ライフサイエンスコーパス: CBG

1 CBG also catalyzes a variety of transglycosylation react

2 targeted modifications of the human alpha1AT-CBG locus on the regulation of cell-specific gene activi

3 e chromatin structure of the entire alpha1AT/CBG locus was reorganized to an expressing cell-typical

4 Human alpha1AT and CBG gene expression was activated in rat hepatoma microc

5 f targeted modifications of the alpha1AT and CBG loci on the regulation of gene activity and chromati

6 cells results in activation of alpha1AT and CBG transcription and chromatin reorganization of the en

7 resulted in activation of both alpha1AT and CBG transcription and gene activation was accompanied by

8 However, alpha1AT and CBG transcription could be rescued by transfecting the c

9 of alpha1AT; three MARs are between ATR and CBG and one MAR is within the CBG gene itself.

10 ATR and approximately 40 kb between ATR and CBG.

11 imal subcluster includes alpha 1AT, ATR, and CBG; it occupies approximately 90 kb of genomic DNA, wit

12 t and quantify CBD, CBDV, Delta(9)-THCV, and CBG in biological matrices.

13 We report here that the alpha1AT-ATR-CBG region contains five distinct MARs.

14 nabivarin (Delta(9)-THCV), and cannabigerol (CBG).

15 ion, using spectral unmixing, green beta-cat-CBG was deconvoluted from a red TCF-dependent FLuc repor

16 -cat click beetle green luciferase (beta-cat-CBG).

17 Gene order within this interval is cen-CBG-ATR-alpha 1 AT-KAL-PCI-AACT-tel.

18 As expected, on cleavage, CBG undergoes the irreversible S-to-R serpin transition,

19 e secreted by Pseudomonas aeruginosa cleaves CBG in zebra finch plasma within its reactive center loo

20 ased plasma corticosterone (CORT), decreased CBG, aphagia and adipsia 24 h after IS.

21 on increased CBT, increased CORT, decreased CBG, adipsia, or aphagia 24 h after IS.

22 ive and exoglycosidase-treated blood-derived CBG of healthy individuals were monitored by gel electro

23 plasma CBG production, and anti-zebra finch CBG antibodies cross-react with CBGs in other birds, ext

24 cosylation of this asparagine in zebra finch CBG does not influence its steroid-binding affinity, but

25 Recombinant zebra finch CBG steroid-binding properties reflect those of the natu

26 stitutions of amino acids within zebra finch CBG that are conserved only in birds reveal how they con

27 ensitivity was 2 ng/mL for CBDV, 4 ng/mL for CBG and THCV, and 7 ng/mL for CBD.

28 ary to derive correct kinetic parameters for CBG.

29 he development of therapeutic strategies for CBG-related vocal and motor disorders.

30 d dysfunction of the cortical-basal ganglia (CBG) song circuit.

31 bol PI) and corticosteroid-binding globulin (CBG) are part of a cluster of six serine protease inhibi

32 cation, the corticosteroid-binding globulin (CBG) binding affinity of the well-known steroid data set

33 Corticosteroid-binding globulin (CBG) delivers anti-inflammatory cortisol to inflamed tis

34 Corticosteroid-binding globulin (CBG) was isolated from chicken serum and identified by m

35 symbol PI), corticosteroid-binding globulin (CBG), alpha 1-antichymotrypsin (AACT), and protein C inh

36 ne encoding corticosteroid-binding globulin (CBG), and the chromatin organization of this approximate

37 y a serpin, corticosteroid-binding globulin (CBG), and their normally equilibrated release can be fur

38 ins such as corticosterone binding globulin (CBG), aphagia and adipsia.

39 pha1AT) and corticosteroid-binding globulin (CBG), as well as an antitrypsin-related sequence termed

40 hat encodes corticosteroid-binding globulin (CBG).

41 m levels of corticosteroid binding globulin (CBG).

42 Cytosolic beta-glucosidase (CBG) from mammalian liver is known for its broad substra

43 kidney contain a cytosolic beta-glucosidase (CBG) that hydrolyses various beta-d-glycosides, but whos

44 birds, extending opportunities to study how CBG regulates the actions of glucocorticoids and sex ste

45 here the crystal structures of cleaved human CBG (cCBG) at 1.8-A resolution and its complex with cort

46 e the first heterologous expression of human CBG, a system that facilitated a detailed assessment of

47 These data indicate that human CBG hydrolyses a broad range of dietary glucosides and m

48 n basal CORT (5 microg/dl) and a decrease in CBG (30% decrease).

49 s, with many DHSs around alpha1AT but few in CBG.

50 A full-length CBG cDNA (cbg-1) was cloned from a human liver cDNA libr

51 ion acceptor specificity of guinea pig liver CBG by several methods.

52 tryptophan that anchors ligands in mammalian CBG steroid-binding sites is replaced by an asparagine.

53 of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden.

54 ch is in a helix-like conformation in native CBG, unwinds and grossly perturbs the hormone binding si

55 was enhanced by sialoglycans on neighboring CBG N-sites.

56 nd documented activation of alpha1AT but not CBG gene expression.

57 cate that the transglycosylation activity of CBG derives from the formation of a covalently linked en

58 ered by the cleavage of the reactive loop of CBG.

59 Measurements of CBG mRNA in zebra finch tissues indicate that liver is t

60 gar intermediate and that the specificity of CBG for transglycosylation reactions is different from i

61 cells failed to activate either alpha1AT or CBG transcription, and chromatin remodeling failed to oc

62 dicate that liver is the main site of plasma CBG production, and anti-zebra finch CBG antibodies cros

63 Zebra finch and rat CBG crystal structures in complex with cortisol resemble

64 The recombinant CBG (reCBG) was purified from the supernatant using a si

65 Phylogenetic comparisons show that reptilian CBG orthologs share this unexpected property.

66 In conclusion, site-specific CBG N-glycosylation regulates the bioavailability of cor

67 covalent enzyme-sugar intermediate and that CBG will transfer sugar residues to primary hydroxyls an

68 We conclude that CBG has adapted an allosteric mechanism of the serpins t

69 These studies indicate that CBG employs a two-step catalytic mechanism with the form

70 er, combined with circuit dysfunction in the CBG song system, offers a model for genetic manipulation

71 etween ATR and CBG and one MAR is within the CBG gene itself.

72 of various Asn(347) glycoforms of uncleaved CBG indicated that multiple Asn(347) glycan features are