ライフサイエンスコーパス: CCHF

1 CCHF virus (CCHFV), a bunyavirus in the Nairovirus genus

2 CCHF virus is endemic in parts of Africa, Asia, the Midd

3 del for studies of CCHF countermeasures, and CCHF-associated CNS disease.

4 y diverse virus strains were determined, and CCHF viruses were found to be highly variable with 20 an

5 en peptides representing Lassa virus GP2 and CCHF virus Gn cleavage sites suggests that amino acids f

6 ntly, there are no atomic structures for any CCHF virus proteins or for any Nairovirus proteins.

7 immunocompromised mice have been reported as CCHF disease models, but detailed characterization is la

8 proteins of Nigerian, Pakistani, and Chinese CCHF virus strains revealed two distinct protein regions

9 ed in the former Soviet Union and the Congo, CCHF has rapidly spread across large sections of Europe,

10 ranging up to 70% based on several factors, CCHF is considered a dangerous emerging disease.

11 he emerging Crimean-Congo hemorrhagic fever (CCHF) in Turkey the government is introducing thousands

12 Crimean-Congo hemorrhagic fever (CCHF) is a severe illness with high case fatality that o

13 Crimean-Congo hemorrhagic fever (CCHF) is a severe viral disease with high fatality rate.

14 causes the Crimean Congo Hemorrhagic Fever (CCHF) is a tick-borne pathogen of the Nairovirus genus,

15 Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic disease seen exc

16 Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed viral hemorrhagic fever ch

17 Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease.

18 Crimean-Congo hemorrhagic fever (CCHF) virus is a tick-borne member of the genus Nairovir

19 Crimean-Congo hemorrhagic fever (CCHF) virus is a tick-borne, negative-sense, single-stra

20 Crimean-Congo hemorrhagic fever (CCHF) virus is the cause of an important tick-borne dise

21 fected with Crimean-Congo hemorrhagic fever (CCHF) virus present with a wide clinical spectrum.

22 hikungunya, Crimean-Congo hemorrhagic fever [CCHF] virus, dengue, Ebola virus, Bundibugyo virus, Suda

23 rmore, there are no POC assays available for CCHF.

24 With fatality rates for CCHF ranging up to 70% based on several factors, CCHF is

25 a clinical severity scoring index (SSI) for CCHF patients and assess the effect of ribavirin and cor

26 rogression closely mimics hallmarks of human CCHF disease, making IFNAR(-/-) mice an excellent choice

27 on and disease have not been investigated in CCHF.

28 gical involvement have also been reported in CCHF.

29 nfirmed by expression of wild-type or mutant CCHF virus glycoproteins in CHO cells engineered to expr

30 Two hundred eighty-one confirmed cases of CCHF were included in the study.

31 00-fold greater sensitivity for detection of CCHF antibodies.

32 a fiber-optic biosensor for the detection of CCHF IgG antibodies.

33 talized patients who received a diagnosis of CCHF at the Infectious Diseases and Clinical Microbiolog

34 Rapid diagnostics of CCHF is vital for appropriate clinical management and pr

35 tion in the CNS for future investigations of CCHF.

36 ropod-borne virus, the genomic plasticity of CCHF virus is surprisingly high.

37 epresent a novel lethal model for studies of CCHF countermeasures, and CCHF-associated CNS disease.

38 ated as a point-of-care diagnostic system of CCHF.

39 alomma marginatum ticks, the best vectors of CCHF.

40 atopoietic CD34+ stem cells with low-passage CCHF virus strains isolated from human patients.

41 These results strongly suggest that CCHF viruses (and other members of the genus Nairovirus)

42 e predicted polyprotein sequences of all the CCHF virus strains and closely resemble the tetrapeptide

43 The apparent lack of SKI-1 cleavage at the CCHF virus Gc RKPL site indicates that related proteases

44 e genus Nairovirus, family Bunyaviridae, the CCHF virus M genome RNA segment encodes the virus glycop

45 Unlike Hantavirus zinc fingers, however, the CCHF virus zinc fingers bind viral RNA and contain conti

46 only passed between animals and humans, the CCHF virus can also be transmitted from human to human w

47 The amino termini of the CCHF virus (Matin strain) G2 and G1 proteins were establ

48 Sequence analysis of the CCHF virus (Matin strain) M RNA segment revealed one maj

49 Here we report the NMR structure of the CCHF virus Gn cytoplasmic tail, residues 729-805.

50 ts provide insight into a likely role of the CCHF virus Gn zinc fingers in Nairovirus assembly.

51 evaluated the fiber-optic biosensor with two CCHF patient sera.

52 pulse-chase analysis and/or reactivity with CCHF virus-specific polyclonal and antipeptide antibodie