ライフサイエンスコーパス: CDH

1 CDH (predominantly left-sided, LCDH) was created in Spra

2 CDH lungs display an increased expression of 2 microRNAs

3 CDH might thus be viewed as an evolutionary atavism.

4 CDH remains a significant cause of neonatal mortality.

5 CDH strongly correlated with likelihood of restoration o

6 CDH was assessed by evaporative stimuli using a visual a

7 CDH was assessed by thermal and evaporative stimuli.

8 map chromosomal anomalies in a cohort of 26 CDH+ patients.

9 We performed exome sequencing in 39 CDH trios and compared the frequency of de novo variants

10 > 1.6 kg) were randomized to either open (5 CDH, 5 EA/TEF) or thoracoscopic (5 CDH, 5 EA/TEF) repair

11 r open (5 CDH, 5 EA/TEF) or thoracoscopic (5 CDH, 5 EA/TEF) repair.

12 s, we did not find COUP-TFII mutations in 73 CDH samples.

13 tify deleterious GATA4 sequence changes in a CDH cohort.

14 ndings in fetuses exposed to Nitrofen with a CDH with those in Nitrofen-exposed fetuses without a CDH

15 those in Nitrofen-exposed fetuses without a CDH, and control fetuses whose mothers received olive oi

16 defective diaphragm vascular development and CDH and that heparan sulfate facilitates angiogenic SLIT

17 in vascular development in the diaphragm and CDH.

18 well as subsequent diaphragm hypoplasia and CDH.

19 r clinical studies on tracheal occlusion and CDH.

20 In PH and CDH defects of ANG-1/TIE-2/BMPR-related signalling are n

21 Anterior CDH is also seen in Gata4(+/-) mice and has been describ

22 7 or Gata4 is sufficient to produce anterior CDH in mice and that haploinsufficiency of SOX7 and GATA

23 ncreasing the electron transfer rate between CDH and the electrode, and (c) facilitating the creation

24 onally mediate the electron transfer between CDH and the electrode.

25 ble to mediate the electron transfer between CDH and the electrode.

26 Although GATA4-deficient mice have both CDH and cardiac defects, no humans with cardiac defects

27 rmined for methyl-1,4-benzoquinone with both CDH and CBQR, whereas the rate of iron reduction by CDH

28 CBQR, whereas the rate of iron reduction by CDH was five times higher than by CBQR, and its activati

29 recent advances in neonatal intensive care, CDH still has a high mortality and morbidity.

30 iaphragm and that FREM1 deficiency can cause CDH in both humans and mice.

31 variants play a significant role in complex CDH cases.

32 As sporadic complex CDH likely has a significant impact on reproductive fitn

33 on, we estimate that 15% of sporadic complex CDH patients are attributable to de novo LGD or deleteri

34 dinucleotide (FAD), a cytochrome domain (CYT(CDH)) containing heme b, and a linker region connecting

35 rect electron transfer (DET) between the CYT(CDH) and the electrode.

36 vel application of cellobiose dehydrogenase (CDH) as sensing element for a Bioelectronic Tongue (BioE

37 ascus thermophilus cellobiose dehydrogenase (CDH) based bioanode and Myrothecium verrucaria bilirubin

38 tion of lactose by cellobiose dehydrogenase (CDH) from the basidiomycete Phanerochaete chrysosporium,

39 Cellobiose dehydrogenase (CDH) is a monomeric extracellular flavocytochrome compos

40 Cellobiose dehydrogenase (CDH) is a promising enzyme for the construction of biofu

41 ar flavocytochrome cellobiose dehydrogenase (CDH) participates in lignocellulose degradation.

42 in cofactor within cellobiose dehydrogenase (CDH) was found to be responsible for the reduction of al

43 ubstrates and with cellobiose dehydrogenase (CDH), a known natural supplier of electrons.

44 Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown.

45 osed of a catalytic dehydrogenase domain (DH(CDH)) containing flavin adenine dinucleotide (FAD), a cy

46 "missed" case of congenital hip dislocation (CDH) can be a disaster for the patient and the outcome m

47 ith anatomically less severe left liver-down CDH had significantly increased need for ECMO if repaire

48 Of these, 99% of left liver-down CDH survived, 91% of right CDH survived, and 76% of left

49 versely, no radical was detected with either CDH or CBQR upon the addition of methyl-1,4-benzoquinone

50 tering strategy identified 27 candidates for CDH.

51 tudy establishes the first genetic model for CDH and identifies a previously unsuspected role for Sli

52 Recently a minimally deleted region for CDH has been identified on chromosome 15q26.1-26.2 by CG

53 entification and prioritization strategy for CDH, an approach that can be extended to other diseases

54 s to indicate root coverage as treatment for CDH.

55 Three new genes CDH-J, PCDH-J and FAT-J were found.

56 neonates participated in the study; four had CDH, and one had primary pulmonary hypertension.

57 o GATA4 mutations have been reported to have CDH.

58 imerism; 4 had complete donor hematopoiesis (CDH).

59 isk of both congenital diaphragmatic hernia (CDH) and cardiac defects.

60 re isolated congenital diaphragmatic hernia (CDH) and changes in tracheal and amniotic fluid of fetus

61 Congenital diaphragmatic hernia (CDH) and esophageal atresia with tracheoesophageal fistu

62 iniscent of congenital diaphragmatic hernia (CDH) cases in humans.

63 etuses with congenital diaphragmatic hernia (CDH) induced by maternal ingestion of 2,4-dichlorophenyl

64 Congenital diaphragmatic hernia (CDH) is a common (1 in 3,000 live births) major congenit

65 Congenital diaphragmatic hernia (CDH) is a common and severe birth defect.

66 Congenital diaphragmatic hernia (CDH) is a common birth defect that results in a high deg

67 Congenital diaphragmatic hernia (CDH) is a common birth malformation with a heterogeneous

68 Congenital diaphragmatic hernia (CDH) is a common life-threatening birth defect.

69 OF REVIEW: Congenital diaphragmatic hernia (CDH) is a rare developmental defect resulting in variabl

70 Congenital diaphragmatic hernia (CDH) is a relatively common birth defect associated with

71 Congenital diaphragmatic hernia (CDH) is a serious birth defect that accounts for 8% of a

72 Congenital diaphragmatic hernia (CDH) is a severe birth defect.

73 Congenital diaphragmatic hernia (CDH) is a significant cause of pediatric mortality in hu

74 Congenital diaphragmatic hernia (CDH) is an often fatal birth defect that is commonly ass

75 Congenital diaphragmatic hernia (CDH) is one of the most common and lethal congenital ano

76 Congenital diaphragmatic hernia (CDH) remains a significant cause of neonatal morbidity a

77 treatments, congenital diaphragmatic hernia (CDH) remains associated with variable survival and signi

78 Congenital diaphragmatic hernia (CDH), a life-threatening anomaly, is a major cause of pe

79 tients with congenital diaphragmatic hernia (CDH), those with agenesis of the diaphragm.

80 inatally in congenital diaphragmatic hernia (CDH), where the typical pulmonary vascular changes are p

81 nfants with congenital diaphragmatic hernia (CDH).

82 s including congenital diaphragmatic hernia (CDH).

83 tients with congenital diaphragmatic hernia (CDH); however, data to support its ongoing use in this p

84 on-isolated congenital diaphragmatic hernia (CDH+) is a severe birth defect that is often caused by d

85 clusion for congenital diaphragmatic hernia (CDH, n=13), and resection of sacrococcygeal teratoma (SC

86 ort due to cervical dentin hypersensitivity (CDH) and esthetic dissatisfaction.

87 Cervical dentin hypersensitivity (CDH) is characterized by tooth pain arising from root ex

88 can cause cervical dentin hypersensitivity (CDH), which is characterized by tooth pain.

89 Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature.

90 poplastic lungs as well as human hypoplastic CDH lungs.

91 f chromosomal regions recurrently altered in CDH, a description of the retinoid hypothesis of CDH, an

92 A decrease in CDH was observed after periodontal surgery for root cove

93 ng of the mechanisms of pulmonary defects in CDH has the potential for creating targeted therapies, p

94 ontaining Robo genes have been documented in CDH.

95 TGF-beta2 expression was lower in CDH lungs.

96 These findings demonstrate that the lungs in CDH are deficiently vascularized at the alveolar surface

97 miR-200b overexpression in CDH lungs results in decreased TGF-beta/SMAD signaling.

98 insic, herniation-independent cause of PH in CDH.

99 Statistically significant reduction in CDH (P <0.001), significant reduction in impact of oral

100 howed statistically significant reduction in CDH and esthetic dissatisfaction with no intergroup sign

101 gions of recurrent copy number variations in CDH, expression profiles of the developing diaphragm, pr

102 r is primarily defective in nitrofen-induced CDH-associated lung hypoplasia.

103 methylation dynamics of 4 TSGs (p15(INK4B), CDH-1, DAPK-1, and SOCS-1) were studied in sequential bo

104 recessive FREM1 mutations can cause isolated CDH in humans.

105 FETO improves survival in isolated CDH with severe pulmonary hypoplasia compared with the s

106 , and 23 of 25 inborn patients with isolated CDH survived (92%).

107 into fetal surgery, whereas those with ITM, CDH, and SCT all exhibited secondary cardiovascular sequ

108 interaction networks expanded from the known CDH-causing genes, and prioritized genes with ultrarare

109 he total capillary surface area for the left CDH and control lungs were 0.7 +/- 0.3 m2 and 2.8 +/- 1.

110 the total alveolar surface area of the left CDH and control lungs were 1.8 +/- 0.8 m2 and 6.1 +/- 1.

111 The reactor was prepared by cross-linking CDH onto aminopropyl-silanised controlled pore glass (CP

112 own, and, despite the identification of many CDH-associated genes, the etiology of CDH is incompletel

113 1, a membrane-type matrix metalloproteinase, CDH-3, a Fat-like protocadherin, and hemicentin, a fibul

114 d characterisation and optimisation of a new CDH/AuNP-based bioanode were performed and the following

115 and highly disruptive variants, in 11.3% of CDH patients.

116 ffect of divalent cations on the activity of CDH was also present for graphite/PEI/MtCDH electrodes b

117 lyethyleneimine (PEI) prior to adsorption of CDH from Myriococcum thermophilum (MtCDH).

118 ns, familial aggregation, and association of CDH with chromosomal abnormalities.

119 Although the exact etiology of most cases of CDH remains unknown, there is a growing body of evidence

120 ges were identified by aCGH in our cohort of CDH+ patients.

121 s concluded that the bioanode, consisting of CDH, produced hydrogen peroxide at toxic concentrations.

122 nd that lung mesenchyme-specific deletion of CDH-implicated genes encoding pre-B cell leukemia transc

123 for the role of FREM1 in the development of CDH comes from an N-ethyl-N-nitrosourea -derived mouse s

124 A4 may each contribute to the development of CDH in individuals with 8p23.1 deletions.

125 likely to play a role in the development of CDH in patients with 15q26 deletions, we did not find CO

126 oding gene-contributes to the development of CDH, we generated mice with a deletion of the second exo

127 ute, along with GATA4, to the development of CDH.

128 oles of specific genes in the development of CDH.

129 play an important role in the development of CDH.

130 previously implicated in the development of CDH.

131 y be helpful for supporting the diagnosis of CDH in unclear cases and thus avoiding unnecessary appar

132 The discovery of CDH loci using standard genetic approaches has been hind

133 guously showed that the cytochrome domain of CDH interacts with the copper site of the LPMO and that

134 FAD) cofactor of the dehydrogenase domain of CDH.

135 f many CDH-associated genes, the etiology of CDH is incompletely understood.

136 as described >350 years ago, the etiology of CDH is poorly understood.

137 g of the heterogeneous molecular etiology of CDH.

138 tients provide evidence for the existence of CDH-related genes on chromosomes 2q37, 6p22-25 and 14q,

139 n reaction in tracheal and amniotic fluid of CDH patients undergoing FETO.

140 Bochdalek-type CDH, the most common form of CDH.

141 is a likely contributor to the formation of CDH in individuals with 15q deletions, and it may also b

142 elopment, a discussion of syndromic forms of CDH, a detailed review of chromosomal regions recurrentl

143 s been reported to be by the reduced heme of CDH.

144 a description of the retinoid hypothesis of CDH, and evidence of the roles of specific genes in the

145 We sought to determine if the lungs of CDH lambs have: (1) a reduction in total capillary surfa

146 have used the nitrofen-induced rat model of CDH, which demonstrates immature lungs by biochemical, m

147 nd improves gas exchange in animal models of CDH, but the effects in humans are still under investiga

148 The exon-intron organization of CDH-J was experimentally verified by PCR with specifical

149 dence for novel genes in the pathogenesis of CDH associated with other anomalies and suggest that de

150 e believe are related to the pathogenesis of CDH.

151 ylation on the electrochemical properties of CDH from Phanerochaete chrysosporium (PcCDH) and Ceripor

152 of dimensions, perceived after reduction of CDH and esthetic dissatisfaction of patients with GRs tr

153 Infants who underwent repair of CDH from 2000 to 2008 at Pediatric Health Information Sy

154 led trial shows that thoracoscopic repair of CDH is associated with prolonged and severe intraoperati

155 d conventional ventilation for the repair of CDH, calling into question the safety of this practice.

156 s in PPF-derived fibroblasts are a source of CDH.

157 Successful treatment of CDH is dependent on the integration of human genomic and

158 contributor to some other Bochdalek-type of CDH.

159 Average yearly hospital volume of CDH repair varied from 1.4 to 17.5 cases per year.

160 io of mortality by yearly hospital volume of CDH repair, after adjustment for salient patient and hos

161 that hospitals which perform high volumes of CDH repair achieve lower in-hospital mortality.

162 tion with a coronally advanced flap (CAF) on CDH, esthetics, and oral health-related quality of life

163 te the effect of surgical defect coverage on CDH and quality of life in patients with GR.

164 ents with pretreatment methylation of p15 or CDH-1 promoters reversed methylation during the first cy

165 nerated from whole exome sequencing of other CDH cohorts or multiplex kindreds and provide ideal cand

166 n markers as well as the expression of other CDH-associated genes.

167 e with diaphragm defects are enriched in our CDH cohort compared with 120 size-matched random gene se

168 SOX7 sequence changes were identified in our CDH cohort.

169 ite recent advances, including nitric oxide, CDH remains an unsolved problem with a mortality rate of

170 d with an isolated left-sided posterolateral CDH covered by a membranous sac who had no features sugg

171 inhibition of RA receptor signaling promotes CDH pathogenesis through a complex gene network.

172 lso has a approximately 980 residue protein (CDH-11 and CG11059) with two cadherin domains and whose

173 Surgical defect coverage may reduce CDH and improve patient quality of life, by keratinized

174 root coverage procedures predictably reduce CDH.

175 inated the flavin radical present in reduced CDH, as detected by low temperature ESR spectroscopy, wh

176 urgical root coverage techniques at reducing CDH in cases of gingival recession.

177 f left liver-down CDH survived, 91% of right CDH survived, and 76% of left liver-up CDH survived.

178 (p < 0.05), respectively, and for the right CDH and control lungs 0.9 +/- 0.3 m2 and 3.8 +/- 1.5 m2

179 (p < 0.01), respectively, and for the right CDH and control lungs 2.5 m2 +/- 0.1 and 11.2 +/- 1.9 m2

180 es including increased survival in high-risk CDH patients.

181 All studies selected isolated severe CDH fetuses with a lung-to-head ratio 1.0 or less and li

182 that patients with anatomically less severe CDH benefit from delayed surgery whereas patients with a

183 ereas patients with anatomically more severe CDH may benefit from a more aggressive surgical approach

184 Thirty-seven patients-27 with left-sided CDH and 10 with right-sided CDH-had umbilical venous cat

185 Sixty-eight neonates-54 with left-sided CDH and 14 with right-sided CDH-had a nasogastric tube.

186 The tubes in 21 patients with left-sided CDH had a normal anatomic course at radiography.

187 The catheters in 12 patients with left-sided CDH had apex leftward convexity.

188 ic tubes in the 14 patients with right-sided CDH had leftward deviation.

189 catheter in eight patients with right-sided CDH had rightward shift; all eight patients had liver he

190 with left-sided CDH and 14 with right-sided CDH-had a nasogastric tube.

191 with left-sided CDH and 10 with right-sided CDH-had umbilical venous catheters.

192 wed no correlation with air blast-stimulated CDH (P = 0.256) or cold stimulus (P = 0.563).

193 the lethally immature lungs of the full-term CDH rats can be improved by biochemical, morphometric, p

194 nerates 1-hexene isotopomers having terminal CDH groups, with an isotope effect of 3.1(1) and 4.1(1),

195 The CDH progresses through continuous growth of the liver in

196 that patients respond differently across the CDH anatomic severity spectrum and lay the foundation fo

197 osomes 2q37, 6p22-25 and 14q, and refine the CDH minimal deleted region on 15q26 to an interval that

198 ental pathways that likely contribute to the CDH phenotype.

199 f these patients, the stomach was within the CDH.

200 that defects in this event may contribute to CDH.

201 TO) to reverse severe lung hypoplasia due to CDH.

202 12.5 when experimental perturbations lead to CDH phenotypes, and E16.5 when the diaphragm is fully fo

203 ically weaker and more compliant, leading to CDH.

204 criptional co-regulator, have been linked to CDH and pulmonary hypoplasia in humans and mice.

205 ic surgery outcomes and variables related to CDH in patients >/=18 years of age were included.

206 it3 developed a central (septum transversum) CDH.

207 mutants of COUP-TFII exhibit Bochdalek-type CDH, the most common form of CDH.

208 fl) embryos developed typical Bochdalek-type CDH.

209 Wild type CDH is only the second example of a b-type heme with Met

210 reas patients with more severe left liver-up CDH survived at a higher rate when repair was performed

211 right CDH survived, and 76% of left liver-up CDH survived.

212 When CDH is antenatally diagnosed, early referral to a tertia

213 uration of hypoplastic lungs associated with CDH.

214 pain dimension had positive correlation with CDH (P <0.05).

215 total of 3367 newborn infants diagnosed with CDH and entered into the registry were reviewed.

216 o decreased in lung tissue from fetuses with CDH compared with the other groups.

217 eased expression of SP-A in rat fetuses with CDH secondary to Nitrofen exposure.

218 R imaging was calculated in 172 fetuses with CDH.

219 s of this protein in lungs from fetuses with CDH.

220 ome sequencing study on 275 individuals with CDH.

221 be found in up to 30.9% of individuals with CDH.

222 nifestation of CLD in surviving infants with CDH is associated with the prenatally determined observe

223 a prospectively on all liveborn infants with CDH over a 10-year period.

224 n a change in the management of infants with CDH with less frequent use of ECMO and a greater use of

225 substrate binding precludes interaction with CDH.

226 ted radiographs obtained in 71 neonates with CDH to determine whether nasogastric tubes, umbilical ve

227 everal predictable patterns in neonates with CDH.

228 l care, more severely affected newborns with CDH are now surviving.

229 Of 3367 patients with CDH (1366 [40.6%] females; median estimated gestational

230 re manifest in all four of the patients with CDH after the airway and lung were filled with radiopaqu

231 are almost invariably seen in patients with CDH and frequently in animal models of this condition.

232 the spectrum of iNO use among patients with CDH and its association with pulmonary hypertension (pHT

233 pected FLV ratio of 5%, 99% of patients with CDH developed CLD, compared with less than 5% of fetuses

234 tandard ventilatory support of patients with CDH has led to significantly improved survival rates.

235 publication of 60 consecutive patients with CDH in 1999 showed that survival was significantly impro

236 ta from 70 centers, iNO use in patients with CDH may be associated with increased mortality.

237 A total of 1,569 patients with CDH were seen between January 1995 and December 2004 in

238 elevant copy number changes in patients with CDH+.

239 ively reviewed 268 consecutive patients with CDH, combining 208 new patients with the 60 previously r

240 For patients with CDH, thoracoscopy was associated with a significant incr

241 ecific treatment protocols for patients with CDH.

242 the pulmonary immaturity of fetal sheep with CDH by physiologic, biochemical, and histologic criteria

243 with cyanide, a mimic of O2 (-) Studies with CDH and its isolated heme b cytochrome domain unambiguou