ライフサイエンスコーパス: CD4 receptor

1 characteristic or atypical expression of the CD4 receptor.

2 n and antagonized the normal function of the CD4 receptor.

3 een the viral gp120 protein and the cellular CD4 receptor.

4 s HIV-1 at the level of interaction with the CD4 receptor.

5 120 recognition that includes mimicry of the CD4 receptor.

6 gp120, which binds with high affinity to the CD4 receptor.

7 p120 protein not recognized by the host cell CD4 receptor.

8 efficiently mediate entry using the macaque CD4 receptor.

9 esus and pig-tailed macaque versus the human CD4 receptor.

10 p120 monomer similar to those induced by the CD4 receptor.

11 minants controlling raft localization of the CD4 receptor.

12 ut not in cells expressing low levels of the CD4 receptor.

13 on the gp120-induced internalization of the CD4 receptor.

14 ole in the HIV-induced downmodulation of the CD4 receptor.

15 d it block the interaction of gp120 with the CD4 receptor.

16 s transfer requires the engagement of T-cell CD4 receptors.

17 f gp120 is essential for HIV binding to host CD4 receptors.

18 he initial binding of HIV virions to surface CD4 receptors.

19 ns of the HIV-1 envelope protein to cellular CD4 receptors.

20 t of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutra

21 Because ligation of the CD4 receptor alone or the CXCR4 receptor alone causes p3

22 the four modular ectodomains (D1-D4) of the CD4 receptor, an important receptor in immune signaling.

23 the high affinity of R3A Env for binding the CD4 receptor and (ii) Nef activity, which is involved in

24 the high affinity of R3A Env for binding the CD4 receptor and (ii) Nef activity, which is involved in

25 HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or CX

26 earrangement of Env upon binding to the host CD4 receptor and chemokine coreceptor drives membrane fu

27 it enhanced exposure after attachment to the CD4 receptor and comprise some of the most conserved and

28 w that sFN-mediated enhancement requires the CD4 receptor and does not alter the specificity of gp120

29 rises from the interaction of gp120 with the CD4 receptor and enables interactions with specific core

30 irus type 1 (HIV-1) Vpu protein binds to the CD4 receptor and induces its degradation by cytosolic pr

31 3) is a protein with a high affinity for the CD4 receptor and is expressed mainly by regulatory T cel

32 ain microglia that express low levels of the CD4 receptor and is the cause of HIV-associated dementia

33 d has important roles in down-regulating the CD4 receptor and modulating T-cell signaling pathways.

34 the viral envelope glycoprotein to both the CD4 receptor and one of several chemokine receptors and

35 HIV-1 infection of DCs via its primary CD4 receptor and secondary chemokine receptors leads to

36 in the trimer is capable of attaching to the CD4 receptor and the coreceptor, and each of the three g

37 envelope glycoprotein gp120 to the cellular CD4 receptor and the coreceptor, usually CCR5 or CXCR4.

38 The roles of the CD4 receptor and the src kinase p56lck were examined in

39 text of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom reso

40 of cells expressing low levels of the human CD4 receptor and with soluble CD4 sensitivity.

41 ral envelope glycoprotein (Env) and cellular CD4 receptors and coreceptors.

42 f this signaling pathway requires functional CD4 receptors and is independent of binding to CXCR4.

43 ts within a given trimer have to bind to the CD4 receptors and to the coreceptors, and how many gp41

44 at two envelope proteins have to engage with CD4-receptors and coreceptors and that two fusion protei

45 es of isolated viral envelope antigens, host CD4 receptors, and cognate antibodies.

46 enal tubular epithelial cells do not express CD4 receptors, and it is unclear how these cells become

47 envelope glycoprotein gp120 to the cellular CD4 receptor, are largely unknown.

48 oluble CD4) or on the T-cell surface (native CD4 receptor) as determined by a competitive gp120 captu

49 pends on membrane expression of the critical CD4 receptor, as well as certain chemokine coreceptors.

50 e show that the spatial orientation of gp120-CD4 receptor binding relative to the site of TCR engagem

51 in VC20013 and an epitope that overlaps the CD4 receptor binding site in VC10014.

52 C01 class of antibodies blocks the conserved CD4 receptor binding site interaction that is necessary

53 r the structurally conserved site of initial CD4 receptor binding.

54 egions of the protein surface to antibody or CD4 receptor binding; the number of glycans that can pot

55 of the viral envelope glycoprotein with the CD4 receptor, binding of the envelope-CD4 complex to che

56 The epitope recognized by b12 overlaps the CD4 receptor-binding site (CD4bs) on gp120 and has been

57 tely mimics native Env spikes, including the CD4 receptor-binding site and the epitope for the VRC PG

58 The latter is different from the fully open, CD4 receptor-bound conformation and may represent an int

59 irus (HIV) entry is mediated not only by the CD4 receptor, but also by interaction with closely relat

60 Ligation of the CD4 receptor by HIV envelope glycoprotein gp120 inhibits

61 Functionally, the observed shape changes in CD4 receptor causes dissociation of lymphocyte kinase fr

62 dependence on the formation of a gp120-human CD4 receptor complex.

63 ti-CD4 mAb to the OKT4A/Leu3a epitope of the CD4 receptor, compound 24 being the most active in this

64 The CD4 receptor contributes to T-cell activation by coligat

65 ce in their ability to infect cells with low CD4 receptor densities, in their sensitivity to soluble

66 ry-based quantitative method to quantify the CD4 receptor density in units of copy number per cell on

67 n the cells of New World monkeys because the CD4 receptor does not efficiently support HIV-1 entry.

68 some isolates of HIV-1 subtype C can use the CD4 receptor encoded by permissive Spix's owl monkey all

69 We found that the CD4 receptors encoded by two other species of owl monkey

70 , including functional differences with host CD4 receptor engagement and possible changes in the CD4

71 local thresholds for signaling propagation, CD4 receptor engagement by gp120-containing ICs all arou

72 gp120 and undergo conformational change upon CD4 receptor engagement by the HIV-1 envelope spike.

73 ion structures emerging on trimeric Env post CD4 receptor engagement.

74 entry into cells by down-modulating surface CD4 receptor expression through binding to the CD4 signa

75 V-1 infection relating to down-regulation of CD4 receptor expression.

76 in (gp120) and cluster of differentiation 4 (CD4) receptor extends beyond residue phenylalanine 43 of

77 do not use nonhuman primate versions of the CD4 receptor for cellular entry, or they do so poorly.

78 in formed syncytia with cells expressing the CD4 receptor for HIV.

79 ptide containing residues 36-59 of the human CD4 receptor includes most of the residues thought to be

80 man immunodeficiency virus type 1 (HIV-1) to CD4 receptors induces multiple cellular signaling pathwa

81 t binding of HIV-1 envelope glycoproteins to CD4 receptor initiates a signaling pathway(s) independen

82 s massive virus internalization requires Env-CD4 receptor interactions but is resistant to inhibition

83 caspase-3 and caspase-6 depended on envelope-CD4 receptor interactions; CCR5-utilizing as well as CXC

84 the HIV-1 gp120 envelope glycoprotein to the CD4 receptor involves exceptional changes in enthalpy an

85 HIV attachment via the CD4 receptor is an important target for developing novel

86 eficiency virus type 1 (HIV-1) gp120 and the CD4 receptor is highly specific and involves relatively

87 iating unilineage precursors showed that the CD4 receptor is present on approximately 15% of the star

88 the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodie

89 The CD4 receptor is required for the entry of human immunode

90 The site on HIV-1 gp120 that binds to the CD4 receptor is vulnerable to antibodies.

91 murine mAb that recognizes an epitope on the CD4 receptor, is a potent immunosuppressive agent in vit

92 ry into HeLa/CD4 cells containing a tailless CD4 receptor, located outside lipid rafts, was fully per

93 Additionally the disabled CD4 receptor may be less able to signal the cell to allo

94 imulated by the binding of HIV-1 or gp120 to CD4 receptors, may play an essential role in the transcr

95 ontain gp120, and suggest that IC binding to CD4 receptors might contribute to the progressive declin

96 HOC with NH2-terminal fused HIV-I CD4 receptor of 183 amino acids can be detected on the T

97 ay, we demonstrate that the stoichiometry of CD4 receptor-oligomeric envelope interaction is 1:1.

98 The HIV envelope binds the CD4 receptor on T cells as soluble shed antigen or as an

99 Engagement of the CD4 receptor on T cells from HIV-uninfected donors befor

100 We hypothesized that Env engagement of the CD4 receptor on T-helper cells results in anergic effect

101 t attaching with their surface spikes to the CD4 receptor on target cells.

102 Viral entry is initiated by binding to the CD4 receptor on the cell surface, which induces large co

103 lowed the virus to infect cells by utilizing CD4 receptors on their surface.

104 Initial signaling through the CD4 receptor played a major role in the sensitization of

105 s or recombinant HIV-1 glycoprotein gp120 to CD4 receptors resulted in association and tyrosine phosp

106 A soluble form of the CD4 receptor (sCD4) can either enhance or inhibit the in

107 and Raf-1 was mediated by stimulation of the CD4 receptors, since it was abolished by preincubation o

108 nodeficiency virus type 1 (HIV-1) virions to CD4 receptors stimulates association of Lck with Raf-1 a

109 When interacting with the CD4 receptor, the HIV gp120 envelope glycoprotein underg

110 lating HIV-1 variants cannot use the macaque CD4 receptor to enter cells and have to be adapted to th

111 use chemokine coreceptors in addition to the CD4 receptor to initiate virus infection.

112 ifferences in the functional capacity of the CD4 receptor to mediate entry mapped to a single amino a

113 HIV-1 use CD4 receptors to infect their primary targets, CD4+ cell

114 Expression of CD4 receptor together with CXCR4 and/or CCR5 coreceptor

115 Binding to the CD4 receptor triggers a cascade of conformational change

116 the HIV-1 envelope gp120 protein to cellular CD4 receptors via a specific and competitive mechanism.

117 ted single-site mutant (F43V) version of the CD4 receptor, was captured onto the sensor surface using

118 d similar infectivity with macaque and human CD4 receptors (within approximately 2-fold).