ライフサイエンスコーパス: COMT

1 COMT activity can also be regulated pharmacologically by

2 COMT activity specifically alters long-latency component

3 COMT and COMT-like genes were clustering with few flavon

4 COMT genetic overactivity produced a selective overdrive

5 COMT genotype did not predict hits or d'.

6 COMT genotype was not related to working memory in this

7 COMT is a bifunctional phenylpropanoid O-methyltransfera

8 COMT is a druggable biological target for the treatment

9 COMT selectively and reversibly modulated the recall of

10 COMT Val158Met genotype data were also obtained from chi

11 COMT-Val-tg mice displayed increased N40 latency and dec

12 irty-four COMT Met(158)Met (Met-COMT) and 33 COMT Val(158)Val (Val-COMT) men were given a single 200-

13 cused on the development of centrally active COMT inhibitors, which can be valuable assets for neurol

14 o determine the effects of the high-activity COMT allele on electrophysiological markers, including t

15 ect not found in subjects with high-activity COMT diplotypes (hazard ratio = 1.42; 95% confidence lim

16 The high-activity COMT genotype in ADHD is associated with antisocial beha

17 hermore, smokers who carry the high-activity COMT-Val allele are more prone to cognitive deficits and

18 TMD incidence in subjects with low-activity COMT diplotypes (hazard ratio = 2.35; 95% confidence lim

19 with COMT diplotypes coding for low-activity COMT, signifying impaired catabolism of catecholamines.

20 ore developed a novel mouse model of altered COMT activity.

21 restored normal event-related activity among COMT-Val-tg mice, suggesting one mechanism through which

22 ciated with disease duration (P = 0.02), and COMT rs6267 T allele (P < 0.01).

23 Span Q = 0.006; Block Design Q = 0.076), and COMT (Behavioral Assessment System for Children-2 Attent

24 .65, 95% CI: 0.53-0.79, P=1.81 x 10(-5)) and COMT rs4680 (Val (G) allele: OR=1.27, 95% CI: 1.14-1.42,

25 ) and in 18 metabolites between C57BL/6J and COMT(-/-) mice (p < 0.05).

26 best predicted by fractional anisotropy and COMT genotype.

27 nd epistasis between the same AKT1, BDNF and COMT functional variants on schizophrenia risk, and phar

28 is with functional polymorphisms in BDNF and COMT--genes also implicated in MTL biology related to AK

29 distribution, and the expression of COMT and COMT-like genes suggest that they have evolved different

30 COMT and COMT-like genes were clustering with few flavonoid and m

31 ergic signaling: DRD2, DRD3, DRD4, DAT1, and COMT.

32 We concluded that depression and COMT rs4680 "GG" and "GA" genotypes and COMT rs6267 "GT"

33 lly significant interaction of diagnosis and COMT genotype was observed, such that schizophrenia hete

34 and COMT rs4680 "GG" and "GA" genotypes and COMT rs6267 "GT" genotype contribute to pain in PD patie

35 um, BDNF Val66Met for CA4/dentate gyrus, and COMT Val158Met for CA2/3 volume changes.

36 g that overall, females outperform males and COMT knockout males outperform their wild-type littermat

37 with respect to other olfactory measures and COMT haplotypes is warranted.

38 infants with NAS, variants in the OPRM1 and COMT genes were associated with a shorter length of hosp

39 046, ERbeta rs1256049, ERbeta rs4986938, and COMT rs4680) among 702 Singapore Chinese female lung can

40 food-restriction condition enhanced sex and COMT differences, revealing that overall, females outper

41 ple regression to examine effects of sex and COMT genotype on N-Back hits, false positives, discrimin

42 manipulations revealed a variety of sex- and COMT-dependent effects.

43 These findings illuminate complex sex- and COMT-related effects and their interactions with environ

44 action between prenatal maternal smoking and COMT Val(158)Met in conduct problems and crime in the 19

45 To functionally assess COMT inactivation of vesicular release of DA we used fas

46 ings are of translational relevance, because COMT inhibitors are used in the adjunctive treatment of

47 vidence was found for an association between COMT genotypes and conduct scores or for an interaction

48 There was no association between COMT genotypes and events or interaction between COMT ge

49 us of depression and the association between COMT rs6267 "GT" genotype and pain severity remained sig

50 on region, and possible associations between COMT variants and neuropsychiatric manifestations in 22q

51 a nominally significant interaction between COMT and sex on false positives, but this was not in the

52 genotypes and events or interaction between COMT genotypes and HVAL concentrations.We report, for th

53 nificantly mediated the relationship between COMT genotype and inhibitory proficiency as indexed by s

54 t time demonstrate an interaction of BDNF by COMT on human cortical plasticity.

55 ivity of children with ADHD was modulated by COMT polymorphism, with Met-carriers exhibiting signific

56 y can also be regulated pharmacologically by COMT inhibitors.

57 ever, despite the established role played by COMT genetic variation in executive functions, its impac

58 ferences in WM performance were predicted by COMT val(158)met status.

59 o of three brown midrib12 mutants that carry COMT gene missense mutations, we determined the apo-form

60 potent inhibition of peripheral and cerebral COMT within the nanomolar range.

61 UFV2, RAB18, as well as ADCYAP1, BDNF, CNR1, COMT, DRD2, DTNBP1, GAD1, GRIA1, GRIN2B, HTR2A, NRG1, RE

62 There are three common COMT haplotypes in the human population reported to have

63 small low nanomolar potent, SAM competitive COMT inhibitors are reported.

64 ey demonstrate the importance of considering COMT genotype when examining the therapeutic potential o

65 pes in Native Americans include OPRM1, CRN1, COMT, GABRA2, MAOA, and HTR3-B.

66 Current COMT inhibitors carry a high risk for toxic effects to h

67 nts were selected from the DRD2, DRD3, DAT1, COMT, DDC, GRIN2B, ADRA2C, SERT, TPH2, HTR2A, OPRK1 and

68 viduals who carried a larger number of DAT1, COMT, DRD2, and DRD4 alleles associated with higher DA t

69 chronically-curtailed sleep and demonstrate COMT-related treatment responses and risk factors for sy

70 ing approach to discover noncatechol derived COMT inhibitors which bind at the SAM binding pocket.

71 Genotyped DNA from blood samples determined COMT diplotypes.

72 immersion varied in subjects with different COMT genotypes.

73 For CpG sites at genes of the dopaminergic (COMT, ANKK1) and the neurotrophic (BDNF, NGFR) system, a

74 netic mutation reducing expression of either COMT or DTNBP1 alone produced working memory advantages,

75 indicate that the OB preferentially employs COMT enzymatic inactivation of vesicular release of DA.

76 ine receptor DRD4 48 bp VNTR, and the enzyme COMT SNP rs4680.

77 sured the amount of the DA breakdown enzyme, COMT, present in the OB.

78 Here we examine COMT in relation to N-Back working memory task performan

79 didate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1).

80 3, BDNF, SLC6A4, CSNK1E, SLC6A2, DRD2, FAAH, COMT, OPRM1).

81 isease and related disorders: (i) rs4680 for COMT Val158Met polymorphism; (ii) rs9468 for MAPT H1 ver

82 We calculated the Kd values for COMT, SAHH, and PRDM2 (24.1 +/- 2.2 muM, 6.0 +/- 2.9 muM

83 Thirty-four COMT Met(158)Met (Met-COMT) and 33 COMT Val(158)Val (Val

84 iabetic mice with a transplanted kidney from COMT(-/-) mice.

85 genes related to dopamine metabolism (e.g., COMT, DAT1, and AKT1) may moderate the effects of cannab

86 silencing of the non-memory permissive gene COMT in the hippocampus.

87 mice overexpressing the human COMT-Val gene (COMT-Val-tg) present exaggerated remote memories (>50 da

88 Depending on genotype, COMT inhibition can enhance or impair working memory and

89 significantly higher in participants having COMT rs4680 "GG" and "GA" genpotypes than those having "

90 Similar to earlier studies, the heterozygous COMT genotype (Met/Val) showed a synergistic effect with

91 yltransferase (COMT) genotype activity (high COMT compared with low or intermediate COMT genotype act

92 158Met mouse lines, which carry either human COMT Val or Met alleles via gene targeting.

93 uable for understanding the effects of human COMT Val158Met polymorphism on cortical development and

94 ese mice (1) support the argument that human COMT Val158Met polymorphism modulates behavioral functio

95 The human COMT gene is associated with a diverse spectrum of human

96 hat transgenic mice overexpressing the human COMT-Val gene (COMT-Val-tg) present exaggerated remote m

97 mployed transgenic mice expressing the human COMT-Val variant to determine the effects of the high-ac

98 We conclude that active site compaction in COMT is modulated by a proximal side chain residing behi

99 her, we hypothesised that any differences in COMT(-/-) mice would be resolved following treatment wit

100 f variations, such as ethnic differences, in COMT genetic effects on the cortico-cerebellar executive

101 ocol for the BDNF Val/Val vs Met genotype in COMT Met homozygotes only (ANOVA, p = 0.027).

102 could be related to the observed increase in COMT expression.

103 iated effects of functional polymorphisms in COMT, DRD2 and AKT1 genes on prefrontal-parietal and pre

104 (eg, increased spatial novelty preference in COMT-Met mice vs wild-type mice).

105 ormalize the aberrant metabolomic profile in COMT(-/-) mice; as this treatment moves into clinical tr

106 o rescue the altered remote memory recall in COMT-Val-tg mice and increased PFC dopamine levels.

107 There was an approximately 50% reduction in COMT mRNA, protein, and enzyme activity levels in 22q11.

108 ly specific: COMT-Met mice had reductions in COMT abundance and activity, compared with wild-type mic

109 rences in metabolites (p < 0.05) remained in COMT(-/-) mice.

110 odified through complex genetic variation in COMT.

111 izes, these data indicate that variations in COMT val(158)met may predict the nature of WM improvemen

112 tiple neuropsychiatric risk genes, including COMT, IFNG, MIR200B, SYNGAP1, and VIPR2 showed associati

113 Individual COMT SNPs (val158met, rs737865, and rs165599) modulated

114 variants within the COMT gene that influence COMT biology and confound conclusions based on associati

115 a significant interaction of tDCS intensity, COMT genotype, and WM task.

116 (high COMT compared with low or intermediate COMT genotype activity).

117 synapses, the DA catalytic pathway involving COMT predominates over re-uptake in OB.

118 absent soluble COMT expression and very low COMT activity in two 22q11.2DS individuals.

119 forms of COMT proteins, membrane-bound (MB) COMT and soluble (S) COMT.

120 MB-COMT is the main form in the brain.

121 The cellular distribution of MB-COMT in cortical neurons remains unclear and the orienta

122 l that the C-terminal catalytic domain of MB-COMT is in the extracellular space, which suggests that

123 ns remains unclear and the orientation of MB-COMT on the cellular membrane is controversial.

124 Analyses of MB-COMT orientation with computer simulation, flow cytometr

125 extracellular space, which suggests that MB-COMT can inactivate synaptic and extrasynaptic dopamine

126 In this study, we demonstrate that MB-COMT is located in the cell body and in axons and dendri

127 These results suggest that MB-COMT specific inhibitors can be developed and that tolca

128 We measured COMT messenger (m)RNA and protein expression and enzyme

129 lele, DAT1 10-repeat allele, and the Met/Met COMT genotype, and with a greater number of these genoty

130 In the placebo group, Met-COMT subjects outperformed Val-COMT subjects on the 2- b

131 roups: it worsened N-back performance in Met-COMT subjects but enhanced it in Val-COMT subjects.

132 Tolcapone made Met-COMT subjects less risk averse but Val-COMT subjects mor

133 Thirty-four COMT Met(158)Met (Met-COMT) and 33 COMT Val(158)Val (Val-COMT) men were given

134 OO and wine consumption and a high metabolic COMT capacity for methylation are key factors for high H

135 tial of disrupting mitochondrial metabolism (COMT, UFD1L, DGCR8, MRPL40, PRODH, SLC25A1, TXNRD2, T10,

136 ology to the catecholamine methyltransferase COMT that is linked to schizophrenia, cause deafness.

137 Human catechol-O-methyltransferase (COMT) catalyzes a methyl transfer from S-adenosylmethion

138 (F5H) and caffeic acid O-methyltransferase (COMT) from Liquidambar styraciflua confirmed the product

139 rphisms in the catechol-O-methyltransferase (COMT) gene affect the relationship.

140 orphism of the catechol-O-methyltransferase (COMT) gene is an important regulator of dopamine in the

141 58)Met) in the catechol-O-methyltransferase (COMT) gene is associated with changes in executive perfo

142 The catechol-O-methyltransferase (COMT) gene is located in the obligatory deletion region,

143 ariants in the catechol-O-methyltransferase (COMT) gene result in a different catabolism of dopamine

144 articular, the catechol-O-methyltransferase (COMT) gene, located on chromosome 22q11.2, regulates cat

145 158Met) in the catechol-O-methyltransferase (COMT) gene, whose protein product degrades synaptically

146 e (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated with risk for opioid addictio

147 stratified by catechol-O-methyltransferase (COMT) genotype activity (high COMT compared with low or

148 Catechol O-methyltransferase (COMT) inhibitors are an established treatment for end-of

149 Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of

150 Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels

151 phism of human catechol-o-methyltransferase (COMT) is one of the most well-studied single-nucleotide

152 Catechol O-methyltransferase (COMT) is the enzyme responsible for the O-methylation of

153 Catechol-O-methyltransferase (COMT) metabolizes dopamine.

154 Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex

155 Additionally, catechol-O-methyltransferase (COMT) polymorphism has been reported to be associated wi

156 l and HVAL and catechol-O-methyltransferase (COMT) rs4680 genotypes were measured.After multivariable

157 DA [indexed by catechol-O-methyltransferase (COMT) Val(158)Met genotype and, at a finer scale, COMT e

158 ionally taking catechol-O-methyltransferase (COMT) Val158Met and kidney and brain (KIBRA) rs17070145

159 The catechol-O-methyltransferase (COMT) val158met polymorphism has received attention in s

160 c variation in catechol-O-methyltransferase (COMT), a regulatory enzyme that controls dopamine availa

161 Catechol-O-methyltransferase (COMT), an important therapeutic target in the treatment

162 lymorphisms in catechol-O-methyltransferase (COMT), DRD2, and DRD4 were evaluated.

163 s generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a natur

164 , catalyzed by catechol-O-methyltransferase (COMT), is investigated using binding isotope effects (BI

165 nts in a gene, catechol-O-methyltransferase (COMT), regulating catechol neurotransmitter catabolism.

166 1 (CNR1), and catechol-o-methyltransferase (COMT), was strongly associated with overall poor perform

167 the mammalian catechol-O-methyltransferase (COMT), which can effect the sequential hydroxylation of

168 it human liver catechol-O-methyltransferase (COMT)-mediated O-methylation of L-DOPA in vitro, only (+

169 lymorphism for catechol-O-methyltransferase (COMT).

170 olymorphism in catechol-O-methyltransferase (COMT).

171 d/5-hydroxyferulic acid O-methyltransferase (COMT).

172 ydroxylase and catechol-O-methyltransferase (COMT).

173 se [F5H1], caffeic acid O-methyltransferase [COMT], and cinnamyl alcohol dehydrogenase6 [CAD6], two m

174 Compared with wild-type diabetic mice, COMT(-/-) mice had decreased hyperfiltration, decreased

175 transferase from Selaginella moellendorffii, COMT, the coding sequence of which is clustered together

176 ent the first SAM-competitive small-molecule COMT co-complex crystal structure.

177 st in DA terminals, the OB contains 50% more COMT per unit of tissue.

178 Moreover, COMT knockout mice were more impulsive compared with wil

179 allele was introduced into the native mouse COMT gene to produce COMT-Met mice, which were compared

180 8; 95% CI: 1.09-1.48; p = 0.002) but neither COMT genotypes nor the possible interaction between gene

181 New nitrocatechol COMT inhibitors based on naturally occurring caffeic aci

182 um metabolic profiles of pregnant Nos3(-/-), COMT(-/-) and C57BL/6J mice were made using a kit from B

183 d carrying the APOE epsilon4 allele (but not COMT alone, or in combination with the APOE genotype) we

184 pone: performance of wild-type mice, but not COMT-Met mice, was improved on the 5-choice serial react

185 voltammetry and pharmacological blockade of COMT.

186 stry behind the discovery and development of COMT inhibitors; (iii) to discuss how the physicochemica

187 current study was to evaluate the effect of COMT hemizygosity and molecular haplotypes on gene expre

188 Our findings confirm a robust effect of COMT hemizygosity on COMT activity and show complex inte

189 working memory predicts that the effects of COMT inhibition will differ according to COMT genotype.

190 These sexually dimorphic effects of COMT on inhibitory brain activation have important impli

191 Moreover, copy number elevations of COMT or Tbx1 reduced the proliferation of adult neural s

192 ogenetic distribution, and the expression of COMT and COMT-like genes suggest that they have evolved

193 There are two major forms of COMT proteins, membrane-bound (MB) COMT and soluble (S)

194 The frequencies of COMT rs4680 "A" allele were higher in PD patients with p

195 gnals, the authors examined the influence of COMT genotype status on the olfactory processing impairm

196 clic voltammetry, we show that inhibition of COMT increases DA signals approximately 2-fold.

197 ore, a significant (P = 0.04) interaction of COMT diplotype and time-varying stress showed that a pos

198 ymorphism, was associated with low levels of COMT expression and with the presence of psychosis and l

199 als the post-methyl-transfer organization of COMT's catalytic groups with reactant molecules and the

200 when examining the therapeutic potential of COMT inhibitors.

201 : (i) to summarize the physiological role of COMT inhibitors in central and peripheral nervous system

202 Association studies of COMT and working memory in healthy volunteers have yield

203 between various Val-containing haplotypes on COMT-3' untranslated region extended mRNA, soluble COMT

204 firm a robust effect of COMT hemizygosity on COMT activity and show complex interactions of variants

205 estigate the potential effects of smoking on COMT-mediated electrophysiological activity.

206 om inattention by overexpression of OPRD1 or COMT, respectively, as well as a distinct cluster of epi

207 No sex- or COMT-dependent differences were present in the basic acq

208 itive performance in males, and particularly COMT knockout males, but not in females.

209 a single 200-mg dose of the brain-penetrant COMT inhibitor tolcapone or placebo in a randomized, dou

210 It is possible COMT is not meaningfully associated with working memory

211 compounds represent a novel series of potent COMT inhibitors that might be further optimized to new d

212 d into the native mouse COMT gene to produce COMT-Met mice, which were compared with their wild-type

213 We demonstrate interactions of the proteins COMT and SAHH with SAH-CC with biotin used in conjunctio

214 the physicochemical properties of recognized COMT inhibitors are understood to exert influence over t

215 for the COMT rs4680 Met allele that reduces COMT enzyme activity showed a relatively more efficient

216 llele to assess the hypothesis that reducing COMT enzymatic activity interacts with genotype to incre

217 mechanistic information, regiocomplementary COMT variants were engineered that deliver either meta-

218 doMet are accepted by the regiocomplementary COMT mutants and can be used to prepare alkylated catech

219 e the clinical benefits of the most relevant COMT inhibitors.

220 Rs776746 (CYP3A5), rs2239393 (COMT) and diabetes were the only factors common in both

221 .69; confidence interval: 1.12-2.55), rs4680 COMT (odds ratio (OR): 1.40; confidence interval: 1.04-1

222 ns, membrane-bound (MB) COMT and soluble (S) COMT.

223 ons and then further O-methylated by human S-COMT in the presence of S-[(3)H]adenosyl-l-methionine as

224 It is concluded that human S-COMT may play a critical role in the detoxication of PAH

225 Human S-COMT was able to catalyze O-methylation of all of the PA

226 nant soluble catechol-O-methyltransferase (S-COMT) is a feasible detoxication step for a panel of str

227 The ability of S-COMT to produce two isomeric products from PAH-catechols

228 perenne) and dicot alfalfa (Medicago sativa) COMTs.

229 Val(158)Met genotype and, at a finer scale, COMT enzyme activity].

230 (5CSRTT) to investigate the effects of sex, COMT genotype, and their interactions with environmental

231 d the recall of remote memories as silencing COMT Val overexpression starting from 30 days after the

232 Phylogenetic analysis reveals that Sm COMT, like F5H, evolved independently from its angiosper

233 t model based on five of the candidate SNPs (COMT, NTRK1, ErbB4, CLU, and HFE) explained approximatel

234 " mutation is associated with absent soluble COMT expression and very low COMT activity in two 22q11.

235 ' untranslated region extended mRNA, soluble COMT and membrane-bound proteins, and enzyme activity.

236 he development of improved and more specific COMT inhibitors.

237 The model proved highly specific: COMT-Met mice had reductions in COMT abundance and activ

238 ally, we examined how the frequently studied COMT Val(158)Met polymorphism interacted with an environ

239 These results demonstrate that COMT genetic variations modulate the retrieval of remote

240 ared with striatum, supporting the idea that COMT enzymatic breakdown, rather than DAT recycling, is

241 e robust; however, despite observations that COMT is estrogenically catabolized, sex differences in i

242 king memory in healthy young adults, or that COMT effects are detectable only in assessments reflecti

243 e Val(158)Met polymorphism, and suggest that COMT's effects are most prominent when the dopamine syst

244 The COMT 158A>G AG/GG genotype was associated with shortened

245 The COMT inhibitor, tolcapone, increased the DA signal appro

246 The COMT rs4680 A allele was positively associated with lung

247 The COMT Val(158)Met polymorphism influences its activity, a

248 The COMT Val158Met polymorphism modulates cortical dopaminer

249 Cortical synaptic dopamine monitored by the COMT Val158Met polymorphism influenced prefrontal contro

250 erved in schizophrenia are influenced by the COMT val158met polymorphism.

251 ad lower E2 levels, while those carrying the COMT Val/Val alleles had higher E2 levels compared to Me

252 ory paradigm, individuals homozygous for the COMT rs4680 Met allele that reduces COMT enzyme activity

253 Individuals were genotyped for the COMT val158met polymorphism.

254 A polymorphism in the COMT gene (rs4680), associated with prefrontal dopaminer

255 unction was indexed by a polymorphism in the COMT gene, differences of which reflect dopamine levels

256 otype at the Val(158)Met polymorphism in the COMT gene.

257 ingle-nucleotide polymorphisms (SNPs) in the COMT, NTRK1, BDNF, ErbB4, CLU, and HFE genes, and invest

258 ingle-nucleotide polymorphisms (SNPs) of the COMT gene and their haplotypes moderate the association

259 ferences emerged after administration of the COMT inhibitor tolcapone: performance of wild-type mice,

260 nts, indicating that the introduction of the COMT overcame the inefficiency of the native pine methyl

261 was associated with hypermethylation of the COMT promoter at a conserved CpG site in exon II.

262 Research on the COMT gene continues to yield interesting findings, inclu

263 CONCLUSIONS/SIGNIFICANCE: The COMT Val158Met polymorphism may be a genetic biomarker f

264 Finally, we show that the COMT inhibitor tolcapone induces cell death via the mech

265 Finally, we demonstrate that the COMT rs74745580 "T" mutation is associated with absent s

266 ved locus of control (LOC), here we used the COMT inhibitor tolcapone in a randomized, double-blind,

267 We assessed whether the COMT Val158Met polymorphism was a novel marker in health

268 complex interactions of variants within the COMT gene that influence COMT biology and confound concl

269 and female wild-type mice ((+/+)) and their COMT knockout littermates ((+/-) and (-/-)) in the five-

270 of COMT inhibition will differ according to COMT genotype.

271 ructure-activity relationships in binding to COMT and the novel off-target HIBCH.

272 this protein is not bound by the less toxic COMT inhibitor entacapone.

273 s of disease, catechol-O-methyl transferase (COMT(-/-)) and endothelial nitric oxide synthase (Nos3(-

274 en two genes--catechol-O-methyl transferase (COMT) and dysbindin (dys; dystrobrevin-binding protein 1

275 ne clearance--catechol-O-methyl transferase (COMT) and two isoforms of monoamine oxidase--modulated d

276 inhibitors of catechol-O-methyl transferase (COMT) for the treatment of Parkinson's disease.

277 E (APOE) and Catechol-O-methyl transferase (COMT) genotypes on estradiol (E2) levels in men (p=0.003

278 ain penetrant catechol-O-methyl transferase (COMT) inhibitor tolcapone [4, 5], we investigated the ca

279 Catecholamine-0-methyl-transferase (COMT) gene variation effects on prefrontal blood oxygena

280 elevations of catechol-O-methyl-transferase (COMT) or Tbx1, two genes encoded in the two small 22q11.

281 catalysis by catechol-O-methyl-transferase (COMT) predominates over DAT re-uptake.

282 We studied catechol-O-methyl-transferase (COMT)(-/-) mice, which have increased renal dopamine pro

283 alytic enzyme catechol-O-methyl-transferase (COMT), but negligible expression of the dopamine transpo

284 Tyrosinase-COMT are shown to provide highly versatile and regiosele

285 ut those with the Met/Met versus the Val/Val COMT genotype showed less middle temporal gyrus activati

286 e Met-COMT subjects less risk averse but Val-COMT subjects more so.

287 in Met-COMT subjects but enhanced it in Val-COMT subjects.

288 bo group, Met-COMT subjects outperformed Val-COMT subjects on the 2- back, and they were more risk av

289 )Met (Met-COMT) and 33 COMT Val(158)Val (Val-COMT) men were given a single 200-mg dose of the brain-p

290 ee well-studied functional genetic variants (COMT Val158Met, BDNF Val66Met, 5-HTTLPR) associated with

291 We found that dopaminergic augmentation via COMT inhibition increased egalitarian tendencies in part

292 is altered in children with ADHD and whether COMT polymorphism is associated with the altered network

293 We found that this was also the case with COMT, but not for other dopaminergic genes.

294 scalation was limited to incident cases with COMT diplotypes coding for low-activity COMT, signifying

295 y is dependent on dosage and correlated with COMT Val/Met genotypes in human lymphoblastoid cells.

296 gyl lignin in TEs, but cotransformation with COMT improved its formation.

297 6 confirmed that the major interactions with COMT were established via the nitrocatechol ring, allowi

298 d to determine whether the effects seen with COMT deficiency were kidney-specific.

299 task relevant genetic factors (e.g., for WM: COMT val(158)met, DAT, BDNF val(66)met).

300 al plasticity, we found a significant BDNF x COMT interaction, showing higher plasticity immediately