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   1 med similarly, irrespective of HIV status or CD4 count.                                              
     2 tracted study sample size, year(s), and mean CD4 count.                                              
     3 immediate initiation of ART, irrespective of CD4 count.                                              
     4 n age at cancer diagnosis by AIDS status and CD4 count.                                              
     5 co, where viral loads are higher for a given CD4 count.                                              
     6 ome isolates were positively correlated with CD4 count.                                              
     7  virologically suppressed patients with high CD4 count.                                              
     8 patients with intermediate and high baseline CD4 counts.                                             
     9 with HIV load and negatively correlated with CD4 counts.                                             
    10 ommended, with earlier ART in those with low CD4 counts.                                             
    11 ssion by reducing viral loads and increasing CD4 counts.                                             
    12 nexpensive, robust, user-friendly method for CD4 counting.                                           
    13 ore advanced disease in South Africa (median CD4 count 102, 213, and 172 cells/microl in South Africa
    14 men, median age 37 years (IQR 30-44), median CD4 count 156 cells per muL (61-253), median plasma HIV 
    15 an immunodeficiency virus coinfected (median CD4 count 16 cells/microL [interquartile range, 6-40]). 
  
    17 fected subjects from Thailand (mean baseline CD4 count, 188 cells/microL; mean viral load, 5.4 log10 
  
    19 uted blocks of size eight, and stratified by CD4 count (220-349 cells per muL vs >/=350 cells per muL
    20 ith HIV with advanced disease (baseline mean CD4 count, 262 cells/mm(3)) before and up to 3 years aft
    21 ractices (adjusted difference of square root CD4 count 3.1, 95% CI -1.2 to 7.4; p=0.16);); in a pre-p
    22 lack, 13% Hispanic; median age was 37 years, CD4 count 321 cells/microL, and viral load 4.5 log10 cop
  
  
    25 50 copies/mL; 99% on antiretrovirals; median CD4 count: 489 cells/microL; HCV treatment naive 29%; HC
    26 th retention than not having an ART-eligible CD4 count (50% versus 32%), an intention-to-treat risk d
  
    28 ted children (median age, 13.8 years; median CD4 count, 770 x 10(6) cells/L; 83% with undetectable HI
    29 th retention than not having an ART-eligible CD4 count (91% versus 21%), a complier causal risk diffe
    30 eiving antiretroviral therapy; 136 (21%) had CD4 counts above 350 cells per muL and had never receive
    31 ation antiretroviral therapy (cART) with low CD4 counts achieve viral suppression but not CD4 cell re
  
    33 rugs, ART initiation year, and baseline age, CD4 count, AIDS, duration of ART) all-cause and cause-sp
    34 no significant associations with viral load, CD4 counts, AIDS, cancer, or mortality in both cohorts b
  
    36 ion, after adjustment for maternal HIV load, CD4 count and cART exposure (adjusted odds ratio, 3.51; 
    37 ded better AMI and mortality prediction than CD4 count and HIV-1 RNA, suggesting that current health 
    38  not started ART, did not have AIDS, and had CD4 count and HIV-RNA viral load measurements within 6 m
  
  
    41 g extended Cox regression models with recent CD4 count and VL analyzed as time-changing covariates.  
  
  
    44 stingly, CCR5 CRPA correlated inversely with CD4 counts and CD4:CD8 ratio specifically in viremic pat
  
    46 buted by patients who received ART, had high CD4 counts and had undetectable HIV RNA, whereas inciden
    47 reduces detectable viral load, and increases CD4 counts and hemoglobin levels in pregnant HIV-infecte
  
  
    50     Over time, KS and NHL occurred at higher CD4 counts and lower HIV RNA values, and KS occurred mor
  
    52 ised to monitoring with or without 12-weekly CD4 counts and to receive 2 nucleoside reverse transcrip
    53 ak positive correlation was observed between CD4+ counts and missing teeth (rho = 0.380, P <0.05), CD
    54 rtunistic oral lesions along with records of CD4+ counts and viral load levels were evaluated in 29 i
    55 art [HR 1.58, 95% CI 1.47-1.69], most recent CD4 count) and retention (ART club membership, baseline 
  
  
  
  
    60 h HIV who received effective ART, had higher CD4 counts, and had suppressed HIV RNA and not by increa
    61 rated rapid, point-of-care HIV screening and CD4 counts, and in-parallel viral load testing, to promo
  
    63 ciparum infection status, hemoglobin levels, CD4 counts, and viral load in pregnant, HIV-positive wom
    64 able changes in subjects' hemoglobin levels, CD4 counts, and viral loads, particularly with helminth 
    65 n multivariable analysis, entry FIB-4, entry CD4(+) count, and cumulative alcohol use remained signif
    66 nterval, 1.34-2.86]), adjusted for age, sex, CD4(+) count, and World Health Organization disease stag
  
  
  
    70 e with the costs of the drugs themselves and CD4 counts are measured every 6 months, but patients are
    71 nterval [CI], -10.7 to 22.4 cells/year), nor CD4 count at ART initiation (beta = -1.1 cells/year; 95%
  
  
  
  
    76 oor CD4 count documentation and lower median CD4 count at ART initiation was associated with increase
    77 conclusion, the CRF01_AE subtype and a lower CD4 count at baseline tend to be associated with the fas
    78 multiplicatively with transmission routes or CD4 count at baseline to contribute to HIV/AIDS progress
  
  
  
    82 cases in categories of ART use, HIV RNA, and CD4 count at diagnosis were described across calendar ti
  
  
  
  
    87  studies conducted in South Africa (N = 14), CD4 count at presentation increased by 39.9 cells/year (
    88 l-based comparison between current standard (CD4 count at presentation of 0.260 x 109 cells/L, univer
    89 at baseline) mortality rate ratios (MRRs) by CD4 count at start of ART (0-49, 50-99, 100-199, 200-349
  
  
    92 oss of LTNP status was associated with lower CD4 counts at 10 years after seroconversion (p < 0.0001)
  
  
  
  
    97 de comparisons, patients with TAMs had lower CD4 counts at treatment initiation than did patients wit
  
  
   100 306) entering clinical HIV care with a first CD4 count between 12 August 2011 and 31 December 2012 in
   101 els, while adjusting for peak HIV RNA, nadir CD4(+)count, CD4/CD8 ratio, CMV IgG levels, time from ED
   102 ine which laboratory parameters (viral load, CD4 count, CD8 count, CD4 %, CD8 %, CD4/CD8) are most st
  
   104 f patients who started ART with low baseline CD4 count converged with mortality of patients with inte
   105 QR 30-42), 11 628 (34%) were men, and median CD4 count count before therapy was 154 cells per muL (IQ
  
   107 e-initiation group) or to defer it until the CD4+ count decreased to 350 cells per cubic millimeter o
   108 fewer women on ART, and in cohorts with poor CD4 count documentation and lower median CD4 count at AR
   109 cumented transfers, and in cohorts with poor CD4 count documentation, whereas higher patient load was
  
  
  
  
   114 ipants started therapy after two consecutive CD4+ counts fell below 250 cells per cubic millimeter or
   115  The decision to start ART was determined by CD4 count for one in four patients (25%) presenting clos
  
   117 eroid response, whereas a larger increase in CD4+ count from baseline to 1 to 3 months corresponded t
   118 IV-1 RNA greater than 5000 copies per mL and CD4 counts greater than 200 cells per muL were randomly 
   119     Furthermore, individuals with HIV-1 with CD4 counts greater than 200 cells/mm(3) displayed higher
  
   121 nce of active tuberculosis, and had baseline CD4 counts greater than 350 cells per muL if they had ne
   122 -1-infected adults on ART for >/= 18 mo with CD4 count > 350 cells/mm3 in a malaria-endemic region in
   123 ated costs averted if ART was initiated at a CD4 count >/=200 cells/microL were estimated using Joint
   124 cted pregnant women (</=28 weeks' gestation, CD4 count >/=200 cells/microL, hemoglobin level >/=7 g/L
   125 10, who were followed from the date they had CD4 count >/=350 cells/muL and were virologically suppre
  
  
   128 1.08-1.34, p = 0.001), and having a baseline CD4 count >350 cells/uL (HR 2.37, 95% CI 1.94-2.89.     
   129 s aged 18-70 years with controlled HIV (with CD4 counts >200 cells per muL and HIV-1 RNA <200 copies 
   130 contacts of HIV-infected index patients with CD4 counts >250 cells/microL and contacts of index patie
  
   132 s on suppressive antiretroviral therapy with CD4+ counts >350 cells/muL and detectable plasma HIV-1 R
   133 ated HIV/AIDS progression compared to higher CD4 count (>/=500) (HR = 4.38, 95%CI: 1.95-9.82, P < 0.0
   134  remain demethylated, despite restoration of CD4+ counts (>/=800 cells per mm(3)) with antiretroviral
   135  starting such therapy in patients after the CD4+ count had declined to 350 cells per cubic millimete
  
   137 continuation after ART-induced recovery with CD4 counts higher than 350 cells per muL reduced admitta
   138 ter <1:64; HR, 1.94 [95% CI, 1.58-2.39]) and CD4 counts (HR, 1.07 for every 100-cell increase [95% CI
   139 ("rapid arm") received a point-of-care (POC) CD4 count if needed; those who were ART-eligible receive
  
   141 ophylaxis should be provided irrespective of CD4 count in settings with a high burden of infectious d
  
  
  
  
   146 e given to ART initiation at higher absolute CD4 counts in such populations to optimize the impact of
  
   148 anges were independent of viral replication, CD4 counts, inflammation, and type of antiretroviral tre
   149 at all people living with HIV, regardless of CD4 count, initiate antiretroviral therapy (ART) upon di
   150 etection, no ART or delayed initiation (when CD4 count is <0.350 x 109 cells/L), reduced investment i
   151 TION: Decreasing monitoring to annually when CD4 count is higher than 200 cells per muL compared with
  
   153 n retention between patients presenting with CD4 counts just above versus just below the 350-cells/mu
  
  
   156 L (lower limit of normal) and 11 (55%) had a CD4 count less than 200 cells/muL; 11 (55%) subjects had
  
   158 ractices versus 73% in control practices had CD4 count less than 350 cells per muL (risk ratio 0.75, 
   159 muL was 2 days shorter (95% CI 1-2) and at a CD4 count less than 350 cells per muL was 5 days shorter
   160 omes were rate of diagnosis, proportion with CD4 count less than 350 cells per muL, and proportion wi
   161  than 500 cells per muL, and initiation at a CD4 count less than 350 cells per muL, respectively.    
  
  
   164 t 7 years with a strategy of initiation at a CD4 count less than 500 cells per muL was 2 days shorter
   165 (95% CI 1.01-1.02) when ART was started at a CD4 count less than 500 cells per muL, and 1.06 (1.04-1.
   166  AIDS: immediate initiation, initiation at a CD4 count less than 500 cells per muL, and initiation at
   167 T with immediate initiation, initiation at a CD4 count less than 500 cells per muL, and initiation at
   168 reening test for people living with HIV with CD4 count less than or equal to 350 cells per muL who ar
   169 osis prevalence and in susceptible patients (CD4 counts less than 200 cells per muL) detection of cho
  
   171    TB-IRIS patients and controls had similar CD4 counts, levels of T-cell-associated immune activatio
   172  adults with HIV, who were naive to ART, had CD4 count lower than 100 cells per muL and HIV RNA great
  
   174 deferred ART eligibility, as determined by a CD4 count < 350 cells/mul, per South African national gu
   175 ) and from 40%/35% to 13%/13% for cases with CD4 count </= 350 cells/mm3 or AIDS (all p < 0.001).    
   176 om 39%/62% to 94%/90% among individuals with CD4 count </= 350 cells/mm3 or AIDS (all p < 0.001).    
   177     In the control arm, 42.3% (83/196) had a CD4 count </= 350 cells/mul at first visit, of whom 92.8
   178  initiation of ART within 3 mo in those with CD4 count </= 350 cells/mul did not differ significantly
   179 ered according to national guidelines, i.e., CD4 count </= 350 cells/mul) contributed to the first ph
   180 nds routinely screening AIDS patients with a CD4 count </=100 cells/microL for cryptococcal infection
   181 unodeficiency virus-infected patients with a CD4 count </=100 cells/microL to detect and treat early 
   182 ses, including 6 stratified by preenrollment CD4 count </=200 cells/muL, were analyzed and compared t
  
   184 aled that a previous diagnosis with CM and a CD4 count </=50 cells/microL were significantly associat
  
  
   187 have an IOP </=10 mm Hg, and patients with a CD4 count </=700 cells/mm(3) were 13 times more likely t
   188 st that the addition of "HIV infected with a CD4 count <100 cells/microL" to the EORTC host criteria 
   189 oma diagnosis (difference = 4; P = .01), and CD4 count <200 cells/microL (vs >/=500) was associated w
   190 n with HIV RNA load >10 000 copies/mL and/or CD4 count <200 cells/microL had lower rates of seroconve
   191  biomarker of more severe immune deficiency (CD4 count <200 cells/mL) had a 44% increased risk of sub
  
   193 orld Health Organization stage 4 event (with CD4 count <250) was 0.96 (95% confidence interval (CI): 
   194  of subtype C-infected women progressed to a CD4 count <350 cells/microL within 2 years of infection.
  
  
   197 ld Health Organization treatment guidelines (CD4 count <500 cells/microL) would require most individu
   198 in 645 HIV-positive, ART-naive patients with CD4 counts </=100 cells/microL in Cape Town, South Afric
  
  
   201        In those with HIV, longer exposure to CD4 counts <200 cells/microL, and, to a lesser extent, h
   202 ized HIV-infected tuberculosis patients with CD4 counts <350 cells/microL were included; tuberculosis
   203 ), and 14% (95% CI, 2%-25%) among those with CD4 counts <350, 350-499, and >/=500 cells/microL, respe
   204 ed with prevalent anal HR-HPV infection were CD4(+)count <350/muL (odds ratio, 2.9; 95% confidence in
   205 -cells/mul threshold, having an ART-eligible CD4 count (<350 cells/mul) was associated with higher 12
   206 0 copies per mL, or >400 000 copies per mL), CD4 count (<50 cells per muL, 50-199 cells per muL, or >
  
  
   209 d with lack of cancer treatment included low CD4 count, male sex with injection drug use as mode of H
   210 fits of offering immediate ART regardless of CD4 count may be larger than suggested by clinical trial
  
   212 ver, current evidence suggests that although CD4 counts may still play a role in guiding clinical car
  
  
   215 n, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascu
   216 after 1 month of tuberculosis treatment at a CD4 count of <100 cells/mm(3) or World Health Organizati
   217 viduals with HIV infection (age >/=18 years, CD4 count of <200 cells per muL, ART naive) and randomly
  
   219 re high risk, 74% had stage III to IV BL and CD4 count of 195 cells per muL (range, 0-721 cells per m
   220 age 56.3%) newly accessed care with a median CD4 count of 250 cells/mul (interquartile range 159-426)
  
  
   223  HIV-1 RNA of at least 1000 copies per mL, a CD4 count of at least 100 cells per muL, and estimated g
   224 pressive antiretroviral therapy with current CD4 count of at least 350 cells per muL and HIV DNA betw
   225 ) on a stable regimen for at least 6 months, CD4 count of more than 100 cells per muL, and no history
  
   227  = 2.4, 95% CI: 1.3, 4.3) than in those with CD4 counts of >/=100 (hazard ratio = 1.1, 95% CI: 0.8, 1
   228 h CDM versus LCM was greater in persons with CD4 counts of <100 (hazard ratio = 2.4, 95% CI: 1.3, 4.3
   229 The strategies were defined by the threshold CD4 counts of 200 cells per muL, 350 cells per muL, and 
   230  with linkage to care with ART initiation at CD4 counts of 350 cells per muL or less reduces HIV inci
  
   232 axis should be given with ART in people with CD4 counts of 350 cells per muL or lower in low-income a
   233 [HR] 0.40, 95% CI 0.26-0.64) when started at CD4 counts of 350 cells per muL or lower with antiretrov
  
  
   236 ntiretroviral therapy to adult patients with CD4 counts of 500 cells per muL or less ranged from $237
   237 ncentrations of at least 1000 copies per mL, CD4 counts of at least 200 cells per muL, estimated glom
   238  women at 14 or more weeks of gestation with CD4 counts of at least 350 cells per cubic millimeter to
   239 estricted to person-time accrued on ART with CD4 counts of at least 500 cells per muL and when white 
   240 e than 10 000 copies per mL among those with CD4 counts of more than 350 cells per muL was cost-effec
  
  
  
   244  total of 2056 patients (41% with a baseline CD4+ count of >/=500 cells per cubic millimeter) were fo
   245  hazard ratio among patients with a baseline CD4+ count of >/=500 cells per cubic millimeter, 0.56; 9
   246  hazard ratio among patients with a baseline CD4+ count of >/=500 cells per cubic millimeter, 0.61; 9
   247 ents, including those with cirrhosis, with a CD4+ count of 200/mm3 or greater or CD4+ percentage of 1
   248 4), including 68 in patients with a baseline CD4+ count of at least 500 cells per cubic millimeter (3
   249 ed previous ART and were starting ART with a CD4+ count of fewer than 100 cells per cubic millimeter.
   250 ticipants who had HIV type 1 infection and a CD4+ count of less than 800 cells per cubic millimeter a
   251  World Health Organization stage 4 events, a CD4+ count of more than 250 cells per cubic millimeter, 
   252 odeficiency virus (HIV) infection who have a CD4+ count of more than 350 cells per cubic millimeter. 
   253 oviral therapy in HIV-positive adults with a CD4+ count of more than 500 cells per cubic millimeter p
   254 domly assigned HIV-positive adults who had a CD4+ count of more than 500 cells per cubic millimeter t
   255 end points (68%) occurred in patients with a CD4+ count of more than 500 cells per cubic millimeter. 
   256 no IPT, both overall and among patients with CD4+ counts of at least 500 cells per cubic millimeter. 
   257 e, and postpartum HIV care engagement (>/= 1 CD4 count or viral load [VL] test within 90 days of deli
   258 , evidence of treatment failure based on one CD4 count or viral load measurement ranged from 86 (32%)
   259 y), associated with retention in care (>/= 1 CD4 count or VL test in each 6-month interval of the per
  
  
   262 th detectable HIV viremia and inversely with CD4 count (p<0.0001), consistent with HIV activation of 
   263 nd HIV risk group (p<0.0001); higher pre-ART CD4 count (p=0.0008) and pre-ART viral load (p=0.0003) w
   264  proportion of KS and NHL occurred at higher CD4 counts (P < .05 for KS and NHL) and with undetectabl
  
   266 use (HR, 1.37 [95% CI, 1.02-1.85], P = .04), CD4(+) count (risk per 100-cell increase: HR, 0.90 [95% 
   267 rt prophylaxis for opportunistic infections, CD4 counts should cease to be required for ART initiatio
  
  
   270  long-term ART, 308/378 (81%) monitored with CD4 counts versus 297/375 (79%) without had VL <1,000 co
   271 , sex, age, year of ART initiation, baseline CD4 count, viral load, and AIDS status, before and after
  
  
  
   275 d 4 of 12 patients, respectively, and median CD4 count was 161 (101-188) cells/microL and 167 (135-13
  
  
  
  
  
  
  
  
  
  
  
   287 n this subpopulation, having an ART-eligible CD4 count was associated with higher 12-month retention 
   288 tion between CMV load in saliva and maternal CD4 count was observed (r = -0.495, n = 22, P = .019).  
   289 dian age was 45 years, 77% were male, median CD4(+) count was 561 cells/microL, and brachial FMD was 
  
   291 ars), almost 62% were female, and the median CD4+ count was 173 cells/mul (IQR 92-254 cells/mul).    
  
   293 nts, 311 (77%) had HIV infection; the median CD4+ count was 340 cells per cubic millimeter (interquar
  
  
  
   297 ositive HIV test or first treatment-eligible CD4 count were randomized to standard or rapid initiatio
   298 bles measured at each study visit except for CD4 counts, which were lower (P < .05) in the latter gro
  
   300 /270) of the women who were HIV-positive had CD4 counts within National Department of Health ART init
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