ライフサイエンスコーパス: CB1 cannabinoid receptor

1 ocannabinoid signaling and activation of the CB1 cannabinoid receptor.

2 is a potent and selective antagonist for the CB1 cannabinoid receptor.

3 ion (LTD), is dependent on activation of the CB1 cannabinoid receptor.

4 to be a suitable radioligand for studies of CB1 cannabinoid receptors.

5 docannabinoids and activation of presynaptic CB1 cannabinoid receptors.

6 ntagonist SR141716A, showing a dependence on CB1 cannabinoid receptors.

7 cts of behavior, contain very high levels of CB1 cannabinoid receptors.

8 dicating that the inhibition was mediated by CB1 cannabinoid receptors.

9 hysiological effects by interacting with the CB1 cannabinoid receptor, a membrane protein belonging t

10 calcium-activated potassium (SK) channel and CB1 cannabinoid receptor activation.

11 op compounds that are potent agonists at the CB1 cannabinoid receptor and that are also easily labele

12 we describe the subcellular localization of CB1 cannabinoid receptors and eCB synthetic machinery at

13 inus is critical for G protein activation by CB1 cannabinoid receptors and that the amino-side IL3 al

14 CB2, as shown by its failure to bind to the CB1 cannabinoid receptor, and has no activity in CB2-def

15 ffect was blocked by pertussis toxin and the CB1 (cannabinoid) receptor antagonist SR141716A.

16 The CB1 cannabinoid receptor antagonist AM 251 [N-(piperidin

17 gonist WIN 55,212-2, and is abolished by the CB1 cannabinoid receptor antagonist AM 251.

18 The CB1 cannabinoid receptor antagonist SR 141716A abolished

19 could readily be prevented by the selective CB1 cannabinoid receptor antagonist SR-141716A.

20 njection of the drug and was reversed by the CB1 cannabinoid receptor antagonist SR141716A.

21 SR141716, a recently developed CB1 cannabinoid receptor antagonist, blocks acute effect

22 on produced by Win55212-2 was blocked by the CB1 cannabinoid receptor antagonist, SR141716 (1 microM)

23 blocked by the specific central cannabinoid (CB1) cannabinoid receptor antagonist N-(piperidin-1-yl)-

24 hemoglobin but was blocked completely by the CB1 cannabinoid receptor antagonists AM251 [N-(piperidin

25 show that in rat cerebellar granule neurons, CB1 cannabinoid receptor antagonists inhibit axonal grow

26 retreatment with the peripherally restricted CB1 cannabinoid receptor antagonists, AM6546 and URB447.

27 The CB1 cannabinoid receptors are among the most highly expr

28 The mechanism by which CB1 cannabinoid receptors are coupled to the Gi/Go class

29 de mobilization and consequent activation of CB1 cannabinoid receptors are necessary and sufficient t

30 equires visual experience and stimulation of CB1 cannabinoid receptors as it is mimicked by administr

31 y confirm structures of three mutants of the CB1 cannabinoid receptor associated with different funct

32 annabimimetic (aminoalkyl)indoles (AAIs) for CB1 cannabinoid receptor binding affinity, based on pKi

33 gions around the AAIs that are important for CB1 cannabinoid receptor binding such as the sterically

34 gest that the binding site region within the CB1 cannabinoid receptor can accommodate a wide range of

35 trate that a population of native and cloned CB1 cannabinoid receptors can exist in a tonically activ

36 CB1 cannabinoid receptors (CB1) are located at axon term

37 eviously shown that the G alpha(o/i)-coupled CB1 cannabinoid receptor (CB1R) activates Rap1 to induce

38 its protective effect was attenuated by the CB1 cannabinoid receptor (CB1R) antagonist N-(piperidin-

39 hich primes the recruitment of beta cells by CB1 cannabinoid receptor (CB1R) engagement.

40 campus, in vivo inhibition of MAGL induces a CB1 cannabinoid receptor (CB1R)-dependent suppression of

41 e cerebellum of mice with global loss of the CB1 cannabinoid receptor (CB1R, Cb1(-/-) mice) and in mi

42 Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating neurogene

43 hannels by activating G(i/o)-protein-coupled CB1 cannabinoid receptors (CB1R)--a possible mechanism u

44 CB1 cannabinoid receptors (CB1Rs) are attractive therape

45 We investigated in mice the role of CB1 cannabinoid receptors (CB1Rs) in memory impairment a

46 etabotropic glutamate receptors (mGluRs) and CB1 cannabinoid receptors (CB1Rs) leads to inhibition of

47 beta Cells express CB1 cannabinoid receptors (CB1Rs), and the enzymatic mac

48 orpus callosum enlargement due to the errant CB1 cannabinoid receptor-containing corticofugal axon sp

49 dings indicate that activation of peripheral CB1 cannabinoid receptors contributes to haemorrhagic hy

50 ence indicates that activation of peripheral CB1 cannabinoid receptors contributes to hemorrhagic hyp

51 injected 16-25 hr previously with rat brain CB1 cannabinoid receptor cRNA.

52 High CB1 cannabinoid receptor densities in mammalian telencep

53 o increased social play, but blockade of NAc CB1 cannabinoid receptors did not antagonize the play-en

54 questration occurs because the population of CB1 cannabinoid receptors exists in both an inactive G-p

55 The CB1 cannabinoid receptor has been shown to play importan

56 We tested the hypothesis that human CB1 cannabinoid receptors (hCB1) can sequester G(i/o)-pr

57 most abundant cannabinoid receptors are the CB1 cannabinoid receptors; however, CB2 cannabinoid rece

58 ng different pharmacological potency for the CB1 cannabinoid receptor, i.e., anandamide and N-(2-hydr

59 The CB1 cannabinoid receptor in N18TG2 neuroblastoma cells i

60 ubunit of the 5-HT3 receptor and the central CB1 cannabinoid receptor in neurons of the rat telenceph

61 The roles of CB1 cannabinoid receptors in regulating neuronal activit

62 re, social play increased phosphorylation of CB1 cannabinoid receptors in the amygdala.

63 , an endogenous cannabinoid ligand, binds to CB1 cannabinoid receptors in the brain and mimics the ne

64 We studied the cellular distribution of CB1 cannabinoid receptors in the superior colliculus of

65 s in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous ca

66 Activation of the CB1 cannabinoid receptor inhibits neurotransmission at n

67 rt the discovery of two structurally related CB1 cannabinoid receptor interacting proteins (CRIP1a an

68 MOR-/-) mice to determine the effects of the CB1 cannabinoid receptor inverse agonist AM251 on feedin

69 -methylpyrazole-3 -carboxamide), implicating CB1 cannabinoid receptor involvement.

70 The CB1 cannabinoid receptor is a constitutively active rece

71 The CB1 cannabinoid receptor is a G-protein coupled receptor

72 0) in the second transmembrane domain of the CB1 cannabinoid receptor is crucial for constitutive act

73 We found that in CB1 cannabinoid receptor knock-out mice, mortality from

74 quent enhancement of anandamide signaling at CB1 cannabinoid receptors localized on sensory nerve end

75 ation of the dorsal and lateral PAG produced CB1 cannabinoid receptor-mediated analgesia accompanied

76 tration of oligonucleotides directed against CB1 cannabinoid receptor mRNA significantly reduced spin

77 smission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid

78 A CB1 cannabinoid receptor peptide fragment from the C-ter

79 ribution of the GRIN-Sprouty2 interaction to CB1 cannabinoid receptor regulation of FGF receptor sign

80 The CB1 cannabinoid receptor, the main molecular target of e

81 The CB1 cannabinoid receptor, the main target of Delta(9)-te

82 oactive constituent of cannabis binds to the CB1 cannabinoid receptor, the present study was designed

83 Exploration of the central CB1 cannabinoid receptors using positron emission tomogr

84 Transient expression of the rat brain CB1 cannabinoid receptor was accomplished through microi

85 the third transmembrane domain of the human CB1 cannabinoid receptor was converted to an alanine to

86 euronal ion channels by the cloned rat brain CB1 cannabinoid receptor was investigated with the use o

87 known target of cannabinoids in the CNS, the CB1 cannabinoid receptor, we have produced a mouse strai

88 Human CB1 cannabinoid receptors were expressed in superior cer

89 ed social play behavior, and blockade of BLA CB1 cannabinoid receptors with the antagonist/inverse ag