ライフサイエンスコーパス: CCT

1 CCT also indicated a sloped correlation to error (correl

2 CCT and corneal power measured using Orbscan II, Pentaca

3 CCT appears to significantly affect the error by up to 4

4 CCT chaperonin further binds and disassembles subcomplex

5 CCT decreased from 644 +/- 67 mum before DMEK to 557 +/-

6 CCT decreased significantly over time.

7 CCT did not show a significant change after 6 months up

8 CCT is efficacious on global cognition, select cognitive

9 CCT was also found to be significantly associated with I

10 CCT was determined bilaterally using handheld ultrasound

11 CCT was measured at baseline, then at 2 weeks and 1, 3,

12 n containing tailless complex polypeptide 1 (CCT), revealed a robust interaction between PDCD5 and CC

13 x chaperonin containing t-complex protein 1 (CCT) was identified, and subsequent studies showed that

14 ludes cytosolic chaperonin containing TCP-1 (CCT; also called TRiC) and its cochaperone phosducin-lik

15 ) (P = .7); Kmin: -0.25 +/- 1.25 D (P = .2); CCT: -16.38 +/- 37 mum (P = .01); GAT-IOP: +1.0 +/- 2.3

16 The crystal structure of a CCT dimer composed of the catalytic and AI segments reve

17 ssess the intrasession repeatability of ACD, CCT, PCT at different nasal and temporal locations, WTW,

18 issue altered, derived from [PTA = (FT + AD)/CCT], where FT = flap thickness, AD = ablation depth, an

19 , corneal curvature (CC), axial length (AL), CCT and IOP.

20 treated compared with fellow eyes, although CCT was increased.

21 aster keratometry values, as well as ACD and CCT measurements.

22 most patients show stable visual acuity and CCT, although ECD decreases.

23 The study suggests that age and CCT are strongly associated with CH and CRF, and that th

24 year after the rejection episodes, BSCVA and CCT in these eyes remained unchanged when compared with

25 n when the analysis was repeated for CRF and CCT.

26 Analysis was repeated for CRF and CCT.

27 age corneal curvature was flatter by 4 D and CCT was reduced by 83 mum (P < 0.0001, for all), postope

28 polymegathism with increased EC density and CCT.

29 T = flap thickness, AD = ablation depth, and CCT = preoperative central corneal thickness.

30 ECD and CCT did not correlate with corneal densitometry, whereas

31 Postoperative BSCVA, ECD, and CCT results were comparable in both groups at 6 and 12 m

32 Thus, GCT and CCT coordinate vegetative and floral transitions by repr

33 and molecular analyses indicate that GCT and CCT operate in parallel to gibberellic acid, a phytohorm

34 ping, suggesting that corneal hysteresis and CCT are not independent risk factors for glaucoma.

35 ount by future studies investigating IOP and CCT as risk factors or diagnostic tests for glaucoma in

36 The IOP and CCT levels are significantly correlated with genetic anc

37 corneal edema, or corneal dystrophy, IOP and CCT readings were available for 3251 Chinese, 3232 Malay

38 ed to investigate the association of IOP and CCT with potential risk factors and genetic ancestry.

39 l accounting for age, race, average IOP, and CCT (P = .015).

40 acam HR exhibited significantly lower Km and CCT measurements (P < .001, for all); however, no signif

41 proportion of Malays with IOP >/=21 mmHg and CCT <555 mum compared with the Chinese or Indians.

42 After the first year, BCVA, MRSE, and CCT showed no change and stabilized, whereas elevation r

43 ealed a robust interaction between PDCD5 and CCT.

44 increased inflammatory cells recruitment and CCT in mice with a cornea scratch.

45 l single nucleotide polymorphisms (SNPs) and CCT using linear regression, adjusting for age, gender a

46 tes, and age on FECD case/control status and CCT.

47 for the comparative effectiveness of UCT and CCT programmes in this region.

48 al technique and the gold standard to assess CCT.

49 iated with an increase of 9.1 mum in average CCT (P = 0.021).

50 y significant difference observed in average CCT amongst glaucoma subtypes.

51 ted significantly with a decrease in average CCT by 6.9 mum (P = 0.015).

52 ere wasn't significant difference of average CCT between the ethnic groups (P = 0.3) and gender (P =

53 The mean baseline CCT measurements were 470.02 mum, 469.79 mum, and 466.66

54 rate of change were associated with baseline CCT (ss = -0.1 to -0.09 and -0.011, respectively, all P

55 The association between CCT and ocular or systemic factors was analyzed with uni

56 ere were no significant associations between CCT and CDR, glaucoma, hypertension, and diabetes.

57 e we report an additional connection between CCT and actin by identifying one of the CCT subunits, CC

58 ally significant inverse correlation between CCT and pO2 in the anterior chamber angle (P = .048).

59 es unique insight into the interplay between CCT and a cochaperone to orchestrate the folding of a pr

60 Pentacam HR had the lowest 95% LoA for both CCT and TCT.

61 The eukaryotic chaperonin TRiC (also called CCT) is the obligate chaperone for many essential protei

62 intervention groups: PRT+CCT, PRT+SHAM CCT, CCT+SHAM PRT and double SHAM.

63 ty of anterior chamber depth (ACD), central (CCT) and peripheral corneal thickness (PCT), white-to-wh

64 ance from the oligomeric molecular chaperone CCT.

65 e poorly characterized eukaryotic chaperonin CCT/TRiC.

66 Here, we identify the chaperonin CCT/TRiC as a critical regulator of telomerase trafficki

67 Mediator CDK8 module encoded by CENTER CITY (CCT; Arabidopsis MED12) and GRAND CENTRAL (GCT; Arabidop

68 ly associated with age (scaled coefficients: CCT 0.62, p < 0.0001; age -0.55, p <0.0001; r2 = 0.25).

69 ciated with age and AL (scaled coefficients: CCT 0.89, p < 0.0001; DCT IOP 0.46, p < 0.01; age - 0.60

70 eronin containing TCP1 or TCP1-Ring complex (CCT/TRiC chaperonin), a complex known to function in pro

71 s of the chaperonin containing TCP1 complex (CCT) were found to interact with V-ATPase for the first

72 tophagy defects in diseases with compromised CCT complex activity.

73 In contrast, CCT but not PRT attenuated decline in overall memory per

74 l sensor and compared with the corresponding CCT values.

75 enerated knock-in mice in which the critical CCT domain Leu502 residue required for high affinity rec

76 CTP:phosphocholine cytidylyltransferase (CCT) interconverts between an inactive soluble and activ

77 nd stromal ulceration resulting in decreased CCT.

78 two rings, each formed from eight different CCT (chaperonin containing TCP-1) subunits.

79 The aim of this study is to evaluate CCT in black patients with newly diagnosed glaucoma and

80 or, and a cryptochrome C-terminal extension (CCT), which is essential for signaling.

81 For CCT, the sample size was too small to test for differenc

82 resent sensitivity of 63% for EV and 40% for CCT.

83 , the intraclass correlation coefficient for CCT was higher than 0.9.

84 h keratoconus that had serial evaluation for CCT, following CXL, using high-definition optical cohere

85 se 1894 scatter units for EV and 630 mum for CCT.

86 ol and are consistent with a direct role for CCT in translocation of LF through the protective antige

87 y process, the Gbeta-CCT and the PhLP1-Gbeta-CCT complexes, were isolated and analyzed by a hybrid st

88 n the Gbetagamma assembly process, the Gbeta-CCT and the PhLP1-Gbeta-CCT complexes, were isolated and

89 OHT group had significantly greater CCT (576.33 +/- 49.32 mum) than the glaucomatous groups

90 d pachymetry determined significantly higher CCT values than Orbscan IIz (P<0.001), Visante (P<0.001)

91 We have expressed each human CCT subunit individually in Escherichia coli to investig

92 ray crystallographic study of a single human CCT subunit in the context of a hexadecameric complex ca

93 The human CCT has eight non-identical subunits and the His147Arg m

94 Mean Orbscan II CCT measurements were not significantly different overal

95 Mean Orbscan II CCT measurements were significantly lower when an acoust

96 USP and HD-OCT showed better agreement in CCT readings at all visits, and may better estimate the

97 Change and rate of change in CCT were determined.

98 FECD was associated with large increases in CCT (31.4-94.2 mum).

99 1 region, which regulate normal variation in CCT, may play a role in the thinning associated with ker

100 controlled by various chaperones, including CCT (chaperonin containing TCP-1)/TCP-1/TRiC.

101 riable linear regression analysis, increased CCT was significantly associated with younger age, male

102 ociated with reduced EC counts and increased CCT.

103 a significant association between increased CCT and younger age, male sex, and higher IOP but not gl

104 orted diabetes was associated with increased CCT.

105 flux is reduced by compromise of individual CCT subunits, various disease-relevant autophagy substra

106 Based on results with insect CCT homologues, translocation of nuclear CCTalpha onto c

107 , while the mean difference between J0, J45, CCT, and ACD measurements was 0.07 D, -0.016 D, -5.05 mu

108 d a complex with CCT and beta-tubulin, a key CCT-folding substrate, and specifically inhibited beta-t

109 It is likely that members of the large CCT family participate in similar complexes with At-NF-Y

110 before rejection (BSCVA, 0.15+/-0.11 logMAR; CCT, 533.8+/-26.0 mum).

111 ore rejection vs. BSCVA, 0.21+/-0.15 logMAR; CCT, 540.0+/-15.0 mum 3 months after rejection).

112 of the minimum angle of resolution [logMAR]; CCT, 554.1+/-39.1 mum at last visit before rejection vs.

113 gressors were older, had significantly lower CCT and baseline IOPs, and were more likely to have pseu

114 Orbscan II measured significantly lower CCT compared with Pentacam (20 mum; P < .0005) and Galil

115 Mean CCT decreased significantly in both groups 1 month after

116 Mean CCT in the eyes with graft failure in the abnormal DM gr

117 Mean CCT of aphakic eyes was higher than in controls (637 vs.

118 Mean CCT values were 555.11 +/- 35.83 mum (USP), 535.82 +/- 4

119 Mean CCT was higher in eyes with IOLs (605 vs. 571 mum, P<0.0

120 Mean CCT, ACD and LT, average keratometry readings of affecte

121 gular TA was detected in 72 eyes (90%); mean CCT was 492+/-62.10 mum; postoperative endothelial cell

122 There was no significant difference in mean CCT and ECD after surgery.

123 here were no significant differences in mean CCT between Galilei and Pentacam HR.

124 The lower mean CCT post-CXL as measured by the latter seems to be corre

125 The mean CCT difference was minimal (1+/-3 mum; P = 0.69) between

126 Following CXL, the mean CCT measurements by dual Scheimpflug, at all follow-up p

127 The mean CCT measurements by the HD-OCT and USP were similar to b

128 However, the mean CCT measurements obtained by dual Scheimpflug tomography

129 Overall, the mean CCT obtained by the USP was similar to that obtained by

130 The mean CCT of Ethiopian glaucoma patients is thinner than Cauca

131 The mean CCT reading was 552.3+/-33.4 mum in Chinese, 540.9+/-33.

132 e of PA, mediated by PAH activity, modulates CCT activity to govern PC content.

133 CXR/MRI) or chest CT plus head and neck MRI (CCT/MRI).

134 All patients underwent CXR/MRI, CCT/MRI, and PET/CT on the same day.

135 traocular distances using SS-OCT were 6 mum (CCT), 16 mum (ACD), 14 mum (AD), 13 mum (LT), 14 mum (VD

136 We found that PRT but not CCT significantly improved global cognition (F(90)=4.1,

137 pared with CXR/MRI (0.184, P = 0.03) but not CCT/MRI (0.094%, P = 0.31).

138 Thus, the combined action of CCT chaperonin with that of TRIP13 ATPase promotes the c

139 her insight into the genetic architecture of CCT and illustrate that the use of minority groups in GW

140 understanding of the genetic architecture of CCT.

141 e was a statistically significant decline of CCT with advanced age (P = 0.02).

142 s, and little is known about the efficacy of CCT in people with mild cognitive impairment or dementia

143 We further show that knockdown of CCT inhibits the acid-induced delivery of LF and the fus

144 CCTepsilon conversely reflect the levels of CCT oligomer, our results suggest that CCTepsilon provid

145 The value of CPTR4 was the quotient of CCT and PCT4.

146 Degree of agreement in and repeatability of CCT and corneal power measures.

147 of EV was significantly higher than that of CCT (P = 0.003), whereas a combination of both factors i

148 accuracy, significantly better than that of CCT, in differentiating actively rejecting from clear gr

149 1, 2016, for randomized controlled trials of CCT in older adults with mild cognitive impairment or de

150 1, 2016, for randomized controlled trials of CCT in older adults with mild cognitive impairment or de

151 ying surprisingly that the effect of loss-of-CCT activity on mutant ATXN3 or huntingtin oligomerizati

152 Smoking had no significant effect on CCT in any model.

153 perative and intraoperative parameters, only CCT and EV were identified as significant factors, predi

154 an for CXR/MRI (C-index, 0.675; P = 0.04) or CCT/MRI (C-index, 0.657; P = 0.02).

155 o relationship between corneal hysteresis or CCT and quantitative measures of optic disc cupping, sug

156 r stage when compared with either CXR/MRI or CCT/MRI (chi(2), P < 0.001 for both).

157 r stages based on PET/CT, but not CXR/MRI or CCT/MRI, were associated with significant differences in

158 in T-complex 1 (TCP-1) ring complex (TRiC or CCT for chaperonin containing TCP-1) have been shown to

159 the mammalian cytosolic chaperonin TRiC (or CCT), primarily through its DNA binding domain (AML1-175

160 the essential eukaryotic chaperonin TRiC (or CCT).

161 ts, requiring the TCP1 Ring Complex (TriC or CCT) chaperonin and five tubulin-specific chaperones, tu

162 The patients CCTs were measured with OCT and USP by three different e

163 ryo-electron microscopy studies of the PDCD5.CCT complex suggested a possible mechanism of inhibition

164 corneal thickness at the 6-o'clock position, CCT, and CV were significantly smaller in the torsional

165 raction, mean astigmatism, and postoperative CCT were tested.

166 Preoperative CCT of 620 microm corresponded to an odds ratio of 1, me

167 Preoperative CCT was the only significant predictor of corneal decomp

168 For each 10-microm increase in preoperative CCT, the odds of developing corneal decompensation incre

169 iding whether to perform a triple procedure, CCT remains a less effective, but adequate, alternative.

170 The CCT proteins (CCT alpha-theta) forms ring complex for its chaperon fun

171 assigned into four intervention groups: PRT+CCT, PRT+SHAM CCT, CCT+SHAM PRT and double SHAM.

172 led that increased VCDR (P = 0.003), reduced CCT (P = 0.045), and reduced superior and inferior retin

173 Regression analysis relating CCT to age, race, and oxygen levels in all 5 locations i

174 For retrospective CCTs, the WMD was 0.23, with a 95% CI of -0.58 to 1.05 (

175 trieved from five RCTs and two retrospective CCTs and subsequently pooled into meta-analyses; however

176 Associations between glaucoma risk, CCT, and pO2 in the AC angle suggest that exposure of th

177 For the whole sample, CCT was 518.67 (+/-39.97) mum.

178 The mean +/- SD CCT in the population was 533.9 +/- 34.0 mum.

179 four intervention groups: PRT+CCT, PRT+SHAM CCT, CCT+SHAM PRT and double SHAM.

180 CCT4 and CCT5, but not the other six CCT subunits, formed high molecular weight complexes wit

181 The SPAK CCT domain defective knock-in animals are viable, and th

182 The SPAK CCT domain knock-in mice showed typical features of Gite

183 aspin, Pph3, the chaperonin containing TCP1 (CCT) and 25 other proteins--define a novel intranuclear

184 utations [in the chaperonin containing TCP1 (CCT) complex and in the proteasome].

185 g the Dmin, e.g., collision cell technology (CCT) and analyte isotope selection, are also discussed.

186 ght source and correlated color temperature (CCT) of 7863 K, producing "cold" white light.

187 ith chromatin via their conserved C-terminal CCT (CONSTANS, CONSTANS-like, and TIMING OF CAB EXPRESSI

188 lose resemblance to the SPAK/OSR1 C-terminal CCT/PF2 domain, which is required for physical interacti

189 SPAK possesses a conserved carboxy-terminal (CCT) domain, which recognises RFXV/I motifs present in i

190 re PT/INR, conventional coagulation testing (CCT) is performed, which is time-consuming and requires

191 f the variation in slopes of VFI change than CCT (17.4% vs. 5.2%, respectively).

192 Our results indicate that CCT domain inhibitors would be effective at reducing BP

193 Here, we show that CCT integrity is essential for autophagosome degradation

194 In this issue, Trinidad et al. show that CCT/TRiC is a chaperone required for p53 folding, thus p

195 entified, and subsequent studies showed that CCT is required for efficient delivery of LF and related

196 Together, these results suggest that CCT is required for efficient delivery of enzymatically

197 The CCT and ECD measures did not change significantly in any

198 The CCT domain defective animals displayed markedly reduced

199 The CCT increased from 483.87 +/- 29.07 to 485.95 +/- 28.43

200 The CCT proteins (CCT alpha-theta) forms ring complex for it

201 The CCT was measured using contact pachymetry.

202 The CCT was measured with ultrasound pachymetry.

203 The CCT was positively correlated to macular bulge height bu

204 The CCT/TRiC (chaperonin containing TCP-1/TCP-1 ring) chaper

205 The CCT/TRiC chaperonin nanomachine undergoes ATP-driven con

206 ignaling state, and ultimately activates the CCT.

207 diated in vivo by an interaction between the CCT domain in SPAK and RFXV/I domains in WNK3 and NKCC1/

208 This work deciphers how the CCT regulatory amphipathic helix functions as a silencin

209 The co-7 mutation in the CCT domain, corresponding to an NF-YA arginine directly

210 the UCT group and by 16.4% (7.8-25.0) in the CCT group by the end of the intervention period.

211 in the UCT group and 7.6% (1.2-14.1) in the CCT group than in the control group.

212 We show that in the CCT soluble form the AI segment functions to suppress kc

213 ntified a network of proteins, including the CCT complex, USP7, Aurora kinase, Nedd4, and Trim24, tha

214 o define the physiological importance of the CCT domain, we generated knock-in mice in which the crit

215 was too small to test for differences of the CCT measurements between the three instruments.

216 as therefore to evaluate the accuracy of the CCT measurements performed by three different observers,

217 ween CCT and actin by identifying one of the CCT subunits, CCTepsilon, as a component of the myocardi

218 ow that an interaction with a subunit of the CCT/TCP-1 ring complex (TRiC) chaperonin complex is invo

219 ponents of the LSm2-8 protein complex or the CCT/TRiC chaperonin.

220 These observations establish that the CCT domain plays a crucial role in controlling SPAK acti

221 t the signal transfer from the flavin to the CCT.

222 affect stress granules differently, with the CCT complex inhibiting stress granule assembly, while th

223 hromes by mediating the interaction with the CCT.

224 OHT patients had thicker CCT; there was no statistically significant difference o

225 Chinese have the thickest CCT but lowest IOP among the 3 major ethnic groups.

226 Reports of central corneal thickness (CCT) among glaucoma patients, particularly for pseudoexf

227 OLMaster 700, and central corneal thickness (CCT) and anterior chamber depth (ACD) values obtained fr

228 En/DM and measure central corneal thickness (CCT) and central En/DM thickness (DMT).

229 astigmatism (TA), central corneal thickness (CCT) and endothelial cell density 12 months postoperativ

230 MAR, keratometry, central corneal thickness (CCT) and higher-order aberrations (HOAs) over a 6 mm pup

231 Murine central corneal thickness (CCT) and inflammatory cell recruitment into the stroma w

232 Central corneal thickness (CCT) and peripheral corneal thickness at 4 mm from the c

233 rate of change in central corneal thickness (CCT) and their determinants.

234 s thickness (LT), central corneal thickness (CCT) and white-to-white (WTW) distance were measured by

235 ll density (ECD), central corneal thickness (CCT) at 6 and 12 months, and rebubbling rate.

236 factor (CRF) and central corneal thickness (CCT) differ between patient groups.

237 aracteristics and central corneal thickness (CCT) from the Infant Aphakia Treatment Study (IATS) pati

238 ll size (CV), and central corneal thickness (CCT) in normal eyes.

239 Central corneal thickness (CCT) is now recognized to have a significant role in ocu

240 Central corneal thickness (CCT) measurement has become an important test in the dia

241 our tonometer and central corneal thickness (CCT) was also evaluated.

242 Central corneal thickness (CCT) was also measured.

243 Central corneal thickness (CCT) was determined by all the 4 techniques.

244 age, gender, and central corneal thickness (CCT) were assessed.

245 teresis, IOP, and central corneal thickness (CCT) were measured; optic disc photographs were analyzed

246 c hemorrhage, and central corneal thickness (CCT) were recorded.

247 eadings (mean-K), central corneal thickness (CCT), and anterior and posterior elevation at the apex a

248 r pressure (IOP), central corneal thickness (CCT), and baseline vertical cup-to-disc ratio (VCDR).

249 ll density (ECD), central corneal thickness (CCT), and graft survival (Kaplan-Meier analysis).

250 flat keratometry, central corneal thickness (CCT), and thinnest corneal thickness (TCT) measurements

251 tometry readings, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT),

252 istances, such as central corneal thickness (CCT), aqueous depth (AD), anterior chamber depth (ACD),

253 ween baseline CH, central corneal thickness (CCT), average intraocular pressure (IOP), and rates of R

254 al zone 2-10 mm), central corneal thickness (CCT), best spectacle-corrected visual acuity (BSCVA), an

255 l acuity (BSCVA), central corneal thickness (CCT), endothelial cell density (ECD) and complication ra

256 l acuity (BSCVA), central corneal thickness (CCT), endothelial cell density (ECD), and need for regra

257 ll density (ECD), central corneal thickness (CCT), graft survival rate, and postoperative complicatio

258 try (Kmax, Kmin), central corneal thickness (CCT), intraocular pressure with Goldmann applanation ton

259 ics, preoperative central corneal thickness (CCT), IOP (using noncontact tonometry), manifest refract

260 i with POAG, with central corneal thickness (CCT), vertical cup-to-disc ratio (VCDR) and with diabete

261 essure (IOP), and central corneal thickness (CCT), while adjusting for potentially confounding factor

262 ivalent (SE), and central corneal thickness (CCT).

263 phy (FECD) and on central corneal thickness (CCT).

264 t refraction (D), central corneal thickness (CCT, micrometers) and endothelial cell density (ECD).

265 c data (age, sex, central corneal thickness [CCT], intraocular pressure [IOP], refraction, medication

266 TG (510.79 +/- 44.37 mum) groups had thinner CCT than PXG (520.48 +/- 38.95 mum), PACG (524.00 +/- 37

267 ch, to further identify loci contributing to CCT.

268 pO2 was not significantly related to CCT at any other location, including beneath the central

269 ecting graft immunologic status, superior to CCT.

270 main with the CONSTANS, CONSTANS-LIKE, TOC1 (CCT) proteins.

271 dicate that computerized cognitive training (CCT) is a safe and efficacious intervention for cognitio

272 ning (PRT), computerized cognitive training (CCT) or combined intervention.

273 sfers (UCTs) and conditional cash transfers (CCTs) on birth registration, vaccination uptake, and sch

274 three retrospective case-controlled trials (CCTs), were included.

275 ross-linked peptides for the chaperonin TRiC/CCT and the 26S proteasome.

276 In eukaryotes, the chaperonin TRiC/CCT is hetero-oligomeric, consisting of two stacked ring

277 etero-oligomeric eukaryotic chaperonin, TRiC/CCT, which contributes to its biosynthesis and activity

278 d by circadian clock, ATP-dependent TCP/TRiC/CCT chaperonin and mitochondrial electron transport chai

279 o centrioles and is associated with the TRiC/CCT cytoplasmic chaperone complex.

280 all visits, and may better estimate the true CCT following CXL as compared to dual Scheimpflug tomogr

281 Two CCT associated SNPs (rs1536482 and rs7044529 near and wi

282 in each site were randomly assigned to UCT, CCT, or control, by drawing of lots from a hat.

283 Main outcome measures were CCT (mum) and its associations with age, sex, IOP, cup-t

284 teresis was also found to be associated with CCT (beta coefficient = 0.02, P < .0005).

285 CRF was positively associated with CCT and DCT IOP and negatively associated with age and A

286 CH was positively associated with CCT and negatively associated with age (scaled coefficie

287 for variables significantly associated with CCT in the univariable analysis.

288 n an intron of WNT7B that is associated with CCT.

289 cts to identify genetic loci associated with CCT.

290 nuclear foci and physically associating with CCT, suggesting an evolutionarily conserved biological f

291 regions and there were no associations with CCT or VCDR.

292 PDCD5 formed a complex with CCT and beta-tubulin, a key CCT-folding substrate, and s

293 nd apparently inactive tertiary complex with CCT preloaded with nascent Gbeta.

294 cts underwent complete eye examination, with CCT measurements at 2 separate visits.

295 ependent, and does not further increase with CCT knockdown in autophagy-defective cells/organisms, im

296 eins mutated to prevent the interaction with CCT show conformational instability and acquire an abili

297 the Gbeta fold, disrupting interactions with CCT and releasing a PhLP1-Gbeta dimer for assembly with

298 he structures show that Gbeta interacts with CCT in a near-native state through interactions of the G

299 ely with age (P = 0.043) and negatively with CCT (P = 0.006).

300 The percentage of participants with CCT <555 mum was 52.8% in Chinese, 68.5% in Malays, and