ライフサイエンスコーパス: CART

1 CART (cocaine and amphetamine regulated transcript) is a

2 CART (Cocaine-Amphetamine-Regulated Transcript) has been

3 CART 55-102 detection on Western blot was unchanged by h

4 CART analysis generated a simple and practical algorithm

5 CART analysis generated an algorithm based on the combin

6 CART analysis identified a small set of patient characte

7 CART analysis revealed potential higher-order gene-gene

8 CART analysis selected a PSA cutoff of more than 1.55 ng

9 CART analysis suggested that resting mean pulmonary arte

10 CART analysis was performed in two steps, initially usin

11 CART elements are commonly overrepresented in diverse se

12 CART induced a long-lasting (>6 h) hypothermia: a 1.5 de

13 CART is widely distributed in the brain of mammals, amph

14 CART peptide distribution largely mirrored, but did not

15 CART peptide does not colocalize with enkephalin-IR in t

16 CART peptide is a novel neurotransmitter that, due to it

17 CART transcript abundance was measured in total hypothal

18 CART treatment of APP/PS1 mice also reduced reactive oxy

19 CART's classification as a catabolic neuropeptide is bas

20 CART-immunoreactive fibers in IN showed a significant re

21 CART-immunoreactive fibers were found in the subpallium,

22 CARTs are structurally unique and operate through an unp

23 TRH neurons from 6.0 +/- 0.9 to 2.3 +/- 0.4 CART-IR varicosities/cell.

24 A CART analysis using multiple screening parameters-C/D, H

25 response element (CRE)-binding protein to a CART promoter CRE site in ischemic brain and rapid activ

26 In addition, CART induced phosphorylation of CREB, IRS, PKB, FoxO1, p

27 In addition, CART is a regulator of neuronal survival.

28 Additionally, CART peptide was higher in the nucleus accumbens (NAc) o

29 over expression of CREB in the NAc affected CART peptide levels, Herpes simplex virus-1 vectors over

30 the distribution of immunoreactivity against CART peptides (CARTp-ir) in the brains of two bird speci

31 NPY, AGRP, CART, and pomc1a somata showed distribution patterns sim

32 l risk ratios were approximately 0.5 for all CART-derived AUC/MIC exposure thresholds, indicating tha

33 Although CART is widely distributed in the brain of a range of ve

34 ve cells of pIII at PND 4 and that Ucn 1 and CART are strongly but not completely co-localized in pII

35 cterize the ontogenetic profile of Ucn 1 and CART during postnatal development in C57BL/6J (B6) mice.

36 d immunohistochemical staining for Ucn 1 and CART showed that Ucn 1-immunoreactivity (ir) was absent

37 tide was not apparent in fasted animals, and CART peptide levels were reduced.

38 Brn-3b and positive for both calretinin and CART retina markers.

39 for immunohistochemical analysis of CART and CART+tryptophan hydroxylase (TPH), CART+estrogen recepto

40 ble analysis, stepwise regression, LASSO and CART.

41 r to that of saliva, as determined by LR and CART.

42 petite control hormones, PYY, alpha-MSH, and CART, are hampered.

43 eta and PR were detected in CART neurons and CART fibers appeared to innervate TPH-positive serotonin

44 First, NPY and CART are coexpressed in the same neurons within the DMH,

45 imals were immunostained with cFos, NPY, and CART antisera.

46 xpression of the anorexigenic genes POMC and CART was up-regulated by 1, 2, 5 and 1, 2, respectively,

47 suppression of anorexigenic systems POMC and CART.

48 st a potential role for NPY, AGRP, POMC, and CART in regulating energetic status in A. burtoni female

49 After 45 min, subjects were sacrificed and CART peptide expression was examined using immunohistoch

50 Effects of CCK on Y2R and CART expression were reduced by CART small interfering R

51 In regular-fed animals, CART peptide levels were lower in the morning compared t

52 y similar pattern of Abeta plaque-associated CART immunoreactivity was observed in the cortex of AD c

53 st (exendin-9-39) in control rats attenuated CART hypothermia and hypophagia, indicating that GLP-1R

54 and cyclophosphamide, frequently used before CART administration, downregulated IDO expression in lym

55 y indicate shared genetic regulation between CART expression and other neurobiological processes refe

56 In birds, CART inhibits food intake, whereas neuropeptide Y (NPY),

57 In both CART and MDR analyses, reflux was also the strongest ind

58 te in ischemic brain and rapid activation by CART of ERK in primary cultured cortical neurons.

59 eatine kinase-MB (CK-MB), and TnI and BNP by CART.

60 the total number of TRH neurons contacted by CART from 99.4 +/- 0.9% on the intact side to 74.3 +/- 9

61 NPY-immunoreactive neurons were contacted by CART-immunoreactive fibers and 96 +/- 2.8% NPY-immunorea

62 ceiving early or delayed therapy, defined by CART timepoint.

63 K on Y2R and CART expression were reduced by CART small interfering RNA or brefeldin A.

64 s, antagonizing this enzyme may benefit CD19-CART therapy.

65 and improved the antitumor activity of CD19-CART in vivo.

66 investigate the effects of tumor IDO on CD19-CART therapy, we used a xenograft lymphoma model express

67 CD19-CARTs inhibited IDO-negative tumor growth but had no eff

68 Because tumor IDO inhibits CD19-CARTs, antagonizing this enzyme may benefit CD19-CART th

69 Inhibition of CD19-CARTs was not mitigated by the incorporation of costimul

70 ons, and leptin suppresses the increased CeA CART expression of leptin-deficient animals.

71 , such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the out

72 vironment suppresses CAR-expressing T cells (CARTs) through the activity of indoleamine 2,3-dioxygena

73 eural injury, we confirmed and characterized CART mRNA and protein up-regulation by estradiol in surv

74 single-expressing CART or pooled combination CART.

75 Conspicuous CART-immunoreactive cells were observed in the bed nucle

76 e only 19% of substance P-IR neurons contain CART.

77 In contrast, CART 1 and 3 have a much more restricted distribution, p

78 In contrast, CART was expressed in climbing fiber bands in all four t

79 comparable to the corresponding conventional CART-19, but with lower cytokine levels, thereby offerin

80 status (incidental vs contributing), current CART, plasma HIV RNA, reading ability, and CD4 cell nadi

81 Both E- and E+P-administration decreased CART gene expression on the microarray and with qRT-PCR.

82 In summary, E decreased CART mRNA, but this effect did not translate to the prot

83 CREB mutant (HSV-mCREB) did not alter either CART mRNA or peptide levels.

84 tive anti-CD123 messenger RNA-electroporated CART (RNA-CART123); (2) T-cell ablation with alemtuzumab

85 iquely, the epiphysis also appears to employ CART as a neurotransmitter.

86 ls also caused a 50% reduction of endogenous CART protein.

87 l support for the hypothesis that endogenous CART peptides in the NAc inhibit the actions of cocaine

88 CART peptides in the NAc and that endogenous CART peptides influence body weight and cocaine-induced

89 Exogenous CART treatment in APP/PS1 mice prevented depolarization

90 s study, we examined the effect of exogenous CART 55-102 on beta cell viability and dissected its sig

91 ized and the protective effects of exogenous CART treatment were examined.

92 Treatment of APP/PS1 mice with exogenous CART ameliorated memory deficits; this effect was associ

93 gainst B-ALL compared with single-expressing CART or pooled combination CART.

94 s for CART and additional considerations for CART's role in brain.

95 ggest a variety of regulatory mechanisms for CART and additional considerations for CART's role in br

96 e widespread neuronal expression pattern for CART 2 and 4 suggests a prominent role for the peptide i

97 tides in vivo in the NAc supports a role for CART peptides in psychostimulant-induced reward and rein

98 omplex, interactive network whereby the four CART gene products may have nonredundant functions in en

99 we have mapped the distribution of the four CART mRNAs in the central nervous system of the adult ze

100 ype/phenotype analyses support findings from CART analyses.

101 Further, CART has been implicated in the transition to puberty.

102 h-old APP/PS1 mice had significantly greater CART immunoreactivity in the hippocampus and cortex.

103 Hindbrain CART application reduced food intake and body weight and

104 othermic and hypophagic effects of hindbrain CART, whereas CART-induced hyperglycemia was not altered

105 tamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the pr

106 cence, which showed that Ucn 1 was absent in CART-positive cells of pIII at PND 4 and that Ucn 1 and

107 N, but also starvation induced a decrease in CART-expressing neurons in this region.

108 vation resulted in a significant decrease in CART-positive cells in the nucleus recessus lateralis (N

109 ERbeta and PR were detected in CART neurons and CART fibers appeared to innervate TPH-p

110 Large species differences in CART mRNA distribution were apparent in the nucleus accu

111 Dramatic species differences also existed in CART peptide distribution, including the medial preoptic

112 t on CART mRNA, but it caused an increase in CART immunostaining.

113 The trends in CART ontogeny suggest that it may be involved in the est

114 Forskolin, which was known to increase CART mRNA levels in GH3 cells, was utilized to show that

115 that over expression of CREB would increase CART peptide levels.

116 However, P administration increased CART-immunopositive area in comparison to the OVX contro

117 on showed that HSV-CREB injections increased CART mRNA and peptide levels.

118 expression of CREB in the rat NAc increased CART mRNA and peptide levels, but it is not known if thi

119 s and that the social environment influences CART expression in the prairie vole in a region- and sti

120 ablishes zebrafish as a model to investigate CART function in physiology and development.

121 kappa.CART expansion peaked 1-2 weeks after infusion, and cell

122 kappa.CART infusion is feasible and safe and can lead to compl

123 5 mg/kg cyclophosphamide 4 days before kappa.CART infusion (0.2 x 108 to 2 x 108 kappa.CARTs/m2).

124 pa.CART infusion (0.2 x 108 to 2 x 108 kappa.CARTs/m2).

125 tically modified to express kappa.CAR (kappa.CARTs).

126 e remission after 2 and 3 infusions of kappa.CARTs, and 1 had a partial response.

127 No toxicities attributable to kappa.CARTs were observed.

128 For comparison, KNN, CART, SIMCA, PLS-DA and PCA-LDA were also used.

129 em for Cardiac Catheterization Laboratories (CART-CL) program.

130 The entopeduncular nucleus is a major CART-containing group in the adult teleost forebrain tha

131 largely mirrored, but did not exactly match, CART mRNA distribution.

132 We found that in mice CART was expressed in climbing fiber bands that generall

133 strogen (E) and progesterone (P) on midbrain CART mRNA and peptide expression and 3) to determine whe

134 ression and 3) to determine whether midbrain CART neurons contain steroid receptors.

135 In these mostly CART-treated persons, mtDNA haplogroup B was associated

136 urthermore, a survival model by multivariate CART analysis that was based on number of adverse factor

137 In the nucleus accumbens (NAcc), CART peptide immunoreactivity (IR) is colocalized with s

138 We also identify a neuropeptide, CART (cocaine- and amphetamine-regulated transcript), th

139 the absence of either MCR3 or MCR4, but not CART, increased lipid deposition and produced comparable

140 The novel CART complex may provide a molecular mechanism for the a

141 ptinemia increases the activity of these NPY/CART neurons.

142 In additional experiments, we observed CART expression in loose clusters of spinocerebellar mos

143 Approximately 86% of CART-IR cells colocalize with substance P, while only 19

144 expression were unaffected by the absence of CART.

145 e thresholds, indicating that achievement of CART-derived AUC/MIC exposure thresholds was associated

146 up); (b) for immunohistochemical analysis of CART and CART+tryptophan hydroxylase (TPH), CART+estroge

147 Stereological analysis of CART immunostaining at five levels of the Edinger-Westph

148 CCK in stimulating expression of Y2R and of CART itself in these neurons in vivo and in vitro, but n

149 ct of E or E+P administration on the area of CART immunostaining.

150 ate whether (1) caudal brainstem delivery of CART produces energetic, cardiovascular, and glycemic ef

151 re was a decrease in the staining density of CART peptide in the NAc of the shRNA injected rats.

152 udy were 1) to determine the distribution of CART immunoreactive neurons in the monkey midbrain, 2) t

153 rmone, we examined the brain distribution of CART mRNA and peptide in monogamous prairie voles compar

154 We studied the distribution of CART-immunoreactivity in the brain of zebra finch, Taeni

155 Enrichment of CART 2 and 4 in the preoptic and tuberal areas emphasize

156 there abundant and overlapping expression of CART 2, 3, and 4 in the EN, but also starvation induced

157 6 h) restraint stress upon the expression of CART mRNA in the hippocampus and the amygdala and the ef

158 Data reveal a novel function of CART in temperature regulation and open possibilities fo

159 d tuberal areas emphasizes the importance of CART in neuroendocrine functions.

160 to starvation underscores the importance of CART neuropeptide in energy processing.

161 finding that CREB can regulate the levels of CART mRNA and peptides in vivo in the NAc supports a rol

162 of drug resistance is a major limitation of CART.

163 The cellular resolution mapping of CART mRNA and the response of CART-expressing nuclei to

164 ors (GLP-1Rs) contribute to the mediation of CART-induced effects.

165 the lesioned side, as well as the number of CART varicosities on the surface of TRH neurons from 6.0

166 The pattern of CART expression in zebrafish suggests conserved evolutio

167 There is a distinct population of CART neurons located in the vicinity of the Edinger-West

168 The presence of CART in substance P NAcc neurons suggests that CART neur

169 We found an up-regulation of CART mRNA in the central amygdala induced by acute but n

170 amine natural variation in the regulation of CART transcript abundance (CARTta) in the hypothalamus.

171 Release of CART peptide (CARTp) from cultured vagal afferent neuron

172 ion mapping of CART mRNA and the response of CART-expressing nuclei to starvation underscores the imp

173 Given the potential role of CART (cocaine- and amphetamine-regulated transcript) in

174 ude that, although the overall topography of CART-expressing afferents is restricted within a conserv

175 ether our data point to the potential use of CART in therapeutic interventions targeted at enhancing

176 The diurnal variation of CART mRNA in the nucleus accumbens paralleled the variat

177 ucleus accumbens paralleled the variation of CART peptide in this region.

178 However, this diurnal variation of CART peptide was not apparent in fasted animals, and CAR

179 -2-, IL-7-, and IL-15-dependent expansion of CARTs; diminished their proliferation, cytotoxicity, and

180 rs, median CD4 nadir 178 cells/mm(3), 72% on CART, and 46% with HAND.

181 dministration alone had a variable effect on CART mRNA, but it caused an increase in CART immunostain

182 mine the effects of acute (30 min) stress on CART mRNA in prepubescent and adult rats.

183 FP profiles in the NG expressed CGRP (5%) or CART (4%).

184 ylase (TPH), CART+estrogen receptors (ER) or CART+progesterone receptors (n=5/group) and (c) for West

185 Sufficient details for our CART procedure are given so that the interested reader c

186 The substance P-CART colocalization exists in a rostro-caudal gradient w

187 type had a significant effect on AGRP, POMC, CART, and NPY-Y1R, with an exercise and genotype interac

188 ur findings indicate that the GLP-1R on POMC/CART-expressing ARC neurons likely mediates liraglutide-

189 revealed that GLP-1 directly stimulates POMC/CART neurons and indirectly inhibits neurotransmission i

190 monstrated that i.v. administration of a rat CART peptide is protective against ischemic brain injury

191 sy fibers in the mouse AZ/PZ, whereas in rat CART immunoreactive mossy fibers terminated predominantl

192 ript (CART) peptide depletion in adult rats, CART shRNAs or scrambled control shRNAs were administere

193 Four monkeys received CART (consisting of the nonpenetrating agents PMPA and R

194 regions of brain from monkeys that received CART as compared with four SIV-infected, untreated contr

195 hoid compartments from animals that received CART.

196 These data show that shRNA can reduce CART peptides in the NAc and that endogenous CART peptid

197 Adrenalectomy reduced CART expression in the dentate gyrus but not the amygdal

198 e, suggesting that the energy status sensing CART circuits is active early in development.

199 othalamus, and pituitary, conspicuously show CART innervations, suggesting functions analogous to tho

200 The actions of CCK in stimulating CART and Y2R expression in vagal afferent neurons and in

201 In this study, CART localization in APP/PS1 mice was characterized and

202 In summary, CART treatment reduced multiple neuropathological measur

203 In individuals with reflux symptoms, CART analysis indicated that strongest interaction was a

204 regionally and time specific manner and that CART is regulated by corticosteroid actions in the hippo

205 Thus, we demonstrate that CART 55-102 protects beta cells against glucotoxicity an

206 xtend our observations by demonstrating that CART peptides also exhibit a diurnal rhythm in several b

207 Our data establish that CART expression is regulated by stress in a regionally a

208 ocaine-mediated reward, we hypothesized that CART could be a target gene for CREB in the NAc and that

209 of the basal ganglia direct pathway or that CART neurons are involved in limbic projections of the N

210 Current hypotheses postulate that CART peptides there oppose the rewarding actions of coca

211 ion and chromatin condensation revealed that CART 55-102 reduced glucotoxicity-induced apoptosis in b

212 We show that CART increased proliferation in INS-1 (832/13) cells, an

213 or characteristic curve analysis showed that CART and logistic regression models had similar accuracy

214 We have recently shown that CART peptides exhibit a diurnal rhythm in blood that is

215 These findings suggest that CART in the NAc is differentially responsive to the sex

216 The findings suggest that CART is an important player in estrogen-mediated neuropr

217 Together, the data suggest that CART neurons in the midbrain have a unique steroid respo

218 RT in substance P NAcc neurons suggests that CART neurons may be a subset of the basal ganglia direct

219 The CART model successfully predicted the 3-month-ahead redu

220 The CART procedure adaptively clusters genes by variances.

221 The CART-immunoreactive system in the zebrafish central nerv

222 absolute value) in patients who achieved the CART-derived day 1 and 2 thresholds for AUC/MIC by broth

223 Cancers that were missed by the CART were Gleason score 6 or less in 93.4% of cases.

224 Disrupting the CART complex results in shunting receptors to a slower r

225 leotide containing the CRE sequence from the CART gene proximal promoter.

226 s found to bind to the CRE sequence from the CART promoter.

227 redicting a dementia diagnosis; however, the CART analysis did reveal important TICV subgroups, inclu

228 fell into any one of three groupings in the CART analysis had lung cancer.

229 r, and number of teeth identified AMI in the CART decision trees.

230 P-CREB bound directly to the CRE site in the CART promoter, using chromatin immunoprecipitation (ChIP

231 analysis was conducted by repetition of the CART analysis in 58 cases and 58 controls, each matched

232 ttributed to the increased expression of the CART gene by direct interaction of P-CREB with the CART

233 -CREB antibodies showed an enrichment of the CART promoter fragment containing the CRE region over Ig

234 was due to a direct action of P-CREB on the CART gene promoter.

235 Therefore, we hypothesized that the CART system may play a role in the regulation of social

236 elative contribution of the brainstem to the CART innervation of the TRH neurons in the PVN, the majo

237 of P-CREB protein and P-CREB binding to the CART promoter CRE-containing region.

238 To examine whether the CART peptide rhythm was dependent on food intake, animal

239 ene by direct interaction of P-CREB with the CART promoter CRE site, rather than by some indirect act

240 short-term combined antiretroviral therapy (CART) on brain virus burden in rhesus monkeys using the

241 tion and combination antiretroviral therapy (CART), and with neurodegenerative diseases.

242 ntiviral agents used in combination therapy (CART) of human immunodeficiency virus type 1 (HIV-1) inf

243 Thus CART is not involved in glucose mobilization.

244 CART and CART+tryptophan hydroxylase (TPH), CART+estrogen receptors (ER) or CART+progesterone recept

245 Clinical Assessment Reporting and Tracking (CART) program representing all 76 VA cardiac catheteriza

246 Clinical Assessment Reporting and Tracking (CART) Program.

247 linical Assessment, Reporting, and Tracking (CART) program.

248 linical Assessment, Reporting, and Tracking (CART) program.

249 caine- and amphetamine-regulated transcript (CART) expression can be used to partition sensory-motor

250 caine- and amphetamine-regulated transcript (CART) gene is regulated by cocaine and other drugs of ab

251 caine- and amphetamine-regulated transcript (CART) has emerged as a potent anorectic agent.

252 caine- and amphetamine-regulated transcript (CART) has recently been reported to attenuate Abeta-indu

253 caine- and amphetamine-regulated transcript (CART) is an islet peptide that promotes glucose-stimulat

254 caine- and amphetamine-regulated transcript (CART) mRNA and peptide expression have been found betwee

255 caine- and amphetamine-regulated transcript (CART) neurons by LepRb neurons, and leptin suppresses th

256 caine- and amphetamine-regulated transcript (CART) neuropeptide has been implicated in the neural reg

257 ocaine and amphetamine regulated transcript (CART) peptide depletion in adult rats, CART shRNAs or sc

258 caine- and amphetamine-regulated transcript (CART) peptidergic system is involved in processing diver

259 ocaine and Amphetamine-Regulated Transcript (CART) peptides are implicated in a wide range of behavio

260 caine- and amphetamine-regulated transcript (CART) peptides are widely distributed throughout the neu

261 caine- and amphetamine-regulated transcript (CART) peptides, have been shown to decrease cocaine rewa

262 caine- and amphetamine-regulated transcript (CART), but the significance of this is unknown.

263 caine- and amphetamine-regulated transcript (CART), orexin, brain-derived neurotropic factor (BDNF),

264 caine- and amphetamine-regulated transcript (CART), that is highly induced in the cerebral cortex by

265 caine- and amphetamine-regulated transcript (CART), which co-localizes with Ucn 1 in the perioculomot

266 caine- and amphetamine-regulated transcript (CART)-expressing neurons in the PVH and AVPV.

267 caine- and amphetamine-regulated transcript (CART).

268 ss cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked e

269 caine- and amphetamine-regulated transcript (CART)] in the hypothalamus.

270 cocaine- and amphetamine-related transcript (CART), galanin, gastrin-releasing peptide (GRP), neurope

271 the cocaine amphetamine-related transcript (CART), melanocortin receptor 3 (MCR3), or melanocortin r

272 ocaine and amphetamine-regulated transcript, CART; pro-opiomelanocortin, pomc1a) neurons in the brain

273 ls: charge-altering releasable transporters (CARTs) for mRNA delivery into cells.

274 sing the classification and regression tree (CART) algorithm can provide improved predictive understa

275 ion, and classification and regression tree (CART) analyses were performed for diagnostic and prognos

276 rametric Classification and Regression Tree (CART) analyses were performed to model group heterogenei

277 Classification and regression tree (CART) analysis and logistic regression analyses were per

278 Classification and Regression Tree (CART) analysis selected a panel of four markers that mos

279 A classification and regression tree (CART) analysis was used to assess combinations of variab

280 Classification and regression tree (CART) analysis was used to determine the delay in approp

281 Classification and regression tree (CART) analysis was used to develop a multivariate algori

282 Classification and Regression Tree (CART) analysis was used to identify day 1 and 2 exposure

283 s, using classification and regression tree (CART) analysis.

284 us), and classification and regression tree (CART) analysis.

285 A Classification and Regression Tree (CART) procedure is introduced for variance stabilization

286 n (MDR), classification and regression tree (CART), and traditional logistic regression (LR) models.

287 SSO) and classification and regression tree (CART).

288 on, and classification and regression trees (CART) analyses were used for statistical analysis.

289 Classification and Regression Trees (CART) analysis of average daily routine and ancillary co

290 sis and classification and regression trees (CART) analysis were used for statistical analysis.

291 ased on classification and regression trees (CART).

292 alectomy and corticosteroid replacement upon CART expression in these regions of the adult rat brain.

293 Using CART analysis, we stratified 2 subgroups of patients wit

294 The hrs/actinin-4/BERP/myosin V (CART [cytoskeleton-associated recycling or transport]) c

295 ical Assessment, Reporting, and Tracking (VA CART) program.

296 rved in intact rats to hindbrain ventricular CART, suggesting that forebrain processing is required f

297 As in other vertebrates, CART in the brain of T. guttata may perform several func

298 ypophagic effects of hindbrain CART, whereas CART-induced hyperglycemia was not altered by GLP-1R blo

299 noreactivity (ir) was absent at PND 1, while CART-ir was already apparent in pIIIu at birth, a findin

300 jected fourth intracerebroventricularly with CART (0.1, 1.0, and 2.0 microg).

301 thalamic slices of fasted birds treated with CART-peptide showed a significant reduction (P < 0.001)