ライフサイエンスコーパス: CDK inhibitor p27

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1 4 (CDK4) and increased the expression of the CDK inhibitor p27.

2 ed CDK2 and CDK4 activity, and increased the CDK inhibitor p27.

3 RB and CDK inhibitor p21 but an increase in CDK inhibitor p27.

4 so, RA treatment increased expression of the cdk inhibitor p27 and decreased activity of cdk 2, cdk 4

5 ally active, increases the expression of the CDK inhibitor p27 and promotes cell cycle arrest.

6 CDK4 and CDK2, respectively) are suppressed, CDK inhibitor p27 and retinoblastoma protein are activat

7 or the ubiquitin-mediated degradation of the cdk-inhibitor p27 and is a bona fide proto-oncoprotein.

8 DK)-2 and CDK-4, increased expression of the CDK inhibitor p27, and shifted the retinoblastoma protei

9 hrough regulating cyclin D turnover, and the CDK inhibitor p27, as shown by depletion studies, functi

10 ential cofactor in the ubiquitination of the Cdk inhibitor p27 by the SCF(Skp2) ubiquitin ligase.

11 CDK inhibitor p27 (CDKN1B) also caused Rb dephosphorylat

12 kp2 (SCF(SKP2)) complex is thought to be the Cdk inhibitor p27 during S phase, whereas the principal

13 ase-associated protein 2), which targets the CDK inhibitor p27 for degradation, reduces neuroblast pr

14 duplication in that blastomere; the related cdk inhibitor p27 has a similar effect.

15 ent overexpression of p21 and/or the related Cdk inhibitor p27 in U937 cells in the absence of 1,25-d

16 e induced upon v-Abl activation; and (2) the CDK inhibitor p27 is decreased upon v-Abl activation.

17 show that a new biological function for the CDK inhibitor p27 is protection of cells from apoptosis

18 Reduced expression of the CDK inhibitor p27(Kip1) (p27) in human lung cancer corre

19 companied by an increase in the level of the Cdk inhibitor p27(Kip1) and a decrease in cyclin A expre

20 ells show a strong decrease in expression of Cdk inhibitor p27(Kip1) and increased expression of sele

21 yc(-/-) cells express elevated levels of the Cdk inhibitor p27(Kip1) and reduced levels of Cdk7, the

22 mediated transcription and expression of the cdk inhibitor p27(Kip1) impairs the proliferation of mel

23 Loss of the CDK inhibitor p27(KIP1) is widely linked with poor progn

24 expression of PKC-delta increased binding of cdk inhibitor p27(Kip1) to cdk4.

25 tly lower, whereas the protein levels of the CDK inhibitor p27(Kip1) were higher in ROCK-inhibited ce

26 m (eg, SCF(Skp2)-directed destruction of the Cdk inhibitor p27(Kip1)).

27 endent kinase (CDK) 2 and CDK4, induction of CDK inhibitor p27(KIP1), and retinoblastoma hypophosphor

28 T cells as evidenced by up-regulation of the CDK inhibitor p27(Kip1), loss of cyclin A, and reduced B

29 Thus, like the Cdk inhibitor p27(Kip1), p130 turnover is regulated by C

30 mechanism of Akt-mediated regulation of the CDK inhibitor p27(kip1).

31 lin D1, and an increase in the levels of the Cdk inhibitor p27(Kip1).

32 ulation or the down-regulation of the cyclin-cdk inhibitor p27 protein following c-Myc activation by

33 as also seen that was due to accumulation of Cdk inhibitor p27 which was an indirect effect of c-myc

34 In the frog, Xenopus laevis, the CDK inhibitor p27(Xic1) (Xic1) inhibits DNA synthesis by

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