized group of HRPKSs was found to contain a C-terminal domain with significant homology to carnitine

84 agment functions to provide stability to the C-terminal domain, which is necessary for lethal toxicit

85 an N-terminal domain, a middle domain, and a C-terminal domain.

86 urrents when expressed in the absence of the C-terminal domain.

87 P orthologues share an extended, cytoplasmic C-terminal domain.

88 through adjacent conserved interfaces in its C-terminal domain.

89 isite for full activity and is mediated by a C-terminal domain.

90 icing isoform (LIG3beta) that differs in the C-terminal domain.

91 important differences in how the Rb and p107 C-terminal domains (CTDs) associate with the coiled-coil

92 ator complex subunit 9 (IntS9) through their C-terminal domains (CTDs).

93 he MAD2-interaction motif (MIM), both N- and C-terminal domains (NTD and CTD) of MAD1 also contribute

94 thermodynamic stability measurements on the C-terminal domains (residues 90-231) of two PrP variants

95 Four cytosolic C-terminal domains form an umbrella-like structure with

96 phosphatase activities, and both the N- and C-terminal domains interact with substrates to increase

97 The N- and C-terminal domains of all gasdermins possess lipid-bindi

98 The N-terminal and C-terminal domains of CA (NTD and CTD, respectively) eng

99 ome association of peptides representing the C-terminal domains of ProP orthologues and variants in v

100 We find that both the N- and C-terminal domains of TTP are involved in an interaction

101 e bioactive LN-511-E8 fragment carrying only C-terminal domains showed similar efficacy as full-lengt

102 the propensity of the intrinsically unfolded C-terminal domains to drive pathological aggregation.

103 The interaction between the N- and C-terminal domains was not DNA-PKcs-dependent, and phosp

104 matics predicts that MOSP consists of N- and C-terminal domains, MOSP(N) and MOSP(C).

105 mains to the ATPase, Rubisco recognition and C-terminal domains.

106 t it bound strongly to monomeric CRP via its C-terminal domains.

107 The C-terminal DSP domain induced phosphorylation of occludi

108 d tail that is rich in basic residues at the C-terminal end is responsible for the interaction with R

109 yosin-X construct with leucine zipper at the C-terminal end of the tail (M10(Full)LZ) and the tail-tr

110 shown for both species that mutations at the C-terminal end of this epitope dramatically improve pres

111 allotypes, and a less variable anchor at the C-terminal end.

112 and hydrophobic and polar amino acids at the C-terminal end.

113 ry that depends on PCNA interaction with the C-terminal endonuclease domain of the MutLalpha PMS2 sub

114 The redox regulated C-terminal extension (CTE) and the associated alternate

115 resent the structure of the human telomerase C-terminal extension (or thumb domain) determined by the

116 s lack TMBS2 and half of ABS1, and present a C-terminal extension containing a proline-rich domain an

117 6SS effectors consists of VgrG proteins with C-terminal extension domains carrying various enzymatic

118 ously reported analogs and relies on the HPF C-terminal extension forming the binding platform for th

119 these two stealth family proteins revealed a C-terminal extension in CsxA, which conferred processivi

120 d them to open the F pocket and expose their C-terminal extension into the solvent.

121 al of the 1291-1302-amino acid region of the C-terminal extension is critical for relieving the auto-

122 The C-terminal extension of capsid protein VP3 folds into a

123 Finally, we find that deleting the C-terminal extension of Lmod1 and Lmod2 results in an ap

124 The large subunit is synthesized with a C-terminal extension, cleaved off by a specific endopept

125 This binding was not affected by cry1's C-terminal extension, which is important for signal tran

126 ongation is affected mainly by the length of C-terminal extension.

127 e developed novel chemical probes, ubiquitin C-terminal fluorescein thioesters UbMES and UbFluor, to

128 of ubiquitin, two interhelical loops of the C-terminal four-helix bundle appear to penetrate the mem

129 nstrate that menin and its calpain-dependent C-terminal fragment (C-menin) regulate the subunit-speci

130 membrane, with a subsequent decrease in APP C-terminal fragment (CTF) content in secreted exosomes,

131 l carcinoma (SCC) EVs were enriched with the C-terminal fragment of desmoglein 2 (Dsg2), a desmosomal

132 oteins (a stable mutant of hGal1 (hGal-1), a C-terminal fragment of hGal-3 (hGal-3C) and hGal-7), wit

133 associated with an ATP analogue, RNA, and a C-terminal fragment of Yra1 (Yra1-C) at 2.6 A resolution

134 ain can interact both with itself and with a C-terminal fragment.

135 This study assesses whether C-terminal fragments (CTF) of the amyloid precursor prot

136 rocessing of amyloid precursor protein (APP) C-terminal fragments (CTFs) by gamma-secretase underlies

137 Moreover, C-terminal fragments exhibited significantly altered mob

138 boxylates can be exploited towards obtaining C-terminal functionalization exclusively.

139 minal acyltransferase domain and a predicted C-terminal glycosyltransferase.

140 to cleave the N-terminal prodomain from the C-terminal growth factor (GF) domain in each monomer, pr

141 n was used to incorporate ts mutations and a C-terminal HA tag.

142 hosphorylation-dependent (40E8 and p396) and C-terminal half (4E4) tau antibodies also reduced tau up

143 dt1 contains two winged-helix domains in the C-terminal half of the protein and a catalytically inact

144 We found that the conserved C-terminal haloacid dehalogenase domain of EYA1, which h

145 Additionally, the N- and C-terminal halves of the TM helix form trimeric cores of

146 lytic domain (LC) disulfide bond linked to a C-terminal heavy chain (HC) which includes a translocati

147 The kink, which reduces the tilt of the C-terminal helical domain relative to the bilayer normal

148 Disruption of the interaction between C-terminal helices and the NBD1 core upon VX-809 binding

149 , held together in part by the Anbu specific C-terminal helices.

150 y; and (v) conformational transitions in the C-terminal helix have specific functional involvements i

151 which the small molecule stabilizes a mobile C-terminal helix inside a hydrophobic crevice of NCS-1 t

152 We also show that the C-terminal helix of the bHLH domain is involved in inter

153 th the N domain of one molecule bound to the C-terminal helix of the neighboring D1 domain.

154 ) permits positively charged residues in the C-terminal helix to engage in DNA binding, triggering a

155 of two helix/loop regions, as well as of the C-terminal helix; (iii) the energy barrier of phospholip

156 letely eliminated antibodies directed to the C-terminal His tag located at the "bottom" of the spike.

157 erminal Gly-rich fragment of rSp0032 and the C-terminal His-rich fragment show unique transformations

158 The C-terminal homology domain (CHD) of Af4 was sufficient t

159 rease the levels of Abeta, Tau and Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in mouse cerebrospinal f

160 s are tail-anchored (TA) proteins, bearing a C-terminal hydrophobic domain that is essential for thei

161 ain associated with DSD activity and a novel C-terminal hydroxyphenylpyruvate dioxygenase-like domain

162 L-37 directly bound to the CAAX motif in the C-terminal hypervariable region of Rac1, and then inhibi

163 The C-terminal in-frame green fluorescent protein fusion may

164 -terminal "thumb" and a disulfide-stabilized C-terminal "index finger," yet how these binding events

165 three factors revealed an alpha-helix in the C-terminal inhibitory domain that packs against the ETS

166 In contrast, the functions of e1a's C-terminal interactions with FOXK, DCAF7, and CtBP are u

167 We show here that N- and C-terminal intrinsically disordered regions account for

168 Ca(2+) current is likely conducted by short C-terminal isoforms of Cav1.3 channels, notably Cav1.342

169 ate with the nuclear envelope (NE) through a C-terminal KASH (Klarsicht/Anc1/Syne homology) domain (F

170 use ER-Golgi-cycling FKBP proteins contain a C-terminal KDEL-like sequence, bind ST-FRB in the Golgi,

171 lates autophosphorylation at His(183) in its C-terminal kinase domain.

172 We also identified the c-terminal LESLL motif as a critical motif for AIRE's mi

173 entral nucleotide-binding (NB) domain, and a C-terminal leucine-rich repeat (LRR).

174 -of-function variants in this domain and the C-terminal likely cause neurodevelopmental disorders wit

175 g GTPase domain, an intrinsically disordered C-terminal linker (CTL), and a C-terminal conserved pept

176 s the 56 amino acid intrinsically disordered C-terminal linker (IDL) that connects the DNA binding do

177 I(3,4,5)P3 binding to Akt(PHD) displaces the C-terminal lobe of CaM but not the weakly binding N-term

178 HNRNPG binds m6A-methylated RNAs through its C-terminal low-complexity region, which self-assembles i

179 A lack of APP C-terminal lysines caused APP redistribution from endoso

180 An APP mutant lacking all C-terminal lysines underwent the most pronounced increas

181 Here, we show that substitution of APP C-terminal lysines with arginine disrupts APP ubiquitina

182 ethyltransferase activity of MEPCE through a C-terminal MEPCE interaction domain (MID).

183 e dominant activity during the N-terminal to C-terminal metamorphosis of FPPase to CPPase, with produ

184 the molecular basis of interactions with the C-terminal MF domain (CMF) of these myosins remains poor

185 Furthermore, it is shown that this type of C-terminal modification may be combined with a second pe

186 rization of HKRD and the interaction between C-terminal module and PIF3, abrogates PHYB nuclear accum

187 Here we show that the C-terminal module of Arabidopsis phytochrome B (PHYB) is

188 we observed that the N-terminal, but not the C-terminal, moiety of MF6p/HDMs has a predicted structur

189 and that the use of allosterically regulated C-terminal motifs could be a common mechanism for PilZ a

190 These adaptors bind cargo via a C-terminal mu-homology domain (muHD); however, few cargo

191 d N-terminal nuclear localization signal and C-terminal nuclear export signal (NES).

192 embryonic stem cells and is dependent on the C-terminal nuclear matrix anchor domain of CIZ1 and the

193 id substitution in the catalytic site of the C-terminal nucleotide binding domain restored proper pro

194 ace between the transmembrane domain and the C-terminal nucleotide binding domain.

195 moval from neurotoxin precursors by cleavage C-terminal of the PQM.

196 ein partners interact via association of the C-terminal or transmembrane segments, with consequences

197 Mutation of the start codon of two C-terminal ORFs in an infectious clone reduced virus yie

198 The C-terminal pair of BRCT domains in Brc1 were previously

199 ficant variability in the orientation of the C-terminal part of the molecule, the region expected to

200 show that a 49-mer peptide derived from the C-terminal part of the Phe521Leufs chain is deposited as

201 at the UbiK protein forms a complex with the C-terminal part of UbiJ, another UQ biogenesis factor we

202 resent study using antibodies against N- and C-terminal parts of human melanopsin, confocal microscop

203 E3 was impaired in both the internal and the C-terminal PBM mutations.

204 th CRIP1a, but that a phosphorylated central C-terminal peptide competed for association with beta-ar

205 crystal structure of this TPR domain with a C-terminal peptide derived from Ssa1, which suggests how

206 cid replacements on lipid association of the C-terminal peptide fully recapitulated their effects on

207 ave solved its structure in complex with the C-terminal peptide of Ku80 at 4.3 angstrom resolution us

208 stin 1, and phosphorylated central or distal C-terminal peptides competed for association with beta-a

209 omplexes demonstrated that central or distal C-terminal peptides competed for the CB1R association wi

210 A C-terminal peripheral modification, introducing a quater

211 Here, we show that C-terminal phosphorylation of melanopsin determines the

212 of a virally encoded melanopsin lacking all C-terminal phosphorylation sites (C terminus phosphonull

213 an N-terminal acetyltransferase domain and a C-terminal phosphotransferase domain that can act synerg

214 ple is the bacterial adhesin FimH, where the C-terminal pilin domain exerts negative allosteric contr

215 as the region encompassing the N-terminal to C-terminal pleckstrin homology domains (PHn-PHc), are au

216 f prefibrillar oligomers, whereas adding the C-terminal polyproline sequence ([Formula: see text]) in

217 ge cytoplasmic N-terminal domain and smaller C-terminal pore-forming domain comprising six transmembr

218 The C-terminal portion of Aap contains a 135-aa-long, prolin

219 Here we present the crystal structure of the C-terminal portion of human POT1 (POT1C) complexed with

220 The conserved C-terminal portion of the peptide is biochemically stabl

221 ding site for potentiating betaEST is in the C-terminal (post-M4) region of the alpha4 subunit.

222 yl methyltransferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and

223 alNAc-Ts exhibit unique long-range N- and/or C-terminal prior glycosylation (GalNAc-O-Ser/Thr) prefer

224 nkyrin repeats of TRPA1 directly bind to the C-terminal proline-rich motif of FGFR2 inducing the cons

225 e phosphorylation of residues in alpha1C and C-terminal proteolytic cleavage of the alpha1C subunit.

226 idines cationic, unambiguously demonstrating C-terminal protonation of H37 in the mutant.

227 uced splice-site mutation that truncates the C-terminal region (CTR) domain of RELN protein and displ

228 ue because it did not seem to contain a RecQ C-terminal region (RQC) found in the other RecQ paralogu

229 n angiosperms and possess a highly conserved C-terminal region containing linear motifs (CKII-acidic,

230 The C-terminal region contains the catalytic glucosyltransfe

231 We demonstrate here that a yeast-specific C-terminal region from Pat1 interacts with several short

232 nding question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA-SP1), wh

233 ne mAb designated 2E8 does not recognize the C-terminal region of DENV NS1 in which host-cross-reacti

234 potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding reg

235 2' sugar modifications and revealed that the C-terminal region of FUS is sufficient to retain ASOs in

236 We have identified a C-terminal region of MTBP (the CTM domain) that binds ef

237 indicates that dramatic rearrangement of the C-terminal region of Nop15 in the pre-ribosome exposes t

238 The interaction occurred through the C-terminal region of RING1B (C-RING1B), with an affinity

239 Additionally, the C-terminal region of the linker forms previously unrepor

240 eractions of the central part of Tm with the C-terminal region of TnI.

241 Our results show that the C-terminal region of TPX2 regulates Kif15 in vitro, cont

242 a cyclin F-specific amino acid motif in the C-terminal region of Vif indicated rescue of the protein

243 ucine-rich motifs (HLMs), spread in the long C-terminal region of yeast Dcp2 decapping enzyme.

244 with deletion of residues 338 to 347 in the C-terminal region, has been an enigma, because the basis

245 a function for other amino acids within this C-terminal region.

246 ities are indirectly regulated by the N- and C-terminal regions flanking the FH1-FH2 domains.

247 tramolecular interactions between the N- and C-terminal regions of alpha-Syn, resulting in the protei

248 hat are localized within and adjacent to the C-terminal regions of each homodimer.

249 nvestigated the specific roles of the N- and C-terminal regions of SS4 by expressing truncated versio

250 in electrophoretic mobility originate in the C-terminal regions of the gamma-tubulins.

251 and B, located on opposite sides of the SczA C-terminal regulatory domain.

252 AD alpha-helix but retaining the most distal C-terminal residues exhibited robust rhythms during the

253 rotofibrils pseudo-equilibrium extend to the C-terminal residues in the Abeta(1-42) isoform but not i

254 s on the formation of hydrogen bonds between C-terminal residues of lentil peptides and residues of t

255 Sec72, even though it lacks the TPR-binding C-terminal residues of Ssa1.

256 that can be attributed to the two additional C-terminal residues that Abeta40 lacks.

257 e insights simpler substrates with only five C-terminal residues were designed, allowing the enzyme t

258 inding partners are each fused to orthogonal C-terminal RNAPs (RNAPC).

259 grin-activating domain and ABD1, whereas the C-terminal rod contains the actin-anchoring ABD2 and ABD

260 d by the SCI's B and C domains encircles the C-terminal segment of the IR alpha-subunit.

261 to an aromatic motif (i.e., pyrene) at their C-terminal, self-assemble to form beta-sheet like struct

262 APOL1 harbors C-terminal sequence variants (G1 and G2), which account

263 pecifically recognize a four-amino acid CAAX C-terminal sequence within their substrates.

264 ZF region; however, a specific role for the C-terminal set of five ZFs remains to be elucidated.

265 ed uptake of tau species, whereas the distal C-terminal-specific antibody (Tau46) had little effect.

266 opioid receptor gene OPRM1 creates multiple C-terminal splice variants.

267 Effects of N-terminal and C-terminal STIM1 antibodies on TRPC1-based SOCs and STIM

268 merase component, which contains a conserved C-terminal structural loop, preferentially binds to and

269 rminal nucleotide-binding domain (NBD) and a C-terminal substrate-binding domain (SBD), which are tet

270 This C-terminal tail displays the binding site for partner pr

271 olved the high-resolution structure of DISC1 C-terminal tail in complex with its binding domain of Nd

272 plained by the lack of an acidic, disordered C-terminal tail in human mtSSB protein.

273 ersely, the interaction of RecQ with the SSB C-terminal tail increases the on-rate of RecQ-DNA bindin

274 We show that the TubZ C-terminal tail is an unstructured domain that fulfills

275 uencing revealed a partial truncation in the C-terminal tail of Env that had emerged in the sort; how

276 In addition, Gbetagamma interacts with the C-terminal tail of GPR124 and promotes the formation of

277 te with Lck in cells and dephosphorylate the C-terminal tail of Lck, which prevents its adoption of a

278 ed by hyperphosphorylation of the inhibitory C-terminal tail of Lck.

279 A lysine residue (Lys(1112)) at the C-terminal tail of mGluR1 (a member of the group I mGluR

280 of naturally occurring protease sites in the C-terminal tail of SUMO proteins.

281 the SAM-binding site, whereas the conserved C-terminal tail of the second monomer provides residues

282 merization and reveal a critical role of the C-terminal tail region of IN in higher order oligomeriza

283 esses a unique, structurally uncharacterized C-terminal tail that plays an important role in autophos

284 rs that contained only one tyrosine in their C-terminal tail.

285 ted to extend the Ser65 loop and shorten the C-terminal tail.

286 tor phosphorylation, often at the receptor's C-terminal tail.

287 s, suppression of bone turnover (assessed by C-terminal telopeptide levels).

288 erminal region comprising the LisH and CTLH (C-terminal to LisH) domains and a newly identified third

289 ses trypsin to enzymatically cleave proteins C-terminal to lysine and arginine residues prior to LCMS

290 ng depends on the presence of Lys274 that is C-terminal to RRM3 and binding to equivalent DNA sequenc

291 By expressing the target protein with SpyTag C-terminal to the SrtA recognition motif, it can be cova

292 g decreased hypoxic activation of HIF-1alpha C-terminal transactivation domain (C-TAD), but not HIF-1

293 We found different levels of C-terminal truncation, soluble protein aggregates, and g

294 Using a series of C-terminal truncations, we show that the CSPG4-binding s

295 talyzes the oxidative decarboxylation of the C-terminal Tyr of the substrate peptide MftA in a reacti

296 talyzes the oxidative decarboxylation of the C-terminal tyrosine (Tyr-30) on the mycofactocin precurs

297 sured by Elmo phosphorylation on a conserved C-terminal tyrosine residue.

298 Remarkably, we found that the C-terminal VxPx motif, required for efficient enrichment

299 ion of HLTF, by directly loading it onto the C-terminal WD40 domain of DCAF1 in complex with the CRL4

300 se questions, constructs containing either a C-terminal wild-type GPI anchor signal sequence or a non