ライフサイエンスコーパス: C-terminal Src kinase

1 as a positive regulator of dCsk (Drosophila C-terminal Src kinase).

2 n was basally associated with c-Src and Csk (C-terminal Src kinase), a negative regulator of Src acti

3 Csk (C-terminal Src kinase), a protein tyrosine kinase, consi

4 ns in Src phosphorylation and recruitment of C-terminal Src kinase, a negative regulator of Src, when

5 e-phosphorylated PAG serves as an anchor for C-terminal SRC kinase, an inhibitor of SRC-family kinase

6 ly kinase negative regulatory proteins, Csk (C-terminal Src kinase), and its transmembrane adaptor, C

7 domain-containing phosphatase-1 (Shp-1) and C-terminal Src kinase, and we use modeling of early TCR

8 Immunolocalization with a C-terminal SRC kinase antibody, which recognizes several

9 This variant exhibits a 50% decrease in C-terminal Src kinase binding affinity and contributes t

10 ing the second phosphorylation event include C-terminal Src kinase (Csk) and Bruton's tyrosine kinase

11 one or both of two known inhibitors of Lck, C-terminal Src kinase (Csk) and protein tyrosine phospha

12 ynamically controlled by the tyrosine kinase C-terminal Src kinase (CSK) and the tyrosine phosphatase

13 hown by inhibition through overexpression of C-terminal Src kinase (Csk) and transdominant negative S

14 We identified C-terminal Src kinase (Csk) as a tyrosine kinase respons

15 study, we assessed the cooperative roles of C-terminal Src kinase (Csk) binding protein (Cbp) and Ca

16 C-terminal Src kinase (Csk) binds to tyrosine phosphoryl

17 The C-terminal Src kinase (Csk) contains a catalytic domain

18 C-terminal Src kinase (Csk) contains a catalytic domain

19 C-terminal Src kinase (Csk) encodes a critical negative

20 The C-terminal Src kinase (Csk) family of protein tyrosine k

21 d that the IGF-IR and IR associated with the C-terminal Src kinase (CSK) following ligand stimulation

22 he crystal structure of the kinase domain of C-terminal Src kinase (CSK) has been determined by molec

23 C-terminal Src kinase (Csk) is a multidomain tyrosine ki

24 The C-terminal Src Kinase (Csk) is a potent inhibitor of Src

25 C-terminal Src kinase (Csk) is a PTK that specifically p

26 C-terminal Src kinase (Csk) phosphorylates and down-regu

27 The C-terminal Src kinase (Csk) phosphorylates and down-regu

28 ras, activation of c-Src through deletion of C-terminal Src kinase (CSK) results in the development o

29 C-terminal Src kinase (Csk) specifically phosphorylates

30 Downregulation of Src family kinases by the C-terminal Src kinase (Csk) suppressed Btk* activation a

31 Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.

32 slocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src

33 xamates as metal-mediated inhibitors against C-terminal Src kinase (Csk), a protein tyrosine kinase.

34 Here we report that C-terminal Src kinase (Csk), a tyrosine kinase that nega

35 that regulate LCK homeostasis, such as CD45, C-terminal Src kinase (CSK), and c-Cbl, in lipid raft do

36 The Src inhibitor, PP2, the C-terminal Src kinase (Csk), and dominant-negative Pyk2

37 The C-terminal Src kinase (Csk), the primary negative regula

38 LLCPKcl4 with an expression construct of the C-terminal Src kinase (CSK), which inhibits Src family k

39 n and are under the principal control of the C-terminal Src Kinase (Csk).

40 on of the SFKs and their negative regulator, C-terminal Src kinase (Csk).

41 on of its C-terminal tail by another kinase, C-terminal Src kinase (Csk).

42 us (Tyr 527 in c-Src), which is catalyzed by C-terminal Src Kinase (Csk).

43 hosphorylation of their C-terminal region by C-terminal Src kinase (Csk).

44 pha receptor-associated factor 2 (TRAF2) and C-terminal Src kinase (Csk).

45 he C terminus of the protein tyrosine kinase C-terminal Src kinase (Csk).

46 ecific interaction between the SH3 domain of C-terminal Src kinase (Csk-SH3) and a proline-rich pepti

47 trate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging

48 The SH2 domain of the C-terminal Src kinase [Csk] contains a unique disulfide

49 lated and subsequently down-regulated by the C-terminal Src kinase, Csk.

50 The Drosophila C-terminal Src kinase (d-Csk) is a genetic modifier of w

51 Mutations in the Drosophila homolog of C-terminal Src kinase (dcsk) were identified as dominant

52 se inhibitor PP2 and the negative regulatory C-terminal Src kinase in GT1-7 cells but not in HEK293 c

53 the aliphatic residues central to the Ptpn22-C-terminal Src kinase interaction.

54 L:OX40 interaction led to the recruitment of C-terminal src kinase into lipid rafts, causing a prefer

55 Csk (C-terminal Src kinase) is a protein tyrosine kinase that

56 Csk (C-terminal Src kinase) is a protein tyrosine kinase that

57 Csk (C-terminal Src kinase) is a protein tyrosine kinase whic

58 al cell adhesion and migration by activating C-terminal Src kinase, leading to inhibition of pp60Src.

59 Transient expression of plasmids containing C-terminal Src kinase or kinase-deficient dominant-negat

60 ring of an inhibitory protein kinase A (PKA)-C-terminal Src kinase pathway assembled in lipid rafts.

61 Further, DCsk (the Drosophila homolog of the C-terminal Src kinase) phosphorylates and interacts gene

62 nhibits TCR-mediated signaling by recruiting C-terminal Src kinase to the membrane and/or receptor co

63 -receptor tyrosine kinases-Abl via pY251 and C-terminal Src kinase via pY239.

64 of SFK activation: release of inhibition by C-terminal Src kinase, weakening of the inhibitory intra

65 culate that the protein-tyrosine kinase Csk (C-terminal Src kinase), which is also activated by Galph