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1 CDP-choline also elevated hypothalamic extracellular tot
2 CDP-choline also provided significant protection for hip
3 CDP-choline caused a dose- and time-dependent increase i
4 CDP-choline liposomes deliver the agent intact to the br
5 CDP-choline restored cardiolipin levels, arachidonic aci
6 CDP-choline treatment significantly attenuated PLA2 acti
7 CDP-choline treatment significantly attenuated the infar
8 ndicate that Sec14p functions to alleviate a CDP-choline pathway-mediated toxicity to yeast Golgi sec
9 this raises the possibility that they use a CDP-choline pathway for the biosynthesis of phosphatidyl
12 line, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); m
14 the phosphatidylethanolamine methylation and CDP-choline pathways are not responsible for generating
15 r in P. falciparum, thus making the SDPM and CDP-choline pathways the only routes for phosphatidylcho
19 nal step of PtdCho synthesis is catalyzed by CDP-choline:1,2-diacylglycerol cholinephosphotransferase
20 n the suppression of the sec14(ts) defect by CDP-choline pathway mutations, indicating a role for pho
23 f CCT activity, the accumulation of cellular CDP-choline, and enhanced radiolabeling of phosphatidylc
24 present in cytidine 5'-diphosphate choline (CDP-choline), are major precursors of the phosphatidylch
25 oline into the cytidine diphosphate-choline (CDP-choline) PC biosynthetic pathway relative to betaine
26 nthesis of phosphatidylcholine from choline (CDP-choline pathway), the parasite synthesizes this majo
27 T. denticola does contain a licCA-dependent CDP-choline pathway for phosphatidylcholine biosynthesis
28 hosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Trepone
35 ; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as dia
36 cell survival questions whether endonuclear, CDP-choline pathway phosphatidylcholine synthesis may oc
37 ance PC synthesis, we developed an assay for CDP-choline, an immediate and rate-limiting precursor in
39 62%) compared to the equivalent dose of free CDP-choline (by 26%) after 1 h focal cerebral ischemia a
40 in vitro phosphatidylcholine formation from CDP-choline and diacylglycerol, and full activity requir
41 ne caused concentration-related increases in CDP-choline levels, and that this effect was mediated by
42 ransferase (lyso-PAF-AT) and DTT-insensitive CDP-choline 1-alkyl-2-acetyl-sn-glycerol cholinephosphot
47 erebroventricular (i.c.v.) administration of CDP-choline was made and blood pressure and heart rate w
49 ould contribute to the beneficial effects of CDP-choline in treating stroke or other brain damage.
52 s inhibitor] 5 min prior to the injection of CDP-choline to determine the effects of these inhibitors
54 a uridine source, enhances the synthesis of CDP-choline, the immediate precursor of PC, in gerbil br
56 n of [methyl-3H]choline into phosphocholine, CDP-choline, and phosphatidylcholine in cells carrying t
57 ly that includes the enzymes that synthesize CDP-choline and CDP-ethanolamine for phosphatidylcholine
64 Taken together, these results suggest that CDP-choline significantly restores Ptd-Cho levels by dif
67 se of choline for PC production via both the CDP-choline and PEMT pathways shows the substantial dema
69 Phospho-choline is converted to PC by the CDP-choline pathway, explaining the phenotype conferred
79 line by ATP, the first committed step in the CDP-choline pathway for phosphatidylcholine biosynthesis
81 rase (CT) is the rate-limiting enzyme in the CDP-choline pathway of PC biosynthesis, which is utilize
82 esis of CCT, the rate-limiting enzyme in the CDP-choline pathway, is elevated in fibroblasts overexpr
83 eport that strains carrying mutations in the CDP-choline pathway, such as cki1, exhibit a choline exc
84 se (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phospha
86 uirement is abrogated by inactivation of the CDP-choline pathway for phosphatidylcholine biosynthesis
87 e to phosphocholine as the first step of the CDP-choline pathway for the biosynthesis of phosphatidyl
88 ng that XBP-1(S) increases the output of the CDP-choline pathway primarily via its effects on CCT.
90 this phospholipid occurs via two routes, the CDP-choline pathway, which uses host choline as a precur
96 sis both as an intact choline moiety via the CDP-choline pathway and as a methyl donor via PE methyla
100 (CCT), the rate-regulatory enzyme within the CDP-choline pathway, by 40% compared with control, but i
102 First, membrane-free nuclei retain all three CDP-choline pathway enzymes in proportions comparable wi
103 holine and cytidine 5'-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylch
104 holine and cytidine 5'-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidyl
105 ked the pressor and bradycardic responses to CDP-choline while neomycine or furegrelate partially att
107 his phosphocholine transferase activity used CDP-choline as a substrate and required a conserved hist
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