ライフサイエンスコーパス: CNG

1 CNG and propane achieve relatively smaller emissions red

2 CNG channels are members of the superfamily of voltage-g

3 CNG channels play an important role in mediating odor de

4 CNG conversion was clearly detrimental from climate chan

5 CNG ion channels are not gated by membrane voltage altho

6 CNG-modulin binds Ca(2+) with a concentration dependence

7 CNG-modulin is expressed in other tissues, such as brain

8 -3 forms a complex with both TAX-2 and TAX-4 CNG channel subunits in AWC.

9 erved in animals lacking the tax-2 and tax-4 CNG channels.

10 ibitor reversed near 0 mV, as expected for a CNG current.

11 nd the other is the non-selective NaK2CNG, a CNG channel pore mimic.

12 Replacing a gasoline CV with a CNG CV, or a CNG CV with a CNG HEV, can provide life cycle air emissi

13 When a CNG mimic is crystallized in the presence of a variety o

14 Replacing a gasoline CV with a CNG CV, or a CNG CV with a CNG HEV, can provide life cyc

15 asoline CV with a CNG CV, or a CNG CV with a CNG HEV, can provide life cycle air emissions impact ben

16 t xCNGA1 incapable of binding cGMP abolished CNG currents and converted growth cone repulsion to attr

17 Although not dominant, ALK-CNG has been reported to be one of the mechanisms of acq

18 ALK-rearrangement, ALK-copy number gain (ALK-CNG)] monitored on crizotinib could predict progression-

19 en baseline numbers of ALK-rearranged or ALK-CNG CTCs and PFS was observed.

20 the presence of ALK-rearrangement and/or ALK-CNG signals.

21 namic change in the numbers of CTCs with ALK-CNG may be a predictive biomarker for crizotinib efficac

22 between the decrease in CTC number with ALK-CNG on crizotinib and a longer PFS (likelihood ratio tes

23 analysis, the dynamic change of CTC with ALK-CNG was the strongest factor associated with PFS (HR, 4.

24 esult in common biophysical models, allowing CNG and HCN channels to be viewed as a single genre.

25 ues indicated that Ufo1 induces rapid CG and CNG hypomethylation of P1-wr repeats during plant develo

26 xposure to Ufo1, a 30-40% decrease in CG and CNG methylation was observed in an upstream enhancer and

27 distinct distribution pattern of the CG and CNG sites, which may provide a foundation for the differ

28 IV buses and the lowest from the ethanol and CNG-fueled buses, which emitted BC only during accelerat

29 nce similarity (24-32%) to eukaryote HCN and CNG channels and that contain a C-linker region.

30 n, to determine whether this part of HCN and CNG channels might be an extension of the permeation pat

31 ts gating but not ion permeation in HCN2 and CNG channels.

32 as HCN channels are activated by voltage and CNG channels are virtually voltage independent, both cha

33 does not require che-6, but requires another CNG, cng-3.

34 cyclic nucleotide-modulated channels such as CNG and HCN channels is promoted by ligand-induced confo

35 n vehicles in nonattainment regions, because CNG vehicles are likely more cost-effective at providing

36 ocal anesthetic tetracaine is known to block CNG channels in a manner that resembles the block of vol

37 he major contributor to cone death caused by CNG channel deficiency.

38 nnels in cone photoreceptors is modulated by CNG-modulin, a Ca(2+)-binding protein.

39 In visual and olfactory sensory cells CNG channels conduct cationic currents.

40 We examined why HCN and certain CNG subunits form functional homomeric channels, whereas

41 , methylcytosines are typically found in CG, CNG, and asymmetric contexts.

42 Loss of CG, CNG, and CNN methylation in Pol IV mutants implicates a

43 s the concentration of cGMP in rods, closing CNG channels, which leads to membrane potential hyperpol

44 Cone CNG channels are composed of at least two different subu

45 part, to tune the interactions between cone CNG channels and membrane-bound phosphoinositides.

46 3 can modulate heterologously expressed cone CNG channels.

47 ort a preferred subunit arrangement for cone CNG channels (B3-B3-A3-A3) that is distinct from the 3A:

48 essed heteromeric (CNGA3 + CNGB3) human cone CNG channels in Xenopus laevis oocytes and characterized

49 duces biosynthesis of CNGA3 and impairs cone CNG channel function.

50 Coexpression of cone CNG beta subunit (CNGB3) does not rescue the consequence

51 authentic Ca(2+)-dependent modulator of cone CNG channel ligand sensitivity.

52 mechanism controls the stoichiometry of cone CNG channels.

53 phosphoinositides (PIPn) regulation of cone CNG channels: N- and C-terminal regulatory modules.

54 important for regulation of recombinant cone CNG channels.

55 of the disease-causing mutations in the cone CNG channel subunit.

56 Mutations in the cone CNG channel subunits CNGA3 and CNGB3 account for >70% of

57 Mutations in the cone CNG channel subunits CNGA3 and CNGB3 are associated with

58 on after cone degeneration in mice with cone CNG channel deficiency.

59 Rod function and survival in mice with cone CNG channel subunit CNGA3 deficiency (CNGA3-/- mice) wer

60 n, suggesting that H3K9 methylation controls CNG DNA methylation.

61 ally, we examine the physiology of different CNG channel subunit combinations.

62 This compound blocked several different CNG channels in the picomolar to nanomolar concentration

63 EGFR CNG was determined by fluorescent in situ hybridization

64 Conclusion EGFR CNG assessed by FISH appears to identify a subgroup of p

65 Losses from six LNG and eight CNG stations were characterized during compression, fuel

66 already evolved a visual system that employs CNG channels and the second messenger cGMP for phototran

67 ich shares sequence similarity to eukaryotic CNG and HCN channels-in the presence of a saturating con

68 rease in CO2 equivalent (CO2e) emissions for CNG buses, a <5% change for exhaust treatment scenarios,

69 ther insight into determinants important for CNG channel binding and activation, we targeted previous

70 placebo according to EGFR copy number gain (CNG) and EGFR, KRAS, BRAF, and PIK3CA mutation status.

71 or frequent tumor-specific copy number gain (CNG) in both lung squamous cell carcinoma (LSCC) and ova

72 KDR copy number gains (CNG), measured by quantitative PCR and fluorescence in s

73 emissions from four compressed natural gas (CNG) and four diesel buses were investigated under stead

74 Compressed natural gas (CNG) and liquefied natural gas (LNG) are the most common

75 led vehicles and the compressed natural gas (CNG) and liquefied natural gas (LNG) fueling stations th

76 iofuels, diesel, and compressed natural gas (CNG) in internal combustion engines; the use of electric

77 s study, we consider compressed natural gas (CNG) use directly in conventional vehicles (CV) and hybr

78 ethanol (RED95) and compressed natural gas (CNG).

79 icle fleet to run on compressed natural gas (CNG).

80 namic balance between influx via cGMP-gated (CNG) channels and extrusion via Na(+)/Ca(2+), K(+) excha

81 ct cellular targets of cGMP: the cGMP-gated (CNG) channels and protein kinase G (PRKG), and how each

82 g the cone outer segment through cGMP-gated (CNG) channels is carried in part by Ca(2+), which is the

83 The ligand sensitivity of cGMP-gated (CNG) ion channels in cone photoreceptors is modulated by

84 rget, the beta-type cyclic nucleotide gated (CNG) channel subunit, TAX-2, was implicated in the short

85 Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-r

86 to daylight closes cyclic nucleotide-gated (CNG) and voltage-operated Ca(2+) -permeable channels in

87 rough the olfactory cyclic nucleotide-gated (CNG) channel and stimulates a depolarizing chloride curr

88 2+ influx through a cyclic nucleotide-gated (CNG) channel followed by Cl- efflux through a Ca2+-activ

89 fects depend on the cyclic nucleotide-gated (CNG) channel gene CNGA2, the function of which in the no

90 subunit of the cone cyclic nucleotide-gated (CNG) channel gene CNGA3.

91 In contrast, the cyclic nucleotide-gated (CNG) channel inhibitor l-cis-diltiazem, as well as the c

92 h regulation on the cyclic nucleotide-gated (CNG) channel is considered a major mechanism of OSN adap

93 The cone cyclic nucleotide-gated (CNG) channel is essential for central and color vision a

94 However, in cyclic nucleotide-gated (CNG) channel knock-out mice OSN axons are only transient

95 cone photoreceptor cyclic nucleotide-gated (CNG) channel plays a pivotal role in phototransducton.

96 a heteromultimeric cyclic-nucleotide-gated (CNG) channel present in these cells.

97 ce with a disrupted cyclic nucleotide-gated (CNG) channel subunit A2.

98 se III (ACIII), and cyclic nucleotide-gated (CNG) channel, as well as disrupted basal body apical mig

99 t activation of the cyclic nucleotide-gated (CNG) channel, leading to Ca2+ gating of Cl- channels; in

100 ction of a designed cyclic nucleotide-gated (CNG) channel, named KcsA-CNG, by addition of a prokaryot

101 ng of the olfactory cyclic-nucleotide-gated (CNG) channel.

102 o two families: the cyclic nucleotide-gated (CNG) channels and the hyperpolarization-activated cyclic

103 that cAMP activates cyclic nucleotide-gated (CNG) channels and thereby induces a Ca(2+) influx, which

104 Cyclic nucleotide-gated (CNG) channels are critical components of the vertebrate

105 Cyclic nucleotide-gated (CNG) channels are expressed in rod photoreceptors and op

106 Cyclic nucleotide-gated (CNG) channels are found in several cell types, and are b

107 Cyclic nucleotide-gated (CNG) channels are the primary targets of light- and odor

108 Cone photoreceptor cyclic nucleotide-gated (CNG) channels are thought to be tetrameric assemblies of

109 Cone photoreceptor cyclic nucleotide-gated (CNG) channels are thought to form by assembly of two dif

110 vate cAMP-sensitive cyclic nucleotide-gated (CNG) channels expressed in Xenopus oocytes.

111 Cyclic nucleotide-gated (CNG) channels from rod photoreceptors exhibit a 3:1 stoi

112 iting activation of cyclic nucleotide-gated (CNG) channels in the cilia.

113 Cyclic nucleotide-gated (CNG) channels localize exclusively to the plasma membran

114 Cyclic nucleotide-gated (CNG) channels of olfactory neurons are tetramers and req

115 Cone photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal role in cone phototransduct

116 Cyclic nucleotide-gated (CNG) channels play a pivotal role in phototransduction.

117 Photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal role in phototransduction.

118 Cyclic nucleotide-gated (CNG) channels play an essential role in the visual and o

119 cone photoreceptor cyclic nucleotide-gated (CNG) channels play pivotal roles in phototransduction.

120 Photoreceptor cyclic nucleotide-gated (CNG) channels regulate Ca(2+) influx in rod and cone pho

121 se to cGMP binding, cyclic nucleotide-gated (CNG) channels serve key roles in the transduction of vis

122 cone photoreceptor cyclic nucleotide-gated (CNG) channels undergoes alternative splicing, generating

123 orant receptors and cyclic nucleotide-gated (CNG) channels, allowing for efficient, spatially confine

124 Cyclic nucleotide-gated (CNG) channels, key players in olfactory and visual signa

125 modulated (HCN) and cyclic nucleotide-gated (CNG) channels, MloK1 lacks a C-linker region, which crit

126 te (cGMP)-sensitive cyclic nucleotide-gated (CNG) channels, revealing a conservation in phototransduc

127 nomenon relevant to cyclic nucleotide-gated (CNG) channels.

128 g a high density of cyclic-nucleotide-gated (CNG) channels.

129 n the related CNGA1 cyclic nucleotide-gated (CNG) channels.

130 sly uncharacterized cyclic nucleotide-gated (CNG) ion channel, encoded by the che-6 locus.

131 Cyclic nucleotide-gated (CNG) ion channels are crucial for phototransduction in r

132 Cyclic nucleotide-gated (CNG) ion channels are nonselective cation channels, esse

133 Cyclic nucleotide-gated (CNG) ion channels mediate sensory transduction in olfact

134 Cyclic nucleotide-gated (CNG) ion channels, despite a significant homology with t

135 rom the activity of cyclic nucleotide-gated (CNG) ion channels.

136 on of photoreceptor cyclic nucleotide-gated (CNG) ion channels.

137 he Ca(2+)-permeable cyclic nucleotide-gated (CNG) transduction channels.

138 nd the opening of a cyclic nucleotide-gated (CNG), non-selective cation channel which depolarizes the

139 s to the opening of cyclic-nucleotide-gated (CNG), nonselective cation channels.

140 An agarose-acrylamide composite native gel (CNG) system has been developed for separating protein co

141 Although having CNG channels open at rest decreases the voltage change r

142 X-4, a gustatory neuron-specific heteromeric CNG channel complex.

143 The report identifies CNG channels as a physiological link that integrates gap

144 The report identifies CNG channels as a possible physiological link between ad

145 onally thought to directly chelate Ca(2+) in CNG channels, but rather by the backbone carbonyl groups

146 ulation plays a role in cone degeneration in CNG channel deficiency.

147 the molecular basis of cone degeneration in CNG channel deficiency.

148 s into the mechanism of cone degeneration in CNG channel deficiency.

149 vidence suggests that the activation gate in CNG channels is not located at the intracellular end of

150 ws us to pinpoint equivalent interactions in CNG channels through structure-based mutagenesis that ha

151 ol 1,4,5-trisphosphate receptor 1 (IP3R1) in CNG channel-deficient mice.

152 Here, we show that ion permeation in CNG channels is tightly regulated at the selectivity fil

153 lates ER stress and IP3R1 phosphorylation in CNG channel-deficient cones.

154 nt protein kinase (protein kinase G, PKG) in CNG channel deficiency.

155 protein may provide insight into its role in CNG channel structure, function, biogenesis, and pathoph

156 d calcium influx serves a modulatory role in CNG-channel mediated signal transduction.

157 e structural mechanism of ion selectivity in CNG channels, particularly their Ca(2+) blockage propert

158 Hence the olfactory response has inward CNG and Cl components that are in rapid succession and n

159 c nucleotide-gated (CNG) channel, named KcsA-CNG, by addition of a prokaryotic cyclic nucleotide-bind

160 KDR CNGs were also associated with significantly increased r

161 , and HIF-1alpha levels in cells bearing KDR CNGs, providing evidence for direct involvement of KDR.

162 Our findings suggest that tumor cell KDR CNGs may promote a more malignant phenotype including in

163 genesis, and HIF-1alpha levels, and that KDR CNGs may be a useful biomarker for identifying patients

164 assessed NSCLC cell lines and found that KDR CNGs were significantly associated with in vitro resista

165 such as lean-burn compressed natural gas (LB-CNG) or hybrid electric buses (HEB), and emissions contr

166 seline gave estimated net present cost of LB-CNG or HEB conversion to be $187 million ($73 million to

167 particulate matter (PM2.5) occurred with LB-CNG buses.

168 Ligand binding to the full-length CNG channel and the isolated CNBD differ, revealing allo

169 o determine the structure of the intact LliK CNG channel isolated from Leptospira licerasiae-which sh

170 Hence, hairpins formed from long CNG sequences are more thermodynamically stable and have

171 matching sequences, mismatches, bulge loops, CNG repeats, dangling ends, inosines, locked nucleic aci

172 esults suggest that Ca2+/calmodulin-mediated CNG channel fast desensitization is less important in re

173 g NCKX4 (NCKX4(-/-)) and Ca(2+)/CaM-mediated CNG channel desensitization (CNGB1(DeltaCaM)).

174 es and approximately 31 bp around methylated CNG sites.

175 rison of the potentials of mean force of NaK-CNG and K(+)-selective channels yields observations that

176 Since NaK-CNG is not selective for K(+) over Na(+), analysis of it

177 el with only three cation-binding sites (NaK-CNG).

178 cone membrane patches containing the native CNG channels shifts the midpoint of cGMP dependence from

179 ipolar disorder: the Clinical Neurogenetics (CNG) pedigrees (in which linkage to illness had been pre

180 base pairs or mismatched substrates with non-CNG repeats.

181 gets for modification in the design of novel CNG channel agonists.

182 However, the absence of CNG channel alone also caused abnormal cGMP accumulation

183 we observed a 2-PAA-dependent activation of CNG channels by a combination of electrophysiology and p

184 siological roles and biophysical behavior of CNG and HCN channels.

185 act both as a permeating ion and blocker of CNG channels and raise the possibility of a similar chem

186 report the discovery and characterization of CNG-modulin, a novel 301 aa protein that interacts with

187 om in length, so the spatial distribution of CNG channels along the length should be important in det

188 Transgenic expression of CNG channel beta-subunit mutants in Xenopus rods showed

189 oach, we found that abolishing expression of CNG channels prolongs rod survival caused by elevated cG

190 charge cluster in the selectivity filter of CNG channels.

191 e segment in both maturation and function of CNG channels.

192 Under physiological conditions, gating of CNG channels contributes approximately 0.06 nS to the re

193 alysis, we identified the orthologue gene of CNG-modulin in zebrafish, eml1, an ancient gene present

194 crystal structure of a bacterial homolog of CNG channel pores, the NaK channel, revealed a Ca(2+) bi

195 cytotoxic effect in cones, independently of CNG channel activity and Ca(2+) influx.

196 known about the subcellular localization of CNG channels or the mechanisms of their membrane partiti

197 2 inhibition in native OSNs causes a loss of CNG channel from cilia and subsequent olfactory dysfunct

198 The compensating loss of CNG channel function in the absence of NCKX1-mediated Ca

199 Methylation of CNG and asymmetric sites appears to be maintained at eac

200 e property, we engineered a set of mimics of CNG channel pores for both structural and functional ana

201 In a mouse model of CNG channel loss-of-function, abolishing PRKG1 expressio

202 des have been shown to facilitate opening of CNG and HCN channels, their effect on EAG and ERG channe

203 not to regular odors through the opening of CNG channels leading to Ca2+ gating of TRPM5.

204 stallography to demonstrate that the pore of CNG channels is highly flexible.

205 DNA methyltransferase, cause a reduction of CNG DNA methylation, suggesting that H3K9 methylation co

206 n our understanding of how the regulation of CNG channels contributes to the physiological properties

207 We investigated the functional role of CNG-modulin in phototransduction in vivo in morpholino-m

208 permeation and the poor ionic selectivity of CNG channels.

209 During light adaptation, the sensitivity of CNG channels to cGMP is decreased by Ca2+, which in conj

210 ere, we report the finding that targeting of CNG channels to the rod outer segment required their int

211 Thus, ankyrin-G is required for transport of CNG channels to the plasma membrane of rod outer segment

212 tical tyrosine residues in rod and olfactory CNG channel subunits does not participate in cone channe

213 nstrate that KIF17 is required for olfactory CNG channel targeting, providing novel insights into mec

214 inhibit activation of heteromeric olfactory CNG channels, composed of CNGA2, CNGA4, and CNGB1b subun

215 The native olfactory CNG channel consists of three distinct subunits: CNGA2,

216 CNGA4, and CNGB1b) make up native olfactory CNG channels and account for the fast inhibition of nati

217 units in properly targeting native olfactory CNG channels remains unclear.

218 N terminus for PIP3 inhibition of olfactory CNG channels and suggest that PIP3 inhibits channel acti

219 anisms of the ciliary targeting of olfactory CNG channels, composed of three subunits: CNGA2, CNGA4,

220 equired for ciliary trafficking of olfactory CNG channels.

221 Native rat olfactory CNG channels, however, are heteromeric complexes of thre

222 Our results show that olfactory CNG channels target to lipid rafts and that disruption o

223 port that the alpha subunit of the olfactory CNG channel, CNGA2, associates with lipid rafts in heter

224 /calmodulin desensitization of the olfactory CNG channel, we introduced a mutation in the channel sub

225 The lack of structural information on CNG channels has prevented mechanistic understanding of

226 lculations using a homology model of an open CNG channel.

227 /D3 cells induces a Ca(2+) influx by opening CNG channels in a cAMP-dependent manner.

228 ntial properties of various eukaryote HCN or CNG channels.

229 that CHE-6 may form together with two other CNG subunits, TAX-2 and TAX-4, a gustatory neuron-specif

230 functional homomeric channels, whereas other CNG subunits only function in heteromeric channels.

231 Furthermore, structural insight from our CNG mimics allows us to pinpoint equivalent interactions

232 e its natural mutation in cone photoreceptor CNG channels is associated with achromatopsia, a human a

233 the functional significance of photoreceptor CNG channel association with membrane microdomains enric

234 emonstrates the association of photoreceptor CNG channels with membrane domains enriched in raft lipi

235 ion and functional activity of photoreceptor CNG channels.

236 cGMP, the native ligand of the photoreceptor CNG channels, has been associated with cytotoxicity when

237 cently demonstrated that in LSCC cells PRKCI CNG functions to drive transformed growth and tumorigeni

238 e assessed whether OSC cells harboring PRKCI CNG exhibit similar PKCiota-dependent Hh signaling.

239 nsformed growth of OSC cells harboring PRKCI CNG, these cells do not exhibit PKCiota-dependent Hh sig

240 nucleotide binding has been shown to promote CNG and HCN channel opening, the precise mechanism under

241 Adding purified recombinant CNG-modulin to cone membrane patches containing the nati

242 n in neonatal mouse retinas markedly reduced CNG channel expression.

243 agments and the cryoEM structures of related CNG, HCN, and KCNH channels.

244 gest that subunit composition of the retinal CNG channel influences localization, leading to disease.

245 The primary subunits of cone and rod CNG channels, CNGA3 and CNGA1, respectively, were hetero

246 s, suppressed expression and function of rod CNG channels and a subsequent 100-fold reduction in rod

247 phosphorylation-dependent modulation of rod CNG channels, but the phosphorylation states of the two

248 cient to mirror the native properties of rod CNG channels, including the inhibition by Ca2+/CaM.

249 well tolerated by olfactory and retinal rod CNG channels.

250 and CNGB1 (the modulatory subunit of the rod CNG channel) with the low buoyant density, caveolin-1-en

251 Similar to rod CNG channels, lavendustin A prevented this regulation, s

252 cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptor cells.

253 model, oligonucleotides of general sequence (CNG)(n), where N = A, C, G, or T and n = 4, 5, 10, 15, o

254 genomes possessing triplet repeat sequences, CNG, where N = A, C, G, or T.

255 e excitatory Cl- current amplifies the small CNG current and crucially depends on a high intracellula

256 An analogous His residue present in some CNG channels is an inhibitory cation binding site.

257 er a novel role for the CNG channel subunit, CNG-3, in short term adaptation.

258 Every subunit in a tetrameric CNG channel contains a cytoplasmic ligand-binding domain

259 , we built a 3D model of the cone tetrameric CNG channel, based on homology to two distinct templates

260 rectly enhance the opening of the tetrameric CNG and HCN channels, although the mechanism remains unc

261 We conclude that CNG-modulin is the authentic Ca(2+)-dependent modulator

262 We demonstrate that CNG-3 is required in the AWC for adaptation to short (th

263 emistry and single-cell PCR demonstrate that CNG-modulin is expressed in cone but not rod photorecept

264 We also provide in vivo data suggesting that CNG-3 forms a complex with both TAX-2 and TAX-4 CNG chan

265 ork direction through the repeats such that (CNG)n hairpin-like structures form, causing DNA polymera

266 The CNG technique is particularly suitable for capturing dyn

267 hile almost all the particles emitted by the CNG buses were in the nanoparticle size range, at least

268 educing the CNG current by desensitizing the CNG channel via Ca(2+)/calmodulin (CaM), to reduce the r

269 thin discrete complexes separated during the CNG run.

270 Here we uncover a novel role for the CNG channel subunit, CNG-3, in short term adaptation.

271 ributed to air quality improvements from the CNG conversion policy in 2010, resulting in a saving of

272 The organics emitted from the CNG-fueled buses were clearly less oxidized compared to

273 In the CNG series, the associated genotypes divided the familie

274 subunit-dependent ciliary trafficking of the CNG channel and offer insight into the mechanisms of cil

275 removal by NCKX4, and desensitization of the CNG channel by Ca(2+)/CaM, interact to regulate the olfa

276 sed, and pheromones elicit activation of the CNG channel leading to Ca2+ gating of TRPM5.

277 to determine the spatial distribution of the CNG channels along the ciliary length.

278 sequence-similarity to the TM domains of the CNG channels, and to reconcile conflicts between the two

279 pathway, which includes the kinetics of the CNG channels, the concentration of Ca ions flowing throu

280 , appears to express a small fraction of the CNG channels, whereas the distal segment contains the ma

281 the air quality and climate benefits of the CNG conversion policy, including monetary valuations, th

282 ative to the silent transgenes at all of the CNG sites monitored within the transgene promoter.

283 ilitate the formation and performance of the CNG system.

284 through mechanisms that include reducing the CNG current by desensitizing the CNG channel via Ca(2+)/

285 The mimics faithfully represent the CNG channels they are modeled after, permeate Na(+) and

286 y transiently perturbed, suggesting that the CNG channel may not be the sole target of cAMP.

287 We demonstrate here that the CNG technique is capable of resolving a complex of RNA p

288 Ca(2+) influx through the CNG channel in turn activates a Ca(2+)-activated Cl(-) c

289 uter segments, coimmunoprecipitated with the CNG channel, and bound to the C-terminal domain of the c

290 ed in OSNs and interacts in complex with the CNG channel.

291 There, CNG channels are gated by the second messengers of the v

292 Furthermore, this CNG electrophoresis can be conveniently coupled to secon

293 al gas, which is advantageous as compared to CNG and LNG in terms of safety and also in terms of temp

294 ion with calmodulin (CaM), binds directly to CNG channels.

295 Similar to CNG and HCN channels, EAG and ERG channels contain a cyc

296 ased fuels currently used in these vehicles, CNG and centrally produced LNG increase emissions by 0-3

297 stress in cone degeneration associated with CNG channel deficiency.

298 mouse retina, we generated mouse lines with CNG channel deficiency on a cone-dominant background, i.

299 Within CNG channel tetramers, specific subunit interactions als

300 gher microvessel density than tumors without CNGs.