ライフサイエンスコーパス: C. elegans

1 C. elegans acclimated to 7% O2 are aroused by CO2 and re

2 C. elegans and other nematodes were attracted to volatil

3 C. elegans could therefore be exploited as a whole-anima

4 C. elegans Girdin also regulates localization of the api

5 C. elegans memorizes a nutrient-associated cultivation t

6 C. elegans Notch signaling maintains a pool of germline

7 ntified the product of the gene C41C4.1 as a C. elegans CS-sulfotransferase and renamed it chst-1 (Ca

8 We have generated a C. elegans model that mirrors this progression and allow

9 to the rescue of the disease phenotype in a C. elegans model of Parkinson's disease.

10 , we conducted a forward genetic screen in a C. elegans model of polyglutamine aggregation and identi

11 DDC bas-1 reduced tau-induced toxicity in a C. elegans model of tauopathy, while loss of no other do

12 Examination of a C. elegans motor neuron revealed how age, MT-associated

13 alcium channels are critical regulators of a C. elegans serotonergic circuit and demonstrate a mechan

14 riction mimetics are mainly effective across C. elegans strains, indicating species and strain-specif

15 orphologies of sensory neuron cilia in adult C. elegans hermaphrodites at high resolution.

16 Specifically, TCS exposure affected C. elegans survival and hMSC proliferation in a dose-dep

17 es may provide survival benefits by allowing C. elegans to temporarily utilize food that is tainted w

18 ttern selectivity varies significantly among C. elegans wild isolates.

19 ens in human cell culture and Drosophila and C. elegans models.

20 f netrin receptors, Unc5H2 (Unc-5 homolog B, C. elegans) and DCC (deleted in colorectal carcinoma), w

21 evidence for a pheromone signal produced by C. elegans larvae that modifies the behaviour of adult a

22 Here we describe an evolutionarily conserved C. elegans protein, VPS-50, that is required for animals

23 pan of wild-type, but not Sir-2.1-deficient, C. elegans.

24 iour is conspecific and pheromone dependent: C. elegans adults respond more strongly to C. elegans la

25 Using two different C. elegans developmental phenotypes, body length and sex

26 It tests a slimmed-down C. elegans tissue ontology for enrichment of specific te

27 phenomena governing cellular behavior during C. elegans larval development.

28 K20me1 on hermaphrodite X chromosomes during C. elegans dosage compensation and demonstrated H4K20me1

29 silicone O-rings to control exposure during C. elegans toxicity testing and compared the results to

30 ganization occurs at the 8-cell stage during C. elegans embryogenesis.

31 lowing us to predict the involvement of each C. elegans neuron in locomotor behaviours.

32 ntact-mediated division orientation in early C. elegans embryos suggesting functional conservation be

33 In early C. elegans embryos the timing of cell division is both i

34 omography of whole mitotic spindles in early C. elegans embryos with live-cell imaging to reconstruct

35 ll culture, and in a Caenorhabditis elegans (C. elegans) infection model.

36 The nematode worm Caenorhabditis elegans (C. elegans) is a versatile and widely used animal model

37 Using the Caenorhabditis elegans (C. elegans) model, various studies have elucidated the r

38 Two papers in Cell exploit C. elegans to infer anticancer drug mechanisms.

39 report the surprising finding that exposing C. elegans to low doses of H2O2 promotes, rather than co

40 tion of plasticity, we ectopically expressed C. elegans CHE-1, a terminal selector of ASE sensory neu

41 AS-expressing C. elegans fed on curli-producing bacteria also had enha

42 pts from five other species (Zebrafish, Fly, C. elegans, Rat, and Sheep).

43 wever, when provided with high-quality food, C. elegans become sated and enter quiescence.

44 bacteria, the major source of nutrients for C. elegans, remain poorly characterized.

45 he first electrophysiological phenotypes for C. elegans models for amyotrophic lateral sclerosis and

46 nalyses to identify the pathway required for C. elegans to detect proteasome dysfunction and activate

47 Our study provides a unique resource for C. elegans, a system in which the prevalence and importa

48 l community formation and suggest a role for C. elegans as a model system for ecology of host-associa

49 In a genetic screen for C. elegans mutants with defects in dopaminergic head neu

50 We screened for C. elegans mutants in which the presumptive mesoderm-der

51 device, we obtain cell-cycle statistics for C. elegans vulval development, a paradigm for organogene

52 We adapted DNase-seq to nuclei isolated from C. elegans embryos and L1 arrest larvae to generate high

53 ct specific miRNAs present in total RNA from C. elegans and pRNAs in total RNA from bacteria.

54 However, C. elegans is not used as extensively as other model org

55 In C. elegans mutants lacking unc-75 or its targets, regene

56 In C. elegans neurons, orthologues of LRRK2 and RAB7L1 act

57 In C. elegans the CELF (CUGBP and Etr-3 Like Factor) family

58 In C. elegans, capable of recognising toxic assemblies of a

59 In C. elegans, indole induces a gene expression profile in

60 In C. elegans, males and hermaphrodites secrete similar ble

61 In C. elegans, post-synaptic Neurexin (NRX-1) and pre-synap

62 In C. elegans, several ankyrin isoforms are produced from t

63 In C. elegans, sexual dimorphism in gonad form and function

64 In C. elegans, we show that ERG-28, an endoplasmic reticulu

65 acking the nanos homologs nos-1 and nos-2 in C. elegans.

66 ematode species and this effect is absent in C. elegans daf-22 larvae which are pheromone deficient.

67 agic activity normally decreases with age in C. elegans, whereas daf-2 and glp-1 long-lived mutants r

68 that influence dauer formation and aging in C. elegans, we utilized the individual gene deletion mut

69 promote the identification of ascarosides in C. elegans and other nematodes.

70 required for ventral nerve cord assembly in C. elegans.

71 behavioural response to food availability in C. elegans.

72 and facilitate decision-making behaviors in C. elegans.

73 ed a nicotinic receptor induced behaviour in C. elegans and increased locomotor activity levels when

74 lates parental-offspring social behaviour in C. elegans and that this provides evidence for evolution

75 olar localization of the other components in C. elegans and in humans.

76 as a subset of neuropeptide connections, in C. elegans based on new and published gene expression da

77 Taking advantage of known connectivity in C. elegans, we identified and studied cell adhesion gene

78 hat promotes clearance of cellular debris in C. elegans, Drosophila and mammals.

79 in particular modified lipid desaturation in C. elegans, revealed by hyperspectral coherent anti-Stok

80 k loop triggered by crossover designation in C. elegans.

81 Since sex determination in C. elegans requires zygotic gene expression to read the

82 abolism to elicit their cytotoxic effects in C. elegans rather than by thymineless death or DNA damag

83 etabolism genes that affect drug efficacy in C. elegans.

84 of ADR-2, the only A-to-I editing enzyme in C. elegans, on the neural transcriptome.

85 L) that robustly controls gene expression in C. elegans from 15 to 25 degrees C.

86 itochondria after embryonic fertilization in C. elegans.

87 gs highlight that studying BPL-1 function in C. elegans could help dissect the roles of this importan

88 isingly, in the absence of ESCRT function in C. elegans, cytokinetic abscission is delayed but can be

89 tivity of structurally related fungicides in C. elegans correlated with their rate of metabolism.

90 signalling regulates mitochondrial fusion in C. elegans, and show that mitochondrial fusion is necess

91 ocol to map the chondroitin glycoproteome in C. elegans, resulting in the identification of 15 novel

92 omatidine extends lifespan and healthspan in C. elegans, an animal model of aging which shares many m

93 nt regulators of autophagy and healthspan in C. elegans, and also modulate mammalian vascular age-ass

94 on, disruption of DKF-2A homodimerization in C. elegans intestine impaired and degraded the immune de

95 y monoamine oxidase that metabolizes 5-HT in C. elegans, and we also found that grk-2 loss-of-functio

96 ansmitter receptors previously implicated in C. elegans foraging decisions NPR-1 and TYRA-3, for NPY-

97 t, muscle tissue-tropic, lethal infection in C. elegans.

98 nisms underlying sensorimotor integration in C. elegans during olfactory steering, when the sinusoida

99 analysis of miRNA-Argonaute interactions in C. elegans and reveal a new role for miRNAs in the germl

100 e quantitative studies of muscle kinetics in C. elegans.

101 a molecular-genetic pathway governing LCD in C. elegans.

102 tant regulators of autophagy and lifespan in C. elegans, a role that may extend to the modulation of

103 ons that mediate regulation of locomotion in C. elegans.

104 Here we show that NMD mediates longevity in C. elegans strains with mutations in daf-2/insulin/insul

105 the modulation of autophagy and longevity in C. elegans with conserved effects in the murine vasculat

106 mediate the effects of PIG-1 kinase loss in C. elegans embryos.

107 ole for BMP signaling in lipid metabolism in C. elegans.

108 ectopic microtubule asters during mitosis in C. elegans zygotes or HeLa cells, respectively.

109 for daughter centrioles to become mothers in C. elegans.

110 cell-autonomous activation of the UPR(MT) in C. elegans dopaminergic neurons.

111 d use of informational suppressor mutants in C. elegans that are able to act on many genes.

112 ng to our model, 20-40% of all mutations in C. elegans wild populations are derived from programmed

113 ritical factors anchoring PLK-1 to the NE in C. elegans.

114 an optimally organized actomyosin network in C. elegans spermathecae.

115 matode prey through the olfactory neurons in C. elegans and related species.

116 m alpha-synuclein-dependent neurotoxicity in C. elegans via a mechanism that is independent of lifesp

117 ied N-glycans, especially those occurring in C. elegans, but novel enzymes can compete against chemic

118 This mechanism occurs in C. elegans, primary rat neurons, and human cells.

119 Using an associative learning paradigm in C. elegans, we investigated the effects of DR as well as

120 that rescues alpha-DC-induced pathologies in C. elegans and mammalian cells.

121 S59L) exhibit loss of function phenotypes in C. elegans genetic complementation assays and dominant n

122 Here, we addressed this problem in C. elegans.

123 laboratory, we identified a novel protein in C. elegans involved in dietary cholesterol uptake, which

124 ification of NRAP-1, an auxiliary protein in C. elegans that modulates NMDAR function.

125 l for the transduction of native proteins in C. elegans, which is based on the encapsulation of the p

126 spensable for promoting synaptic rewiring in C. elegans.

127 not an obligatory feature of feeding RNAi in C. elegans.

128 al of these proteins play important roles in C. elegans development.

129 18 in an unbiased genome-wide RNAi screen in C. elegans These two E2s have nonoverlapping biochemical

130 Through genetic screening in C. elegans, we uncover two metformin response elements:

131 on of how the variant landscape is shaped in C. elegans.

132 stress, increased neuropeptide signaling in C. elegans enhances their decision-making accuracy and e

133 t stores and organismal behavioral states in C. elegans, and establish a paradigm for the elucidation

134 Our results uncover key steps in C. elegans germline formation and define a set of conser

135 he maximal number of fucose substitutions in C. elegans, which in part may be due to different method

136 1A, the axonal-transport kinesin for SVPs in C. elegans.

137 a conserved cannabinoid signaling system in C. elegans and also modulate monoaminergic signaling, po

138 a conserved cannabinoid signaling system in C. elegans, demonstrates the cannabinoid-dependent activ

139 To identify critical neural ADAR targets in C. elegans, we performed an unbiased assessment of the e

140 Here, we review recent studies of TEI in C. elegans.

141 Our data suggest that in C. elegans promoters, nucleosome fragility is in large p

142 We previously showed that, in C. elegans cilia, the deglutamylase CCPP-1 affects cilia

143 Es during the oocyte-to-embryo transition in C. elegans.

144 idence for vertical pathogen transmission in C. elegans.

145 ing portal for studying natural variation in C. elegans Additionally, researchers outside of the C. e

146 maps in several eukaryotes tested, including C. elegans and A. thaliana.

147 hamnosus and Pseudomonas fluorescens induces C. elegans stress resistance.

148 blishment and proliferation of an infection, C. elegans survival was prolonged when RpoN* was express

149 stimulus-evoked calcium responses of intact C. elegans at various life stages.

150 regates with size up to 200 nm within intact C. elegans.

151 ease-associated human tubulin mutations into C. elegans genes and examined their impact on neuronal d

152 euronal migration during development and its C. elegans orthologue MIG-10 also supports synaptogenesi

153 retained the dsRNA transport activity of its C. elegans ortholog, and this transport is important for

154 Recordings from small invertebrates like C. elegans are especially challenging because they under

155 n accumulated on high dietary glucose limits C. elegans longevity.

156 hat can monitor SL1 trans-splicing in living C. elegans.

157 espan and limits nucleolar size in the major C. elegans longevity pathways, as part of a convergent m

158 ins or have orthologs identified in mammals, C. elegans, or S. cerevisiae in addition to 595 novel ca

159 Tomatidine improves many C. elegans behaviors related to healthspan and muscle he

160 ions in the gustatory neuron ASER to mediate C. elegans pathogen avoidance response.

161 span ( 25%) in wild type and tauopathy model C. elegans at least as effectively as other anti-aging c

162 n resolution in the brain of a freely moving C. elegans undergoing large motion and deformation.

163 calcium imaging recordings in freely moving C. elegans, this analysis pipeline located 156 neurons f

164 ascaroside profiling of wild-type and mutant C. elegans facilitates the analysis of all basic ascaros

165 Here, we show that natural C. elegans isolates differ in nictation.

166 that are absent in the free-living nematode C. elegans, it has ncRNA families that are enriched in p

167 at TCS induces toxicity in both the nematode C. elegans and human mesenchymal stem cells (hMSCs) by d

168 The PHC neuron pair of the nematode C. elegans differentiates in a strikingly sex-specific m

169 or femtosecond laser axotomy in the nematode C. elegans for immobilization of the animals for surgery

170 The nematode C. elegans provides a unique opportunity to address this

171 In the nematode C. elegans, serotonin neurons that drive female reproduc

172 In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is hi

173 full somatic nervous system of the nematode C. elegans, we address how biological network architectu

174 dels, the bacterium E. coli and the nematode C. elegans, we performed three-way high-throughput scree

175 The nematode C. elegans, whose food uptake consists of pumping bacter

176 erent olfactory neuron types in the nematode C. elegans.

177 or to high-resolution systematic analyses of C. elegans morphogenesis.

178 a powerful and scalable tool for analysis of C. elegans behavior and aging.

179 d fit to a large-scale kinematic analysis of C. elegans behavior at submicron resolution.

180 tion resulting from the foraging behavior of C. elegans, which has important population-level consequ

181 died were able to spread across the cells of C. elegans tissues before forming spores, with two speci

182 te tau toxicity, we screened a collection of C. elegans mutations in dopamine-related genes (n = 45)

183 ffects of injuries on the neural dynamics of C. elegans, showing how damaging the network degrades it

184 This work enhances the effectiveness of C. elegans for convenient toxicity assessment, which cou

185 onal studies, we uncover the early events of C. elegans brain assembly.

186 longum strain BB68 affects the longevity of C. elegans were assessed.

187 ly used methods for long-term measurement of C. elegans are limited by low throughput and the difficu

188 rates the value of systematic mutagenesis of C. elegans for focused investigation of human disease pr

189 of RPM-1 protein complexes in the neurons of C. elegans elucidated two further discoveries: FSN-1 bin

190 in vivo Using the mechanosensory neurons of C. elegans, we found collapse prior to axon termination

191 ted longitudinal imaging of large numbers of C. elegans confined to individual wells.

192 v-3 locus encodes the O. tipulae ortholog of C. elegans mig-13, and we further show that Cel-mig-13 m

193 ent discovery of a natural viral pathogen of C. elegans and development of diverse artificial infecti

194 s, another natural intracellular pathogen of C. elegans, and is distinct from responses to extracellu

195 al information ("longitudinal profiling") of C. elegans, which we posit embodies the benefits of both

196 ve fucose residues modify the core region of C. elegans N-glycans and that the alpha1,3-fucose on the

197 ine analysis of the tissue-specific roles of C. elegans proteins.

198 is work will also enhance the sensitivity of C. elegans based drug discovery platforms.

199 Here we show that a diverse set of C. elegans heterochromatin proteins act together with th

200 demonstrate its capabilities, two strains of C. elegans nematodes with different levels of expression

201 statistical genetics and genomics studies of C. elegans and to connect the results to human disease.

202 The study of C. elegans has led to ground-breaking discoveries in gen

203 BKIP-1, an auxiliary subunit of C. elegans SLO-1, facilitates SLO-1 membrane trafficking

204 KIP-1 also serves as an auxiliary subunit of C. elegans SLO-2, a high-conductance K(+) channel gated

205 Nutritional status has a major influence on C. elegans behavior.

206 Here, we discuss recent research on C. elegans DCC in the context of canonical condensin mec

207 the endocytic transport function of the only C. elegans syndapin, SDPN-1.

208 f small animals such as Drosophila larvae or C. elegans worms has become an integral subject of biolo

209 of NMDA-gated current in Xenopus oocytes, or C. elegans muscle cells, depends on NRAP-1 and that reco

210 In the holocentric organism C. elegans, CENP-A is positioned periodically along the

211 omechanics of touch using the model organism C. elegans.

212 etry data from humans and the model organism C. elegans.

213 By using the whole-organism C. elegans coupled with versatile biochemical, biophysic

214 facilitate studies of ERK signaling in other C. elegans contexts, and the design features will enable

215 gical aging also mitigates toxicity in other C. elegans models of ALS, suggesting that the (PR)50 dip

216 ide fragments that are sufficient to protect C. elegans against Salmonella pathogenesis in a tol-1-de

217 Expression of RpoN* protected C. elegans in a paralytic killing assay, whereas worms s

218 et al. use the workhorse of aging research, C. elegans, to identify specific mechanisms by which gut

219 Small animals such as the roundworm C. elegans are excellent models for studying bacterial i

220 The roundworm C. elegans is a mainstay of aging research due to its sh

221 Furthermore, we demonstrate that silencing C. elegans orthologs of PD-related genes also increases

222 lep-2 encodes the sole C. elegans ortholog of the Makorin (Mkrn) family of prot

223 electron microscopy and tomography of staged C. elegans embryos to demonstrate that BBs remodel to su

224 Our results suggest C. elegans stores a memory of recent O2 experience in th

225 to simultaneously follow development of ten C. elegans larvae at high spatiotemporal resolution from

226 navigation under low oxygen conditions that C. elegans prefers.

227 We demonstrate that C. elegans glia are key for assembly initiation, guiding

228 Our results indicate that C. elegans are able to judiciously make a decision to st

229 Here, we show that C. elegans males exhibit an altered, male-specific expre

230 Here, we show that C. elegans oocytes delay key events in anaphase, includi

231 The C. elegans ascr#3 (asc-DeltaC9; C9) pheromone triggers a

232 The C. elegans nervous system mediates protective physiologi

233 We identified a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal c

234 legans Specifically, we show that CUA-1, the C. elegans homolog of ATP7A/B, localizes to lysosome-lik

235 estriction via splicing factor 1 (SFA-1; the C. elegans homologue of SF1, also known as branchpoint b

236 From this screen, we identified HLH-3, the C. elegans homolog of a mammalian proneural protein (Asc

237 of variant types are not constant across the C. elegans genome.

238 this system to study how bacteria affect the C. elegans response to chemotherapeutics.

239 Although the C. elegans genome encodes five tubulin tyrosine ligase-l

240 MinION-derived genome assembly expanded the C. elegans reference genome by >2 Mb due to a more accur

241 e have previously established a role for the C. elegans dosage compensation protein DPY-21 in the con

242 This study demonstrates a role for the C. elegans ephrin EFN-4 in axon guidance.

243 l model of random search abstracted from the C. elegans connectome and fit to a large-scale kinematic

244 erhaps surprising and not predicted from the C. elegans model.

245 Secreted MSPds derived from the C. elegans VAPB homolog VPR-1 promote mitochondrial loca

246 Here, we identified the C. elegans orthologue of mammalian mediator of ErbB2-dri

247 were classified as active </= 200 muM in the C. elegans assay.

248 ic properties of two neuronal classes in the C. elegans central nervous system, using VGLUT-pHluorin

249 udies of cell lineage differentiation in the C. elegans embryo containing approximately 200 conserved

250 to degenerate following ciliogenesis in the C. elegans embryo, although neither BB architecture nor

251 es is necessary for silencing in vivo in the C. elegans embryo, and for the recruitment of the Ccr4-N

252 um between germ granules and P bodies in the C. elegans embryo.

253 third of the body wall muscles (BWMs) in the C. elegans embryo.

254 ion of germline stem cell progenitors in the C. elegans gonad.

255 umulation of proliferative germ cells in the C. elegans hermaphrodite is sensitive to the organismal

256 rgic innervation of GABAergic neurons in the C. elegans motor circuit alters GABAergic neuron synapti

257 t here a comprehensive map of neurons in the C. elegans nervous system that contain the neurotransmit

258 y more than 90% of all neuron classes in the C. elegans nervous system.

259 n vitro and in vivo functional assays in the C. elegans oocyte, we provide novel evidence that the ki

260 One sms-1 isoform is expressed in the C. elegans pharynx, and its transgene rescues the sms-1

261 inase activity gradients and polarity in the C. elegans zygote.

262 tage of the naturally large endosomes of the C. elegans coelomocyte, we visualized complementary ESCR

263 ans Additionally, researchers outside of the C. elegans community can benefit from public mappings an

264 Loss of the C. elegans DDC gene, bas-1, ameliorated the behavioral d

265 We found that increased levels of the C. elegans Gemin3 ortholog, MEL-46, ameliorates these de

266 Through analysis of the C. elegans host response to intracellular infection, we

267 mined that miR-2 regulates expression of the C. elegans M2 muscarinic receptor (m2R) ortholog, GAR-2.

268 Asymmetric divisions are a feature of the C. elegans seam lineage, in which a series of post-embry

269 Loss of the C. elegans SMN ortholog, SMN-1, causes NMJ defects.

270 provide an in-depth characterisation of the C. elegans wild-type embryo proteome and phosphoproteome

271 During the asymmetric division of the C. elegans zygote, the RNA-binding protein MEX-5 forms a

272 llel to mitophagic pathways dependent on the C. elegans PINK1 homolog, which is necessary for cellula

273 Here, we introduce a new platform, the C. elegans Natural Diversity Resource (CeNDR) to enable

274 Here we show that the C. elegans SHN-1/Shank binds L-type calcium channels and

275 enorhabditis elegans Here we report that the C. elegans transcription factor ETS-5, an ortholog of ma

276 Here we show that the C. elegans VAP homolog VPR-1 is essential for gonad deve

277 Here, we used the C. elegans germline as a model for identifying molecular

278 Using the C. elegans Munc13 ortholog UNC-13, we show that deletion

279 Three C. elegans zipt genes were regulated in zinc-deficient c

280 ntually suppressed to restore homeostasis to C. elegans hermaphrodites.

281 ith the administration of native proteins to C. elegans have limited the range of applications of thi

282 : C. elegans adults respond more strongly to C. elegans larvae compared to other nematode species and

283 proach and positive selection for transgenic C. elegans, we explored the biochemical relationship bet

284 drove reporter gene expression in transgenic C. elegans Overall, we provide experimental annotation o

285 In turn, C. elegans starts to vacate the pathogenic bacteria lawn

286 We have identified myrf-1 and myrf-2, two C. elegans homologs of Myrf family transcription factors

287 Our analyses included wild type C. elegans but also a mutant lacking two HS sulfotransfe

288 embly produced a highly contiguous wild-type C. elegans genome containing 48 contigs (N50 contig leng

289 Using C. elegans, we show that alpha-tubulin isotype TBA-6 scu

290 Research activity using C. elegans as a model system is as vibrant as ever, and

291 dopamine neuron dysfunction and death using C. elegans mutants for three mitochondria-related genes

292 Finally, a phenotypic drug screen using C. elegans identified podocarpic acid as a novel activat

293 in-based drug discovery studies that utilize C. elegans as a model organism.

294 When C. elegans first encounters pathogenic bacteria P. aerug

295 iments were also conducted to verify whether C. elegans are really able to detect the rigidity of sub

296 We studied 69 genes whose C. elegans orthologs were neuronal signalling genes with

297 so introduced the use of collections of wild C. elegans to study naturally occurring genetic variatio

298 Among wildtype C. elegans, individual nucleolar size varies, but is hig

299 rved cholesterol binding (CRAC) domains with C. elegans ChUP-1.

300 Our results support the model that young C. elegans males sense external environment and oxygen t