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1 the seven transmembrane helices of the human C5a receptor.
2 he seven transmembrane segments of the human C5a receptor.
3 t couples in neutrophils is reported to be a C5a receptor.
4 kely G protein linked, but distinct from the C5a receptor.
5 ue to inhibition of C5a interaction with the C5a receptor.
6 er in mice treated with an antagonist of the C5a receptor.
7 icular, in ligand-mediated activation of the C5a receptor.
8  the order CXCR2 > CXCR1 > formyl peptide or C5a receptors.
9 onstitutively express functionally competent C5a receptors.
10 man and murine brains constitutively express C5a receptors.
11 human neuroblastoma cells express functional C5a receptors.
12  in CMs, which required availability of both C5a receptors.
13 e show that activation of complement C5a and C5a receptor 1 (C5aR1) controls GC accumulation and the
14 tracellular C5 activation and stimulation of C5a receptor 1 (C5aR1), which is negatively regulated by
15 , whereupon it interacts with the complement C5a receptor 1 expressed on tumor infiltrating myeloid-d
16 educing RPS19 in tumor cells or blocking the C5a receptor 1-RPS19 interaction decreases RPS19-mediate
17 t and third extracellular loops of the human C5a receptor, a GPCR that binds a 74-amino acid peptide
18 ), can act as agonists or antagonists to the C5a receptor, a member of the GPCR family.
19 ttle energy transfer is observed between the C5a receptor and a co-expressed yeast pheromone receptor
20 5a can bind to two distinct receptors (i.e., C5a receptor and C5a receptor-like 2 [C5L2]).
21 with cDNAs encoding the complement component C5a receptor and PLC beta2 but not in cells transfected
22 sepsis by using antibody-induced blockade of C5a receptors and knockout mice.
23 L, signalling pathways downstream of C3a and C5a receptors and membrane C5b-9 assembly, and the preve
24 production of MIP-2 and KC by PTECs, whereas C5a receptor antagonism and prevention of membrane attac
25 d opsonization >2-fold, and compstatin and a C5a receptor antagonist (C5aRa) impaired granulocyte act
26  were alleviated by pretreating cells with a C5a receptor antagonist (C5aRant) or a C5a antibody.
27  Here, oral delivery of a cyclic hexapeptide C5a receptor antagonist (PMX205) for 2-3 mo resulted in
28                  We investigated the role of C5a-receptor antagonist (C5aRA) solely and in combinatio
29        In mice, loss of C5 or injection of a C5a-receptor antagonist significantly reduced the level
30          C5aRAM and C5aRAD are novel, potent C5a receptor antagonists devoid of agonist or proinflamm
31                      Novel recombinant human C5a receptor antagonists were discovered through modific
32 -deficient mice and mice given injections of C5a-receptor antagonists developed significantly less pa
33 osition in mice deficient in C3a receptor or C5a receptor, as well as in wild-type mice depleted of h
34 increase is prevented by blockade of the C5a-C5a receptor axis.
35                                     Neuronal C5a receptors bound C5a-coated fluorescent microspheres,
36 ent human serum resulted in up-regulation of C5a receptor, but not C3a receptor.
37 TGF-beta), and whereas TGF-beta1 induced C3a/C5a receptor (C3aR/C5aR) expression, pharmacologic C3aR/
38          The functions of glial-cell C3a and C5a receptors (C3aR and C5aR) appear to be similar to im
39 roid was assayed for the presence of C3a and C5a receptors (C3aR and C5aR) using RT-PCR and immunohis
40 sponses, requires autocrine C3a receptor and C5a receptor (C3ar1/C5ar1) signaling.
41 HNFAG09, with 37% nucleotide identity to the C5a receptor (C5a-R, CD88) was identified.
42  autoantibody-induced arthritis requires the C5a receptor C5aR and FcgammaRs, but the simultaneous ne
43  the e2 loop with a smaller e2 loop from the C5a receptor (C5aR) abolished binding of 125I-C3a and C3
44                 Furthermore, blockade of the C5a receptor (C5aR) abrogated the ability of hepatocytes
45 biting signaling of the complement component C5a receptor (C5aR) altered the composition and diversit
46 irst evidence that human T cells express the C5a receptor (C5aR) and are chemotactic to C5a.
47 signals transmitted through T cell-expressed C5a receptor (C5aR) and C3a receptor (C3aR) to activatio
48  functions through two identified receptors, C5a receptor (C5aR) and C5L2.
49        Little is known about the role of the C5a receptor (C5aR) and its presence in different organs
50 onocytic cell line U937 transfected with the C5a receptor (C5aR) and loaded with a fluorescent intrac
51                                   Complement C5a receptor (C5aR) antagonism in C3aR(-/-) mice also re
52                               Small molecule C5a receptor (C5aR) antagonist development is hampered b
53 the terminal complement component C5 and the C5a receptor (C5aR) are upregulated in spinal microglia
54 nt, these changes being complement (C5a) and C5a receptor (C5aR) dependent.
55 been shown to be an important inducer of the C5a receptor (C5aR) during sepsis.
56 ast cancer that the complement anaphylatoxin C5a receptor (C5aR) facilitates metastasis by suppressin
57                 The complement anaphylatoxin C5a receptor (C5aR) has been implicated in inflammatory
58 d the role of the active fragment complement C5a receptor (C5aR) in dental nerve regeneration in rega
59  prevented by the deficiency of either C3 or C5a receptor (C5aR) in the APC, demonstrating a link bet
60   We found that mice deficient in MCs or the C5a receptor (C5aR) injected with pathogenic anti-BP180
61                Because the expression of the C5a receptor (C5aR) is significantly increased in brain
62  there are some suggestions that C5a and the C5a receptor (C5aR) might be directly linked to apoptosi
63 naphylatoxin C5a results in reduction of the C5a receptor (C5aR) on neutrophils.
64 a (tC5aF) and flow cytometry to identify the C5a receptor (C5aR) on trout leukocytes.
65 lacking the chemotactic or adhesion receptor C5a receptor (C5aR) or CD11a/lymphocyte function-associa
66 e show that pharmacological targeting of the C5a receptor (C5aR) or the bradykinin B2 receptor (B2R)
67  that local pharmacological targeting of the C5a receptor (C5aR) prior to initial allergen sensitizat
68 8(+) T cells lacking C3a receptor (C3aR) and C5a receptor (C5aR) proliferate weakly to allogeneic DCs
69 ells deficient in C3a receptor (C3aR) and/or C5a receptor (C5aR) responded weakly in allogeneic hosts
70                 Complement fragment 5a (C5a)-C5a receptor (C5aR) signaling plays an essential role in
71                Both mRNA and protein for the C5a receptor (C5aR) were constitutively expressed on car
72 in untreated fibroblast cultures express the C5a receptor (C5aR), here we show that all dental pulp f
73 f a cyclic peptide antagonist (C5aRa) to the C5a receptor (C5aR), the binding of murine 125I-C5a to m
74                                              C5a receptor (C5aR)-targeting of C3aR-deficient mice dur
75 ciated with increased levels of mRNA for the C5a receptor (C5aR).
76  protein-coupled receptors, C3a receptor and C5a receptor (C5aR).
77 ffects of C5a are mediated by its binding to C5a receptor (C5aR, CD88).
78             The NH(2)-terminal domain of the C5a receptor (C5aR/CD88) contributes substantially to it
79 pressed both the C3a receptor (C3aR) and the C5a receptor (C5aR; CD88) on the cell surface.
80 own that mice deficient either in complement C5a receptor (C5aR; CD88) or TLR2 are highly and similar
81 ibody raised against residues 9 to 29 of the C5a receptor (C5aR; CD88), we demonstrate that noncystei
82 cule that mediates its effects by binding to C5a receptor (C5aR; CD88).
83 ins C3a and C5a (ie, C3a receptor [C3aR] and C5a receptor [C5aR]), and C3a and C5a are generated duri
84               The biological significance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane recep
85                          The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded
86 d the potential of peritoneal TLR2, TLR4 and C5a receptors, C5aR and C5L2, as therapeutic targets in
87                            Absence of either C5a receptor (C5aR1 or C5aR2) diminished development of
88 C5a upregulation and was markedly reduced by C5a receptor (C5aR1) knock-out or treatment with the C5a
89         We demonstrate a crucial role of the C5a receptor, C5aR1, in the development of inflammatory
90 in left ventricular (LV) CMs, requiring both C5a receptors, C5aR1 and -2.
91 e have analyzed the expression of the second C5a receptor C5L2, the putative "default" or nonsignalin
92                                     A second C5a receptor, C5L2, has also been cloned but has receive
93 ptor C5aR, but was independent of the second C5a receptor, C5L2.
94 Phis and in the second by treatment with the C5a receptor (CD88) agonist EP67, which invokes MPhi pro
95              Pharmacological blockade of the C5a receptor considerably impaired tumor growth to a deg
96 ed with pertussis toxin, suggesting that the C5a receptor couples to both Galpha15 and Galphai in viv
97                                              C5a receptor deficiency, which also lessens myeloid-deri
98                                 In contrast, C5a receptor deficient mice, which bear C5L2 alone, do n
99 cordingly, we found enhanced Th1 immunity in C5a receptor-deficient mice, something that conferred pr
100                                        These C5a-receptor-deficient mice challenged with sublethal in
101 al reactive oxygen species (ROS), which were C5a-receptor dependent.
102           In contrast, the interleukin-8 and C5a receptors did not couple to Galphaq in either COS-7
103 gulator of cell polarity, with inhibition of C5a receptors during embryogenesis leading to abnormal b
104 sonance energy transfer experiments on human C5a receptors expressed in the lower eukaryote Saccharom
105                       The oligomerization of C5a receptors expressed in yeast displays characteristic
106  disulfide-trapping experiments to show that C5a receptors, expressed in mammalian cells, reside in m
107              IL-17 is produced by complement C5a-receptor-expressing T-cells.
108           We report that genetic ablation of C5a receptor expression completely protects mice from ar
109 Based on these observations, we propose that C5a receptors form higher order oligomers (i.e. tetramer
110                      To begin to address how C5a receptors form oligomers, we now use fluorescence re
111 a (C5a) for the knockdown of seven proteins (C5a receptor; G-beta-2; G-alpha,i-2,3; regulator of G-pr
112  N-terminal segment with that from the human C5a receptor had minimal effect on C3a binding, substitu
113                         We conclude that the C5a receptor has a non-redundant function, and is requir
114  co-transfected with both G alpha 16 and the C5a receptor, iC5b67 could neither activate phospholipas
115                            Expression of the C5a receptor in the central nervous system has been demo
116 lar levels of energy transfer between tagged C5a receptors in endoplasmic reticulum compared with pla
117          Overexpression of various mammalian C5a receptors in HEK cells confirms that cytotoxicity to
118 ct surfaces, we demonstrate cross-linking of C5a receptors in membranes prepared from both human neut
119 f murine sepsis, we investigated the role of C5a receptors in septic lymphopenia.
120 w that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermat
121         Similarly, antagonists of the C3a or C5a receptors inhibited tumor growth.
122 plement heat-inactivation, C5 depletion, and C5a receptor inhibition suppressed the priming effect of
123                               In conclusion, C5a receptor inhibition with avacopan was effective in r
124  (CCX168), an orally administered, selective C5a receptor inhibitor, could replace oral glucocorticoi
125 we show that Ab's or peptides that block C5a-C5a receptor interactions prevent pregnancy complication
126                The Galpha(i)-protein-coupled C5a receptor is a critical regulator of IgG FcR function
127 rprisingly the carboxyl-terminal tail of the C5a receptor is the most important specificity determina
128  that is, complement receptor C5a (C5aR) and C5a receptor-like 2 (C5L2), in sepsis have been demonstr
129 s through its two receptors, C5aR (CD88) and C5a receptor-like 2 (C5L2).
130 o distinct receptors (i.e., C5a receptor and C5a receptor-like 2 [C5L2]).
131 neither activate phospholipase C nor inhibit C5a receptor-mediated activation of phospholipase C. iC5
132 n the premetastatic lungs through complement C5a receptor-mediated proliferation but not through recr
133 bit distinct inhibitory effects on fMLP (and C5a) receptor-mediated superoxide production, but have n
134                        The absence of either C5a receptor mitigated sepsis-induced reductions in the
135 ression is almost completely absent, whereas C5a receptor mRNA and protein expression is maintained.
136  collection of 133 functional mutants of the C5a receptor obtained in a mutagenesis screen targeting
137  receptor (encoded by STE2), indicating that C5a receptor oligomerization is both receptor-specific a
138 lian accessory proteins are not required for C5a receptor oligomerization.
139 ntine receptor that is co-expressed with the C5a receptor on many cells including polymorphonuclear n
140 gineered near a proposed binding site in the C5a receptor on transmembrane helices III and VI can sel
141 ic TNF-alpha in the absence of C3a receptor, C5a receptor, or hepatic macrophages.
142 shown that antibody-induced blockade of C5a, C5a receptors, or IL-17A greatly reduced the harmful out
143 ng of the C5a component of complement to the C5a receptor plays an important role in CD8(+) T cell re
144 histones appearing in septic plasma required C5a receptors, polymorphonuclear leukocytes (PMNs), and
145 lates the Gi proteins known to couple to the C5a receptor, produced minimal inhibition of C5a-induced
146                              Blockade of the C5a receptor rendered human monocytes unable to produce
147 te that simultaneous blockade of the C3a and C5a receptors represents a promising neuroprotective str
148  conducted to address the functional role of C5a receptors revealed that C5a triggered rapid activati
149                              Interception of C5a receptor signaling resulted in suppression of IL-6/T
150  phagocytosis could be prevented by blocking C5a receptor signaling.
151 of the carboxyl-terminal tail did not impair C5a receptor signaling.
152                   In particular, blockade of C5a receptor significantly reduced myeloid-derived suppr
153 f IL-6/TNFalpha induction and lack of C3 and C5a receptor stimulation attenuated nuclear factor-kappa
154                                              C5a receptors tagged with variants of the green fluoresc
155 s showed significant expression of the trout C5a receptor (TC5aR) message in PBLs and kidney.
156 idues on the intracellular face of the human C5a receptor that are involved in G protein activation,
157                    Functional roles for both C5a receptors, that is, complement receptor C5a (C5aR) a
158 tructural model of the inactive state of the C5a receptor, the preserved residues reside on one half
159  V, VI, and VII of the human chemoattractant C5a receptor to random saturation mutagenesis.
160 trophils and U937 cells transfected with the C5a receptor (U937-C5aR cells) and comparing chemotaxis
161            Strong cell surface expression of C5a receptors was detected on PMN, whereas NK cells comp
162                        Engagement of C3a and C5a receptors was ruled out.
163 , internalization of the FPR, as well as the C5a receptor, was demonstrated to be independent of the
164 We found that the complement effect required C5a receptor, was evident at physiologically relevant le
165  might be involved in the oligomerization of C5a receptors, we constructed receptors with individual
166 or B, C3 and properdin, and C3a receptor and C5a receptor were detected in grade 3 versus grade 0 or
167 erefore different from that reported for the C5a receptor, which is required for the initial inductio
168                                              C5a receptors with a cysteine in the first intracellular
169 opy to measure the kinetics of movement of a C5a receptor-yellow fluorescent protein fusion in living

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