ライフサイエンスコーパス: C4bp

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1 C4bp alpha-chain monomers did not bind gonococci, indica

2 C4bp contains seven identical alpha-chains and one beta-

3 C4bp-Por1B interactions were ionic in nature (inhibited

4 Using fAb fragments against C4bp SCR1, C4bp binding to Por1A and Por1B strains was i

5 gesting a novel interaction between OmpA and C4bp.

6 ly described adjuvant IMX313, a hybrid avian C4bp oligomerization domain, could increase T cell respo

7 Microbial surface-bound C4bp demonstrated cofactor activity.

8 nococci together formed a negatively charged C4bp-binding domain.

9 Por1B gonococci bound chimpanzee C4bp and resisted killing by chimpanzee serum, providing

10 wed that the loop 1 of Por1A is required for C4bp binding.

11 onococci was restored in these sera by human C4bp.

12 nding to CCP3 sequences block the binding of C4bp to OmpA and also significantly enhance serum bacter

13 Binding of C4bp to OmpA is not significantly inhibited in the prese

14 We found that OmpA binds the alpha-chain of C4bp, which is composed of eight homologous complement c

15 cocci, indicating that the polymeric form of C4bp was required for binding.

16 normal serum, underscoring the importance of C4bp in mediating gonococcal serum resistance.

17 down-regulatory protein C4b-binding protein (C4bp) to evade killing by human complement.

18 esistance by binding to C4b binding protein (C4bp), a complement fluid phase regulator.

19 e complement regulator, C4b-binding protein (C4bp).

20 Binding studies using mutants of recombinant C4bp that lack one CCP at a time suggest that CCP3 is th

21 Only recombinant C4bp mutant molecules containing the NH2-terminal alpha-

22 Using fAb fragments against C4bp SCR1, C4bp binding to Por1A and Por1B strains was inhibited in

23 irtually all mammals, bound species-specific C4bp and uniformly resisted serum complement-mediated ki

24 ted by high salt or by heparin), whereas the C4bp-Por1A bond was hydrophobic.

25 experimentally with this organism and whose C4bp molecules did not bind to N. gonorrhoeae.

26 e that the N terminus of OmpA interacts with C4bp.

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