ライフサイエンスコーパス: CDR

1 CDR formation appears as a fast redistribution of connex

2 CDR formation does not depend on membrane trafficking or

3 CDR formation may reflect lipid-phase separation events

4 CDR was determined from stereoscopic photographs by two

5 CDR was significantly higher in patients screened with D

6 CDRs predicted to bind the minimal FLAG peptide (Asp-Tyr

7 CDRs represent a unique type of structure that forms tra

8 CDRs were calculated.

9 hild), CDR 2+ ($11.20); the CDR 3+ ($13.00); CDR 2+, culture CDR negatives ($16.42); CDR 3+, culture

10 For the group with at least 1 CDR of 0.6 or greater, sensitivity of FDT was 66% (95% C

11 (3) clinical decision rule (CDR) score >/=2 (CDR 2+); (4) CDR score >/=3 (CDR 3+); (5) treating those

12 re we show that MYBL2, a gene within the 20q CDR, is expressed at sharply reduced levels in CD34+ cel

13 DR) score >/=2 (CDR 2+); (4) CDR score >/=3 (CDR 3+); (5) treating those with a CDR score >/=2 plus t

14 decision rule (CDR) score >/=2 (CDR 2+); (4) CDR score >/=3 (CDR 3+); (5) treating those with a CDR s

15 00); CDR 2+, culture CDR negatives ($16.42); CDR 3+, culture CDR negatives ($23.89); and culture all

16 f-score: 0.807) and chemicals (BioCreative 5 CDR corpus, NER f-score: 0.914, normalization f-score 0.

17 scanning reveal that the majority of the 52 CDR residues are utilized differently for the two antige

18 A complete mutational scan of the 66 CDR residues identified 28 residues as important for the

19 in cortical PiB binding and progression to a CDR higher than 0 at follow-up.

20 R, 9-24) observed in countries (N=48) with a CDR ranging from greater than 7.2% but less than or equa

21 ore >/=3 (CDR 3+); (5) treating those with a CDR score >/=2 plus those with CDR score <2 and positive

22 re CDR negatives); (6) treating those with a CDR score >/=3 plus those with CDR score <3 and positive

23 resulting CDR3-grafted HC was paired with a CDR-grafted light chain, displayed on the surface of HEK

24 foundation for the rational design of active CDR-derived peptides.

25 omatic (CDR = 0.5), and 33 overtly affected (CDR > 0.5) autosomal dominant Alzheimer's disease mutati

26 tical mediators of specificity and affinity, CDRs may also be the primary drivers of biotherapeutic d

27 ain triggers a destabilizing response in all CDR loops in the VL domain and vice versa.

28 r that provides access to assignments of all CDR structures in the PDB to our classification system.

29 in the VL domain are likely to stabilize all CDR loops in the VH domain, and, when these residues are

30 e entropy loss of only the CDR3, but not all CDRs, correlated significantly with the kinetic and affi

31 6 points [95% CI, 0.32-0.80]; P < .001), and CDR-Sum of Boxes (mean difference, 0.23 points [95% CI,

32 39), FPR false-positive rate (P = .004), and CDR cancer detection rate (P < .001) of screening mammog

33 es in FPR false-positive rate (P = .011) and CDR cancer detection rate (P = .001) and a nonsignifican

34 no significant associations between CCT and CDR, glaucoma, hypertension, and diabetes.

35 ically rigidified, whereas the VL domain and CDR L2 loop become more flexible during affinity maturat

36 ne usage, rate of somatic hypermutation, and CDR-H3 length and composition.

37 showed that both Valpha/Vbeta interface and CDR residues were important in maintaining binding to MA

38 r FPR false-positive rate , sensitivity, and CDR cancer detection rate at all annual interpretive vol

39 s in SMA clustered around the N-terminus and CDR loops experience considerable conformational exchang

40 inear relationship between RGC estimates and CDRs indicated that eyes with a large CDR would require

41 ulation of SHM in both framework regions and CDRs contributed to the clonal affinity and antigenicity

42 buted to ASAP1 control of cell spreading and CDRs.

43 on FAs, cell migration, cell spreading, and CDRs.

44 rived from rare precursors with long anionic CDR H3s that are often deleted in the B cell repertoire.

45 demonstrated that functional human antibody CDR fusions can be efficiently engineered by grafting th

46 reviously performed a clustering of antibody CDR conformations and defined a systematic nomenclature

47 e results illustrate the utility of antibody CDR fusions as a general and effective strategy to gener

48 e results illustrate the utility of antibody CDR fusions as a general and versatile strategy for gene

49 sisting of quinine and reconfigured antibody CDR plays a critical role in recognition of its target e

50 onstrate that arginine mutations in antibody CDRs display context-dependent impacts on specificity an

51 ion involves binding of the drug to antibody CDRs, causing it to acquire specificity for a site on a

52 Among many effects, stabilizing any CDR loop in the VH domain triggers a destabilizing respo

53 ns for specificity were enriched in arginine CDR mutations and displayed low specificity.

54 r specificity were also enriched in arginine CDR mutations, but these antibodies possessed significan

55 ned by the relative contribution of arginine CDR residues to the overall antibody affinity.

56 e hydrophobic environments near the arginine CDR mutations.

57 Ninety-seven asymptomatic (CDR = 0), 25 mildly symptomatic (CDR = 0.5), and 33 over

58 here we used single-codon libraries of both CDR and non-CDR residues to generate a deep mutational s

59 g the clinical dementia rating sum of boxes (CDR-sb) scores.

60 nts), Clinical Dementia Rating Sum of Boxes (CDR-Sum of Boxes; 0 [best] to 18 [worst] points), and Lo

61 imal geometric orientations, one achieved by CDR H3 ontogenies and the other achieved by VH-gene-rest

62 h future cognitive deficits as determined by CDR.

63 ctions were influenced most by the VHH CDR3 (CDR, complementarity-determining region) elements, with

64 ieved through mutations in the third H chain CDR (HCDR3) that conferred a markedly faster on-rate and

65 designed heavy and light or just heavy chain CDRs were synthesized and screened for peptide binding b

66 s recognition of the Fab HM14c10 light chain CDRs.IMPORTANCE A chimeric yellow fever-dengue live-atte

67 especially concerning for positively charged CDR mutations that are linked to antibody polyspecificit

68 west cost were treat all ($11.19 per child), CDR 2+ ($11.20); the CDR 3+ ($13.00); CDR 2+, culture CD

69 ased use of alleles that encode the critical CDR-H2 Phe54 (F-alleles) to make broadly neutralizing an

70 11.20); the CDR 3+ ($13.00); CDR 2+, culture CDR negatives ($16.42); CDR 3+, culture CDR negatives ($

71 re <2 and positive cultures (CDR 2+, culture CDR negatives); (6) treating those with a CDR score >/=3

72 ture CDR negatives ($16.42); CDR 3+, culture CDR negatives ($23.89); and culture all ($27.21).

73 re <3 and positive cultures (CDR 3+, culture CDR negatives); and (7) treat none.

74 ose with CDR score <2 and positive cultures (CDR 2+, culture CDR negatives); (6) treating those with

75 ose with CDR score <3 and positive cultures (CDR 3+, culture CDR negatives); and (7) treat none.

76 rgy-biochar systems (BEBCS) can also deliver CDR, they are not included in any IPCC scenario.

77 a Rating [CDR] score, 0) or had AD dementia (CDR score, >0) were included.

78 tions but also mutation pairs from different CDRs that synergistically improve both binding functions

79 n and Vm24-toxin were grafted into different CDRs of the humanized antibodies BVK and Synagis (Syn) u

80 grafting the native hormones into different CDRs of the humanized antibody Herceptin.

81 een photograph reading and OCT in estimating CDR.

82 teractions, and it is unclear to what extent CDRs can accumulate charged residues to increase antibod

83 Unlike the other five CDR loops, CDR H3 does not adopt canonical conformations

84 Five CDRs contact the C5 macroglobulin 7 domain, which contai

85 e was 0.00 (2.60); for MMSE, 29.0 (1.2); for CDR-Sum of Boxes, 0.04 (0.14); and for Logical Memory De

86 No single threshold for CDR or asymmetry ruled out glaucoma.

87 trended toward significance, especially for CDRs, but cannot fully explain the observed changes in e

88 sion decreases the number of cells that form CDRs, as well as the area of the CDRs.

89 the roles of the hypervariable and germline CDR loops in engaging peptide and MHC.

90 ction and antigen recognition where germline CDR loop structure has been modified by multiple glycine

91 CDR and noted possible evidence of glaucoma (CDR >/= 0.7 or the presence of a notch or disc hemorrhag

92 oral epigenetic alterations in hematopoietic CDRs points to sets of genes that are tightly regulated

93 The resulting Herceptin CDR fusion proteins were expressed in good yields in mam

94 we then generated a bi-functional Herceptin-CDR fusion protein in which both hEPO and hGCSF were gra

95 However, CDR responses depend on membrane lipids, can be modified

96 r if affinity mutations in the hypervariable CDRs generally impact antibody stability and to what ext

97 nd molecular dynamics simulations identified CDR residues that were predicted to be important in the

98 AG and with the severity of abnormalities in CDR and visual field.

99 hat expressed aspartic acid/glutamic acid in CDR L2.

100 The difference in CDR estimates between the 2 methods was equal to or grea

101 There was no significant difference in CDR measurement between cameras after adjusting for grad

102 The increase in CDR H3 loop rigidity is consistent with other studies in

103 of large RGC numbers for a small increase in CDR.

104 ograph reading by clinicians agree poorly in CDR assessment.

105 SAP1 did not rescue NM2A knockdown defect in CDRs.

106 residues in variable domains, especially in CDRs (complementarity determining regions) of an antibod

107 ent RhoA activation, actin reorganization in CDRs, cell migration, and fibronectin remodeling.

108 howed lower cognitive performance, increased CDR-SOB, higher amyloid burden and worse clinical progre

109 sion DBT plus synthetic 2D imaging increases CDRs with recall rates comparable to those of FFDM.

110 false-positive (FP) recalls, and incremental CDR for each modality; these were compared using McNemar

111 : 13 tomosynthesis-detected BCs (incremental CDR, 4.0 per 1,000 screens; 95% CI, 1.8 to 6.2) versus 2

112 rsus 23 ultrasound-detected BCs (incremental CDR, 7.1 per 1,000 screens; 95% CI, 4.2 to 10.0), P = .0

113 randomly selected participants with initial CDR less than 0.6.

114 1 by a modification of its lipid-interacting CDR H3.

115 d each mechanism of resistance varies in its CDR dynamics.

116 yers through two hydrophobic residues in its CDR H3 (third heavy-chain complementarity-determining re

117 MHC surface, with the receptor utilizing its CDR loops in a cooperative fashion such that specificity

118 es and CDRs indicated that eyes with a large CDR would require loss of large RGC numbers for a small

119 d a heat map for the essential non-germ-line CDR residue content of each antibody.

120 ugh initial selection of B cells with a long CDR H3, and limited subsequent somatic hypermutation.

121 of influenza haemagglutinin (HA) via a long CDR H3.

122 ows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for cr

123 Unlike the other five CDR loops, CDR H3 does not adopt canonical conformations and must b

124 al and neonatal deaths if countries with low CDR increased their rates to a range of greater than 7.2

125 ing caesarean delivery in countries with low CDRs could avert as many as 163 513 maternal deaths and

126 tal deaths occurred in 45 countries with low CDRs in 2013 and 2012, respectively.

127 his model assumes that if countries with low CDRs increased their rates of caesarean delivery to grea

128 Two masked readers measured CDR and noted possible evidence of glaucoma (CDR >/= 0.7

129 made great strides, but accurately modeling CDR H3 loops remains elusive.

130 Non-CDR residues included those at the interface of the TCR

131 found that the proline at position 41, a non-CDR residue in heavy chain variable regions (VH), is imp

132 d single-codon libraries of both CDR and non-CDR residues to generate a deep mutational scan of a hum

133 insertion of a full-length protein into non-CDR loops of antibodies provides a feasible approach to

134 sors (CDR score, >/=0.5) and nonprogressors (CDR score, 0) and between APOE epsilon4 carriers and non

135 chain 1 in contrast to the commonly observed CDR heavy chain 3, providing a unique perspective into a

136 omass, BEBCS may allow earlier deployment of CDR at lower carbon prices when long-term improvements i

137 The regulation of CDR area by RhoG is independent of Rac1 function.

138 ctor, Trio, play a role in the regulation of CDR dynamics, particularly by modulating their size.

139 yeast display to enrich for C05 variants of CDR H3 that bind to H1 and H3 HAs.

140 g and solubility to residues at the edges of CDRs, and provide guidelines for designing other grafted

141 t restrict the conformational flexibility of CDRs and enhance the kinetics and affinity of immunoglob

142 The formation of CDRs involves a drastic rearrangement of the cytoskeleto

143 8852 binds through a coordinated movement of CDRs to a highly conserved epitope encompassing a hydrop

144 l a novel role for RhoG in the regulation of CDRs and the cellular processes associated with their fo

145 Effect of camera modality on CDR measurement; inter- and intraobserver agreement for

146 M2A rescued the effect of ASAP1 knockdown on CDRs but ASAP1 did not rescue NM2A knockdown defect in C

147 male sex, and higher IOP but not glaucoma or CDR.

148 s but does not affect the mean SHM levels or CDR H3 lengths.

149 Somatic hypermutation in the other CDRs of PGT145 were crucially involved in stabilizing th

150 t a similar strategy can be applied to other CDRs and show that a CDRH2-peptide fusion binds CXCR4 wi

151 The CFI scores between clinical progressors (CDR score, >/=0.5) and nonprogressors (CDR score, 0) and

152 n applied to a benchmark set of high-quality CDR H3 loops, the average minimum root mean square devia

153 We incorporated a cell death rate (CDR) function into a previous dynamical PSA model that w

154 Results Cancer detection rate (CDR) for DBT plus synthetic 2D imaging was 9.30 per 1000

155 per 1000 screens, or cancer detection rate (CDR), 5.1 (95% CI: 5.0, 5.2); sensitivity, 86.9% (95% CI

156 lines, US incremental cancer detection rate (CDR), and estimated costs were evaluated.

157 mography recall rate, cancer detection rate (CDR), and positive predictive values (PPVs) for digital

158 ome measures included cancer detection rate (CDR), number of false-positive (FP) recalls, and increme

159 edition and included cancer detection rate (CDR), positive predictive value of biopsy recommendation

160 to a country-level caesarean delivery rate (CDRs) of roughly 19.0%, cesarean delivery rates and mate

161 positive rate ], and cancer detection rate [ CDR cancer detection rate ]).

162 Recall rate, CDR, PPV of positive screening result (PPV1), PPV of bio

163 Conclusion Recall rate, CDR, PPV2, and PPV3 of digital mammography increased aft

164 stigated using the Clinical Dementia Rating (CDR) and the Informant Questionnaire on Cognitive Declin

165 ognitively normal (Clinical Dementia Rating [CDR] of 0) middle-aged research volunteers (n = 169) enr

166 ively normal (CN) (Clinical Dementia Rating [CDR] score, 0) or had AD dementia (CDR score, >0) were i

167 To compare cup-to-disc ratio (CDR) measurements from images taken with a portable, 45-

168 48 participants with initial cup-disc ratio (CDR) of 0.6 or greater and 423 images of 360 eyes of 180

169 In the POAG group, optic cup-to-disc ratio (CDR) was positively correlated with deep white matter hy

170 tions with age, sex, IOP, cup-to-disc ratio (CDR), glaucoma, hypertension, and diabetes.

171 Recommended CDRs were achieved by 92.1% of radiologists in community

172 considered when making conclusions regarding CDRs in clinical practice.

173 A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myelopr

174 vy chain complementarity-determining region (CDR) 3 grafting combined with somatic hypermutation in v

175 fine the complementarity determining region (CDR) 3alpha and CDR3beta regions of individual T-cell re

176 thin the complementarity-determining region (CDR) 3beta loop.

177 de novo complementarity determining region (CDR) design to engineer targeted antibody-antigen intera

178 gle-step complementarity-determining region (CDR) germ-lining.

179 elusive complementarity determining region (CDR) H3 loop.

180 ng loop (complementarity-determining region (CDR) H3) characteristic of this category of antibodies.

181 upported complementarily determining region (CDR) loop conformation were identified.

182 Complementarity determining region (CDR) loop flexibility has been suggested to play an impo

183 of five complementarity determining region (CDR) loops for CD1c recognition.

184 ns using complementarity-determining region (CDR) loops that are either germ line-encoded (CDR1 and C

185 ning all complementarity-determining region (CDR) loops, as well as sulfatide recognition separately

186 s in the complementarity determining region (CDR) loops, which usually contact the antigen.

187 multiple complementarity-determining region (CDR) loops.

188 of the two complementary determining region (CDR) methionine residues had little or no impact on anti

189 ultralong complementary-determining region (CDR) of a bovine antibody.

190 ltralong complementarity-determining region (CDR), we have developed a versatile approach for generat

191 residue, complementarity-determining region (CDR)-H3 segments.

192 B4 using complementarity-determining region (CDR)-restricted mutagenesis and tailored selection and s

193 n in its complementarity determining region (CDR).

194 tations in complementary determining region (CDR)1 and CDR2 coincided with a combination of overlappi

195 in third complementarity-determining region (CDR-H3) antibodies in the antigen-experienced repertoire

196 in third complementarity-determining region (CDR-L3) amino acid sequences and/or Vkappa,lambda-Jkappa

197 within complementarity-determining regions (CDR) induce rich behavior in dynamic response.

198 AT/IMGT complementarity determining regions (CDR) into a human IgG germline framework.

199 to six complementarity determining regions (CDR) of the TCR.

200 ms) formation of connexin-depleted regions (CDRs) inside GJ plaques between cells exposed to AB5 tox

201 entify 32,662 chromatin determinant regions (CDRs), genomic regions with different epigenetic charact

202 oops of complementarity-determining regions (CDRs) 1 and 2.

203 l three complementarity-determining regions (CDRs) and also within framework 3, and thus, VH-B1a and

204 in the complementarity-determining regions (CDRs) are especially important because they can impair t

205 n their complementarity-determining regions (CDRs) during affinity maturation to enhance electrostati

206 lobulin complementarity-determining regions (CDRs) from the crystal structures of 34 low-affinity T-c

207 binding complementarity determining regions (CDRs) in a single LC-MS/MS experiment.

208 of the complementarity determining regions (CDRs) of antibodies is critically important for antibody

209 y short complementarity determining regions (CDRs) of high diversity adjacent to framework regions sh

210 y-chain complementarity determining regions (CDRs) of single-chain antibody (scAb) fragments is demon

211 nto the complementarity-determining regions (CDRs) of single-domain (VH) antibodies.

212 nges in complementarity-determining regions (CDRs) of the TCR seen in comparison of unliganded and bo

213 to the complementarity-determining regions (CDRs) of these antibodies and define in crystal structur

214 h their complementarity-determining regions (CDRs) or framework regions.

215 vity of complementarity-determining regions (CDRs) via Sap9-produced large proteolytic peptides (3.4

216 n their complementarity-determining regions (CDRs) without compromising thermodynamic stability is cr

217 in the complementarity determining regions (CDRs), can result in the production of an antibody with

218 of the complementarity determining regions (CDRs), which are most significant for functional selecti

219 tacting complementarity-determining regions (CDRs), with CDR1 and CDR2 encoded by the V segment and C

220 in the complementarity determining regions (CDRs).

221 f their complementarity determining regions (CDRs).

222 nown as complementarity-determining regions (CDRs).

223 heavy chain complementarity domain regions (CDRs) of HM14c10, while fewer interactions are observed

224 require atmospheric carbon dioxide removal (CDR).

225 ertainty, antibody-antigen docking resamples CDR loop conformations and can use multiple models to re

226 18 months using the Cognitive Drug Research (CDR) and Cambridge Neuropsychological Test Automated Bat

227 weeks 30-38 post-infection with a 35-residue CDR H3, and neutralized the virus that superinfected thi

228 Circular dorsal ruffles (CDRs) are actin-rich structures that form on the dorsal

229 adhesions (FAs) and circular dorsal ruffles (CDRs), cell spreading and migration.

230 e (culture all); (3) clinical decision rule (CDR) score >/=2 (CDR 2+); (4) CDR score >/=3 (CDR 3+); (

231 cale and the Clinical Dementia Rating Scale (CDR).

232 individuals (Clinical Dementia Rating scale [CDR] global scores of 0, above cutoff on the modified Mi

233 g affinity and suggests a role for secondary CDR loops in establishing antibody stability.

234 These results support in silico CDR design of antibody specificity as an emerging antibo

235 improved by taking into account simultaneous CDR loops conformation and VH/VL orientation optimisatio

236 Peptides corresponding to all six CDR regions were synthesized and tested for Rev binding.

237 throughout the framework and in four of six CDRs in one design and atomic accuracy in the entire Fv

238 key immune host species, binary substitution CDR cassettes were inserted into preferred human framewo

239 ymptomatic (CDR = 0), 25 mildly symptomatic (CDR = 0.5), and 33 overtly affected (CDR > 0.5) autosoma

240 findings highlight the plasticity of the TCR CDRs.

241 anel on Climate Change scenarios assume that CDR within the energy sector would be delivered using bi

242 The CDR 2+ is the preferred strategy at less than $150/quali

243 The CDR loops are scaffolded by canonical framework regions

244 The CDR was 17 per 1000 screening examinations (95% confiden

245 The CDR-H3 in each case was also augmented with 1 +/- 1 rand

246 all ($11.19 per child), CDR 2+ ($11.20); the CDR 3+ ($13.00); CDR 2+, culture CDR negatives ($16.42);

247 Thus, we analyze the CDR levels and their time-dependent oscillations to iden

248 b showed that deamidation of the drug at the CDR leads to a loss of recognition by the antibodies use

249 on all three monoclonal antibodies to be the CDR H3 loop of the Fab region, and show that they all ha

250 and, when these residues are not buried, the CDR loops in the VL domain are also likely to be stabili

251 rystal structures the changes induced in the CDR by this interaction.

252 disc photograph were 1.6% (3 of 180) in the CDR less than 0.6 group and 31.4% (172 of 548) in the CD

253 than 0.6 group and 31.4% (172 of 548) in the CDR of 0.6 or greater group.

254 ubgroups, while significantly increasing the CDR.

255 gA 5I2 is the predominant involvement of the CDR light chain 1 in contrast to the commonly observed C

256 Although the majority of the CDR loops of the 2C TCR rigidify upon binding, the CDR3b

257 mutations could change the structure of the CDR loops.

258 a systematic nomenclature consisting of the CDR, length and an integer starting from the largest to

259 his work demonstrates the versatility of the CDR-fusion strategy for generating functional human anti

260 ic groups also showed greater decline on the CDR-SB (P<0.04), a global clinical assessment.

261 lay an essential role beyond scaffolding the CDR loops and their unusual contribution to potency and

262 Through signaling, the CDR response may enable cells to sense exposure to AB5 t

263 , HDX-MS and SPR analysis confirmed that the CDR regions of VHH6 interact simultaneously with IL-6 an

264 of culturing all children compared with the CDR 2+ strategy costs more than $125 000/quality-adjuste

265 ut not by a nonneutralizing variant with the CDR-H3 loop deleted.

266 stulated to establish weak contacts with the CDR-H3 loop of the antibody, which are believed to be cr

267 y specific chemical modifications within the CDR, hydrogen-deuterium exchange mass spectrometry (HDX

268 the frameworks is to human germlines and the CDRs to the germlines of mice or other species sources.

269 the most common degradation pathways in the CDRs of a mAb and identified correlations between chemic

270 f Asp isomerization and Met oxidation in the CDRs of a model monoclonal antibody (mAb1).

271 rapidly assign multiple Xle residues in the CDRs of mAbs.

272 to recruit mutations to key residues in the CDRs of the IgV region.

273 ion, some of the overlapping hotspots in the CDRs were at sites in which replacement mutations could

274 y, half of the key affinity mutations in the CDRs were destabilizing.

275 o 19 redundant non-germ-line residues in the CDRs.

276 o identify fold-stabilizing mutations in the CDRs.

277 and predicted for each of them which of the CDRs may bind the Ag on its own as a peptide.

278 ions in the most hydrophobic portions of the CDRs, whereas the less specific antibodies contained arg

279 s that form CDRs, as well as the area of the CDRs.

280 variable segment and not enriched within the CDRs.

281 vels of somatic hypermutation, both in their CDR and framework-variable regions.

282 sitive Ag-driven selection pressure in their CDRs in contrast to non-pSS controls.

283 relate with positively charged H chain third CDR.

284 to form a very rare alpha helix in its third CDR of the H chain.

285 toire displayed unique features in the third CDR of Ig H chains with minor alterations along the immu

286 MMR and NMR observed in countries with those CDRs.

287 h antigen-binding sites built from the three CDR loops and, also, nonconventional libraries with anti

288 By mutating all three CDRs of each antibody chain simultaneously, we were able

289 rine antibody, we modified MMGZ01 Fv through CDR grafting and the reconstructed antibody (H3L2) maint

290 -SEE IgEs as conventional antibodies through CDRs or simultaneously as conventional antibodies and as

291 antibodies and as "superantibodies" through CDRs and framework regions to SEEs in SEE-anti-SEE IgE-F

292 l comorbidity (NPC) score and compared it to CDR, IQCODE, and NPI scores.

293 Indels are localized to CDRs, and secondary mutations within insertions further

294 ng as antigens in the conventional manner to CDRs and as superantigens to framework regions of anti-S

295 receptor (IL-6R) by using side chains of two CDR residues filling the site I cavities of IL-6, thus m

296 es (3.4 kDa on average) containing up to two CDRs per peptide; (iii) reduced artifact introduction du

297 e and developmental ontogeny into two types: CDR H3-dominated and VH-gene-restricted.

298 an antibody repertoire composed of ultralong CDR H3s that fold into a diversity of minidomains genera

299 Deep sequencing reveals that ultralong CDR H3s contain a remarkable complexity of cysteines, su

300 tionship between estimated RGCs and vertical CDR was best represented using a third degree polynomial

301 Healthy eyes had a mean vertical CDR of 0.45 +/- 0.15 vs. 0.80 +/- 0.16 in glaucomatous e

302 ive selection of somatic mutations in the VH CDR and altered VH CDR3 physicochemical properties.

303 le in the cellular functions associated with CDR formation, including macropinocytosis, receptor inte

304 y Rac1 has been consistently associated with CDR formation, whereas the role of other GTPases in this

305 3 and 2012, respectively, for countries with CDR 7.2% or less (N=45) with available data from the Wor

306 -protein interaction, hotspots grafting with CDR loop swapping is an attractive route to the rational

307 those with a CDR score >/=2 plus those with CDR score <2 and positive cultures (CDR 2+, culture CDR

308 those with a CDR score >/=3 plus those with CDR score <3 and positive cultures (CDR 3+, culture CDR

309 rcentiles observed for countries (N=48) with CDRs ranging from greater than 7.2% but less than or equ

310 These residues form hydrogen bonds with CDRs of the Ab other than H CDR3.