ライフサイエンスコーパス: CC chemokine

1 inactivating CXC chemokines and inactivating CC chemokines.

2 se of infectious viral particles and CXC and CC chemokines.

3 s and destroys many of these proinflammatory CC chemokines.

4 in the zebrafish genome that encode putative CC chemokines.

5 served synteny between teleost and mammalian CC chemokines.

6 at sequestering and scavenging inflammatory CC chemokines.

7 ner that now engages functional responses to CC chemokines.

8 th high affinity to multiple proinflammatory CC chemokines.

9 ytoid DC subsets and their responsiveness to CC chemokines.

10 ding conventional receptors for inflammatory CC chemokines.

11 e binding affinity between vCCI and multiple CC chemokines.

12 s so by facilitating removal of inflammatory CC chemokines.

13 ternalizes and degrades most proinflammatory CC-chemokines.

14 argeting CCL2 and CCL13 in addition to other CC-chemokines.

15 ine milieu and caused significant release of CC-chemokines.

16 racting with up to 14 different inflammatory CC-chemokines.

17 g, internalizing, and degrading inflammatory CC-chemokines.

18 ted protein-2, CCL15/MIP-1delta/hemofiltrate CC chemokine-2/leukotactin-1, and CCL23/CKbeta8/myeloid

19 A subset of CC chemokines, acting through CC chemokine receptors (CC

20 dothelia venules, and production of IL-6 and CC chemokines, all characteristics of mucosal lymphoid t

21 rat cytomegalovirus (RCMV) encodes multiple CC chemokine-analogous proteins, including r129 (HCMV UL

22 d considerably less TNF-alpha, IL-6, and CXC/CC chemokine and soluble ICAM-1 proteins in bronchoalveo

23 ox infection and is able to selectively bind CC chemokines and inhibit their interactions with host r

24 ophage populations in response to a range of CC chemokines and other chemoattractant signalling molec

25 and scavenger receptor for most inflammatory CC chemokines and prevents the development of exacerbate

26 cine induced the significant upregulation of CC chemokines and the downmodulation of CCR5 expression

27 We therefore investigated the role of CC chemokines and their receptors in hepatic fibrogenesi

28 CC chemokines and their receptors play a fundamental rol

29 onocyte chemoattractant protein-1 (MCP-1), a CC chemokine, and interleukin-8 (IL-8), a CXC chemokine,

30 hatic endothelium, internalizes and degrades CC chemokines, and D6(-/-) mice demonstrated increased c

31 y secretory IgA antibodies, up-regulation of CC chemokines, and the first demonstration of protective

32 ncept that an innate mechanism consisting of CC chemokines, APOBEC3G, and adaptive immunity by CD4 an

33 The zebrafish CC chemokines are highly clustered on several chromosome

34 CXC and CC chemokines are involved in numerous biological proces

35 The N termini of CC chemokines are shown to be involved in receptor bindi

36 blood group Ag (dfy) binds selective CXC and CC chemokines at high affinity and is expressed on eryth

37 nificant time-related decrease in IL-17A and CC chemokine attractant ligand-20 in CD25KO LGs.

38 R, transforming growth factor-beta1, IL-17A, CC chemokine attractant ligand-20) and Th-1-associated c

39 , and use it to identify 10 novel polyvalent CC-chemokine binding evasin-like peptides from salivary

40 Dog tick saliva contains polyvalent CC-chemokine binding peptides termed evasins 1 and 4, th

41 nt negative Toll/IL-1 signaling adapter, and CC-chemokine binding protein (MVADelta4-HIV); (ii) harbo

42 elucidate the ligand-binding surface of the CC chemokine-binding proteins Evasin-1 and Evasin-4, pro

43 Each of these CC chemokines binds EVM1 with 1:1 stoichiometry and equi

44 to the inserted domain, producing a typical CC chemokine "body" containing even further-increased CC

45 ACKR2 binds many inflammatory CC chemokines but cannot stimulate cell migration or act

46 Neutralization of CC chemokines by the broad-spectrum CC chemokine inhibit

47 and it remains controversial whether dimeric CC chemokines can bind and activate their receptors.

48 ression of metalloproteases (MMP-9, ADAM-8), CC chemokines (CCL-20), CXC chemokines (IL-8, CXCL-10, C

49 7) (Cys + 4), are crucial for binding of the CC chemokines CCL1 (agonist) and MC148 (antagonist), res

50 Although recent studies have suggested that CC chemokine CCL2 may directly affect the angiogenesis,

51 IFN-beta and the peripheral induction of the CC chemokine CCL2.

52 y of the CXCL1 dimer is novel: dimers of the CC chemokines CCL2 and CCL4 are inactive, and the dimer

53 icated that macrophages and the inflammatory CC-chemokine CCL2, which is scavenged by ACKR2, are asso

54 n-8) were found to be the most abundant, but CC chemokines (CCL2/monocyte chemotactic protein 1 and C

55 nd biological properties of the prototypical CC chemokine, CCL2.

56 ial cells, cause excessive production of the CC chemokine CCL3 (also known as MIP-1alpha), which recr

57 -4), Th1 cytokines (IL-2 and IL-21), and the CC chemokine CCL3 (MIP-1).

58 Hypoxia promoted secretion of CC chemokines Ccl3/4/5 and macrophage migration inhibito

59 Recent studies showed that the CC chemokine CCL6 enhanced antimicrobial immunity during

60 show that syndecan-1 ectodomains bind to the CC chemokines (CCL7, CCL11, and CCL17) implicated in all

61 s cancer-related inflammation genes (CXC and CC chemokines, chemokine receptors, cytokines and Cox-2)

62 etion of IL-8, a CXC chemokine, and MCP-1, a CC chemokine, confirmed the inhibitory effect of a proge

63 onflicting results and indicate that dimeric CC chemokines do not bind to their receptors with affini

64 an atypical viral chemokine consisting of a CC chemokine domain and a unique non-chemokine domain, b

65 CC chemokines exist in equilibrium between monomeric and

66 CCL11/eotaxin-1 is a potent eosinophilic CC chemokine expressed by primary human fibroblasts.

67 Human CC chemokine expression was assessed by means of quantit

68 uppression of CCR5-using HIV-1 by increasing CC chemokine expression.

69 ecreted (RANTES, or CCL5) is a member of the CC chemokine family of proteins, strongly chemoattractan

70 essed and secreted; CCL5) is a member of the CC chemokine family of proteins, which is strongly chemo

71 Results are discussed in terms of CXC and CC chemokine function and have significant biological im

72 cate, physiologically relevant regulation of CC chemokine functions.

73 d the genomic sequences and structures of 23 CC chemokine genes.

74 n can be protumorigenic, and proinflammatory CC chemokines have been linked with various aspects of c

75 ver, the interactions between vCCI and other CC chemokines have not yet been fully explored.

76 Ltn-CC1) or third disulfide (Ltn-CC3) in the CC chemokine, HCC-2.

77 genin (ANG), growth factors, and the CXC and CC chemokines IFN-gamma inducible protein (IP)-10, growt

78 without the availability of similar sets of CC chemokines in closely related species or a sequenced

79 emonstrate the importance of proinflammatory CC chemokines in de novo tumorigenesis and reveal chemok

80 HHV-6A U51 has been reported to bind to CC chemokines including RANTES, but the biological funct

81 upffer cells displayed strong suppression of CC chemokine-induced migration.

82 lysis provides insight into the mechanism of CC-chemokine inhibition employed by the poxvirus family

83 The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokine

84 The soluble poxvirus-encoded protein viral CC chemokine inhibitor (vCCI), a CC chemokine inhibitor,

85 ation of CC chemokines by the broad-spectrum CC chemokine inhibitor 35k efficiently reduced hepatic f

86 otein viral CC chemokine inhibitor (vCCI), a CC chemokine inhibitor, can bind to human CC chemokines

87 In turn, this NKp30-induced secretion of cc-chemokines is able to significantly suppress the repl

88 receptor ACKR2, which scavenges inflammatory CC-chemokines, is differentially expressed during mammar

89 -alpha) markedly increased the expression of CC chemokine ligand (CCL) 20, a CC chemokine receptor (C

90 N-formyl methionyl leucyl phenylalanine and CC chemokine ligand (CCL) 3 (neutrophils), or upon stimu

91 ar cells (FRCs), through their expression of CC chemokine ligand (CCL)19 and CCL21, attract and retai

92 d can reduce CXC chemokine ligand (CXCL)12-, CC chemokine ligand (CCL)19-, or CCL21-induced cell migr

93 Levels of the CC chemokine ligand (CCL)2, CCL3, CCL5, CCL19, CCL20, an

94 e show that a latency-associated increase in CC chemokine ligand (CCL)8 results in the recruitment of

95 tor 9 (CCR9), which is a unique receptor for CC chemokine ligand (CCL25), is mainly expressed on lymp

96 be activated to secrete when stimulated with CC chemokine ligand 11 (eotaxin-1).

97 Additionally, CXCL9 was shown to inhibit CC chemokine ligand 11-induced eosinophil chemotaxis in

98 endothelial growth factor receptor 2, CCR3, CC chemokine ligand 11/eotaxin-1, and CC chemokine ligan

99 CC chemokine ligand 14, CCL14, is a human CC chemokine t

100 C5aR-targeted mice produced large amounts of CC chemokine ligand 17 (CCL17) and CCL22 ex vivo, sugges

101 e thymus- and activation-regulated chemokine/CC chemokine ligand 17 (TARC/CCL17) and macrophage-deriv

102 The CC chemokine ligand 18 (CCL18) is one of the most highly

103 CC chemokine ligand 18 (CCL18), acting through CC chemok

104 CC chemokine ligand 18 (CCL18)/pulmonary and activation-

105 rete immunosuppressive (interleukin [IL] 10, CC chemokine ligand 18) and tumor-promoting (IL-6, IL-8)

106 The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2

107 kine ligand 9 (CXCL9) and CXCL10, as well as CC chemokine ligand 2 (CCL2) and CCL5, were prominently

108 mice that lack the monocyte chemoattractant CC chemokine ligand 2 (CCL2) and found that biomaterials

109 evels of monocyte chemoattractant protein 1 [CC chemokine ligand 2 (CCL2) in the systematic nomenclat

110 The CC chemokine ligand 2 (CCL2) may contribute to the tumor

111 CC chemokine ligand 2 (CCL2), a ligand of CC chemokine r

112 e overexpression of APOE, interleukin-6, and CC chemokine ligand 2 (CCL2).

113 hat is activated primarily by the endogenous CC chemokine ligand 2 (CCL2).

114 of murine PD, several chemokines, including CC chemokine ligand 2 (CCL2, Monocyte Chemoattractant Pr

115 Obese adipose tissue exhibits increases in CC chemokine ligand 2 (CCL2, or monocyte chemoattractant

116 ession of monocyte chemoattractant protein-1/CC chemokine ligand 2 (MCP-1/CCL2), a chemokine required

117 k inflammatory cytokines TNF-alpha, IL-6, or CC chemokine ligand 2 succumb to infection with A/Vietna

118 cyte chemoattractant protein-1 (MCP-1)/CCL2 (CC chemokine ligand 2).

119 NF) alpha, interleukin (IL) 1beta, IL-6, and CC chemokine ligand 2.

120 leukin 8, and monocyte chemotactic protein-1/CC chemokine ligand 2.

121 x with C chemokine ligand 1/lymphotactin and CC chemokine ligand 2/monocyte chemoattractant protein 1

122 d the macrophage inflammatory protein 3alpha/CC chemokine ligand 20 (CCL20) produced by epithelial ce

123 d Piasy inhibits, keratinocyte production of CC chemokine ligand 20 (CCL20), a psoriatic chemokine es

124 C-X-C motif) ligand 1 (CXCL1), CXCL8 and the CC chemokine ligand 20 (CCL20).

125 CC chemokine ligand 20 induction by tumor necrosis facto

126 downstream effector molecules (IL-17, IL-22, CC chemokine ligand 20, and beta-defensin 4).

127 Ectopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to d

128 to secondary lymphoid tissue chemokine (SLC)/CC chemokine ligand 21 (CCL21) were significantly lower

129 CXC chemokine ligand 13 (CXCL13), CC chemokine ligand 21 (CCL21), and CCL19 are constituti

130 emokine ligand 12 (CXCL12) but not CXCL13 or CC chemokine ligand 21.

131 CCR3, CC chemokine ligand 11/eotaxin-1, and CC chemokine ligand 24/eotaxin-2 all reduced CNV area an

132 toxin-sensitive chemoattractant signaling by CC chemokine ligand 25 through CC chemokine receptor 9,

133 CC chemokine ligand 27 (CCL27) was expressed in the epid

134 We previously found CC chemokine ligand 3 (CCL3) to be a potent effector of

135 Both CC chemokine ligand 3 and vascular endothelial growth fa

136 CC chemokine ligand 5 (CCL5) and CCL3 are critical for i

137 Pretreatment of control mice with CC chemokine ligand 5 [CCL5 (RANTES)] enabled naloxone t

138 Interestingly, plasma levels of chemokines CC chemokine ligand 5 and CXC-chemokine ligand 4 were in

139 ve) mechanism driven in part by constitutive CC chemokine ligand 5 expression in the lungs.

140 d in Trim32-deficient keratinocytes, whereas CC chemokine ligand 5 induction by tumor necrosis factor

141 apy on antigen-stimulated secretion of IL-4, CC chemokine ligand 5, and IFN-alpha.

142 ndritic cells and chemokine mRNA expression (CC chemokine ligand [CCL]5, CCL2, and CC chemokine recep

143 n a significant up-regulation of E-selectin, CC chemokine ligand-2, and interleukin-6 promoter activi

144 nflammatory monocytes (IMs) recruited by the CC-chemokine ligand 2 (CCL2).

145 ugh induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes

146 ssive PMN (PMN-II) with abilities to produce cc-chemokine ligand-2 and IL-10.

147 mediates their migration towards endogenous CC chemokine ligands such as CCL2.

148 predominant in solution and forms a specific CC chemokine-like dimer.

149 We have produced a covalent dimer of the CC chemokine macrophage inflammatory protein-1beta (MIP-

150 ng enzyme catalytic polypeptide 3 G/F/H) and CC chemokines (macrophage inflammatory protein 1-alpha,

151 esses by demonstrating that IL-13 stimulates CC chemokines, matrix metalloproteinases, mucin genes, a

152 The CC chemokine MCK-2 encoded by mouse CMV (MCMV) has an at

153 port that the murine cytomegalovirus-encoded CC chemokine, MCK2, enhanced CCR2-dependent recruitment

154 by the murine cytomegalovirus (MCMV)-encoded CC chemokine, MCK2, which promotes recruitment of CX3CR1

155 ng affinity between vCCI and other wild type CC chemokines, MCP-1 (monocyte chemoattractant protein-1

156 study, we describe the interactions of three CC chemokines, MCP-1/CCL2, MCP-2/CCL8, and MCP-3/CCL7, w

157 17) implicated in allergic diseases, inhibit CC chemokine-mediated T cell migration, and suppress all

158 llergic lung inflammation via suppression of CC chemokine-mediated Th2 cell recruitment to the lung.

159 vides the first definitive evidence that the CC chemokine MIP-1beta dimer is not able to bind or acti

160 The CC chemokines MIP-1alpha, MIP-1beta, and RANTES and thei

161 CD8(+) T cells produced abundant amounts of CC chemokines (MIP-1beta, MIP-1alpha, and RANTES) but no

162 n orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1beta (macrophage inflammatory protein

163 nverse correlation between the proportion of CC chemokine-modulated CCR5-expressing CD4(+) T cells an

164 The CC chemokine Monocyte Chemoattractant Protein (MCP)-1/CC

165 ded by marked and selective induction of the CC chemokine monocyte chemoattractant protein-1 (MCP-1).

166 or activate its receptor and implicates the CC chemokine monomer as the sole receptor-interacting un

167 Bronchial epithelial cells (BECs) produce CC chemokines, notably CCL26 (eotaxin-3), which recruits

168 Mouse CCL8 is a CC chemokine of the monocyte chemoattractant protein (MC

169 ly on two dimerization motifs represented by CC-chemokine or CXC-chemokine dimer interfaces.

170 homology among monomer folds of all CXC and CC chemokines permits heterodimer assembly, our calculat

171 RANTES, a CC chemokine, plays an important role in the inflammator

172 ization of late memory CD8(+) T cells toward CC chemokine production and away from IL-2 production su

173 n coinfected tissues by up-regulation of the CC chemokine RANTES, a well-known inhibitor of R5 HIV-1

174 similar experiments were conducted with the CC chemokine RANTES, and it was demonstrated that the pr

175 icular, the content of T lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, and CCR5 receptors

176 nophil signaling molecules [eg, eotaxins and CC chemokine receptor (CCR) 3] in IL-13-mediated airway

177 CC chemokine receptor (CCR) 4 was dispensable for donor

178 The authors compared CC chemokine receptor (CCR) expression by mouse liver my

179 points to cross-talk between FcepsilonRI and CC chemokine receptor (CCR)-mediated signaling pathways

180 sted naloxone-induced down-regulation of the CC chemokine receptor (CCR)5 in NY1DD mice but not in co

181 xpression of CC chemokine ligand (CCL) 20, a CC chemokine receptor (CCR)6 ligand, in human keratinocy

182 The mechanisms by which CC chemokine receptor (CCR)7 ligands are selectively pre

183 Among 11 surveyed chemokine receptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CX

184 CC chemokine receptor 1 (CCR1) is found on a variety of

185 CC chemokine receptor 10 and its ligand, CCL27, are impo

186 m of vitamin D3, signaled T cells to express CC chemokine receptor 10, which enabled them to migrate

187 CC Chemokine Receptor 2 (CCR2) and its endogenous ligand

188 ing restrictions to a linear aminobutyramide CC chemokine receptor 2 (CCR2) antagonist lead (2) led t

189 The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2 (CCR2) are expressed in the hear

190 CC chemokine receptor 2 (CCR2) is essential to acute ske

191 Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a

192 CC chemokine receptor 2 (CCR2) is one of 19 members of t

193 with relatively high numbers of parasites in CC chemokine receptor 2 (CCR2) KO mice, indicating that

194 dels that the expression of the inflammatory CC chemokine receptor 2 (CCR2) on donor-derived CD8+ T c

195 We show that inhibition of CC chemokine receptor 2 (CCR2) receptor signaling with p

196 huGFAP-CCL2hi tg+ mice lacking CC chemokine receptor 2 (CCR2) were normal, showing that

197 Herein, we describe a soluble mimic of CC chemokine receptor 2 (CCR2), dubbed CROSS-N(2)E3(2),

198 CC chemokine ligand 2 (CCL2), a ligand of CC chemokine receptor 2 (CCR2), is essential to mount an

199 egeneration was examined in mice lacking the CC chemokine receptor 2 (CCR2).

200 ssion (CC chemokine ligand [CCL]5, CCL2, and CC chemokine receptor 2 [CCR2]) remained unchanged.

201 ice was reduced by 67%, but was unaltered in CC chemokine receptor 2(-/-) (CCR2(-/-)), CCR3(-/-), or

202 ory chemokine/receptor and cytokines (MCP-1, CC chemokine receptor 2, and interleukins 1beta and 6),

203 y activity is demonstrated to be mediated by CC chemokine receptor 3 (CCR3).

204 This study demonstrates that expression of CC chemokine receptor 4 (CCR4) by DCs is required for EA

205 ive of this study was to examine the role of CC chemokine receptor 4 (CCR4) in macrophage polarizatio

206 CC chemokine receptor 4 (CCR4) is expressed by Th2 and r

207 One candidate, CC chemokine receptor 4 (CCR4), is expressed by innate a

208 amulizumab, a defucosylated, humanized, anti-CC chemokine receptor 4 monoclonal antibody, in 41 pretr

209 However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated

210 ecurrent somatic mutations in CCR4, encoding CC chemokine receptor 4.

211 T-cell expression levels of CC chemokine receptor 5 (CCR5) are a critical determinan

212 iency virus-HIV chimera (SHIV) that uses the CC chemokine receptor 5 (CCR5) co-receptor.

213 CC chemokine receptor 5 (CCR5) is a receptor for chemoki

214 CC Chemokine Receptor 5 (CCR5) is an important mediator

215 CC chemokine receptor 5 (CCR5) is prominently expressed

216 CC chemokine receptor 5 (CCR5) is the major HIV-1 corece

217 CC chemokine receptor 5 (CCR5) is the receptor for sever

218 The CC chemokine receptor 5 (CCR5) is used by the human immu

219 eptor, CD4, and through a coreceptor, either CC chemokine receptor 5 (CCR5) or CXC chemokine receptor

220 We demonstrate that signaling through the CC chemokine receptor 5 (CCR5) prevents uncontrolled pos

221 globulin (Ig) G4 monoclonal antibody against CC chemokine receptor 5 (CCR5) with robust in vitro acti

222 a32, a complete loss-of-function mutation in CC chemokine receptor 5 (CCR5), has been previously asso

223 deficiency virus type-1 (HIV-1) co-receptor, CC chemokine receptor 5 (CCR5).

224 These cells expressed high levels of CC chemokine receptor 5 and were commonly double negativ

225 CC chemokine receptor 5 antagonists are a new class of a

226 SIV hosts from AIDS and the discovery of low CC chemokine receptor 5 expression on CD4+ T cells as a

227 Because CC chemokine receptor 6 (CCR6) deficiency affects the ge

228 r gut homing, as indicated by high levels of CC chemokine receptor 6 and integrin beta7 expression.

229 CC chemokine receptor 7 (CCR-7) is expressed on mature d

230 In this study we identify residues on CC chemokine receptor 7 (CCR-7) that are involved in ago

231 that, even when LN retention signals such as CC chemokine receptor 7 (CCR7) are down-regulated, T cel

232 CC chemokine receptor 7 (CCR7) is expressed in IIP biops

233 s T helper 1 (Th1) effector memory cells and CC chemokine receptor 7 (CCR7)(+) cells resembling centr

234 that migration to lymph nodes occurred in a CC chemokine receptor 7-independent manner but, overall,

235 Although the CC chemokine receptor 7-positive (CCR7+) population of b

236 chemokine ligand 18 (CCL18), acting through CC chemokine receptor 8 (CCR8) on mononuclear cells, was

237 svirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous

238 sm depended on alpha(4) beta(7) integrin and CC chemokine receptor 9 (CCR9) expression by LSEC-primed

239 CC chemokine receptor 9 (CCR9), which is a unique recept

240 re a gut-homing phenotype (alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to

241 signaling by CC chemokine ligand 25 through CC chemokine receptor 9, and binding of the integrins al

242 ors cyclo-oxygenase-2 and 5-lipoxygenase and CC chemokine receptor antagonist Met-RANTES.

243 When EGFP-NPs from CC chemokine receptor CCR2 knock-out mice were transplan

244 rmore that DARC hetero-oligomerizes with the CC chemokine receptor CCR5.

245 zin-1-yl]ethoxy}ethanol (ZK 756326), for the CC chemokine receptor CCR8.

246 did translational studies to examine CXC and CC chemokine receptor expression by flow cytometry on ne

247 etic ablation or pharmacologic inhibition of CC chemokine receptor type 2 (CCR2) reduced macrophage (

248 in rectal tissue (both P < .001), and plasma CC chemokine receptor type 5 (CCR5) ligand (macrophage-i

249 reted), the ligands for HIV entry coreceptor CC chemokine receptor type 5.

250 CC chemokine receptor type 9 (CCR9) activation by CCL25

251 Here we show that a promiscuous CC chemokine receptor, D6, can function as a coreceptor

252 dial smooth muscle cells, express functional CC chemokine receptor-1 (CCR1) and respond to RANTES by

253 ession (IL-2, -4, -6, -10, and IFN-gamma and CC chemokine receptor-1 [CCR1]) was assayed in the lymph

254 uctures of PXR LBD with Adnectin-1 and CCR1 (CC chemokine receptor-1) antagonist Compound-1 were dete

255 g with our previously described(20) class of CC chemokine receptor-3 (CCR3) antagonist, we improved t

256 A subset of CC chemokine receptor-6(+) (CCR6(+)), gammadelta-low (GD

257 This study investigates whether cytokine and CC-chemokine receptor (CCR) production by DCs stimulated

258 Mice with genetic deficiency of CC-chemokine receptor (CCR) type 5, the common receptor

259 are rapidly mobilized upon inflammation in a CC-chemokine receptor 2-dependent manner, and the noncla

260 6- and 2.4-fold increases in Ly6-C(high) and CC-chemokine receptor 2-positive cells in lesions of apo

261 e in the airways of allergic mice upregulate CC-chemokine receptor 4 (CCR4) expression.

262 nce assay (HTRF) to quantify properly folded CC-chemokine receptor 5 (CCR5).

263 CC-chemokine receptor 7 (CCR7) is expressed on the surfa

264 A subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is instrumental in

265 r appears to be present in a large number of CC chemokine receptors and thereby could play a more gen

266 uitment upon exposure to DEPs and that these CC chemokine receptors are important in the DEP-induced

267 1, MCP-2, RANTES, MIG, IP-10, I-TAC, and two CC chemokine receptors CCR2 and CCR5 were highly express

268 We hypothesized that CC chemokine receptors CCR2, CCR5, and CCR6 critically m

269 ng assays, we determined that r129 binds rat CC chemokine receptors CCR3, CCR4, CCR5, and CCR7.

270 ration was associated with downregulation of CC chemokine receptors in renal macrophages.

271 rotein-coupled receptors that includes other CC chemokine receptors, INCB3344 is at least 100-fold se

272 cture (CLP), blood PMN demonstrated mRNA for CC chemokine receptors.

273 (ACKR2) binds and scavenges proinflammatory CC-chemokines, regulates cutaneous T-cell positioning, a

274 CC chemokines represent the largest subfamily of chemoki

275 f MMP processing of all 14 monocyte-directed CC chemokines revealed that each is precisely cleaved by

276 crease in the expression of the nonsignaling CC chemokine scavenging receptor D6 in whole lung sample

277 s in models of inflammation, suggesting that CC-chemokine scavenging by D6 is an important component

278 MT6-MMP processes seven each of the CXC and CC chemokine subfamilies.

279 emokines while retaining selectivity for the CC chemokine subfamily.

280 Our data therefore support a role for the CC chemokine system in hepatic fibrogenesis and suggest

281 atic cirrhosis, confirming activation of the CC chemokine system in human fibrogenesis.

282 action between vCCI and eotaxin-1 (CCL11), a CC chemokine that is an important factor in the asthma r

283 CC chemokine ligand 14, CCL14, is a human CC chemokine that is of recent interest because of its n

284 We hypothesized that the CC chemokines that are associated with a Th2 profile (CC

285 D6 is a scavenging-receptor for inflammatory CC chemokines that are essential for resolution of infla

286 recorded with IL-15 receptors, APOBEC3G and CC chemokines, the latter downmodulating CCR5 molecules.

287 ession, IFN-lambda induced the expression of CC chemokines, the ligands for CCR5.

288 Expression of a CC chemokine thymus-expressed chemokine (TECK) has previ

289 a CC chemokine inhibitor, can bind to human CC chemokines tightly to impair the host immune defense.

290 charged BBXB motif is key for the binding of CC chemokines to GAG.

291 a "silent" receptor, as it can bind CXC and CC chemokines to undergo ligand-induced receptor interna

292 talurus punctatus, we identified 26 distinct CC chemokine transcripts and obtained the genomic sequen

293 13Phe) caused vMIP-II to form a pH-dependent CC chemokine-type dimer as determined by analytical ultr

294 CCL-2, a CC chemokine, was released by the liver in response to a

295 BEC3G was significantly upregulated, as were CC chemokines which induce downregulation of CCR5 in CD4

296 l activity of inflammatory mediators such as CC chemokines, which have been implicated in a wide rang

297 gland expresses high levels of inflammatory CC-chemokines, which are essential in vivo regulators of

298 owed a significant decrease in the levels of CC chemokines, while exposure to R5-subtype HIV gp120 ha

299 CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inh

300 and -4 use different pharmacophores to bind CC chemokines, with the principal binding occurring thro