ライフサイエンスコーパス: CD40L

1 CD40L and CpG significantly increased the level of IL-10

2 CD40L and other TNF superfamily ligands are noncovalent

3 CD40L has been shown to potentiate platelet activation a

4 CD40L immunoprecipitates, however, showed severely reduc

5 CD40L is a key stimulator of dendritic cells and B cells

6 CD40L is up-regulated on lymphocytes and CD40 on hepatoc

7 CD40L plays an important role in malignant B cell biolog

8 CD40L rapidly and transiently inhibits expression of the

9 CD40L(+) CD8(+) T cells are detectable among human antig

10 CD40L(+) CD8(+) T cells display potent helper functions

11 CD40L, although having no effect on Blimp-1 as a single

12 When culturing such IL-21(+)CD40L(-) Th cells with B cells, the former directly indu

13 ing a mouse model in which B cells express a CD40L transgene (CD40LTg) and receive autocrine CD40/CD4

14 D-L1-expressing functional itBreg cells in a CD40L- and B cell-activating factor receptor-dependent m

15 ry disseminated mycobacterial infection in a CD40L-deficient patient by recombinant human IFN-gamma (

16 CD86 engagement on a CD40L/IL-4-primed murine B cell activates signaling inte

17 ppression and TE can be uncoupled and that a CD40L dAb with an inert Fc tail is expected to be effica

18 Here, we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA

19 IL-15-activated CD40L(+) ILC3s helped B-cell survival, proliferation, an

20 These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effec

21 M-CSF, HGF), T-cell development/activation (CD40L, IL-7, CCL25, IL-2RB, IL-15RA, CD6) and angiogenes

22 hout IFN-alpha, and compared with activators CD40L plus IL-21, to identify differentially responsive

23 To be active, CD40L must cluster CD40 receptors on responding cells.

24 Additionally, CD40L-induced naive B cell genes were also significantly

25 ciated with the variant isoform CD44v6 after CD40L activation, seemed to facilitate hyaluronan recogn

26 Thus, IL-21 and CD40L collaborate through at least two distinct mechanis

27 lated with increased expression of IL-21 and CD40L in Tfh cells from Sfpi1(lck-/-) mice compared with

28 l PC differentiation required both IL-21 and CD40L.

29 demonstrated reduced chemokine ligand-3 and CD40L expression that resulted in compromised CD8+ T cel

30 We found that IL-4 and CD40L are expressed by intratumoral TFH and induce produ

31 id follicles and ability to express IL-4 and CD40L.

32 receptor, and treating B cells with IL-5 and CD40L resulted in the expansion of a B cell population e

33 B cells stimulated with IL-5 and CD40L were potent inducers of apoptosis in activated pri

34 FACS analysis and CD40L binding studies revealed unchanged CD40 expression

35 in D (SPD), HIV-1 Gag as a test antigen, and CD40L, where SPD serves as a scaffold for the multitrime

36 olos and Ikaros protein levels and BAFF- and CD40L-induced proliferation, plasmablast differentiation

37 sion of the costimulatory molecules CD27 and CD40L.

38 ate expressed high levels of CD69, CD28, and CD40L; differentially expressed IL-27 and IL-10 anti-inf

39 n addition, B cells expressing both CD40 and CD40L have been identified in human diseases such as aut

40 Blockade of the interaction between CD40 and CD40L induces long-term cardiac allograft survival in ra

41 es indicate that the interaction of CD40 and CD40L is critical for IL-12 production and resistance to

42 We show that although CD40 and CD40L knockout (KO) mice are highly susceptible to L. ma

43 Leishmania major infection in both CD40- and CD40L-deficient mice after treatment with rIL-12.

44 esults show that dual stimulation by CpG and CD40L for 48 h is optimal for IL-10 induction, and this

45 e analyses on resting B cells and on EBV and CD40L/IL-4 blasts after 7 days culture.

46 ere differentially expressed between EBV and CD40L/IL-4 blasts.

47 CTLA-4 blockade increased IFN-gamma and CD40L production, while PD-1 blockade strongly augmented

48 Stimulation of DC with IFN-gamma and CD40L resulted in rapid induction of IDO1 and IDO2 trans

49 rsistent autoimmune disease in an IFN-I- and CD40L-dependent manner when transferred to wild-type mic

50 T-cell costimulator (ICOS)/ICOS ligand, and CD40L/CD40 hindered GC formation and cGVHD.

51 ocyte-derived and primary DCs in an MR1- and CD40L-dependent manner.

52 Anti-CD40L treatment significantly limited the expansion and

53 diet, we used two agents (CTLA-4 Ig and anti-CD40L antibody) that block co-stimulation, which is esse

54 functions and hypothesized that DST and anti-CD40L mAb-modulated FRC interactions with CD4(+) T cells

55 nor-specific splenocyte transfusion and anti-CD40L monoclonal antibody were used as tolerogen.

56 vascularized skin allografts induced by anti-CD40L Abs was associated with a combined lack of indirec

57 essions by FRC, which were inhibited by anti-CD40L mAb.

58 Conversely, anti-CD40L mAb inhibited FRC inflammatory responses.

59 mitantly either treated with CTLA-4 Ig, anti-CD40L antibody or an IgG control (300 microg/week).

60 affect GCB cells in Sfpi1(lck-/-) mice, anti-CD40L treatment of immunized Sfpi1(lck-/-) mice decrease

61 n of a combination of CTLA-4Ig and MR1 (anti-CD40L mAb) for blockade of these interactions induces to

62 tory blockade through multiple-doses of anti-CD40L antibody.

63 munized or tolerized by DST or DST plus anti-CD40L mAb.

64 Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrated positive clinical effects in

65 Furthermore, the anti-CD40L dAb-Fc exhibited a notable efficacy comparable to

66 cific BALB/c splenocyte transfusion -/+ anti-CD40L monoclonal antibody), or made tolerant and receive

67 ever, short-term treatment of mice with anti-CD40L Abs achieved long-term survival of vascularized sk

68 t, when the same mice were treated with anti-CD40L blockade plus drug-modified DCs, skin graft surviv

69 Mice treated with anti-CD40L exhibited reduced weight gain, which was accompani

70 Costimulatory blockade with anti-CD40L monoclonal antibody (mAb) plus donor-specific sple

71 1 effector functions on CD4(+) TILs, such as CD40L and IFNgamma expression.

72 ules that control T-helper function, such as CD40L and SAP.

73 enes relevant for T cell activation, such as CD40L, IRAK1, IRAK2, STAT1, and c-Myb in the list of val

74 which plays a vital role downstream of BAFF, CD40L, lymphotoxin, and other inflammatory mediators.

75 roperties related to the interaction between CD40L and CD40, and exert a hitherto undescribed immunor

76 results demonstrate that VLP-membrane-bound CD40L serves as a novel adjuvant for an HIV vaccine.

77 was shown to inhibit production of IL-12 by CD40L-activated DCs.

78 duces only CCL17 but enhances stimulation by CD40L of both CCL17 and CCL22.

79 ss TCRalpha, TCRbeta, CD152 (CTLA-4), CD154 (CD40L), T-bet, GATA-3, and STAT-1.

80 es, and dendritic cells by its ligand CD154 (CD40L) is essential for the development of humoral and c

81 ination required T cell expression of CD154 (CD40L) and target cell expression of CD40.

82 Furthermore, old CD154 (CD40L)-deficient mice did not accrue ABCs, confirming th

83 CD4, CD8), the costimulatory molecule (CD28, CD40L), and alphabeta receptors on T lymphocytes, as wel

84 FN-gamma(+) IL-2(+/-) TNF-alpha(+)) and CD4 (CD40L(+/-) IFN-gamma(+) IL-2(+) TNF-alpha(+)) T-cell sub

85 emic B cells are in close contact with CD4(+)CD40L(+) T cells.

86 e ligand of the costimulatory receptor CD40 (CD40L) and the Notch ligand Delta-like 1 (DLL1).

87 CD40-CD40L interactions play a critical role in regulating im

88 We show that CD28-CD80/86 and CD40-CD40L costimulatory interactions, which mediate negative

89 cooperativity between CD28-CD80/86 and CD40-CD40L pathways is required for normal medullary epitheli

90 l help, the dependence on IL-2/CD25 and CD40-CD40L pathways, and the ability to proliferate in vitro

91 Combined absence of CD28-CD80/86 and CD40-CD40L results in profound deficiency in mTEC development

92 Blocking CD40-CD40L costimulatory signals induces transplantation tole

93 tion of CD32B on B cells is mediated by CD40-CD40L interactions and is potentiated by IL-4 and inhibi

94 tural requirements needed for efficient CD40-CD40L inhibition, and serve to guide the search for such

95 The inflammatory CD40-CD40L pathway is implicated in various autoimmune diseas

96 Because blockade of CD40-CD40L interactions results in tolerance in mice, identif

97 Loss of CD4(+) T cells or CD40-CD40L interaction leads to reduced B cell homeostatic pr

98 novel small-molecule inhibitors of the CD40-CD40L interaction designed starting from the chemical sp

99 ng endogenous host CD103(+) DCs and the CD40-CD40L pathway can similarly induce rapid accumulation of

100 Tumor elimination via NOS2 required the CD40-CD40L pathway.

101 sion, our data suggest that therapeutic CD40-CD40L blocking agents may prove efficacious not only in

102 interaction with CD4(+) T cells through CD40-CD40L, and activated FRC interacted directly with CD4(+)

103 tion between FRC and CD4(+) T cells via CD40-CD40L, thereby altering FRC gene expression of immune re

104 he HLA-DRB1*04:02 allele and leads, via CD40-CD40L-dependent T cell-B cell interaction, to the produc

105 Blocking of costimulatory CD28/B7 and CD40/CD40L interactions is an experimental approach to immune

106 eir emergence required MHC class II and CD40/CD40L interactions.

107 ansgene (CD40LTg) and receive autocrine CD40/CD40L signaling, we show that CD40LTg B cells stimulated

108 In recent years, the CD40/CD40L system has been implicated in the pathophysiology

109 The CD40/CD40L-assisted crosstalk between mesenchymal stromal cel

110 due to viral-promoter-dependent constitutive CD40L expression.

111 2Ralpha) in normal, but not STAT3-deficient, CD40L-stimulated naive B cells.

112 more, proliferation in response to high-dose CD40L was altered and immunoglobulin production was elev

113 1beta receptors on CD4(+) T cells, eliciting CD40L, proliferation, and up-regulation of CD45RO(+) mem

114 ) cells, including Il21 and Tnfsf5 (encoding CD40L).

115 the transgene paralleled that of endogenous CD40L in unedited T cells, both at rest and in response

116 a Nef-dependent manner, they barely express CD40L.

117 Platelets express CD40L and are a major source of soluble CD40L.

118 In summary, T cells expressed CD40L, and the resulting increased production of Wnt10b

119 ific for this lipid simultaneously expressed CD40L, IFN-gamma, IL-2, and TNF-alpha.

120 40L at relatively lower levels, we expressed CD40L in a membrane-bound form, along with SIV antigens,

121 and effector memory CD8(+) T cells expresses CD40L, one key molecule for CD4(+) T-cell-mediated help.

122 trolled by the hTERT promoter and expressing CD40L (CGTG-401) was constructed and nine patients with

123 Thus, B cells expressing CD40L can be a therapeutic goal to regulate inflammatory

124 ivation of CLL cells with CXCL12, fibroblast CD40L(+), BCR cross-linking, or autologous nurse-like ce

125 -related changes, with key contributions for CD40L and IFNgamma signaling in the antitumor responses

126 ptor signaling pathway and the receptors for CD40L, BAFF and TLR ligands.

127 f IgHV and IgHJ usage, clustering apart from CD40L/IL-21 and control conditions.

128 y, we investigated macrophage functions from CD40L-deficient patients.

129 Macrophages from CD40L-deficient patients exhibited defective fungicidal

130 ells to bind HEp-2 cells, whereas those from CD40L/IL-21-stimulated cells did not.

131 pGag), DNA vaccination of mice with pSPD-Gag-CD40L induced an increased number of Gag-specific CD8(+)

132 This plasmid, pTrimer-Gag-CD40L, was only weakly active on CD40-bearing cells and

133 This SPD-Gag-CD40L protein activated CD40-bearing cells and bone marr

134 ovirus 5 (Ad5) vaccine incorporating SPD-Gag-CD40L was much stronger than Ad5 expressing Gag alone (A

135 e CCR3-PI3K-AKT signaling modulates the GLI2-CD40L axis, and GLI2 is required for CCR3-PI3K-AKT-media

136 In Huh7.5 cells with replicating HCV, CD40L prevented production of infectious viral particles

137 However, CD40L stimulation promoted the firm, CD44-mediated adhes

138 Human CD40L(+) ILC3s provide innate B-cell help and are involv

139 their versatile functional capacities, human CD40L(+) CD8(+) T cells are promising candidate cells fo

140 t B cells with cells stably expressing human CD40L results in increased Erk phosphorylation and incre

141 y of bone marrow malignancies, we identified CD40L as a novel GLI2 target gene in stromal cells.

142 ells and in mice deficient for MHC class II, CD40L, and CD28.

143 hat Fn14 activation by soluble TWEAK impairs CD40L-CD40 signaling complex formation and inhibits CD40

144 Furthermore, in CD40L-deficient 2F5 KI mice, we demonstrate that these B

145 and Wnt10b, ovx fails to expand ST-HSPCs in CD40L-null mice and in animals lacking global or T-cell

146 nment associated with a relative increase in CD40L and IFNgamma expression on intratumoral CD4(+) TIL

147 Disease reactivation in CD40L KO mice was associated with impaired IL-12 and IFN

148 It has been shown that TRAF2 plays a role in CD40L-mediated platelet activation.

149 d that GLI2 overexpression induced increased CD40L expression, and, conversely, GLI2 knockdown reduce

150 Moreover, rfhSP-D inhibited CD40L/IL-4- and IL-21-mediated IgE production (77.12%; P

151 frequently expressed OX40 and intracellular CD40L.

152 B cells in limiting dilution upon irradiated CD40L-expressing EL4.B5 cells and testing the culture su

153 0 weeks old) were cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9) agonist cytid

154 CD40 ligand (CD40L) deficiency predisposes to opportunistic infection

155 rowth factor for ILC3s, induced CD40 ligand (CD40L) expression on circulating and tonsillar ILC3s.

156 Loss of CD40 ligand (CD40L) expression or function results in X-linked hyper-

157 ntact that is dependent on CD40-CD40 ligand (CD40L) interactions; and (iv) fully activated CD4(+) alp

158 CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) supe

159 CD4+ T cells that express CD40 ligand (CD40L), along with other accessory immune and stromal ce

160 matured by addition of LPS and CD40 ligand (CD40L), with or without ESAT-6.

161 ch involves the contribution of CD40 ligand (CD40L)-expressing bystander mast cells infiltrating SMZL

162 there was strong inhibition of CD40 ligand (CD40L)-induced activation of MAPKs in TWEAK-primed cells

163 e T-cell costimulatory molecule CD40 ligand (CD40L).

164 s are exposed to high levels of CD40 ligand (CD40L, CD154) in chronic inflammatory diseases.

165 CD40 ligand (CD40L, CD154) is a membrane protein that is important fo

166 osis factor receptor family, and its ligand, CD40L (CD154), are important regulators of the antiviral

167 weeks ex vivo with stromal or lymphoid-like (CD40L) cells to determine which interactions could suppo

168 In the human PRDM1 locus, CD40L treatment enhanced the ability of STAT3 to upregul

169 ESAT-6 inhibited LPS/CD40L-induced DC production of IL-12 and enhanced that o

170 in vitro and highlight the importance of MC CD40L signaling in the colon.

171 factors (TRAFs) plays key roles in mediating CD40L-CD40 signaling.

172 st expression of the co-stimulatory molecule CD40L, and promoted the development of antibody-secretin

173 Moreover, CD40L is required for ovx to increase SC production of t

174 , termed a "domain Ab" (dAb), against murine CD40L was identified and fused to a murine IgG1 Fc domai

175 g retroviral gene transfer to correct murine CD40L expression restored immune function; however, trea

176 tion domain-like receptor, and noninfectious CD40L stimulation.

177 evealed unchanged CD40 expression and normal CD40L-CD40 interaction in TWEAK-primed cells.

178 TLR activators, but not CD40L/IL-21, similarly promoted increased sharing of CDR

179 The absence of CD40L dysregulated the macrophage transcriptome, which w

180 Absence of CD40L impairs macrophage development and function.

181 cell surface, which enhances accumulation of CD40L and chromogranin B granules at the human TFH cell

182 ontrolling the transcriptional activation of CD40L in bone marrow-derived stromal cells.

183 wnregulates NFAT-driven promoter activity of CD40L and IL-17.

184 ively, our results highlight the benefits of CD40L adjuvant for enhancing antiviral humoral and cellu

185 Here, we utilized the benefits of CD40L, a costimulatory molecule that can stimulate both

186 Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrate

187 Moreover, Ab-mediated blockade of CD40L counteracted the effect of platelets and platelet

188 Blockade of CD40L during Ag-specific interactions with CD4 SP, but n

189 Blockade of CD40L-Mac-1 interaction with anti-Mac-1 mAb led to spont

190 However, the consequences of CD40L deficiency on macrophage function remain to be inv

191 We sought to determine the effect of CD40L absence on monocyte-derived macrophage responses.

192 In addition, the effect of CD40L absence on the macrophage transcriptome before and

193 The antiviral effect of CD40L required activation of c-Jun N terminal kinases (J

194 atient T cells restored normal expression of CD40L and CD40-murine IgG Fc fusion protein (CD40-muIg)

195 action, primarily due to their expression of CD40L and secretion of IL-4.

196 In order to modulate local expression of CD40L at relatively lower levels, we expressed CD40L in

197 ly relevant because CD4 T cell expression of CD40L correlated with the frequency of CD32B low/neg cel

198 after CD40 ligation and higher expression of CD40L on activated T cells compared with healthy control

199 tions, as evidenced by reduced expression of CD40L on Tfh cells and reduced B cell proliferation in t

200 To produce a soluble form of CD40L that clusters CD40 receptors necessitates the use

201 that expresses a multitrimer soluble form of CD40L, leading to strongly protective CD8(+) T cell resp

202 lation represents a novel helper function of CD40L and a superior mechanism of intercellular communic

203 Inhibition of CD40L partially prevented the antiviral activity of the

204 irmed in cell assays including inhibition of CD40L-induced activation in NF-kappaB sensor cells, THP-

205 olars on day 0, followed by the injection of CD40L and CpG into the palatal gingiva on days 3, 6, and

206 cantly increased after gingival injection of CD40L and CpG.

207 cantly decreased after gingival injection of CD40L and CpG.

208 data support a model in which high levels of CD40L, present on circulating T cells in patients with R

209 orts to characterize downstream mediators of CD40L signaling, we have identified GPR120 and KDM6B as

210 NFATc2 as a key transcriptional modulator of CD40L expression in megakaryocytes and inflammatory acti

211 The broad occurrence of CD40L(+) CD8(+) T cells in cellular immunity implicates

212 nderlines the importance and practicality of CD40L as an adjuvant for vaccines against infectious dis

213 ck-/-)) demonstrated increased production of CD40L and IL-21 in vitro.

214 a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor micr

215 rs, modulates NFATc2-dependent regulation of CD40L expression in megakaryocytes.

216 o CD8+ T cells due to aberrant regulation of CD40L expression.

217 Treg-like cells, and showed up-regulation of CD40L, PD-1, and inducibl T-cell costimulator (ICOS), wh

218 e diseases via the expression and release of CD40L, an important modulator of inflammation and adapti

219 Attesting to the relevance of CD40L and Wnt10b, ovx fails to expand ST-HSPCs in CD40L-

220 ficient patients reveal the critical role of CD40L-CD40 interaction for the function of T, B, and den

221 ollectively, our data reveal a novel role of CD40L-Mac-1 interaction in IL-12 production, development

222 In this study, we used gene signatures of CD40L stimulation derived from human immature dendritic

223 g impaired formation or reduced stability of CD40L-CD40 signaling complexes.

224 Studies of CD40L-deficient patients reveal the critical role of CD4

225 This enhancement was dependent on CD40L, indicating that Myd88 and FcRgamma, presumably on

226 ased CD86 expression, which was dependent on CD40L, suggesting that T cells interact with B cells in

227 We determined that stimulation with only CD40L+IL-21 was sufficient to induce robust proliferatio

228 Furthermore, blockade of CD40 or CD40L accessory molecules largely neutralized the EV aug

229 K expression is especially induced by CpG or CD40L in combination with IL-21, but not BCR stimulation

230 ost vaccine regimens that included GM-CSF or CD40L adjuvants and conferred significant but incomplete

231 ns in which a soluble form of TRAIL, FasL or CD40L is genetically fused to a high-affinity anti-fluor

232 oding sequence (green fluorescent protein or CD40L) upstream of the translation start site within exo

233 ctivity in megakaryocyte diminishes platelet CD40L implicates the NFATc2/EGR-1 axis as a key regulato

234 Emerging evidence suggests that platelet CD40L is dynamically regulated in several chronic inflam

235 ers on human dendritic cells and potentiated CD40L activity.

236 oma antigen using autologous peptide-pulsed, CD40L/IFN-gamma-matured DCs.

237 ion, and, conversely, GLI2 knockdown reduced CD40L expression.

238 ene repair to restore endogenously regulated CD40L, and the potential for its use in T-cell therapy f

239 , the T cells became activated, up-regulated CD40L, and inhibited HCV replication.

240 increased surface expression of P-selection, CD40L and major histocompatibility complex class I.

241 ttern of DC responsiveness to the Th signal, CD40L.

242 Similarly, CD40L prevented replication of HCV in PHH, in synergy wi

243 We then tested the potential of DNA/SIV-CD40L vaccine to adjuvant the DNA prime of a DNA/modifie

244 through their secretion of IL-6 and soluble CD40L (sCD40L).

245 In contrast, soluble CD40L in combination with IL-2 and IL-21 induces these a

246 The use of soluble CD40L multimers may help to improve vaccination response

247 In contrast, the addition of soluble CD40L multimers to T cell/B cell cultures redirects B ce

248 or blood cultured in the presence of soluble CD40L.

249 ress CD40L and are a major source of soluble CD40L.

250 lls, whereas addition of recombinant soluble CD40L mimicked the effects on IL-10 production.

251 of Cd40(+/+) mice by treatment with soluble CD40L and were dependent on PKC-beta and PKC-gamma, resp

252 Strikingly, CD40L or IFNgamma blockade compromised the ability of PL

253 -12 from infected macrophages and found that CD40L engagement of CD40 amplified the IL-12 response in

254 tiation toward plasma cells, indicating that CD40L determines the direction of IL-21-dependent B cell

255 sed malignant B cell growth, indicating that CD40L in the tumor microenvironment promotes malignant B

256 Gene set variation analysis revealed that CD40L-responsive genes in immature dendritic cells and n

257 f AM14 Tg Act1(-/-) B cells, suggesting that CD40L-mediated signals are required for the retention of

258 The CD40L-adjuvanted vaccine enhanced the functional quality

259 Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and infla

260 We coexpressed the CD40L with our DNA/SIV vaccine such that the CD40L is an

261 rporation of TLR3 and TLR8 agonists into the CD40L/IFN-gamma activation protocol corrected the IL-12p

262 Notably, the CD40L adjuvant enhanced the control of viral replication

263 for CCR3-PI3K-AKT-mediated regulation of the CD40L promoter.

264 ctly binds and regulates the activity of the CD40L promoter.

265 ested the immunogenicity and efficacy of the CD40L-adjuvanted vaccine in macaques using a heterologou

266 Our results demonstrated that the CD40L adjuvant enhanced the functional quality of anti-E

267 It is known that the CD40L and IL-21/STAT3 signaling pathways play critical r

268 CD40L with our DNA/SIV vaccine such that the CD40L is anchored on the membrane of SIV virus-like part

269 We propose that the CD40L-CD40 signaling axis provides a stop signal to moti

270 Noteworthy, our findings reveal that the CD40L/CD40 axis plays a significant role in MC-driven ex

271 These CD40L containing SIV VLPs showed enhanced activation of

272 CB-derived Bregs can be potentiated through CD40L signaling, suggesting that inflammatory environmen

273 activation while maintaining full binding to CD40L.

274 ation but does not prompt cell death, due to CD40L-induced cFLIP expression and limited RIP1 cleavage

275 ling nanotube-like structures in response to CD40L-expressing Th cells or rCD40L.

276 ant to secondary L. major challenge, treated CD40L KO reactivated their lesion after cessation of rIL

277 ations, and favored secretion of IgM, unlike CD40L/IL-21, which drove IgM and IgG more evenly.

278 n IL-12p35 transcription was identified upon CD40L/IFN-gamma activation in clinical nonresponder pati

279 bition of FOXP3/NFAT interaction upregulated CD40L expression on effector T cells and enhanced T cell

280 In addition, CD4(+) T(RCM) upregulated CD40L and secreted IL-2 following polyclonal stimulation

281 ction by dendritic cells and macrophages via CD40L-macrophage Ag 1 (Mac-1) interaction is responsible

282 lymph nodes, focusing on its regulation via CD40L-dependent, T-cell-mediated activation of CLL cells

283 oduction and IgM autoantibody formation were CD40L independent.

284 on profiling studies of FL biopsies, whereas CD40L correlated with both CCL17 and CCL22.

285 y growing lymphoblastoid cell lines, whereas CD40L/IL-4 blasts have finite proliferation lifespans.

286 In particular, stimulation of CLL cells with CD40L results in substantial resistance mediated by indu

287 Stimulation of healthy donor B cells with CD40L, anti-IgM, IL-21, CpG, IFN-alpha, IL-6 or BAFF ind

288 growth in malignant B cells cocultured with CD40L-expressing stromal cells.

289 is factor alpha alone or in combination with CD40L or interleukin-17.

290 Crosses with CD40L-deficient mice revealed that increased IL-6 produc

291 ns of proliferation similarly differed, with CD40L/IL-21 inducing proliferation of most memory and na

292 CD40 interacts with CD40L and plays an essential role in immune regulation a

293 tential therapeutic option for patients with CD40L deficiency.

294 not in those stimulated to proliferate with CD40L/IL-4, despite their similarities in the cell pathw

295 E production by B cells when stimulated with CD40L, IL-4, and IL-21 was also determined.

296 d IL-10 secretion in B cells stimulated with CD40L.

297 D25-deficient, naive B cells stimulated with CD40L/IL-21.

298 miRNA expression in B cells stimulated with CD40L/IL-4, and those infected with EBNA-2- and LMP-1-de

299 generated by physiological stimulation with CD40L plus IL-4.

300 and clinical outcomes upon vaccination with CD40L/IFN-gamma-matured, IL-12p70-producing DCs.