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1 ural activity and its implication for neural codes.
2 ssification of Diseases 9th or 10th Revision codes.
3 national Classification of Diseases, billing codes.
4 h Revision, Clinical Modification (ICD-9-CM) codes.
5 f Federal Regulations, and state legislative codes.
6 re Economic Research Service Urban Influence Codes.
7 tences on both speech recognition and neural coding.
8 ed on stimulus features) interact in sensory coding.
9 mpal representations and support prospective coding.
10 fication of Diseases, Ninth Revision [ICD-9] codes 295, 297 and 298, except 298A and 298B) and narrow
11 eases, Ninth Revision, Clinical Modification codes 299.0, 299.8, or 299.9 recorded in Kaiser Permanen
12 Classification of Diseases-Ninth Revision-CM codes 35.05 and 35.06) between January and November 2013
13 structure, which in turn improves population-coding abilities.
14 the thiol-redox proteomic technique, isotope-coded affinity tag labeling, to quantify the extent of N
15 alled SNOxICAT (S-nitrosothiol redox isotope-coded affinity tag), we found that exposure to NO2(-) un
16                 A common variant (rs1619661; coded allele: T) significantly modified the QT-PM10 asso
17 subjects failed to identify any large-effect coding alleles of lower frequency influencing the risk o
18            In silico analysis indicated that coding amino acids encoded at these three SNP sites were
19 e large, generalist, motile species, such as cod and haddock.
20 noses were identified using Medicare billing codes and categorized as nonmelanoma skin cancer (NMSC),
21 l Classification of Diseases, Ninth Revision codes and clinical data.
22 strate their active participation in spatial coding and contextual representation.
23  UTRs, and introns), while being depleted in coding and intergenic regions, and these findings may ha
24  were G:C to A:T, their distribution between coding and non-coding regions and synonymous-to-non-syno
25               For somatic point mutations in coding and non-coding regions of the genome, we propose
26          Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite
27                We describe new mechanisms of coding and noncoding alteration and identify ten recurre
28 g to take shape, but it's clear that in both coding and noncoding RNAs, dynamic modifications represe
29                                 We sequenced coding and regulatory elements for 608 genes potentially
30 , which could lead to alterations in sensory coding and taste-related behaviors.
31 lective accumulation of rare variants in the coding and the UTR sequences within the genes of suicide
32 on in stress granules correlates with longer coding and UTR regions and poor translatability.
33 ort, medical record billing codes, procedure codes, and death records.
34 15% redundant indels in dbSNP, 29% in COSMIC coding, and 13% in COSMIC noncoding datasets across all
35 undant indels in dbSNP; 2,118 more in COSMIC coding, and 553 more in COSMIC noncoding indel dataset i
36                                      The non-coding ASCC3 isoform counteracts the function of the pro
37 otably, this includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the
38     We show that the introgression of Bcl-xL-coding Bcl2l1 transgene into NF-kappaB signalling-defici
39  light emitting diodes, solar cells, optical codes, biomedicine and so on.
40 BX1, which colocalizes with the EMSY protein coded by C11orf30.
41 icted "noncoding RNAs" to conventional mRNAs coded by protein-coding genes.
42 by out-of-field excitation enhances temporal coding by expanding the range of theta phase precession.
43 ens concerns the acute regulation of sensory coding by the auditory cortex as demonstrated by electro
44 olfactory sensory neurons increases the odor-coding capacity, providing a means of efficient sensory
45 n with data; development of a coding scheme; coding, charting and cross comparison of data; interpret
46 ies such deaths by assigning them diagnostic codes corresponding to "legal intervention" in accordanc
47 ribution of NMDAR hypofunction to predictive coding deficits in schizophrenia.
48 nvirus genome harbors 465 genes, with a high coding density.
49 ggest diagnostic, procedure, and therapeutic codes derived from insurance billing claims accurately r
50 been suggested that social prediction errors-coding discrepancies between the predicted and actual ou
51 ion study (GWAS) risk variants reside in non-coding DNA sequences.
52                                          Non-coding DNA variants are suspected to account for a subst
53 Here, we develop a statistically founded non-coding driver-detection method, ncdDetect, which include
54 thogonal AP firing, which may support sparse coding during hippocampal information processing.
55 n of NMDARs causes dysfunction in predictive coding during vocalization in a manner similar to the dy
56 he NMDAR antagonist, ketamine, on predictive coding during vocalization in healthy volunteers and com
57 udies, however, have shown that neural value coding dynamically adapts to the statistics of the recen
58 analyses of a spatially resolved data set on cod eggs covering a period (1959-1993) with large change
59 s of this model predict that sparse assembly codes emerge in this microcircuit motif under spike timi
60 ative splicing (AS) that occurs at the final coding exon (exon 47) of the Cav2.1 voltage-gated calciu
61 ted Health Problems, Tenth Revision [ICD-10] codes F20 to F29 and International Classification of Dis
62 ults and highlight the importance of neurons coding feature values for parallel learning of values fo
63                                 Single units coded for diverse conjunctions of variables, with differ
64 mbination evolve between a target locus that codes for a seasonally selected trait and a plasticity m
65 RC1, activates transcription of Sall4, which codes for a transcription factor essential for subsequen
66 e of five diagnosis codes plus two treatment codes for any skin-directed therapy were likely to accur
67 eases, Ninth Revision, Clinical Modification codes for each hospitalization.
68 orm allows the generation of binary temporal codes for efficient data encoding.
69                                     Only the codes for infrequently used B-scan ultrasonography (PPV,
70                      The Epulopiscium genome codes for many of the conserved positional guide protein
71 embly of RNAP, E. coli mutants lacking rpoZ (codes for omega) are viable due to the association of RN
72 ve sensory information, while frontal cortex codes for prospective action.
73 heories positing that parietal cortex mainly codes for retrospective sensory information, while front
74 t identification of the blaOXA48 gene, which codes for the carbapenemase OXA-48, in lysate samples fr
75 ases were identified using glaucoma surgical codes for trabeculectomy, complicated trabeculectomy, gl
76  missense mutations in the RPS23 gene, which codes for uS12, are reported in two unrelated individual
77 terpenes express, at very high levels, genes coding for a unique pair of ferredoxin and ferredoxin-NA
78  the supply of full-length, functional mRNAs coding for a variety of proteins essential to cell growt
79 it is not surprising that mutations in genes coding for components of the ubiquitin system cause immu
80 inants, the strain over-expressing zwf gene (coding for glucose-6-phosphate dehydrogenase), WX-zwf, p
81                            However, the gene coding for hexokinase-2, which catalyzes the first step
82                                     The gene coding for middle T antigen (MT) is the murine polyomavi
83 hat under favourable growth conditions mRNAs coding for proteins involved in the translation machiner
84 hat these gram-negative bacteria carry genes coding for thiol-disulfide oxidoreductases in their geno
85 events based on primary discharge diagnostic codes from hospital admissions in NYS.
86  recently emerging features that distinguish coding from noncoding transcription and discuss how thes
87                                Rare missense coding FYCO1 variants were present in 11.3% of sIBM pati
88  and ecologically important fishes, Atlantic cod (Gadus morhua) and haddock (Melanogrammus aeglefinus
89  subsequent medieval (1066-1280 CE) Atlantic cod (Gadus morhua) specimens from excavation sites in Ge
90               We also report a novel protein-coding gene evolution-D6Ertd527e-in which an MT LTR prov
91 he lncRNA, its binding protein MYH9, and the coding gene FOXE1 underlies the predisposition to PTC tr
92 the neighboring transcription of the protein-coding gene SLC3A2 in cis by binding the Mediator comple
93 encompassing the 3' end of the delta protein-coding gene.
94       The four mt genomes contain 12 protein-coding genes (viz.
95 long inverted repeat with one or two protein-coding genes and conserved non-coding regions putatively
96 on of extracellular matrix remodeling-enzyme coding genes and increased levels of some of their inhib
97 lymerase II (pol II) transcribes all protein-coding genes and many noncoding RNAs.
98 bio-annotations of both high-quality protein coding genes and ncRNAs, we considered the associations
99 functional interrogation of not only protein-coding genes but also noncoding DNA.
100 historical focus on transcription of protein-coding genes has left the roles of Pol III in organismal
101        Transcriptional regulation of protein-coding genes is a major mechanism of controlling cellula
102 s adaptability, as many mutations in protein-coding genes occurred during the outbreak.
103 ts shifts the steady-state output of protein-coding genes toward circular RNAs.
104 ximately one-quarter of A. baumannii protein coding genes were differentially expressed in vivo compa
105  mRNAs, which consisted of 17 unique protein-coding genes yielding a 17-gene signature.
106  this study, we highlight that together with coding genes, (antisense) long non-coding RNAs are dereg
107         Each mitogenome contained 13 protein coding genes, 2 ribosomal RNA and 22 transfer RNA genes,
108 expressed, annotated genes, 78 novel protein-coding genes, and 567 putative long intergenic noncoding
109 al information for almost 80 million protein-coding genes, including a comprehensive set of general a
110 l proportion of the reads mapping to protein-coding genes, long ncRNAs, and antisense RNAs were due t
111 ly through eliminating non-essential protein coding genes, rDNA and LTRs.
112 8) in 1,354 significantly identified protein-coding genes, with skipped exon and alternative first ex
113 e observed for all but 265 annotated protein-coding genes.
114 litates transcription termination at protein-coding genes.
115 RNAs" to conventional mRNAs coded by protein-coding genes.
116 and even supporting evolution of new protein-coding genes.
117 exons is found to be extensive among protein coding genes: 23.5%-59.3% (95% confidence interval) of h
118 and the mechanisms by which variation in non-coding genetic sequences contributes to disease.
119 urons helps functional interpretation of non-coding genetic variants associated with these diseases.
120 improve the functional interpretation of non-coding genetic variants in the molecular genetic dissect
121  predict pathogenicity of synonymous and non-coding genetic variants, and provide a web server of pre
122 and extends potential involvement of the non-coding genome in its pathogenesis.
123 entified sequence variants, localized to non-coding genomic regions, associated with kidney function.
124 , the proposed combination of revenue center codes had 94.6% sensitivity (95% CI, 94.3-94.9%) and 96.
125 s of voltage- and calcium-gated ion channels coded in NEURON to 211 clusters.
126 h as those that use high-dimensional quantum codes in a modular architecture, have potential benefits
127 ed patients who take TOAMs via National Drug Codes in Part D claims.
128 rom International Classification of Diseases codes in Sweden.
129 cts of noise, motivating the search for such codes in the brain.
130 activity on spatial learning and hippocampal coding in a plus maze task that requires both structures
131 ontal cortex are involved in vibrotactile WM coding in humans.
132 igh-dimensional rsc structure on information coding in the neuronal ensembles.
133   Our results support the argument that odor coding in the olfactory bulb depends on the recent histo
134 an provide powerful insights into population coding in touch.
135 nonsense and three missense changes) and two coding indels, one of them found in two unrelated patien
136 The two primary theories of peripheral pitch coding involve stimulus-driven spike timing, or phase lo
137 ately 300 nanoparticles from (Bu4N)5Na3[(1,5-COD)Ir.P2W15Nb3O62] (abbreviated hereafter as (COD)Ir.PO
138 D)Ir.P2W15Nb3O62] (abbreviated hereafter as (COD)Ir.POM(8-), where POM(9-) = the polyoxometalate, P2W
139 form counteracts the function of the protein-coding isoform, indicating crosstalk between them.
140                          Exchange of the 1,3-COD ligand by PMe3 led to [Si(II)(Xant)Si(II)]Ni(PMe3)2,
141  approach identified two long intergenic non-coding(linc)RNAs, lincRNA-Cox2 and lincRNA-AK170409, tha
142 ime, that of vitamin A, naturally present in cod liver oil.
143 ow attenuation on VNCa images by using color-coded maps and performed a quantitative analysis of CT n
144                     This fundamental sensory coding mechanism facilitates spatial discrimination and
145 des a comprehensive picture of the olfactory coding mechanisms of bed bugs that will ultimately contr
146 As but have also recently been identified in coding (messenger) RNAs as well.
147 sory representation, but also its underlying coding metric.
148 peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (D
149                  We propose that similar DNA codes might be used to confer multiple regulatory functi
150  may be closely related to mixture of sparse coding models.
151                               Over 4 million coding mutations are described in v78 (September 2016),
152                      The extent to which non-coding mutations contribute to Mendelian disease is a ma
153 tification of causal variants has discovered coding mutations in some AD-associated genes, a lot of r
154  individuals with inherited loss-of-function coding mutations in TERT or poly(A)-specific ribonucleas
155        In summary, WES identified sixty-five coding mutations including forty-three mutations not rep
156 stinguishing fillets and patties of Atlantic cod (n=80) from those of haddock (n=90), in comparison w
157  comparison, the NO2(-) spiked cultures with COD:N = 4:1 showed significantly higher (p = 0.028) N2O
158 atch cultures under four conditions: initial COD:N ratios of 11:1 and 4:1 with and without nitrite sp
159 responsible for inhibiting expression of the coding NDC80 mRNA isoform.
160  pair of the genome that may be transcribed: coding, noncoding, and intergenic regions, as well as re
161 t, we characterized the unique expression of coding, noncoding, and intergenic RNAs in the mature mou
162 of different transcript types (i.e., protein coding, noncoding, and pseudogenes) was associated with
163 ciation was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293,
164 educes the peripheral temporal resolution in coding odor stimuli and allows for robust olfactory beha
165 t demand that clinicians sacrifice their own codes of conduct out of cultural respect.
166 s by forbidding judgment on foreign societal codes of conduct.
167      Understanding representations of neural codes of hippocampal-neocortical networks during sleep w
168 rtical responses, adult patterns in cortical coding of binaural timing cues were measured.
169 tional separation reveals action-independent coding of declarative memory-based familiarity and confi
170 uning of neural activity and impaired sparse coding of information, and deficits in the temporal tuni
171                                              Coding of itch versus pain has been heatedly debated for
172                                 Fine-grained coding of location is thought to depend on the hippocamp
173 re, we demonstrate sexually dimorphic neural coding of odorants by olfactory sensory neurons (OSNs),
174 zed by an iridium complex generated from [Ir(COD)OMe]2 and chiral dinitrogen ligands that we recently
175 few studies have addressed the issue of odor coding on top of continuous odorous backgrounds.
176 ome sequencing did not reveal any pathogenic coding or canonical splicing mutations within the linkag
177 splayed a positive correlation with the anti-cod PAV polyclonal antibody, but no correlation with the
178 We found that at least one of five diagnosis codes plus two treatment codes for any skin-directed the
179            Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may pred
180 ICANCE STATEMENT The integrin beta3 Leu33Pro coding polymorphism has been associated with autism spec
181                                    The ITGB3 coding polymorphism Leu33Pro (rs5918, Pl(A2)) produces h
182 ntrachromosomal rearrangements fusing the 3' coding portion of the EGFR gene to the 5'-UTR of the SEC
183 pected large proportion of NATs with protein coding potential, as estimated by ribosome release score
184                Thus, we hypothesize that the coding principle of facial features in the middle patch
185 based on self-report, medical record billing codes, procedure codes, and death records.
186                     Theories like predictive coding propose that lower-order brain areas compare thei
187 t extends 13 nucleotides into the N-terminal coding region and, when a mRNA structure overlaps or par
188 ition gene, while the analysis of the entire coding region of the FANCM gene in familial index cases
189 ion of any intergenic or deeply intronic non-coding region, indicating that proximal regulatory seque
190 in RNA (shRNA) targeted against the reporter coding region, we have characterized the dynamics of the
191 le small open reading frames upstream of the coding region.
192  and a shorter construct containing only the coding region.
193             RNAs with 3' ends within protein-coding regions and introns were less stable than mRNAs t
194 T, their distribution between coding and non-coding regions and synonymous-to-non-synonymous mutation
195 ed a greater contribution of SNPs in protein-coding regions and within 3'-UTR regions of genes.
196                     However, because protein-coding regions are under high selective constraints, the
197 odel specifically studies the effects of non-coding regions of DNA (in this case, CpG sites) on mappi
198 or somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an inte
199 r two protein-coding genes and conserved non-coding regions putatively involved in replication and/or
200 e show that editing levels in non-repetitive coding regions vary more between tissues than editing le
201 outside of functionally well-defined protein coding regions.
202 tely predict all or even most of the protein-coding regions.
203 mutations occur at similar frequencies as in coding regions.
204 terious genomic variation, especially in non-coding regulatory regions of human genome.
205  whole-exome sequencing, and variants in non-coding regulatory regions.
206 ngs show the importance of investigating non-coding regulatory variants when determining risk factors
207 ments are transformed into meaningful memory codes relies on the ability to integrate them with exist
208 with the expression of an antisense long non-coding RNA (lncRNA) that has previously been shown to pr
209 ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibitio
210                      Furthermore, a long non-coding RNA antisense to FOXM1 (FOXM1-AS) promotes the in
211 ps among RNAs for mutation detection and non-coding RNA classification.
212 tional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100
213  the complex, underscoring its role as a non-coding RNA processing/degradation unit.
214  a chromatin environment that influences non-coding RNA production, DNA methylation, and transcriptio
215             MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have roles in
216 racterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-restr
217 genomic output is transcribed as non-protein coding RNA, <2% of the protein data bank structures comp
218          To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered thro
219  transcription of a wide variety of long non-coding RNAs (lncRNAs) in the genomes of several organism
220         New evidence indicates that long non-coding RNAs (lncRNAs) play crucial roles in epigenetic a
221                            Although long non-coding RNAs (lncRNAs) regulate various cellular events,
222 have vastly expanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary conserva
223  small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo trans-splicing and polyad
224 r, we identify multiple neurite-targeted non-coding RNAs and RNA-binding proteins with potential regu
225 ther with coding genes, (antisense) long non-coding RNAs are deregulated in skin tissue of systemic s
226  might be attributed to the hypothetical non-coding RNAs embedded within the gene.
227 PIWI-interacting RNAs (piRNAs) are small non-coding RNAs essential for animal germ cell development.
228                      Various families of non-coding RNAs have been identified as substrates of the co
229 raconserved regions (T-UCRs) encode long non-coding RNAs implicated in human carcinogenesis.
230 utant are correlated with changes in the non-coding RNAs produced by Pol IV and Pol V.
231          In trypanosomes, all mRNAs, and non-coding RNAs such as small nucleolar RNAs (snoRNAs) and l
232 6-30-nucleotide germ line-specific small non-coding RNAs that have evolutionarily conserved function
233            MicroRNAs (miRNAs) are small, non-coding RNAs that play critical roles in the post-transcr
234            Recently, site-specific small non-coding RNAs, also termed DNA damage response RNAs (DDRNA
235     The NtcA regulon also included eight non-coding RNAs, of which Ncr1071, Syr6 and NsiR7 were exper
236  bias transcription toward coding versus non-coding RNAs.
237 for the quality control of mitochondrial non-coding RNAs.
238 s to the analysis of sleep-associated neural codes (SANCs).
239 ction measures and a manualised consultation-coding scheme were used.
240  familiarisation with data; development of a coding scheme; coding, charting and cross comparison of
241  evolutionarily plastic both at the level of coding sequence and expression across A. thaliana access
242 al start codon while the bulk of the protein-coding sequence evolved through a CAG repeat expansion.
243  analyzed the genetic variation in the FOXP2 coding sequence in 63 chimpanzees, 11 bonobos, 48 gorill
244                              Each gene has a coding sequence insertion/deletion mutation within the S
245 l II into transcriptional elongation) to the coding sequence of an active gene, ADH1, independently o
246 nce to missense variation within the protein-coding sequence of genes.
247 ion because overexpression of a noncleavable coding sequence of MYB83 significantly increased plant s
248 ion of an mRNA, despite carrying a canonical coding sequence, can directly cause gene repression.
249               Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated qual
250 ity and/or translation, while changes in the coding sequences lead to mRNAs encoding distinct protein
251 nor the implications of DTU on their protein coding sequences or functions, are currently well unders
252 r have largely focused on genes, whereas non-coding sequences remain relatively unexplored.
253             Further analysis of the AraEXLB8 coding sequences showed high conservation across the Ara
254 fected by recurrent mutations disrupting non-coding sequences was similar to that affected by recurre
255 including density of ribosomal footprints on coding sequences, 5' leader ribosomal densities, distrib
256 l densities, distribution of ribosomes along coding sequences, and ribosome codon occupancies.
257 ty patterns and coverage similarities across coding sequences, and showed that they yield comparable
258 ally, Rho promotes termination at the end of coding sequences, but it can also terminate transcriptio
259 y activating transcription, altering protein-coding sequences, producing noncoding RNAs, and even sup
260                    To remove rRNA and enrich coding sequences, subtractive hybridization procedures h
261 r to that affected by recurrent mutations to coding sequences.
262 create in-frame and frameshift insertions in coding sequences.
263 l tool for the genome-wide detection of AARS coding sequences.
264 rent 3' untranslated regions (3'UTRs) and/or coding sequences.
265 her, these results indicate a functional non-coding SNP in EPHA2 promoter affects PAX2 binding and re
266 te loss-of-function effects of multiple rare coding SNVs found in SCZ subjects in the GIT1 (G protein
267                                   Predictive coding suggests that the brain infers the causes of its
268 approach is also suggestive in many cases of coding techniques that can approach fundamental limits i
269  sum, the decline in the ecological role for cod that began with overfishing in this ecosystem will l
270 tified brain regions support action category codes that are important for action recognition and acti
271  frontal cortex that exhibit action category codes that are similar across viewing of dynamic videos
272 atterns of persistent activity, it might use codes that minimize the effects of noise, motivating the
273 s are accounted for by a model of numerosity coding that has been used to explain neural responses in
274 ntity in propagated calls relies on a neural coding that is robust to intensity changes, signals' qua
275 o the raw data were masked to study group by coding the groups until after the analyses were complete
276 eristics of a proposed set of revenue center codes to correctly identify ICU stays among hospitalized
277 seases, Ninth Revision-Clinical Modification codes to identify patients primarily admitted for EH (n
278 comes Study (CANTOS) used computer-generated codes to randomly allocate 10 061 men and women with a h
279 the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on tran
280 also monitored the behaviors of X-linked non-coding transcripts before and after XCI.
281 satellite array produces a unique set of non-coding transcripts, and RNAs present at active centromer
282 as integrated into a needle to receive Golay-coded transmissions from the probe and these data were p
283  of MFC reward signaling have inferred value coding upon temporally sustained activity during the per
284     Validating the accuracy of billing claim codes used during the care of diabetic retinopathy is a
285 ently, a novel partial loss-of-function AKT2 coding variant (p.Pro50Thr) was identified that is nearl
286 d fine-mapping analyses identified a protein-coding variant, rs4788863 in SLC16A5, that was associate
287 n the Hutterites suggest that these rare non-coding variants are likely to mediate their effects on l
288 mulants inhibit DA reuptake and multiple DAT coding variants have been reported in patients with neur
289                             We identified 14 coding variants in 13 genes, of which 8 variants were in
290                                              Coding variants in the APOL1 gene are associated with ki
291 lated genetic risk factors for AD, including coding variants in the gene TREM2 (triggering receptor e
292                              Among these non-coding variants, somatic insertions are among the least
293  analyzed and replicated genome-wide protein coding variation in a total of 8,227 individuals with T2
294 ensive assessment of the consequences of non-coding variation.
295 tivity between this region and general value coding ventromedial prefrontal cortex (vmPFC) predicted
296 ed by evolution to bias transcription toward coding versus non-coding RNAs.
297                       The Gini index for zip codes was divided into quartiles for low, low-middle, hi
298 ata indicated that multiple counties and ZIP codes were affected.
299                                    Procedure codes were used to determine the either an open approach
300 sification of Disease, 9th and 10th Revision codes, who were assessed between the years 1991-2016 and

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