ライフサイエンスコーパス: CERT

1 CERT downregulation in breast cancer cells enhanced ErbB

2 CERT has a C-terminal START domain for ceramide binding

3 CERT mutant embryos accumulate ceramide in the ER but al

4 CERT transfers ceramide from the endoplasmic reticulum t

5 CERT's N-terminal pleckstrin homology (PH) domain target

6 affinity and ceramide transfer activity of a CERT-serine-rich phosphorylation mimic.

7 In spite of ceramide accumulation, CERT mutant mice do not die as a result of enhanced apop

8 inferred from ectopic expression of IncD and CERT in the host cell.

9 CV secretion/release by attenuating OSBP and CERT functions by phosphorylation inhibition.

10 ed in lipid transfer and metabolism, such as CERT.

11 Both CERT isoforms, when immobilized, were found to bind the

12 PKD attenuates the function of both CERT and OSBP by phosphorylation at their respective Ser

13 al levels of ceramide phosphoethanolamine by CERT in vivo is required to prevent oxidative damages to

14 PtdIns(4)P binding and ceramide transfer by CERT.

15 rs of University of California, Riverside/CE-CERT environmental chamber data on 17 aromatic hydrocarb

16 or Environmental Research and Technology (CE-CERT) Atmospheric Processes Lab using two biomass fuel s

17 after irradiation, consistent with decreased CERT function, whereas the CERT inhibitor N-(3-hydroxy-1

18 lanogaster mutant flies lacking a functional CERT (Dcert) protein using chemical mutagenesis and a We

19 e in vivo consequences of loss of functional CERT protein.

20 xplored the function of Gpbp and GpbpDelta26/CERT during embryogenesis in zebrafish.

21 type is mediated by Gpbp but not GpbpDelta26/CERT, suggesting that Gpbp is an important factor for no

22 olesterol and cholesterol depletion, impairs CERT Golgi localization, and promotes Golgi fragmentatio

23 at the plasma membrane, thereby implicating CERT loss in the progression of TNBCs.

24 integrity caused by ceramide accumulation in CERT mutant mice primarily affects organogenesis rather

25 ing UVB irradiation, revealing that inactive CERT can attenuate a key metabolic protective mechanism

26 trachomatis at that time, this model of IncD-CERT interaction was inferred from ectopic expression of

27 B, and we determined that, at the inclusion, CERT-VAPB interaction relied on the FFAT domain of CERT.

28 Thus, UVB-induced CERT homotrimer formation accounts, at least in part, fo

29 dence that by regulating cellular SM levels, CERT determines the signaling output of the EGF receptor

30 ression of nonphosphorylatable serine mutant CERT S132A or OSBP S240A.

31 at the massive IncD-dependent association of CERT with the inclusion led to an increased recruitment

32 VB-treated keratinocytes, HPA-12 blockade of CERT function increased keratinocyte apoptosis, decrease

33 APB interaction relied on the FFAT domain of CERT.

34 protein CERT that relied on the PH domain of CERT.

35 this article, we report a novel function of CERT in the innate immune response.

36 mutations increase the Golgi localization of CERT inside the cell, consistent with enhanced PtdIns(4)

37 nt structural insight into the regulation of CERT function and localization.

38 4-kinases are involved in the regulation of CERT-mediated ceramide transport.

39 e function of ceramide transport protein (or CERT) required for sphingomyelin synthesis occur(s) in U

40 he recruitment of the lipid transfer protein CERT and the ER-resident protein VAPB to the inclusion.

41 expression of the ceramide transfer protein CERT is reduced in TNBCs.

42 ve recruitment of the lipid transfer protein CERT that relied on the PH domain of CERT.

43 he recruitment of the lipid transfer protein CERT to the inclusion.

44 se IIIbeta and the ceramide transfer protein CERT, mediate PKD signaling to influence vesicle traffic

45 Ceramide transfer protein (CERT) and oxysterol-binding protein (OSBP) play a crucia

46 nt recruitment of ceramide transfer protein (CERT) for sphingomyelin synthesis.

47 Ceramide transfer protein (CERT) functions in the transfer of ceramide from the end

48 Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum

49 ltidomain protein ceramide transfer protein (CERT).

50 The ceramide transporter protein (CERT) and its longer splicing isoform CERTL are known to

51 cently identified ceramide transfer protein, CERT, is responsible for the bulk of ceramide transport

52 also function as ceramide transfer proteins (CERT).

53 inding activity was decreased in recombinant CERT proteins containing the UVB-induced homotrimer.

54 also induced the rapid formation of a stable CERT homotrimer complex in keratinocytes as determined b

55 In this study, we show that CERT is an essential gene for mouse development and embr

56 ane sensing process are conserved across the CERT, OSBP and FAPP family.

57 The middle region domain of the CERT protein was required for the homotrimer formation,

58 part of ceramide in the START domain of the CERT protein.

59 nt with decreased CERT function, whereas the CERT inhibitor N-(3-hydroxy-1-hydroxymethyl-3-phenylprop