ライフサイエンスコーパス: CHI3L1

1 ggressive metastatic cancer phenotype (SPP1, CHI3L1).

2 red genetically to overexpress or lack mouse CHI3L1.

3 augment the expression of WAT and pulmonary Chi3l1.

4 lens epithelium, and TM and did not express CHI3L1.

5 ted TMSCs began expressing TM marker protein CHI3L1.

6 We determined that Chitinase 3-like-1 (Chi3l1), a conserved prototypic chitinase-like protein,

7 Inhibition of CHI3L1 activity would be a novel therapeutic approach fo

8 Importantly, CHI3L1 administered after C. albicans inoculation also h

9 pe (MUM1), lymphoproliferation (SPP1, TCL1A, CHI3L1), aggressive clinical behavior (SPP1, CHI3L1, MUM

10 Chi3l1 also played a critical role in WAT accumulation a

11 mal human bronchial epithelial cells express CHI3L1 and secrete YKL-40 under base-line culture condit

12 t RLH activation inhibits tumor induction of Chi3l1 and the expression of receptor IL-13Ralpha2 and p

13 the fibrosis was due to interactions between CHI3L1 and the receptor CRTH2, which trafficked normally

14 (BRP-39), also known as chitinase 3-like 1 (CHI3L1) and encoded by the Chi3l1 gene, is expressed at

15 Mouse breast regression protein 39 (BRP-39; Chi3l1) and its human homologue YKL-40 are chitinase-lik

16 function and expression of TM markers AQP1, CHI3L1, and TIMP3.

17 on in its encoding gene (chitinase 3-like 1 [CHI3L1]) and are increased in patients with several dise

18 the functional role of CHI3L1 in vivo, anti-CHI3L1 antibody was administered into the dextran sulfat

19 ys exacerbate pulmonary fibrosis and suggest CHI3L1 as a potential biomarker for pulmonary fibrosis p

20 Chi3l1 augments macrophage bacterial killing by inhibiti

21 NA (siRNA), corneas treated with recombinant CHI3L1 before C. albicans inoculation had markedly ameli

22 tudies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Ralpha2.

23 between the degree of kidney injury and both Chi3l1/Brp-39 expression in the kidney and its levels in

24 We evaluated the regulation of Chi3l1 by an HFD and Th2 inflammation.

25 eased release of chitinase 3-like protein 1 (CHI3L1), CHI3L2, complement factor B, matrix metalloprot

26 interaction between TMEM219 and IL-13Ralpha2-Chi3l1 complexes.

27 3Ralpha2, a recently identified receptor for Chi3l1, consistent with a key role for Chi3l1 in melanom

28 vivo neutralization experiments showed that CHI3L1 contributes to the facilitation of bacterial inva

29 een 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites in whole-blood DNA, and circulating YKL

30 determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1 singl

31 These data demonstrate that CHI3L1-dependent pathways exacerbate pulmonary fibrosis

32 epithelial apoptosis but exhibit exaggerated CHI3L1-driven fibroproliferation, which together promote

33 Purified CHI3L1 efficiently activated the NF-kappaB signaling pat

34 case (RLH) innate immune response to control Chi3l1 elaboration and pulmonary metastasis.

35 compressive stress) applied for 3 h induces CHI3L1 expression by approximately 4-fold compared with

36 ted the corneal from C. albicans and induced CHI3L1 expression in C57BL/6 mouse corneas.

37 and RT-PCR analyses significantly increased CHI3L1 expression in non-dysplastic mucosa from patients

38 s mechanical stress-induced up-regulation of CHI3L1 expression in normal human bronchial epithelial c

39 rate that mechanical stress potently induces CHI3L1 expression leading to increased secretion of YKL-

40 of EGFR utilizing EGF-family ligands induces CHI3L1 expression.

41 SNPs spanning the CHI3L1 gene were genotyped in 259 Yale Center for Asthma

42 hitinase-like protein YKL-40, encoded by the CHI3L1 gene, is a biomarker and functional effector of c

43 itinase 3-like 1 (CHI3L1) and encoded by the Chi3l1 gene, is expressed at high levels by macrophages

44 The effects of CHI3L1 genetic variation on circulating YKL-40 levels ar

45 Following adjustment for CHI3L1 genotype, significantly greater levels of YKL-40

46 IL-13Ralpha2 uses to mediate the effects of Chi3l1 has not been defined.

47 Chitinase 3-like 1 (CHI3L1) has been shown to play a role in promoting antib

48 CHI3L1, however, played a detectable but minor role in f

49 factor-related activation-induced cytokine, CHI3L1, IL-16, and matrix metalloproteinase-12 were card

50 This study sought to elucidate the role of CHI3L1 in augmenting the corneal innate immune response

51 etween asthma and obesity and the role(s) of Chi3l1 in fat accumulation have not been defined.

52 knowledge, we investigated the production of Chi3l1 in melanoma lung metastases.

53 r for Chi3l1, consistent with a key role for Chi3l1 in melanoma spread.

54 at the protein level of ECM-related SPP1 and CHI3L1 in PCNSL cells was demonstrated by immunohistoche

55 We confirmed roles for Sema7a and Chi3l1 in pulmonary metastasis of EMT6 breast cancer cel

56 n were significantly promoted in response to CHI3L1 in these cells.

57 To examine the functional role of CHI3L1 in vivo, anti-CHI3L1 antibody was administered in

58 tically modified mice to define the roles of Chi3l1 in white adipose tissue (WAT) accumulation and Th

59 strate that TMEM219 plays a critical role in Chi3l1-induced IL-13Ralpha2 mediated signalling and tiss

60 hese responses and the pathways that control Chi3l1-induced tumor responses are poorly understood.

61 In addition, Chi3l1 inhibited Sirt1 expression, and the deficient vis

62 These studies demonstrate that Chi3l1 is a multifaceted immune stimulator of tumor prog

63 CHI3L1 is a susceptibility gene for asthma, bronchial hy

64 CHI3L1 is an inflammation-associated molecule, and its e

65 NP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function

66 Chi3l1 is induced by a variety of cancers where it porte

67 Chi3l1 is induced by an HFD and Th2 inflammation, and si

68 This is the first report demonstrating that CHI3L1 is induced during fungal infection, where it acts

69 These data demonstrate that Chi3l1 is induced during infection, where it promotes ba

70 The prototypic chitinase-like protein Chi3l1 is induced in cancers and portends a poor prognos

71 ays using intracellular bacteria showed that CHI3L1 is required for the enhancement of adhesion and i

72 Microarray analysis identified that CHI3L1 is up-regulated specifically in inflamed mucosa.

73 The glycoprotein YKL-40 (CHI3L1) is a secreted chitinase family protein that indu

74 Chitinase 3-like-1 (Chi3l1) is an evolutionarily conserved moiety that plays

75 Here, we demonstrated that circulating CHI3L1 levels are higher in HPS patients with pulmonary

76 of LINE1 sites but led to demethylation of a CHI3L1 locus that is hypomethylated in RA FLS.

77 In summary, CHI3L1 may contribute to the proliferation, migration, a

78 Chitinase 3-like-1 (CHI3L1) messenger RNA and protein expressions were exami

79 on injury (U-IRI) led to sustained low-level Chi3l1 mRNA expression by renal cells and promoted macro

80 CHI3L1), aggressive clinical behavior (SPP1, CHI3L1, MUM1), and aggressive metastatic cancer phenotyp

81 S. pneumoniae-infected Chi3l1 null mice exhibit exaggerated lung injury, inflam

82 deficient visceral fat and Th2 responses in Chi3l1 null mice were reversed by Sirt1 inhibition.

83 iptase-PCR showed high expression of CITED1, CHI3L1, ODZ1, and SCEL in 6/6 additional PTCs.

84 he numerous additional genes include CITED1, CHI3L1, ODZ1, N33, SFTPB, and SCEL.

85 determine the effect of genetic variation in CHI3L1 on asthma severity and YKL-40 expression in subje

86 In this study, we investigated the role of CHI3L1 on CECs during the development of colitis-associa

87 The biological function of CHI3L1 on CECs is unclear.

88 Notably, antiserum raised against Chi3l1 or Sema7a phenocopied the reduction produced by g

89 In mouse strains with genetic deletions of Chi3l1 or Sema7a, there was a significant reduction in p

90 AnkG, and MUC1 but not TM markers AQP1, MGP, CHI3L1, or TIMP3.

91 roles likely contributed to the retention of Chi3l1 over species and evolutionary time.

92 CHI3L1 plays a pathogenic role in colitis, presumably by

93 Therefore, secretory CHI3L1 plays an important role in inflammation-induced l

94 c chitinase-like protein chitinase 3-like-1 (CHI3L1) plays a protective role in the lung by ameliorat

95 all asthmatic children were genotyped for a CHI3L1 promoter single nucleotide polymorphism (rs495092

96 ymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) promoter, the gene encoding YKL-40, are associat

97 ochemical staining showed strong staining of CHI3L1 protein around tumor areas in these mouse models.

98 The expression of CHI3L1 protein clearly was detectable in lamina propria

99 patients revealed a significant elevation of CHI3L1 protein concentration in human serum samples from

100 mation-induced lung cancer mouse models, the CHI3L1 protein concentration was also highly increased i

101 wnstream genes products, chitinase 3-like 1 (CHI3L1) protein, showed increased concentration in both

102 ten candidate genes (ORMDL1, ORMDL2, ORMDL3, CHI3L1, RAD50, IL13, IL4, STAT6, FOXP3, and RUNX3) was a

103 he trafficking and effector functions of two CHI3L1 receptors.

104 ession in animal models, and that miR-24 and CHI3L1 represent novel plasma biomarkers of AAA disease

105 rough which Sem7a and its receptors regulate Chi3l1, revealing a host axis involving IL13Ralpha2 that

106 CHI3L1 CpG sites mediate the association of CHI3L1 single nucleotide polymorphisms (SNPs) with YKL-4

107 was more severe in the corneas treated with Chi3l1 small interfering RNA (siRNA), corneas treated wi

108 In our study YKL-40 levels, but not CHI3L1 SNPs or methylation levels, were associated with

109 Associations between 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites i

110 the blood and (2) whether these biomarkers (CHI3L1 SNPs, methylation profiles, and YKL-40 levels) ar

111 TMEM219 or IL-13Ralpha2 similarly decreased Chi3l1-stimulated epithelial cell HB-EGF production and

112 A promoter SNP (-131C-->G) in CHI3L1, the chitinase 3-like 1 gene encoding YKL-40, was

113 hese animals have a defect in the ability of CHI3L1 to inhibit epithelial apoptosis but exhibit exagg

114 copied one another as regards the ability of Chi3l1 to inhibit oxidant-induced apoptosis and lung inj

115 first animal study linking overexpression of CHI3L1 to various lung tumor mouse models.

116 in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the cont

117 CHI3L1 treatment resulted in the induction of the antimi

118 We characterized the mechanisms that Chi3l1 uses to foster tumor progression and the ability

119 However, the mechanisms that Chi3l1 uses to mediate these responses and the pathways

120 associated with truncal adiposity, and serum Chi3l1 was associated with persistent asthma and low lun

121 As determined by IHC, CHI3L1 was expressed in specific cell types in the crypt

122 We found that Chi3l1 was induced during pulmonary melanoma metastasis

123 SNPs nor methylation levels at CpG sites in CHI3L1 were associated with asthma.

124 Fifteen SNPs in CHI3L1 were associated with FEV1, serum YKL-40 levels, o

125 Finally, serum and sputum Chi3l1 were positively associated with truncal adiposity

126 n of chilectins is pronounced in mammals and CHI3L1 (with a proposed function in immunity) is found i

127 zed human astrocytes stably transfected with CHI3L1/YKL-40 exhibited changes in gene expression simil

128 We found that CHI3L1/YKL-40 was significantly associated with both chr

129 Chitinase 3-like-1 (CHI3L1/YKL-40) is a protein secreted from restricted cel