ライフサイエンスコーパス: CD40 ligand

1 teract with CD4 T cells (the major source of CD40 ligand).

2 ies, such as those that target CD4 or CD154 (CD40 ligand).

3 onocyte-derived dendritic cells matured with CD40 ligand.

4 itic cells, in part through up-regulation of CD40 ligand.

5 costimulation can be achieved by addition of CD40 ligand.

6 lls at a site that differs from that used by CD40 ligand.

7 actor, Toll-like receptor (TLR) ligands, and CD40 ligand.

8 e-forming enzyme perforin, and expression of CD40 ligand.

9 ed signaling platforms that serve to cluster CD40 ligand.

10 s using guanylic acid-grade soluble trimeric CD40 ligand.

11 ure to interferon-alpha, interferon-gamma or CD40 ligand.

12 mplicated in resistance to malaria: G6PD and CD40 ligand.

13 ched membrane domains prevents clustering of CD40 ligand.

14 CD4(+)CD28(null) T cells to express CD25 and CD40 ligand.

15 cy disorder caused by genetic alterations in CD40 ligand.

16 IFN-gamma but released it when stimulated by CD40 ligand, a cytokine found in atheroma.

17 ion is triggered upon activation of IPC with CD40 ligand, a signal physiologically delivered by CD4 T

18 ic cell transfusion in combination with anti-CD40 ligand Ab (DST/anti-CD40L).

19 g properties of rATG on CD27- naive B cells, CD40 ligand-activated B cells, and plasma cells in vitro

20 st, naive CD8 T cells primed with allogeneic CD40 ligand-activated monocyte-derived DCs (DC1) differe

21 , and such transmission is also augmented by CD40 ligand activation.

22 ed apoptosis of B cell targets stimulated by CD40 ligand alone was increased in the absence of Btk.

23 ng costimulation blockade (CTLA4-Ig and anti-CD40 ligand) alone or in combination with donor cells en

24 In this study we show that soluble CD40 ligand also promotes the formation of complexes bet

25 ed by stimulation with interleukin 4/soluble CD40 ligand and by stroma cell contact.

26 resulting in enhanced expression of CD25 and CD40 ligand and down-regulation of CD62L.

27 xP3 Tg mice display reduced up-regulation of CD40 ligand and fewer IFN-gamma-producing cells.

28 tion to plasmablasts in vitro in response to CD40 ligand and IL-21 was abolished.

29 s is elicited by external stimuli, including CD40 ligand and IL-4, provided by bystander immune cells

30 scripts in vitro unless exposed to exogenous CD40 ligand and IL-4.

31 e IgG, IgA, or IgE upon in vitro exposure to CD40 ligand and IL-4.

32 naive B cells ex vivo with a combination of CD40 ligand and interleukin 4.

33 Gene induction by TNF, CD40 ligand and interleukin-1beta was attenuated in cpdm

34 Stimulation of B cells with CD40 ligand and interleukin-4 promoted their ability to

35 ressing T cells depends on clustering of the CD40 ligand and is abrogated by inhibition of CD40 ligan

36 have introduced two new biomarkers, soluble CD40 ligand and ischemia-modified albumin, which may aid

37 sma levels of soluble P-selectin and soluble CD40 ligand and serum TxB2 were significantly higher in

38 ranscription as well as its targets, such as CD40 ligand and Th1/Th2 cytokines.

39 nse to signals from activated T cells and to CD40-ligand and soluble T cell-derived signals.

40 activation of B cells by T cells via CD154 (CD40 ligand) and cytokines.

41 natriuretic peptide, interleukin-6, soluble CD40 ligand, and insulin-like growth factor binding prot

42 natriuretic peptide, interleukin-6, soluble CD40 ligand, and insulin-like growth factor binding prot

43 , hemostasis (von Willebrand factor, soluble CD40 ligand, and P-selectin), pulmonary inflammation and

44 y C-reactive protein, interleukin-6, soluble CD40 ligand, and peripheral blood leukocyte subsets in p

45 s such as plasma soluble P-selectin, soluble CD40 ligand, and serum thromboxane B2 (TxB2) were measur

46 CD40 ligand- and Toll-like receptor 9-mediated signaling

47 icient (apoE(-/-)) mice but only slightly in CD40 ligand(-/-)apoE(-/-) mice, compared with apoE(-/-)

48 we show that patient B cells stimulated with CD40 ligand are impaired in both p65 and c-Rel activatio

49 CD40 and CD154 (CD40 ligand) are surface molecules that are central to t

50 growth factor (EGF), HER2, osteoactivin, and CD40-ligand, are increased in the medium of BT474 breast

51 went blood draw the next morning for soluble CD40 ligand, asymmetric dimethylarginine (ADMA), and nit

52 In vivo blockade of CD40 ligand attenuated B-cell abnormalities in a mouse m

53 interferon gamma (IFN-gamma), TNF-alpha, or CD40 ligand but did depend on cell-to-cell contact.

54 B cell receptor triggering was reversed with CD40 ligand, but not B cell activation factor.

55 NFalpha, interferon-gamma, IL-1alpha, and/or CD40 ligand, but not by IL-18.

56 lin M syndrome due to impaired expression of CD40 ligand by CD4(+) T cells.

57 etry and the expression of activation marker CD40 ligand by CD4(+)T cells.

58 The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central

59 ains that contain a Glu or Gln residue (Tnf5/CD40 ligand, C79a/Ig-alpha, C79b/Ig-beta, and Fut3/alpha

60 me-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8(+) T cells to HIV-1 in vitro.

61 We previously showed that a stromal cell/CD40 ligand (CD154) culture system reproduced this switc

62 CD40 ligand (CD154) expression has been shown to be regu

63 Abnormalities in B-lymphocyte CD40 ligand (CD154) expression have been described for a

64 Platelets are an abundant source of CD40 ligand (CD154), an immunomodulatory and proinflamma

65 in producers of interleukin (IL)-21, express CD40 ligand (CD154), and are located within the germinal

66 During cognate interaction with CD40 ligand (CD154)-expressing T cells, Ag-presenting ac

67 cells transduced with an adenovirus encoding CD40-ligand (CD154) caused rapid reductions in leukemia-

68 with normal dendritic cells (DCs) or with a CD40-ligand (CD154)-expressing fibroblast cell line.

69 vidence supports a role of the CD40 receptor-CD40 ligand (CD40-CD40L) interaction in the pathogenesis

70 etry was used to assess SEB-induced CD69 and CD40 ligand (CD40-L) expression and IFN-gamma production

71 Hyper-IgM syndromes result from mutations in CD40 ligand, CD40, AID, or UNG in 70-80% of affected pat

72 CD28-B7 and CD40 ligand-CD40 (CD40L-CD40) costimulatory pathways aff

73 CD4+ T cells and platelets express CD40 ligand (CD40L) and are reported to mediate proinfla

74 infection, we asked whether blockade of the CD40 ligand (CD40L) and CD28 costimulatory pathways impa

75 Interactions between CD40 ligand (CD40L) and CD40 have been shown to have plu

76 luding mutations of the genes coding for the CD40 ligand (CD40L) and IKK-gamma (NEMO) genes, both X-l

77 ophage colony-stimulating factor (GM-CSF) or CD40 ligand (CD40L) and investigated their biological ac

78 mice (8 to 10 weeks old) were cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9)

79 proinflammatory and proatherogenic mediators CD40 ligand (CD40L) and thromboxanes (TXs).

80 age-mediated repression and identify soluble CD40 ligand (CD40L) as a second repressive factor secret

81 Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammato

82 udy, we critically examined the role of CD28/CD40 ligand (CD40L) costimulation and the common gamma-c

83 sCD40-immunoglobulin (Ig), blocking the CD40-CD40 ligand (CD40L) costimulatory pathway, from genetica

84 CD40 ligand (CD40L) deficiency causes recurrent sinopulm

85 CD40 ligand (CD40L) deficiency predisposes to opportunis

86 It is known that CD40 ligand (CD40L) exists in platelets, that a soluble

87 iple functions, such as cytokine production, CD40 ligand (CD40L) expression (associated with the cost

88 IL-12 production and up-regulation of CD40 ligand (CD40L) expression are impaired in the PBMC

89 Deficiency in CD40 ligand (CD40L) expression is associated with impair

90 5, a potent growth factor for ILC3s, induced CD40 ligand (CD40L) expression on circulating and tonsil

91 Loss of CD40 ligand (CD40L) expression or function results in X-

92 nventional T cells differ in their 4-1BB and CD40 ligand (CD40L) expression signatures, allowing a cl

93 CD40 ligand (CD40L) expression was enhanced on unpolariz

94 ence implicates the proinflammatory cytokine CD40 ligand (CD40L) in atherosclerosis and accumulating

95 eviously, we detected high levels of soluble CD40 ligand (CD40L) in CSF and plasma of HIV-infected pa

96 f tissue factor gene expression triggered by CD40 ligand (CD40L) in this cell type remain unknown.

97 studies demonstrated a requirement for CD40-CD40 ligand (CD40L) interaction in the development of re

98 To explore the role of CD40/CD40 ligand (CD40L) interaction in this model, Wt mice g

99 ralization of IL-12 and blockade of the CD40/CD40 ligand (CD40L) interaction in vivo did not alter th

100 CD40-CD40 ligand (CD40L) interactions appear to play pathogen

101 CD40-CD40 ligand (CD40L) interactions play a critical role in

102 CD40-CD40 ligand (CD40L) interactions play a significant role

103 ent induction of IL-12 is regulated via CD40/CD40 ligand (CD40L) interactions, we examined the effect

104 ll-to-cell contact that is dependent on CD40-CD40 ligand (CD40L) interactions; and (iv) fully activat

105 rove vaccine immunogenicity, we incorporated CD40 ligand (CD40L) into the dSIV envelope.

106 CD40 ligand (CD40L) is an essential effector cytokine fo

107 The blockade of CD40 ligand (CD40L) is effective in autoimmune disease p

108 show that the T-cell costimulatory molecule CD40 ligand (CD40L) is required for ovx to expand SCs; p

109 CD40 ligand (CD40L) is upregulated on activated CD4 T ce

110 X-linked hyper-IgM syndrome (X-HIGM) due to CD40 ligand (CD40L) mutations are susceptible to fungal

111 Binding of CD40 by CD40 ligand (CD40L) on activated CD4+ T cells provides a

112 Costimulation through the CD40-CD40 ligand (CD40L) pathway is critical to allograft rej

113 ss-talk of cluster of differentiation (CD)40/CD40 ligand (CD40L) plays a key role in CD4(+) T-cell pr

114 the control of the cell activation-dependent CD40 ligand (CD40L) promoter.

115 Expression of CD40 ligand (CD40L) proximate to the MM cells might serv

116 CD40/CD40 ligand (CD40L) signaling contributes to proinflamma

117 CD40/CD40 ligand (CD40L) signaling is a potent activator of e

118 Although the CD40-CD40 ligand (CD40L) signaling pathway has been implicate

119 Activation of B-CLL cells through CD40 ligand (CD40L) stimulation decreases expression of

120 the type 1 or type 2 pathways, respectively, CD40 ligand (CD40L) strongly activates both.

121 The CD40-CD40 ligand (CD40L) system (CD154) is a central means of

122 vestigated the capacity of IFN-gamma and the CD40 ligand (CD40L) to affect the expression and functio

123 Furthermore, T cells, through CD40 ligand (CD40L) to CD40 costimulation, promote OPG p

124 t an approach to arm an oncolytic virus with CD40 ligand (CD40L) to stimulate beneficial immunologic

125 CD40 ligand (CD40L) transduction of antigen-pulsed dendr

126 ey capsule can synergize with transient anti-CD40 ligand (CD40L) treatment to induce robust donor-spe

127 We have previously shown that combining CD40 ligand (CD40L) with Leishmania antigen preferential

128 CD40 ligand (CD40L), a member of the tumor necrosis fact

129 CD40 ligand (CD40L), a member of the tumor necrosis fact

130 ) and a second cassette encoding full-length CD40 ligand (CD40L), a molecule expressed on activated C

131 CD4+ T cells that express CD40 ligand (CD40L), along with other accessory immune a

132 mutations in forkhead box protein 3 (FOXP3), CD40 ligand (CD40L), and IL-10 receptor alpha(IL10RA), a

133 pid raft fraction of PMN membranes expressed CD40 ligand (CD40L), CD28, and leukocyte function-associ

134 bution of the major costimulatory molecules, CD40 ligand (CD40L), CD80, and CD86, in the priming of C

135 s in peripheral blood mononuclear cells [ie, CD40 ligand (CD40L), IL-23alpha subunit p19 (IL23A), adr

136 were characterized by the activation markers CD40 ligand (CD40L), interleukin-2 (IL-2), tumor necrosi

137 stimuli, such as the B-cell receptor (BCR), CD40 ligand (CD40L), or interleukin-4 (IL-4).

138 ype switching, is caused by mutations of the CD40 ligand (CD40L), which is normally expressed on acti

139 s, which were matured by addition of LPS and CD40 ligand (CD40L), with or without ESAT-6.

140 CD40 ligand (CD40L)-deficient C57BL/6 mice failed to con

141 CD40 ligand (CD40L)-deficient mice have been shown to ha

142 ealed that protective immunity requires CD40/CD40 ligand (CD40L)-dependent, interleukin-12 (IL-12)-dr

143 al cells, which involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infi

144 Likewise, there was strong inhibition of CD40 ligand (CD40L)-induced activation of MAPKs in TWEAK

145 CD40 ligand (CD40L)-induced cell survival was associated

146 We compared the roles of CD28- and CD40 ligand (CD40L)-mediated costimulation in C. muridar

147 ascular endothelial cells (HIMEC) induced by CD40 ligand (CD40L)-positive T cells and soluble CD40L a

148 lets express CD40 led us to hypothesize that CD40 ligand (CD40L)-positive T cells could bind to plate

149 sed on costimulation blockade, in particular CD40 ligand (CD40L)-specific antibodies, have been highl

150 clearance in a manner partially dependent on CD40 ligand (CD40L).

151 tumor necrosis factor alpha (TNF-alpha), and CD40 ligand (CD40L).

152 der caused by mutations in the gene encoding CD40 ligand (CD40L).

153 mor-associated antigen fragment fused to the CD40 ligand (CD40L).

154 pe 5 fiber, phage T4 fibritin, and the human CD40 ligand (CD40L).

155 al role of the T-cell costimulatory molecule CD40 ligand (CD40L).

156 The interaction between CD40 ligand (CD40L, CD154) and its receptor CD40 on anti

157 B cells are exposed to high levels of CD40 ligand (CD40L, CD154) in chronic inflammatory disea

158 CD40 ligand (CD40L, CD154) induces apoptosis of tumor ce

159 CD40 ligand (CD40L, CD154) is a membrane protein that is

160 ding CD28/B7 molecules (CD80 and CD86), CD40/CD40 ligand (CD40L, CD154), and LFA-1 (CD18)/ICAM-1 (CD5

161 sogenic population induced to proliferate by CD40-ligand (CD40L) and IL4 has revealed that EBV can ov

162 atase 4 (DUSP4) that shortened expression of CD40-ligand (CD40L) and inducible T-cell costimulator (I

163 HIGM patients who carry mutations in the CD40-ligand (CD40L) gene expressed by CD4(+) T cells suf

164 LL) treated with adenovirus CD154 (Ad-CD154, CD40 ligand [CD40L]) gene therapy experienced rapid redu

165 te chemoattractant protein 1, nitrotyrosine, CD40 ligand [CD40L], and monocyte function).

166 e sites in the promoter of the gene encoding CD40 ligand (Cd40lg), and maximum Cd40lg promoter activi

167 The functional significance of CD40 ligand clustering is indicated by the finding that

168 D40 ligand and is abrogated by inhibition of CD40 ligand clustering.

169 n, syndecan-1), platelet activation (soluble CD40 ligand), coagulation activation/inhibition (prothro

170 together with TriMix, a mix of mRNA encoding CD40 ligand, constitutive active Toll-like receptor 4 an

171 s have shown that iNKT-produced IFNgamma and CD40 ligand contribute to this dendritic cell maturation

172 hat CD28 but not ICOS, OX40, 4-1BB, CD27, or CD40 ligand costimulation maintained high levels of Foxp

173 idenced by increased serum levels of soluble CD40 ligand costimulatory molecules.

174 srupting either the CD80/86-CD28 or the CD40-CD40 ligand costimulatory pathway abrogates T-dependent

175 The CD80/86-CD28 and CD40-CD40 ligand costimulatory pathways are essential for Th

176 ma(IL2RG) gene as well as IL-10 receptor and CD40 ligand deficiencies had normal or near-normal mitog

177 immunodepression favoring cryptosporidiosis (CD40 ligand deficiency [n = 1], human immunodeficiency v

178 IgE-expressing B cells in control subjects, CD40 ligand-deficient patients, and patients with atopic

179 ed proliferation and SHM and were present in CD40 ligand-deficient patients, indicating a GC-independ

180 pression of P-selectin, glycoprotein 53, and CD40 ligand, demonstrating tonic inhibition of platelet

181 ding constitutively active TLR4 (caTLR4) and CD40 ligand (DiMix-DCs), or these factors together with

182 emarkably, both B cell-activating factor and CD40 ligand do not significantly induce expression of NI

183 in priming these cells for their response to CD40 ligand during airway inflammation.

184 The CD40/CD40 ligand dyad in endothelial cells (EC) has a central

185 Thus, we find no evidence that CD40 ligand-expressing CD4 T cells are required to activ

186 D40 on B lymphocytes upon co-incubation with CD40 ligand-expressing T cells depends on clustering of

187 IFN-gamma production was correlated with CD40 ligand expression on the tumor and inversely with i

188 D28-induced IL-2 production, and TCR-induced CD40 ligand expression, both key functions of activated

189 CD154 (CD40 ligand) expression on CD4 T cells is normally tight

190 lso had reduced CMV-specific IL-2 and CD154 (CD40 ligand) expression, suggesting an early blockade in

191 terestingly, platelet-derived excess soluble CD40 ligand found in the plasma and cerebrospinal fluid

192 yper-IgM) syndrome who, due to a mutation in CD40 ligand gene, do not have a classical, class-switche

193 3, 4, 5, and 9) and other factors, including CD40 ligand, GM-CSF, and IL-4 as well as the neuropeptid

194 ptor depends on reciprocal clustering of the CD40 ligand (gp39, CD154).

195 ulated serum concentrations of CD40 antigen, CD40 ligand, IL-16, monocyte chemotactic protein-1, and

196 In this study, we show that CD40 ligand, IL-2, and IL-10 together drive this transit

197 ts of B-cell function after stimulation with CD40 ligand, IL-21, or both; and differential gene expre

198 We aimed to study in detail the kinetics of CD40 ligand/IL-21-induced B-cell differentiation to defi

199 that CD86 and/or beta(2)AR stimulation on a CD40 ligand/IL-4-activated B cell increases the level of

200 ease the level of IgG1 protein produced by a CD40 ligand/IL-4-activated B cell.

201 el of mature IgG1 transcription increases in CD40 ligand/IL-4-activated B cells following stimulation

202 study, we report that, in comparison with a CD40 ligand/IL-4-primed murine B cell alone, beta2AR eng

203 hibited IL-23 production induced by TSLP and CD40 ligand in a signal transducer and activator of tran

204 restimulated by the activated T-cell signal CD40 ligand in the absence of cmvIL-10.

205 hey responded to Ag in vivo and up-regulated CD40 ligand in vitro.

206 HeLa) epithelial cells upon stimulation with CD40 ligand, indicating that Act1 is involved in this si

207 to IL-4 priming, DCs activated with TSLP and CD40 ligand induce the differentiation of naive CD4(+) T

208 ous, apoptotic CD8(-) cells and matured with CD40 ligand induced gamma interferon production in autol

209 NF kappa B activation and protects them from CD40 ligand-induced apoptosis.

210 Lipopolysaccharide- and CD40 ligand-induced maturation of iLC derived from laten

211 express it, renders these cells sensitive to CD40 ligand-induced NF kappa B activation and protects t

212 depleting Abs targeting CD4, CD8, and CD154 (CD40 ligand) induces dominant transplantation tolerance

213 ound no evidence of any requirement for CD40-CD40 ligand interaction at this level.

214 CD40-CD154 (CD40 ligand) interaction in the co-stimulatory pathway i

215 7.1/B7.2 interactions, but not CTLA4 or CD40-CD40 ligand interactions.

216 l help, B7-dependent costimulation, and CD40/CD40 ligand interactions.

217 8/B7 and with anti-CD154 mAb to inhibit CD40/CD40-ligand interactions.

218 cells, B7-dependent costimulation, and CD40-CD40-ligand interactions.

219 2) and/or the beta2-adrenergic receptor on a CD40 ligand/interleukin-4-activated B cell increased the

220 Clustering of the CD40 ligand is mediated by an association of the ligand

221 cells by exposure to lipopolysaccharide and CD40 ligand is not sufficient to trigger virus reactivat

222 CD154 (CD40 ligand) is a type II transmembrane protein that bel

223 enovirus encoding a chimeric, membrane-bound CD40 ligand (ISF35).

224 ation of donor dendritic cells (DC) and anti-CD40 Ligand (L) (CD154) monoclonal antibody (mAb) marked

225 8 T cell response by activating APC via CD40-CD40 ligand (L) interactions.

226 monstration that activated platelets express CD40 ligand (L) provides a mechanism of interaction with

227 nd thrombin-antithrombin complex and soluble CD40 ligand levels were elevated compared with wild-type

228 n OSA and control children; however, soluble CD40 ligand levels were higher in OSA children and were

229 ADMA was found in children with OSA, soluble CD40 ligand levels were increased in OSA and reflected t

230 geneic intact active bone and transient anti-CD40 ligand mAb therapy.

231 nce induced with intact active bone and anti-CD40 ligand mAbs.

232 tosis is only achieved by membrane-presented CD40 ligand (mCD40L), as soluble receptor agonists are b

233 =5) or treatment with MR1 (hamster antimouse CD40 ligand monoclonal antibody) 500 microg intraperiton

234 In many situations, anti-CD154 (CD40 ligand) monoclonal antibody (mAb) treatment is very

235 treated with a tolerogenic protocol of anti-CD40 Ligand MR1 mAb and CTLA4Ig.

236 nd MMF, a monoclonal antibody against murine CD40 ligand (MR1), recombinant murine Ctla4Ig, and a com

237 Prior treatment with CD40 ligand normalized subsequent responses of xid B cel

238 ivities were maintained due to expression of CD40 ligand on a subset of CD4(+) Foxp3+ T cells.

239 ly requires engagement of CD40 on B cells by CD40 ligand on Ag-activated CD4(+) T cells.

240 cells undergo CSR upon engagement of CD40 by CD40 ligand on CD4+ T cells.

241 Constitutive expression of CD40 ligand on HMC-1 surface was not altered by NECA.

242 tes and depended on interactions between the CD40 ligand on NK cells and CD40 on infected monocytes.

243 endent upon engagement of CD40 on B cells by CD40 ligand on T cells.

244 r and lung, while the IL-4 response required CD40 ligand only in the spleen.

245 Treatment of CLL or normal B cells with CD40-ligand or B-cell-activating factor upregulated miR-

246 onse to stimulation with lipopolysaccharide, CD40 ligand, or anti-IgD plus appropriate cytokines.

247 )-1alpha, -4, -10, -13, -17, and -18; and/or CD40 ligand, or combinations thereof), with FKN mRNA bei

248 te BAFF and APRIL upon stimulation by T cell CD40 ligand, our findings indicate that NHL B cells dere

249 ic regression analysis showed plasma soluble CD40 ligand (p < 0.001) and soluble P-selectin (p < 0.00

250 se to all the toll-like receptor ligands and CD40 ligands, pDCs rapidly make large amounts of IFN-alp

251 F [epidermal growth factor], sCD40L [soluble CD40 ligand], PDGF [platelet-derived growth factor], RAN

252 cleotides containing certain CpG motifs plus CD40 ligand plus GM-CSF led to increased MHC class II, C

253 pically similar population of CD4(+) Foxp3+, CD40 ligand-positive T cells was found in diseased liver

254 ecretion coincident with diminished IL-6 and CD40 ligand production.

255 igate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the treatment of the disease.

256 for cancer treatment: CD30/CD30 ligand, CD40/CD40 ligand, receptor activator of nuclear factor-kappaB

257 In Model 2, only soluble CD40 ligand remained strongly associated with death/MI w

258 transfection, ligation of CD40 with soluble CD40 ligand resulted in a significant increase in VEGF t

259 a under the curve (AUC) for IL-6 and soluble CD40 ligand (sCD40L) and chronic viremia was observed on

260 High levels of circulating soluble CD40 ligand (sCD40L) are frequently found in patients wi

261 Soluble CD40 ligand (sCD40L) has been implicated in the developm

262 High levels of the soluble fragment of CD40 ligand (sCD40L) have previously been associated wit

263 Elevated plasma concentrations of soluble CD40 ligand (sCD40L) indicate increased risk for future

264 Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammato

265 in vitro effects of rhIFN-gamma and soluble CD40 ligand (sCD40L) treatment on macrophages.

266 relation between AF and preoperative soluble CD40 ligand (sCD40L), a proinflammatory marker released

267 wn to cause the release of a soluble form of CD40 ligand (sCD40L), a prothrombotic and proinflammator

268 arlier reported that the soluble form of the CD40 ligand (sCD40L), is involved in thrombosis by stabi

269 , fibrinogen, von Willebrand factor, soluble CD40 ligand (sCD40L), soluble P-selectin (sCD62P) concen

270 the proinflammatory, prothrombotic cytokine CD40 ligand (sCD40L).

271 LR4 activation by releasing IL-6 and soluble CD40 ligand (sCD40L).

272 tivator inhibitor type 1 [PAI-1] and soluble CD40 ligand [sCD40L]) in recently vaccinated individuals

273 , and platelet-derived inflammation (soluble CD40 ligand [sCD40L]) were measured using enzyme-linked

274 of a membrane-bound ligand of CD40 (soluble CD40 ligand; sCD40L) was significantly elevated in the s

275 mycophenolic acid was accompanied by reduced CD40 ligand serum levels and the prevention of IgM-to-Ig

276 subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractan

277 llograft rejection associated with both CD40-CD40 ligand signaling as well as VEGF expression and fun

278 These B cells probably require CD40/CD40 ligand signaling for their generation and have a un

279 These data suggest that the CD40-CD40 ligand signaling pathway regulates B7h expression o

280 ility complex (MHC) class II and CD40-CD154 (CD40 ligand) signaling.

281 ion using either a soluble recombinant human CD40 ligand (srhCD40L) or anti-CD40 monoclonal antibody

282 can be up-regulated by chemokine CXCL13 and CD40 ligand stimulation in wild-type B cells, elevation

283 DCs to produce large amounts of IL-12 after CD40 ligand stimulation, similar to IL-4 priming of DCs.

284 ability to produce IL-12p70 after subsequent CD40 ligand stimulation.

285 macrophage migration inhibitory factor, and CD40 ligand, that promote atherosclerotic lesion formati

286 ression of forkhead box P3 and expression of CD40 ligand; that loss of CD4 expression protects these

287 timulate microbe-specific T cells to express CD40 ligand, thereby licensing APCs that bear both micro

288 as essential for this process in response to CD40 ligand, TNFalpha, and IL-1.

289 We found that TSLP synergized with CD40 ligand to promote DC activation and pathogenic IL-2

290 mmunized T cells use IL-4 and IL-10 (but not CD40 ligand) to 'educate' dendritic cells, which in turn

291 endent Bcl-2 family members by anti-Ig after CD40 ligand treatment.

292 izing factor IL-12p70 in response to LPS and CD40 ligand triggering.

293 We investigated the effect of recombinant CD40 ligand trimer (CD40LT) on the functional capacity o

294 ed with a defined cocktail of cytokines or a CD40 ligand trimer matured fully, as measured by the ind

295 adily induced by B cell-activating factor or CD40 ligand, two major physiological inducers of p100 pr

296 effects on platelet biomarkers (P-selectin, CD40 ligand, urinary 11-dehydrothromboxane B(2)).

297 Finally, CD40 ligand was essential for induction of IFN-gamma in

298 [IQR, 1.5-2.21] at BL; P=0.002), and soluble CD40 ligand was significantly decreased at 60 minutes (8

299 e chemotactic protein-1 (MCP-1), and soluble CD40 ligand were also observed in the experimental group

300 tivated LDM expressing high levels of CD154 (CD40 ligand) with human cholangiocytes resulted in (1) C