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1 t ion-permeation properties are conferred by C-terminal region.
2 y of the amino acid changes occurring in the C-terminal region.
3 ptor, CdiA delivers a toxin derived from its C-terminal region.
4 ion range, and are partly conferred by WRN's C-terminal region.
5 nding site to the conformationally malleable C-terminal region.
6 ontains a tryptophan-rich (TR) domain in the C-terminal region.
7 ng at the N terminus propagates to the ATP7B C-terminal region.
8 bohydrate binding module (CBM) followed by a C-terminal region.
9 E activation within the switch regions and a C-terminal region.
10 to force owing to the high stability of the C-terminal region.
11 a function for other amino acids within this C-terminal region.
12 of MBD1-c but HDAC3 preferably bound to the C-terminal region.
13 causes an increase of the flexibility of the C-terminal region.
14 n the N-terminal region and the other in the C-terminal region.
15 posure of a hydrophobic motif located at the C-terminal region.
16 ys similarities to gp18-like proteins in its C-terminal region.
17 ich Sec insertion is normally limited to the C-terminal region.
18 mains, a DNA-binding homeodomain (HD), and a C-terminal region.
19 in-binding sequence (CBS) located within its C-terminal region.
20 o conserved cysteine residues located in the C-terminal region.
21 gh mediating the local unfolding of the Mad2 C-terminal region.
22 d state, with structure apparent only in the C-terminal region.
23 he reported functional regulation of the p53 C-terminal region.
24 region and residues 30-36 (AIIGLMV) from the C-terminal region.
25 regions of Abeta: the central region and the C-terminal region.
26 uggesting enhanced local cleavage of the CgA C-terminal region.
27 rming a catalytic domain and extended N- and C-terminal regions.
28 with Titin truncations in the N-terminal and C-terminal regions.
29 are involved in RAD51 interaction via their C-terminal regions.
30 BC-ATPase fold embedded between novel N- and C-terminal regions.
31 ger composite NC domain formed by the N- and C-terminal regions.
32 erwise highly divergent nature of the N- and C-terminal regions.
33 n complex with a segment of their respective C-terminal regions.
34 N-terminal domain of sigma(B) via its N- and C-terminal regions.
35 on was likely affected by its N-terminal and C-terminal regions.
36 rent dynamic interactions involving loop and C-terminal regions.
38 ays a previously unrecognized element in its C-terminal region, a 'gatekeeper' helix, which extends o
39 In the Ca(2+)/NCS-1.D2R peptide complex, the C-terminal region adopts a 310 helix-turn-310 helix, whe
42 e present study, we identified a NiV-G stalk C-terminal region (amino acids 159 to 163) that is impor
43 sensor that detects RNA viruses through its C-terminal region and activates the production of antivi
45 hen constructed two deletion mutants lacking C-terminal regions and mutants with point mutations of t
46 unique arrangement of the CBS domains in the C-terminal region, and propose how they interact with th
47 of PINK1, including the architecture of the C-terminal region, and reveals how the N lobe of PINK1 b
48 ch to ECL2 established the importance of its C-terminal region, and site-directed mutagenesis of each
49 AF2 binds to multiple motifs within the TAF8 C-terminal region, and these interactions dictate TAF2 i
50 , palm, and thumb subdomains), a hydrophobic C-terminal region, and two magnesium ions coordinated in
51 All mutants contained the essential N- and C-terminal regions, and as expected, all maintained the
52 wo Plus-C proteins localizes in their N- and C-terminal regions, and their concerted conformational c
53 sing truncated MeCP2 lacking both the N- and C-terminal regions (approximately half of the native pro
54 ent selection pressures acting on the N- and C-terminal regions are consistent with their protein str
55 ed type-III effector AvrRps4; however, their C-terminal regions are dissimilar, indicating that they
56 ia the IgA-binding region but rather via the C-terminal region, as demonstrated by flow cytometry.
57 r report the crystal structure of the MMADHC C-terminal region at 2.2 A resolution, revealing a modif
58 ates of Cdk5, which phosphorylates it in its C-terminal region at Ser(549) (site 6) and Ser(551) (sit
60 ues in the vicinity of the pocket and in the C-terminal region at the dimeric interface exhibits pert
61 to attach to mitotic chromosomes, while the C-terminal region binds TR DNA and also associates with
62 1-mediated retroviral silencing requires the C-terminal region, but not the enzymatic activity, of th
63 -607 and SmgGDS-558 directly bind the GTPase C-terminal region, but the specificity of the SmgGDS spl
65 putative transmembrane domain [TM], and the C-terminal region [C]) were obtained commercially and va
67 epsin B cleaved chemokines especially in the C-terminal region, cathepsins K, L, and S cleaved chemok
71 ion to binding to the thick filament via its C-terminal region, cMyBP-C can also interact with actin
73 f low complexity and unknown function, and a C-terminal region composed of five SH3b peptidoglycan (P
74 ealing a pilin-like protein with an extended C-terminal region composed of two discrete domains conne
76 n angiosperms and possess a highly conserved C-terminal region containing linear motifs (CKII-acidic,
79 CC MBS (localized within and adjacent to the C-terminal region) contributing to the dimer-dimer inter
80 uced splice-site mutation that truncates the C-terminal region (CTR) domain of RELN protein and displ
81 A new Reln mutant with a truncation of the C-terminal region (CTR) domain shows that Reln mutation
84 exhibits shifts in cytoplasmic loops and the C-terminal region (CTR) to occlude the cytoplasmic exit
85 of commonality in the function of the N- and C-terminal regions during the mechanochemical cycle of a
86 horylation of Ngn2 occurs in both the N- and C-terminal regions, either side of the conserved basic H
90 ctivity and generated fragments (lacking the C-terminal region) endowed of potent proangiogenic activ
94 We demonstrate here that a yeast-specific C-terminal region from Pat1 interacts with several short
95 lar dichroism of the isolated CBM, and a CBM-C-terminal region fusion revealed folded domains dominat
96 tutions in the conserved helix alpha6 of the C-terminal region generated Spx substrates that were deg
97 The present article shows that the WDR62 C-terminal region harbors a novel dimerization domain co
99 nuclear localization of PA-X mediated by its C-terminal region has a significant impact on shutoff ac
100 erase and methyltransferase (MTase), and the C-terminal region has the polymerase (POL), all of which
101 with deletion of residues 338 to 347 in the C-terminal region, has been an enigma, because the basis
102 scopy assays indicated that the Rec10 N- and C-terminal regions have complex interactions with Rec25.
105 ed on the crystal structures of the p25 (p35 C-terminal region including AD)-Cdk5 complex, we simulat
106 has some severing activity, addition of the C-terminal region increases severing potency by 40-fold,
108 nt forms an intricate closed ring, while the C-terminal region is a more regular, superhelical struct
110 We propose that the flexible nature of the C-terminal region is essential to allow it to modulate i
111 h kinase-mediated phosphorylation within the C-terminal region is inhibitory and regulates catalytic
112 lization, it has also been reported that the C-terminal region is involved in p130Cas FA targeting.
115 odimers linked to DNA-PKcs via flexible Ku80 C-terminal regions (Ku80CTR) in a complex stabilized thr
116 of nucleocapsid borne NP and display of the C-terminal region likely serves as a bountiful affinity
117 n against hydrogen/deuterium exchange in the C-terminal region near the N-glycan sites, suggesting th
119 Abeta and residues 30-36 (AIIGLMV) from the C-terminal region of Abeta assemble to form homotetramer
123 e increased conformational distortion at the C-terminal region of alphaF helix containing 110-114 res
124 igate the interaction between the disordered C-terminal region of Artemis and the DNA binding domain
127 he structural pocket proximal to S184 in the C-terminal region of Bax, directly activating its proapo
129 from synthetic peptides corresponding to the C-terminal region of beta3-tubulin, whereas cytosolic ca
130 dies identified phosphorylation sites in the C-terminal region of BRM at SnRK2 target sites that are
131 hat the barrel partially opens, allowing the C-terminal region of BSSalpha that houses the glycyl rad
132 MAD-1 coiled-coil segment interacted with a C-terminal region of BUB-1 that contains its kinase doma
133 nding question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA-SP1), wh
135 -binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferent
137 fied and conserved Sufu-binding motif in the C-terminal region of Ci/Gli and provides mechanistic ins
141 dies showed the existence of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1)
142 ne mAb designated 2E8 does not recognize the C-terminal region of DENV NS1 in which host-cross-reacti
143 potentially harmful events, we replaced the C-terminal region of DENV NS1 with the corresponding reg
146 and structural approaches, we find that the C-terminal region of DRC2 is critical for the coassembly
150 ance and suggests that this highly conserved C-terminal region of ferlins represents a functionally s
153 was identified around residue Ser-250 in the C-terminal region of FtsQ and a membrane-proximal intera
154 which efficiently competes with ZipA for the C-terminal region of FtsZ, a central hub for multiple in
155 2' sugar modifications and revealed that the C-terminal region of FUS is sufficient to retain ASOs in
163 an E3 ubiquitin ligase, interacted with the C-terminal region of HSPA5 and mediated HSPA5 ubiquitina
164 ial nuclear localization signal (NLS) in the C-terminal region of I2 (PP2A) containing a conserved ba
167 ap the RNA chaperone domain (RCD) within the C-terminal region of La in close proximity to a novel AK
168 cal assays and mutagenesis indicate that the C-terminal region of LcrG (residues 52-73) is important
169 f Ly49B, demonstrating unexpectedly that the C-terminal region of Ly49s can play a significant role i
172 itulated in a strain lacking only the unique C-terminal region of MceG, suggesting an important funct
173 glutamate-rich protein fused in frame to the C-terminal region of merozoite surface protein 3 (MSP3).
174 n, and to a 25-residue-long peptide from the C-terminal region of MG491 by surface plasmon resonance
175 inds via its substrate-binding domain to the C-terminal region of MRTF-A and that CCTepsilon is able
177 cture of MtTOP1 by first predicting that the C-terminal region of MtTOP1 contains four repeated domai
178 region of MUC5B (D1-D2-D'-D3 domains, NT5B), C-terminal region of MUC5B (D4-B-C-CK domains, CT5B) and
180 proteolytic product p22-FLIP all require the C-terminal region of NEMO/IKKgamma (amino acids 272-419)
181 indicates that dramatic rearrangement of the C-terminal region of Nop15 in the pre-ribosome exposes t
182 n of human FLASH and YARP interacts with the C-terminal region of NPAT and that this interaction is e
185 Antibody binding studies revealed that the C-terminal region of one of the two b subunits is princi
188 full-length p17 demonstrating that the final C-terminal region of p17 is irrelevant for the protein's
191 ever, the N-terminal region of pp150 and the C-terminal region of pUL96, which are critical for these
192 he RbpA-sigma interaction is mediated by the C-terminal region of RbpA and sigma domain 2, and S. coe
194 the central part of M-Tha, and the specific C-terminal region of RelAp43 are required for this inter
196 tingly, the Walker A motif is located in the C-terminal region of RNase R, whereas the Walker B motif
197 nd identify an 18 amino acid sequence in the C-terminal region of S2 -SLF1 (SLF1 of S2 haplotype) tha
201 ture-function analysis demonstrates that the C-terminal region of TACC2 is both necessary and suffici
204 he MORF-MORF protein connections require the C-terminal region of the central conserved MORF box.
205 is proposed to be its active state, but the C-terminal region of the enzyme adopts a distinct confor
206 ibrinogen induced a structural change in the C-terminal region of the fibrinogen beta-chain (beta384-
207 lasia (mes) mice harbour a truncation in the C-terminal region of the Hh-ligand receptor, Patched-1 (
212 ring the parasite's hepatic replication, the C-terminal region of the parasitic PV membrane protein e
213 atory mechanism does not require the diverse C-terminal region of the PilA pilins but specifically in
215 y the presence of distinct insertions at the C-terminal region of the protein responsible for a struc
216 static interaction of the positively charged C-terminal region of the protein with a negatively charg
220 a small conformational change induced in the C-terminal region of the tetratricopeptide repeat (TPR)
222 IgG that targets amino acid residues in the C-terminal region of the V3 loop crown, suggesting the i
229 nserved catalytic site was identified in the C-terminal region of TRP120, and TRP120 autoubiquitinati
230 a cyclin F-specific amino acid motif in the C-terminal region of Vif indicated rescue of the protein
232 that synthetic peptides corresponding to the C-terminal region of wt-MoaA rescue the GTP 3',8-cyclase
235 These studies show that the central and C-terminal regions of Abeta can preferentially segregate
237 ins the two surfaces to which the apical and C-terminal regions of AgI/II noncompetitively adhere.
238 termolecular interactions between the N- and C-terminal regions of alpha-syn play critical roles in m
239 tramolecular interactions between the N- and C-terminal regions of alpha-Syn, resulting in the protei
242 the FG/GLFG region of Nup98 binds to N- and C-terminal regions of DHX9 in an RNA facilitated manner.
245 e N-terminal THAP DNA binding domain and the C-terminal regions of human THAP9 can also mobilize Dros
246 ion assays suggested that the N-terminal and C-terminal regions of ICP4 cooperate to mediate gene exp
249 this autoinhibition and that both the N- and C-terminal regions of Rhp26 are needed for its proper fu
250 nvestigated the specific roles of the N- and C-terminal regions of SS4 by expressing truncated versio
251 bly of peptides derived from the central and C-terminal regions of the beta-amyloid peptide (Abeta).
252 study the insertion capacity of hydrophobic C-terminal regions of the BH3-only proteins Bik, Bim, No
255 sue of the JCI, Xu et al. show that specific C-terminal regions of the MOR can modulate side effects
258 ho and ERK pathways, with the N-terminal and C-terminal regions of the receptor playing key roles in
259 fluences interactions between N-terminal and C-terminal regions of the subdomain that are important i
261 ted peptides with sequences derived from the C-terminal regions of two LsbB-related bacteriocins inhi
262 ion inhibitory element when expressed at the C-terminal regions of ubiquitin-dependent and -independe
263 The crystal structure of the 341-residue C-terminal region outlines a unique architecture; in vit
264 NuMA localization to minus-ends involves a C-terminal region outside NuMA's canonical microtubule-b
266 hat the first 15 residues of the PA-X unique C-terminal region play a critical role in shutoff activi
268 c) and lower levels of fragments lacking the C-terminal region (proangiogenic) are present in circula
269 onent of PIPn regulation that depends on the C-terminal region rather than the nearby N-terminal regi
272 omprises the capsid assembly domain, and the C-terminal region (residues 150-183) is responsible for
273 Deletion mapping studies showed that the C-terminal region (residues 54-64) is required for the a
275 ue because it did not seem to contain a RecQ C-terminal region (RQC) found in the other RecQ paralogu
276 but not isoform3 (i3) which shares a common C-terminal region, suppresses these malignant properties
277 ement of an N-terminal region and a proximal C-terminal region that comprises multiple cholesterol re
278 erminus, a hydrophobic core and a more polar C-terminal region that contains the cleavage site for th
279 ely dynamic region and a structured, helical C-terminal region that encompasses a membrane associated
280 s a stretch of hydrophobic residues from the C-terminal region that form a hydrophobic cleft, an adja
281 in the RNase III domain, and two were in the C-terminal region that has no homology to known motifs.
282 HCMV fusion factor has a Cys residue in the C-terminal region that is palmitoylated and mediates met
284 g a role of membrane anchor, an unstructured C-terminal region that is weakly associated with the mem
285 s experiments we identified a portion of the C-terminal region that mediates toxin binding to mammali
286 n into fragments containing the endorepellin C-terminal region that regulate angiogenesis and matrix
287 at SCR contains an amino acid segment at the C-terminal region that shows a remarkable affinity for c
289 pke in vivo and in vitro, whereas a separate C-terminal region was required for Sstn localization to
291 crassus TR restricted Sec insertion into the C-terminal region, whereas the 3'-UTR of TR3 conferred u
292 ponsible for periodontitis, cleaved the MUC2 C-terminal region, whereas the N-terminal region was una
293 pe G nsLTPs (LTPGs) have a GPI-anchor in the C-terminal region which attaches the protein to the exte
295 ficant conformational variations of the KaiB C-terminal region, which is functionally important in ma
296 ths detected using mAbs against the head and C-terminal regions, which are widely separated in the te
297 e find that deleting residues 623-641 of the C-terminal region, while retaining the IEEVD motif, caus
299 amide shifts are localized mostly to N- and C-terminal regions within the rigid beta structure in th
300 eta42, only differ by two amino acids in the C-terminal region, yet they display markedly different a
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