ライフサイエンスコーパス: CC chemokine receptor

1 dies indicate the potential involvement of a CC chemokine receptor.

2 gesting that MIP-3alpha acts through a novel CC chemokine receptor.

3 ne receptor CXCR4 as well as to a variety of CC chemokine receptors.

4 n L1.2 cells tranfected with seven different CC chemokine receptors.

5 unusual among known CC chemokines and known CC chemokine receptors.

6 cture (CLP), blood PMN demonstrated mRNA for CC chemokine receptors.

7 is an orphan receptor with homology to other CC chemokine receptors.

8 CC chemokine receptor 1 (CCR1) is expressed in neutrophi

9 CC chemokine receptor 1 (CCR1) is found on a variety of

10 nal down-modulation of the RANTES receptors, CC chemokine receptor 1 and CC chemokine receptor 5, dur

11 The total CC chemokine receptor 1 pool (surface and intracellular

12 ES was directly correlated with the level of CC chemokine receptor 1 surface expression.

13 cal laser scanning microscopy showed reduced CC chemokine receptor 1, but not CC chemokine receptor 5

14 inal tail), and 2) the N-terminal segment of CC chemokine receptor 1, which does not bind CXC chemoki

15 CC chemokine receptors 1 and 3 (CCR1 and CCR3) are expre

16 essing a hemagglutinin-tagged version of the CC-chemokine receptor 1 (CCR1), and using these reagents

17 dial smooth muscle cells, express functional CC chemokine receptor-1 (CCR1) and respond to RANTES by

18 The CC chemokine receptor-1 (CCR1) is a prime therapeutic ta

19 ession (IL-2, -4, -6, -10, and IFN-gamma and CC chemokine receptor-1 [CCR1]) was assayed in the lymph

20 uctures of PXR LBD with Adnectin-1 and CCR1 (CC chemokine receptor-1) antagonist Compound-1 were dete

21 CC chemokine receptor 10 and its ligand, CCL27, are impo

22 m of vitamin D3, signaled T cells to express CC chemokine receptor 10, which enabled them to migrate

23 Disruption of CC chemokine receptor 2 (CCR2) abolished both CNS inflam

24 CC Chemokine Receptor 2 (CCR2) and its endogenous ligand

25 ing restrictions to a linear aminobutyramide CC chemokine receptor 2 (CCR2) antagonist lead (2) led t

26 ocyte chemotactic protein-1 [MCP-1]) and its CC chemokine receptor 2 (CCR2) are critical regulators o

27 The CC chemokine ligand 2 (CCL2) and CC chemokine receptor 2 (CCR2) are expressed in the hear

28 Presently, we investigated the role of CC chemokine receptor 2 (CCR2) in acute EAE.

29 n the present study we addressed the role of CC chemokine receptor 2 (CCR2) in M. tuberculosis infect

30 CC chemokine receptor 2 (CCR2) is a prominent receptor f

31 CC chemokine receptor 2 (CCR2) is essential to acute ske

32 Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a

33 CC chemokine receptor 2 (CCR2) is one of 19 members of t

34 with relatively high numbers of parasites in CC chemokine receptor 2 (CCR2) KO mice, indicating that

35 dels that the expression of the inflammatory CC chemokine receptor 2 (CCR2) on donor-derived CD8+ T c

36 We show that inhibition of CC chemokine receptor 2 (CCR2) receptor signaling with p

37 huGFAP-CCL2hi tg+ mice lacking CC chemokine receptor 2 (CCR2) were normal, showing that

38 Herein, we describe a soluble mimic of CC chemokine receptor 2 (CCR2), dubbed CROSS-N(2)E3(2),

39 CC chemokine ligand 2 (CCL2), a ligand of CC chemokine receptor 2 (CCR2), is essential to mount an

40 man brain microvessels, which suggested that CC chemokine receptor 2 (CCR2), the recognized receptor

41 egeneration was examined in mice lacking the CC chemokine receptor 2 (CCR2).

42 ssion (CC chemokine ligand [CCL]5, CCL2, and CC chemokine receptor 2 [CCR2]) remained unchanged.

43 ice was reduced by 67%, but was unaltered in CC chemokine receptor 2(-/-) (CCR2(-/-)), CCR3(-/-), or

44 ory chemokine/receptor and cytokines (MCP-1, CC chemokine receptor 2, and interleukins 1beta and 6),

45 are rapidly mobilized upon inflammation in a CC-chemokine receptor 2-dependent manner, and the noncla

46 6- and 2.4-fold increases in Ly6-C(high) and CC-chemokine receptor 2-positive cells in lesions of apo

47 To understand the regulation of CC chemokine receptor 3 (CCR3) expression, its gene stru

48 The CC chemokine receptor 3 (CCR3) is expressed by eosinophi

49 The CC chemokine receptor 3 (CCR3) plays an important role i

50 axin induces chemotaxis mediated through the CC chemokine receptor 3 (CCR3) present on basophils as w

51 y activity is demonstrated to be mediated by CC chemokine receptor 3 (CCR3).

52 CC chemokine receptor-3 (CCR-3) is a major receptor invo

53 g with our previously described(20) class of CC chemokine receptor-3 (CCR3) antagonist, we improved t

54 Eotaxin and other CC chemokines acting via CC chemokine receptor-3 (CCR3) are believed to play an i

55 actic and activating peptides acting through CC chemokine receptor-3 (CCR3).

56 This study demonstrates that expression of CC chemokine receptor 4 (CCR4) by DCs is required for EA

57 The role of CC chemokine receptor 4 (CCR4) during the development an

58 ive of this study was to examine the role of CC chemokine receptor 4 (CCR4) in macrophage polarizatio

59 CC chemokine receptor 4 (CCR4) is expressed by Th2 and r

60 One candidate, CC chemokine receptor 4 (CCR4), is expressed by innate a

61 ve also examined the interaction of MDC with CC chemokine receptor 4 (CCR4), recently shown to be a r

62 amulizumab, a defucosylated, humanized, anti-CC chemokine receptor 4 monoclonal antibody, in 41 pretr

63 However, this is not related to CC chemokine receptor 4, cutaneous lymphocyte-associated

64 ecurrent somatic mutations in CCR4, encoding CC chemokine receptor 4.

65 e in the airways of allergic mice upregulate CC-chemokine receptor 4 (CCR4) expression.

66 ssion of coreceptors, cytokine regulation of CC chemokine receptor 5 (CCR5) and CD4 expression on mon

67 The differential use of CC chemokine receptor 5 (CCR5) and CXC chemokine recepto

68 In particular, immature DC express CC chemokine receptor 5 (CCR5) and migrate in response t

69 matory proteins 1alpha and 1beta to activate CC chemokine receptor 5 (CCR5) and the ability to inhibi

70 T-cell expression levels of CC chemokine receptor 5 (CCR5) are a critical determinan

71 independent of the presence of a mutation in CC chemokine receptor 5 (CCR5) associated with resistanc

72 iency virus-HIV chimera (SHIV) that uses the CC chemokine receptor 5 (CCR5) co-receptor.

73 In the current study, we characterized CC chemokine receptor 5 (CCR5) expression and function o

74 CC chemokine receptor 5 (CCR5) functions physiologically

75 of a 32 bp deletion (Delta32) allele of the CC chemokine receptor 5 (CCR5) gene are reported to be m

76 CC chemokine receptor 5 (CCR5) has recently been identif

77 n the present study, we explored the role of CC chemokine receptor 5 (CCR5) in a murine model of chro

78 CC chemokine receptor 5 (CCR5) is a coreceptor for cellu

79 CC chemokine receptor 5 (CCR5) is a receptor for chemoki

80 CC Chemokine Receptor 5 (CCR5) is an important mediator

81 CC chemokine receptor 5 (CCR5) is expressed preferential

82 CC chemokine receptor 5 (CCR5) is prominently expressed

83 CC chemokine receptor 5 (CCR5) is the major HIV-1 corece

84 CC chemokine receptor 5 (CCR5) is the receptor for sever

85 The CC chemokine receptor 5 (CCR5) is used by the human immu

86 us 24-bp deletion (Delta24) was found in the CC chemokine receptor 5 (CCR5) of 11 out of 15 red-cappe

87 f the viral envelope glycoprotein gp120 with CC chemokine receptor 5 (CCR5) or CXC chemokine receptor

88 eptor, CD4, and through a coreceptor, either CC chemokine receptor 5 (CCR5) or CXC chemokine receptor

89 glycoproteins, CD4 and a coreceptor, usually CC chemokine receptor 5 (CCR5) or CXC receptor 4 (CXCR4)

90 We demonstrate that signaling through the CC chemokine receptor 5 (CCR5) prevents uncontrolled pos

91 laria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women

92 s of HIV-1 require the cell-surface receptor CC chemokine receptor 5 (CCR5) to infect specific leukoc

93 globulin (Ig) G4 monoclonal antibody against CC chemokine receptor 5 (CCR5) with robust in vitro acti

94 a32, a complete loss-of-function mutation in CC chemokine receptor 5 (CCR5), has been previously asso

95 of both CXC chemokine receptor 4 (CXCR4) and CC chemokine receptor 5 (CCR5), major coreceptors for T

96 Human CC chemokine receptor 5 (CCR5), mediates the activation

97 Expression of CC chemokine receptor 5 (CCR5), the major coreceptor for

98 Polymorphisms in CC chemokine receptor 5 (CCR5), the major coreceptor of

99 Genetic variation in CC chemokine receptor 5 (CCR5), the major HIV-1 corecept

100 8-coated beads are resistant to infection by CC chemokine receptor 5 (CCR5)-dependent HIV-1 isolates.

101 -SIGN1 is expressed on endothelial cells and CC chemokine receptor 5 (CCR5)-positive macrophage-like

102 CD25, CXC chemokine receptor 4 (CXCR4), and CC chemokine receptor 5 (CCR5).

103 lines by blocking interaction of gp120 with CC chemokine receptor 5 (CCR5).

104 deficiency virus type-1 (HIV-1) co-receptor, CC chemokine receptor 5 (CCR5).

105 These cells expressed high levels of CC chemokine receptor 5 and were commonly double negativ

106 CC chemokine receptor 5 antagonists are a new class of a

107 normal CD45 splicing and the presence of the CC chemokine receptor 5 deletion 32 (CCR5del32) allele,

108 SIV hosts from AIDS and the discovery of low CC chemokine receptor 5 expression on CD4+ T cells as a

109 The human gene for CC chemokine receptor 5, a coreceptor for human immunode

110 ANTES receptors, CC chemokine receptor 1 and CC chemokine receptor 5, during culture.

111 wed reduced CC chemokine receptor 1, but not CC chemokine receptor 5, expression by HaCaT cells at lo

112 viral burden and further implicate roles for CC chemokine receptor 5, macrophages, and Vpr in the lif

113 ll expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replica

114 macaques with CXC chemokine receptor 4- and CC chemokine receptor 5-specific simian/human immunodefi

115 ng genetic variants of their major receptor, CC chemokine receptor 5.

116 iruses were found to play important roles in CC-chemokine receptor 5 (CCR5) coreceptor utilization, a

117 To investigate nonhuman primate CC-chemokine receptor 5 (CCR5) homologue structure and f

118 The CC-chemokine receptor 5 (CCR5) is the major coreceptor f

119 t on macrophagetropic viruses that enter via CC-chemokine receptor 5 (CCR5), despite binding to the s

120 nce assay (HTRF) to quantify properly folded CC-chemokine receptor 5 (CCR5).

121 chemokine receptor 4 (CXCR4), but not of the CC-chemokine receptor 5 in purified populations of prima

122 detected for galactosyl ceramide but not for CC-chemokine receptor 5, CXC-chemokine receptor 4, or CD

123 vated by typical chemokine receptors such as CC-chemokine receptor-5 (CCR5).

124 Because CC chemokine receptor 6 (CCR6) deficiency affects the ge

125 as that of memory markers such as CD45RO and CC chemokine receptor 6 (CCR6).

126 r gut homing, as indicated by high levels of CC chemokine receptor 6 and integrin beta7 expression.

127 C-type chemokine that binds to and activates CC chemokine receptor-6 (CCR6).

128 A subset of CC chemokine receptor-6(+) (CCR6(+)), gammadelta-low (GD

129 CC chemokine receptor 7 (CCR-7) is expressed on mature d

130 In this study we identify residues on CC chemokine receptor 7 (CCR-7) that are involved in ago

131 that, even when LN retention signals such as CC chemokine receptor 7 (CCR7) are down-regulated, T cel

132 CC chemokine receptor 7 (CCR7) is expressed in IIP biops

133 s T helper 1 (Th1) effector memory cells and CC chemokine receptor 7 (CCR7)(+) cells resembling centr

134 Desensitization of the TCA-4 receptor, CC chemokine receptor 7 (CCR7), blocked T(GFP) cell adhe

135 ndary lymphoid chemokine (SLC), a ligand for CC chemokine receptor 7 (CCR7), has been demonstrated to

136 by functional deletion (desensitization) of CC chemokine receptor 7 (CCR7), the receptor for SLC and

137 xis of lymphocytes and DCs via its receptor, CC chemokine receptor 7 (CCR7).

138 ELC stimulated cells transfected with EBI-1/CC chemokine receptor 7 (CCR7).

139 CD27Lo CD28Lo CD45RA- CD62 ligand- (CD62L-) CC chemokine receptor 7- (CCR7-) interleukin-7 receptor

140 that migration to lymph nodes occurred in a CC chemokine receptor 7-independent manner but, overall,

141 Although the CC chemokine receptor 7-positive (CCR7+) population of b

142 CC-chemokine receptor 7 (CCR7) is expressed on the surfa

143 otaxis assay system, we demonstrate that the CC chemokine receptor-7 (CCR7) ligands 6Ckine and macrop

144 CC chemokine receptor 8 (CCR8) has been detected in vitr

145 The CC chemokine receptor 8 (CCR8) is expressed on monocytes

146 The CC chemokine receptor 8 (CCR8) is expressed on monocytes

147 chemokine ligand 18 (CCL18), acting through CC chemokine receptor 8 (CCR8) on mononuclear cells, was

148 svirus (KSHV) that selectively activates the CC chemokine receptor 8 (CCR8), for which the endogenous

149 sm depended on alpha(4) beta(7) integrin and CC chemokine receptor 9 (CCR9) expression by LSEC-primed

150 CC chemokine receptor 9 (CCR9) is a specific receptor fo

151 Here we report that GPR-9-6, now called CC chemokine receptor 9 (CCR9), is a receptor for thymus

152 CC chemokine receptor 9 (CCR9), which is a unique recept

153 Hence, GPR-9-6 has been designated as CC chemokine receptor 9 (CCR9).

154 re a gut-homing phenotype (alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to

155 signaling by CC chemokine ligand 25 through CC chemokine receptor 9, and binding of the integrins al

156 r appears to be present in a large number of CC chemokine receptors and thereby could play a more gen

157 0), IL-1 binding proteins, G protein-coupled CC chemokine receptor, and epidermal growth factor-like

158 ors cyclo-oxygenase-2 and 5-lipoxygenase and CC chemokine receptor antagonist Met-RANTES.

159 uitment upon exposure to DEPs and that these CC chemokine receptors are important in the DEP-induced

160 CC chemokine receptors are important modulators of infla

161 in human T cells selectively through CCR8, a CC chemokine receptor associated with Th2 lymphocytes.

162 used CCR3 as an entry cofactor, despite this CC chemokine receptor being expressed on the cell surfac

163 addition, we demonstrate that IL-15 induces CC chemokine receptors, but not CXC chemokine receptors,

164 or cells resulted in decreased expression of CC chemokine receptor (CCR) 1 and increased CCR7 express

165 icular, the content of T lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, and CCR5 receptors

166 nophil signaling molecules [eg, eotaxins and CC chemokine receptor (CCR) 3] in IL-13-mediated airway

167 CC chemokine receptor (CCR) 4 was dispensable for donor

168 CCR5Delta32, a 32-base pair deletion of the CC chemokine receptor (CCR) 5 gene, is associated with s

169 The chemokine receptors CC chemokine receptor (CCR) 7 and CXC chemokine receptor

170 The authors compared CC chemokine receptor (CCR) expression by mouse liver my

171 Cytokine and CC chemokine receptor (CCR) gene expression was analyzed

172 ne receptor messenger RNA (mRNA) expression, CC chemokine receptor (CCR) protein activation during th

173 points to cross-talk between FcepsilonRI and CC chemokine receptor (CCR)-mediated signaling pathways

174 Human melanoma cells frequently express CC chemokine receptor (CCR)10, a receptor whose ligand (

175 We tested the hypothesis that the CC chemokine receptor (CCR)2 and CCR5 and the chemokine

176 Mice deficient for the major MCP-1 receptor, CC chemokine receptor (CCR)2, did not develop EAE after

177 Here we report that deficiency in CC chemokine receptor (CCR)2, the receptor for MCP-1, co

178 CD4 cells from allergic individuals express CC chemokine receptor (CCR)3 and CCR4 after expansion in

179 s, which uniformly express the TARC receptor CC chemokine receptor (CCR)4.

180 sted naloxone-induced down-regulation of the CC chemokine receptor (CCR)5 in NY1DD mice but not in co

181 HisRS selectively activated CC chemokine receptor (CCR)5-transfected HEK-293 cells,

182 xpression of CC chemokine ligand (CCL) 20, a CC chemokine receptor (CCR)6 ligand, in human keratinocy

183 resses LC markers: E-Cadherin, Langerin, and CC chemokine receptor (CCR)6.

184 The mechanisms by which CC chemokine receptor (CCR)7 ligands are selectively pre

185 Responses to the CC chemokine receptor (CCR)7 ligands secondary lymphoid

186 L-selectin and required chemokines that bind CC chemokine receptor (CCR)7.

187 Recently, it has been shown that CC chemokine receptor (CCR)8 is selectively expressed by

188 re that vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8 that is preferentially expr

189 This attraction is mediated by CC chemokine receptor (CCR)9, a chemoattractant receptor

190 CC-chemokine receptor (CCR) 6 is the only known receptor

191 erized PMN priming and maturation factor, on CC-chemokine receptor (CCR) expression in PMN was invest

192 This study investigates whether cytokine and CC-chemokine receptor (CCR) production by DCs stimulated

193 Mice with genetic deficiency of CC-chemokine receptor (CCR) type 5, the common receptor

194 n-1beta, monocyte chemoattractant protein-1, CC-chemokine receptor (CCR)-1, CCR2, CCR5, and F4/80) th

195 A genetic defect in a CC-chemokine receptor (CCR)-5, the principal coreceptor

196 CC-chemokine/CC-chemokine receptors (CCR), including CCR2/ MCP-1 (mon

197 e biology, we investigated the expression of CC chemokine receptors CCR1, CCR2, CCR3, CCR5, CXCR3, an

198 The receptor cavity shares six residues with CC-chemokine receptors CCR1 through CCR4, while seven re

199 When EGFP-NPs from CC chemokine receptor CCR2 knock-out mice were transplan

200 1, MCP-2, RANTES, MIG, IP-10, I-TAC, and two CC chemokine receptors CCR2 and CCR5 were highly express

201 We hypothesized that CC chemokine receptors CCR2, CCR5, and CCR6 critically m

202 blood vessels in the lungs by acting on the CC chemokine receptor CCR3, which is located on the leuk

203 ng assays, we determined that r129 binds rat CC chemokine receptors CCR3, CCR4, CCR5, and CCR7.

204 rmore that DARC hetero-oligomerizes with the CC chemokine receptor CCR5.

205 CC chemokine receptors CCR5 and CCR2 are both expressed

206 Multiple extracellular domains of the CC-chemokine receptor CCR5 are important for its functio

207 The CC-chemokine receptor CCR5 has been shown to be the majo

208 The CC-chemokine receptor CCR5 is required for the efficient

209 The CC-chemokine receptor CCR5 mediates fusion and entry of

210 reted), which are the natural ligands of the CC-chemokine receptor CCR5, inhibit replication of MT-2-

211 Here we demonstrate that, like the CC-chemokine receptors CCR5 and CCR2b, CXCR4 is posttran

212 Genetic variations in the CC chemokine receptor (CCR5) leading to reduced or absen

213 Among 11 surveyed chemokine receptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CX

214 zin-1-yl]ethoxy}ethanol (ZK 756326), for the CC chemokine receptor CCR8.

215 A subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is instrumental in

216 cells in the joint, mediated in part by such CC chemokine receptors (CCRs) as CCR2 and CCR5, respecti

217 iral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and

218 , interleukin 1 receptor (IL-1R), and type 8 CC-chemokine receptors; cytokine binding proteins (BP),

219 Here we show that a promiscuous CC chemokine receptor, D6, can function as a coreceptor

220 The CC chemokine receptor encoded by the human cytomegalovir

221 ls transfected with human and murine CCR2, a CC chemokine receptor expressed on monocytes.

222 did translational studies to examine CXC and CC chemokine receptor expression by flow cytometry on ne

223 Thus, CCR2B is the first member of the CC chemokine receptor family shown to be a glycoprotein

224 hemotaxis does not occur at the level of the CC chemokine receptor for MCP-1, CCR2, since MIF does no

225 description of functional promoters for any CC chemokine receptor gene, and we speculate that the co

226 chromosome 3q22, which is distinct from most CC chemokine receptor genes at 3p21.

227 In an effort to map the closely linked CC chemokine receptor genes, we identified a novel chemo

228 Although CC chemokine receptors have been found predominantly on

229 EC is significant, more so as it and several CC chemokine receptors have been shown to serve as fusio

230 used to reveal expression of various CXC and CC chemokine receptors in human umbilical vein EC.

231 ration was associated with downregulation of CC chemokine receptors in renal macrophages.

232 rotein-coupled receptors that includes other CC chemokine receptors, INCB3344 is at least 100-fold se

233 r, PAF did not provide sufficient signal for CC chemokine receptor ligand 2 (CCL2) production in cell

234 putative seven transmembrane receptor, CCRL1-CC chemokine receptor like 1.

235 nines and tyrosines in the N-termini of many CC chemokine receptors suggests that these posttranslati

236 emonstrate that pUL21.5 protein is a soluble CC chemokine receptor that functions as a decoy to modul

237 ceptor US28 but do not express mRNA of other CC chemokine receptors that bind RANTES (CCR1, CCR4, CCR

238 etic ablation or pharmacologic inhibition of CC chemokine receptor type 2 (CCR2) reduced macrophage (

239 in rectal tissue (both P < .001), and plasma CC chemokine receptor type 5 (CCR5) ligand (macrophage-i

240 reted), the ligands for HIV entry coreceptor CC chemokine receptor type 5.

241 CC chemokine receptor type 9 (CCR9) activation by CCL25

242 fected cells express mRNA of the CMV-encoded CC chemokine receptor US28 but do not express mRNA of ot

243 Thus, through expression of the CC chemokine receptor US28, CMV may utilize resident G p