ライフサイエンスコーパス: CAM

1 CAM blood vessels were observed to infiltrate the human

2 CAM endorsement was significantly associated with uncont

3 CAM evolved in four terrestrial lineages during the late

4 CAM is associated with stomatal closure during the day a

5 CAM pathway genes were enriched with cis-regulatory elem

6 CAM plants thus promise to be a source of highly functio

7 CAM PPC is regulated posttranslationally by a circadian

8 CAM represents the first step toward an exhaustive chara

9 CAM use definitions included any use, dietary supplement

10 CAM use was high among patients with early-stage breast

11 CAM-lipid complex sizes were relatively independent of c

12 CAMs have the potential to aid in the treatment of IBD,

13 CAMs of various forms are used by more than half of pati

14 The 3D-CAM delirium diagnosis was compared with the reference s

15 The 3D-CAM did well in patients with dementia (sensitivity, 96%

16 The 3D-CAM operationalizes the CAM algorithm using a 3-minute s

17 Median administration time for the 3D-CAM was 3 minutes (interquartile range, 2 to 5 minutes),

18 ic features were identified to create the 3D-CAM.

19 For prospective validation, 3D-CAM assessments were administered by trained research as

20 20 items that best operationalized the 4 CAM diagnostic features were identified to create the 3D

21 aseline interviews assessed current use of 5 CAM modalities (vitamins and/or minerals, herbs and/or b

22 , protein and metabolite abundances across a CAM diel cycle and, where applicable, compare the observ

23 dietary supplement use, mind-body use, and a CAM index summing the 5 modalities.

24 ple domains at the extracellular region of a CAM plays a positive role in regulating its trans-intera

25 between different extracellular domains of a CAM.

26 ated dark CO2 fixation, malate accumulation, CAM productivity, and core circadian clock robustness.

27 s representing ICS beliefs (alpha = .59) and CAM endorsement (alpha = .68).

28 demands to identify negative ICS beliefs and CAM endorsement and (2) evaluated the clinical utility o

29 utility in that knowledge of ICS beliefs and CAM endorsement prompted providers to initiate discussio

30 Negative ICS beliefs and CAM endorsement were common and associated with uncontro

31 synthesis, as well as its variations, C4 and CAM.

32 To exploit the potential of CAM crops and CAM bioengineering, it will be necessary to elucidate th

33 onals B97-D3BJ, MN12-L, M06-L, B3LYP-D3, and CAM-B3LYP reproduce the experimentally observed activati

34 Ticagrelor and CAM, when applied to a 3-dimentional printed resorbable

35 an steroidogenesis, steroid biosynthesis and CAMs signaling pathways.

36 flammation and angiogenesis in zebrafish and CAMs in vivo, respectively.

37 requires both NL2 and Slitrk3 (ST3), another CAM.

38 We apply CAM to dissect dynamic contrast-enhanced magnetic resona

39 The Arabic CAM-ICU appeared to be valid and reliable tool for diagn

40 o critical care nurses when using the Arabic CAM-ICU compared with the reference standard were 81% (6

41 CAM-ICU was explored by comparing the Arabic CAM-ICU ratings and the total score of SOFA (severity of

42 the CAM-ICU into Arabic language, the Arabic CAM-ICU was administered by two well-trained critical ca

43 The convergent validity of the Arabic CAM-ICU was explored by comparing the Arabic CAM-ICU rat

44 Interrater reliability for the Arabic CAM-ICU, overall and for mechanically ventilated patient

45 ctive value (PPV and NPV) for the two Arabic CAM-ICU raters, where calculations were based on conside

46 afish, chick chorioallantoic membrane assay (CAM), and a porcine skin wound model, respectively.

47 -CAM is carried out in an (16)O2 atmosphere, CAM nitro groups contain both (18)O and (16)O, suggestin

48 Baseline CAM use was reported by 598 women (87%).

49 There was no association between CAM use and chemotherapy initiation among women for whom

50 tome atlas allowed us to distinguish between CAM-related and non-CAM gene copies.

51 viding the first cis-regulatory link between CAM and circadian clock regulation.

52 that perturbing the only known link between CAM and the circadian clock feeds back to perturb the ce

53 five currently used vaccine strains, AIK-C, CAM-70, Edmonston-Zagreb, Moraten, and Shanghai-191.

54 strates transcriptional regulation of the C3-CAM transition.

55 species consumed a diet with significant C4/CAM foods, differing from its putative ancestor Au. anam

56 By CAD/CAM technique, it can correct jaw deformities simultaneo

57 ique, or group B using an individualized CAD/CAM zirconia abutment (CARES abutment; Institut Strauman

58 e computer-aided design and manufacture (CAD/CAM) technique was used to guide bony mass removal and l

59 nts veneered with pressed ceramics or on CAD/CAM zirconia abutments veneered with hand buildup techni

60 eriod of time, due to physical strength, CAD/CAM fabrication, and low cost.

61 We found calcium/calmodulin (CAM)-dependent protein kinase kinase 2 (CAMKK2) is signi

62 ation, and enhance angiogenesis in a chicken CAM model.

63 in a U87 glioblastoma tumor model on chicken CAM, with the aim of applying this model for screening o

64 The ultimate step in chloramphenicol (CAM) biosynthesis is a six-electron oxidation of an aryl

65 le and the active metabolite of clopidogrel (CAM), an alternative P2Y12 antagonist, inhibited osteocl

66 Gene co-expression clusters containing CAM pathway genes are enriched with clock-associated cis

67 es and two existing orchid genomes, covering CAM and C3 plants, with an emphasis on comparing 13 gene

68 nce for the most commonly used and discussed CAMs.

69 Oncologists should consider discussing CAM with their patients during the chemotherapy decision

70 ven lower than normal controls in the double CAM alpha(1)A/B-AR mice for p38, NF-kappaB, and the IL-6

71 to inform efforts to engineer more efficient CAM traits into economically valuable C3 crops.

72 different tumor xenografts in a chick embryo CAM model.

73 ased water-use efficiency (WUE), and enables CAM plants to inhabit water-limited environments such as

74 ection in the noise-free case, which enables CAM to identify the mixing matrix not only in the exact-

75 f more drought-tolerant crops via engineered CAM.

76 cers were injected directly into the exposed CAM vasculature.

77 c marker Rab7 in axons that highly expressed CAM-kinase-kinase (CAMKK), an upstream activator of CaMK

78 , from C3 photosynthesis to weakly expressed CAM in response to drought stress.

79 d building blocks of CAM and will facilitate CAM-into-C3 photosynthesis engineering to enhance water-

80 ntraclass correlation coefficient = 0.77 for CAM items and 0.79 for ICS items).

81 n available for completing such analyses for CAM cropping systems.

82 ng that NAD-ME was the key decarboxylase for CAM.

83 biology approaches need to be developed for CAM engineering.

84 are unlikely to be evolutionary drivers for CAM photosynthesis.

85 sion and physiology data provide a model for CAM-specific carbohydrate flux and long-distance hexose

86 Infrastructure will be needed for CAM model systems, field trials, mutant collections, and

87 ld understand the nature of and evidence for CAMs for IBD so that rational advice can be offered to p

88 ediate, P, which reacts with NH2-CAM to form CAM.

89 g domains of SYG-1 and SYG-2 with those from CAM complexes that assume alternative docking geometries

90 l and -translational hierarchies that govern CAM in Agave.

91 dietary supplement users and women with high CAM index scores were less likely than nonusers to initi

92 To determine how CAM arises within a population and changes over time, he

93 in the evolution of CAM in orchids; however, CAM may have evolved primarily by changes at the transcr

94 the Confusion Assessment Method for the ICU (CAM-ICU).

95 the Confusion Assessment Method for the ICU (CAM-ICU).

96 Importantly, CAM requires no a priori information on the number, iden

97 coculture assays and induced angiogenesis in CAM assays.

98 is is a first step in quantifying changes in CAM plant productivity with variables such as the mean t

99 g circadian clock cis-regulatory elements in CAM-related genes might be a critical step in the evolut

100 The transition in CAM expression from low to high volume/area tissues (eli

101 omotes MCL homing and invasion and increases CAM-DR through the direct regulation of CXCR4 and FAK ex

102 -scale expression dataset of drought-induced CAM demonstrates transcriptional regulation of the C3-CA

103 ew insight into how cell divisions influence CAM within a tissue.

104 e development/maintenance, presumably by its CAM-like activity.

105 ssion patterns, with several that target key CAM-related genes.

106 PDN1 also inhibited L1-CAM-dependent neurite elongation in cerebellar granule n

107 e required during the early navigation of L1-CAM(+) thalamic fibers in the VTel, and that the misguid

108 ealed that many species capable of low-level CAM activity are nested within the peak of C3 -type isot

109 ation in such species, plants with low-level CAM should prove valuable models for investigating the d

110 classically activated (pro-inflammatory; M1/CAM) toward an alternatively activated (anti-inflammator

111 Cationic amphiphilic macromolecules (CAMs) containing a hydrophobic alkylated mucic acid segm

112 d design (CAD)/computer-aided manufacturing (CAM)-fabricated high-strength ceramics-namely, alumina a

113 new technique, component-activity matching (CAM), to select candidate ligands that "explain" pattern

114 Association of the maximum CAM-S score during hospitalization with hospital and pos

115 (LM), (3) colour alteration mechanochromism (CAM) and (4) encryption mechanochromism (EM).

116 and complementary and alternative medicine (CAM) endorsement are 2 that are more prevalent in black

117 of complementary and alternative medicines (CAMs), or nonallopathic therapies, for inflammatory bowe

118 meetings (Classification of Atrophy Meeting [CAM]) on conventional and advanced imaging modalities us

119 t of the Classification of Atrophy Meetings (CAM) program, an international group of experts surveyed

120 d the chick embryo chorioallantoic membrane (CAM) assay to test the hypothesis that melanoma growth i

121 ified chick embryo chorioallantoic membrane (CAM) assay, associated with a decrease of HIF-1alpha and

122 genesis ex vivo in chorioallantoic membrane (CAM) assays.

123 t the chick embryo chorioallantoic membrane (CAM) can be used as a bioreactor to culture and study th

124 Using a chicken chorioallantoic membrane (CAM) model, we demonstrated that Nef synergistically pro

125 nd metastasis in a chorioallantoic membrane (CAM) model.

126 tumors on chicken chorioallantoic membrane (CAM) provides a more rapid, low cost, and ethically sust

127 d angiogenesis in chorioallantoic membranes (CAMs) and HUVECs.

128 n adults with community-acquired meningitis (CAM).

129 components of crassulacean acid metabolism (CAM) - nocturnal fixation of atmospheric CO2 and its pro

130 Crassulacean acid metabolism (CAM) is a CO2 fixation pathway that maximizes water-use

131 Crassulacean acid metabolism (CAM) is a specialized mode of photosynthesis that featur

132 ht resilience, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximi

133 Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthes

134 Crassulacean acid metabolism (CAM) photosynthesis functions as an endogenous circadian

135 Crassulacean acid metabolism (CAM) photosynthesis is an adaptation to water and atmosp

136 ion pathway of crassulacean acid metabolism (CAM) photosynthesis results in an up to 80% higher water

137 hich occurs in Crassulacean acid metabolism (CAM) photosynthesis, allowing a system-level analysis of

138 e evolution of crassulacean acid metabolism (CAM) photosynthesis.

139 in C3, C4, and crassulacean acid metabolism (CAM) plants are considered, and the roles of the alpha a

140 reasoned that crassulacean acid metabolism (CAM) plants must possess thermostable Rca to support Cal

141 xation in some Crassulacean acid metabolism (CAM) species.

142 O2 fixation in Crassulacean acid metabolism (CAM) species.

143 rop possessing crassulacean acid metabolism (CAM), a photosynthetic carbon assimilation pathway with

144 lants that use crassulacean acid metabolism (CAM).

145 nthesis termed Crassulacean acid metabolism (CAM).

146 The Confusion Assessment Method (CAM) is the most widely used diagnostic algorithm, and o

147 ns, we describe convex analysis of mixtures (CAM), a fully unsupervised in silico method, for identif

148 vel BSS method, Convex Analysis of Mixtures (CAM), for separating non-negative well-grounded sources,

149 Validated with predesigned mixtures, CAM on the gene expression data from peripheral leukocyt

150 sa21, functions as a cell adhesion molecule (CAM) in axonal growth cones (GCs) of the developing brai

151 (CNTN4) is a complex cell adhesion molecule (CAM) localized at neuronal membranes, playing a key role

152 that IgSF9 acts as a cell adhesion molecule (CAM) to maintain synapses.

153 2 (NL2), a synaptic cell adhesion molecule (CAM).

154 sponse of increased cell adhesion molecules (CAM), trophic and anti-inflammatory factors.

155 mainly mediated by cell adhesion molecules (CAM).

156 Cell adhesion molecules (CAMs) are crucially involved in these processes.

157 Cell adhesion molecules (CAMs) play a central role in the barrier function of ECs

158 Cell adhesion molecules (CAMs) play a crucial role in the formation of the nodes

159 -2 are multipurpose cell adhesion molecules (CAMs) that have evolved across all major animal taxa to

160 ne receptors called cell adhesion molecules (CAMs), which are expressed on cell surfaces.

161 geting via multiple cell adhesion molecules (CAMs), which mimics the strategy of leukocytes to adhere

162 d requires specific cell adhesion molecules (CAMs).

163 to the L1 family of cell-adhesion molecules (CAMs).

164 migration known as coherent angular motion (CAM).

165 Therefore, multi-CAM targeting may aid the optimization of some therapeut

166 overexpress constitutively active mutation (CAM) alpha(1)A-ARs or CAM alpha(1)B-ARs under the regula

167 based on the domain organization of neuronal CAM, which is engaged in maintaining neuron-neuron adhes

168 per explores the nonlinear dynamics of a new CAM photosynthesis model (Bartlett et al., 2014) and inv

169 e-turnover reaction between (18)O2-P and NH2-CAM is carried out in an (16)O2 atmosphere, CAM nitro gr

170 on oxidation of an aryl-amine precursor (NH2-CAM) to the aryl-nitro group of CAM catalyzed by the non

171 A catalytic cycle is proposed in which NH2-CAM reacts with P to form NH(OH)-CAM and diferric CmlI.

172 eroxo intermediate, P, which reacts with NH2-CAM to form CAM.

173 Finally, the reformed P oxidizes NO-CAM to CAM with incorporation of a second O2-derived oxy

174 2 binding, while itself being oxidized to NO-CAM.

175 s to distinguish between CAM-related and non-CAM gene copies.

176 and other CAM species in comparison with non-CAM species.

177 1(IGPR-1) was recently identified as a novel CAM expressed in ECs, the molecular mechanisms underlyin

178 chiasm midline in vivo, and Plexin-A1 and Nr-CAM expression in RGCs is downregulated.

179 data for Kalanchoe fedtschenkoi, an obligate CAM species within the core eudicots with a relatively s

180 (miRNA) expression patterns in the obligate CAM plant pineapple [Ananas comosus (L.) Merr.].

181 genic RNA interference lines of the obligate CAM species Kalanchoe fedtschenkoi with reduced activiti

182 ion of transgenic RNAi lines of the obligate CAM species Kalanchoe fedtschenkoi with reduced levels o

183 molecular convergence and building blocks of CAM and will facilitate CAM-into-C3 photosynthesis engin

184 dramatic changes in the light/dark cycle of CAM CO(2) fixation.

185 ereas A2BR blockade abrogated the effects of CAM.

186 cell divisions drive the robust emergence of CAM and facilitate switches in the direction of collecti

187 sion underpins the independent emergences of CAM from C3 photosynthesis.

188 a system-level analysis of the energetics of CAM.

189 candidate genes for targeted engineering of CAM into C3 photosynthesis crop species.

190 for developing systems-level evaluations of CAM agricultural production include: improvement of phys

191 lays no substantial role in the evolution of CAM in orchids; however, CAM may have evolved primarily

192 ion available on the origin and evolution of CAM is scant, however.

193 of key genes in the origin and evolution of CAM.

194 t both oxygen atoms in the nitro function of CAM derive from O2.

195 ecursor (NH2-CAM) to the aryl-nitro group of CAM catalyzed by the non-heme diiron cluster-containing

196 urements, we found highly elevated levels of CAM-cycle enzyme transcripts and their metabolic product

197 nomic features, and regulatory mechanisms of CAM.

198 ese findings highlight the dynamic nature of CAM and suggest that regulating cell division is crucial

199 dietary supplement use and higher number of CAM modalities used but not mind-body practices were ass

200 ailable genetic tools to the optimization of CAM species for commercial production.

201 ading to the multiple independent origins of CAM photosynthesis within the family Bromeliaceae and in

202 The superior performance of CAM against a panel of benchmark BSS techniques is demon

203 To exploit the potential of CAM crops and CAM bioengineering, it will be necessary t

204 ences were used to: assess the prevalence of CAM in Eulophiinae orchids; characterize the ecological

205 embranes to approach the physical process of CAM-mediated adhesion.

206 e now underway to assess the productivity of CAM crop species and to harness the WUE of CAM by engine

207 ll be required to assess the productivity of CAM crops, while new synthetic biology approaches need t

208 We found high rates of CAM endorsement (93%), negative ICS beliefs (68%), and u

209 By varying the weight ratio of CAM to lipid, cationic complexes with varying compositio

210 Several weight ratios of CAM-lipid complexes were found to have similar delivery

211 elements, suggesting circadian regulation of CAM.

212 al., 2014) and investigates the responses of CAM plant carbon assimilation to different combinations

213 ctivity, and the classic circadian rhythm of CAM CO(2) fixation were lost, or dampened toward arrhyth

214 An improved understanding of CAM has potential for high returns on research investmen

215 f CAM crop species and to harness the WUE of CAM by engineering this pathway into existing food, feed

216 hese barriers have limited the acceptance of CAMs by physicians.

217 factors including conformational changes of CAMs and cellular factor including fluctuations of plasm

218 One interesting feature of CAMs is that almost all of their extracellular regions c

219 A generic model of CAMs was constructed based on the domain organization of

220 n which NH2-CAM reacts with P to form NH(OH)-CAM and diferric CmlI.

221 Then the NH(OH)-CAM rereduces the enzyme diiron cluster, allowing P to r

222 Accordingly, the aerobic reaction of NH(OH)-CAM with diferric CmlI yields P and then CAM without an

223 athway intermediate, shown here to be NH(OH)-CAM.

224 nsity functionals (omegaB97X-D, LC-omegaPBE, CAM-B3LYP, B3LYP, B97-D3BJ, B3LYP-D3, BP86-D3, PBE0-D3,

225 drill-hole defect, and implanted the bone on CAM or in vitro control-culture.

226 these challenges is to increase reliance on CAM crops, such as Agave and Opuntia, for biomass produc

227 Previous empirical studies on CAM have correlated biological constants (e.g. enzyme ki

228 One CAM member, platelet-endothelial-cell adhesion molecule-

229 Finally, if more than one CAM is introduced on each side of cell surfaces, the lat

230 e dark period in K. fedtschenkoi, optimizing CAM-associated dark CO2 fixation, malate accumulation, C

231 ively active mutation (CAM) alpha(1)A-ARs or CAM alpha(1)B-ARs under the regulation of large fragment

232 identified genes with circadian oscillation, CAM-related functions, and source-sink relations.

233 rate metabolism in K. fedtschenkoi and other CAM species in comparison with non-CAM species.

234 The activity of other CAM enzymes was reduced as a consequence of knocking out

235 III) domains that are shared with many other CAMs.

236 regulating its trans-interaction with other CAMs from the opposite side of cell surfaces.

237 ed with the C3/C4 CO2 pathway, which permits CAM plants to adapt to arid environments.

238 he rNAD-ME1 line, suggesting that perturbing CAM in K. fedtschenkoi feeds back to perturb the central

239 Pineapple CAM photosynthesis evolved by the reconfiguration of pat

240 Our findings reveal how unique postsynaptic CAMs work in concert to control synaptogenesis and estab

241 reduces surface levels of the Wnt receptors CAM-1/Ror and LIN-18/Ryk.

242 of how this molecular timekeeping regulates CAM is unknown.

243 vert cell adhesion-mediated drug resistance (CAM-DR) to the same levels as SOX11(-) MCL cells.

244 with cell adhesion-mediated drug resistance (CAM-DR), which is the most important form of drug resist

245 and cell adhesion-mediated drug resistance (CAM-DR).

246 tion of the IGF-1R/PI3K/AKT pathway reversed CAM-DR by promoting EZH2 dephosphorylation and H3K27 hyp

247 terophylly) evolved in the most species-rich CAM lineages.

248 mechanical approaches (CASPT2/MM and PCM/TD-CAM-B3LYP).

249 In this study, we discovered that CAM alpha(1)A-AR mice in vivo have cardiac hypertrophy i

250 ng quantitative image analysis, we find that CAM is significantly reduced when mitosis is suppressed.

251 This advantage is significant in that CAM can achieve all of its goals using only a small numb

252 The findings in the paper indicate that CAM-lipid complexes can serve as a novel and efficient s

253 A mechanistic finding that emerged is that CAM operates with a diel redox poise that is shifted rel

254 The CAM algorithm integrates plug-in noise filtering using s

255 The CAM can turn fluorescence from green to yellow to orange

256 The CAM model (Bartlett et al., 2014) consists of a Calvin c

257 The CAM neuroplastin-65 (Np65) highly expressed during perio

258 The CAM pathway provides excellent opportunities to genetica

259 The CAM-S provides a new delirium severity measure with stro

260 cal, complemented by DFT computations at the CAM-B3LYP level applied to the bicarbonate radical itsel

261 During the CAM, a consortium of international experts evaluated the

262 al evolution of these variables entrains the CAM cycle with prevailing environmental conditions.

263 n malic acid uptake and release, forcing the CAM system with periodic daily fluctuations in light exp

264 er, the degree to which plants engage in the CAM cycle relative to regular C3 photosynthesis is highl

265 d in vivo for antiangiogenic activity in the CAM model and in a xenografted ovarian carcinoma tumor (

266 genesis by activating the AKT pathway in the CAM model, as well as nude mice.

267 hasone reduced blood vessel formation in the CAM.

268 o be offset by the higher flux demand of the CAM cycle.

269 and reliability of the Arabic version of the CAM-ICU.

270 noma proliferation and in vivo growth on the CAM in human melanoma models.

271 to endochondral condensations (Sox9+) on the CAM-implanted bone cylinders, correlating with a signifi

272 ovarian carcinoma tumor (A2780) grown on the CAM.

273 The 3D-CAM operationalizes the CAM algorithm using a 3-minute structured assessment wit

274 kinetic parameters) with expression over the CAM diel cycle.

275 he use of reserves for growth to support the CAM-cycle and the synthesis of compatible solutes.

276 tequilana Rca isoforms demonstrated that the CAM Rca isoforms are approximately10 degrees C more ther

277 After translating the CAM-ICU into Arabic language, the Arabic CAM-ICU was adm

278 Angiogenesis was modeled using the CAM assay and changes in blood vessel formation were rec

279 OH)-CAM with diferric CmlI yields P and then CAM without an external reductant.

280 These CAMs are the targets of autoimmunity in inflammatory neu

281 ral binding (cis-interactions) between these CAMs will positively correlate with their trans-interact

282 persists in the absence of each one of these CAMs.

283 NA binds more tightly at pH=7.4 than pH=5 to CAM-lipid (1:10 w/w).

284 t there is no overall energetic advantage to CAM, despite the potential for suppression of photorespi

285 abled the evolutionary transition from C3 to CAM.

286 Finally, the reformed P oxidizes NO-CAM to CAM with incorporation of a second O2-derived oxygen ato

287 e has transitioned from C3 photosynthesis to CAM, with CAM-related genes exhibiting a diel expression

288 These findings indicate that the switch to CAM is associated with environmental change.

289 results strongly suggest that antibodies to CAMs may be pathogenic and induce demyelination via func

290 erize an epigenetic mechanism that underlies CAM-DR and suggest that kinase inhibitors to counteract

291 o define the cellular behaviour underpinning CAM.

292 lular, platelet-endothelial, and/or vascular CAMs (ICAM-1, PECAM-1, VCAM-1).

293 tic factor and interleukin-6 (IL-6), whereas CAM alpha(1)B-AR mice expressed activated nuclear factor

294 infer divergence times; and estimate whether CAM is associated with niche shifts.

295 We investigated whether CAM evolution can be associated with the availability of

296 examined a priori hypotheses testing whether CAM use was associated with chemotherapy initiation, adj

297 Among 614 adults with CAM, 407 patients (66.3%) did not have an indication for

298 sitioned from C3 photosynthesis to CAM, with CAM-related genes exhibiting a diel expression pattern i

299 Usefulness of head CT in patients with CAM without an indication for imaging is limited and has

300 signaling that was AR subtype-specific with CAM alpha(1)A-AR mice secreting atrial naturietic factor