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1 ains two breast cancer susceptibility gene 1 COOH terminus (BRCT) motifs, which are present in severa
2 Competition of TNP-ATP binding to the Kir1.1 COOH terminus by MgATP was complex with both Mg(2+) and
5 and encodes a variant protein that carries a COOH terminus different from that of IIp45 due to a fram
6 e single baculovirus iap repeat (BIR) and a -COOH-terminus coiled domain instead of a RING finger.
7 roteolytic activity that liberates the Abeta COOH terminus from the beta-amyloid precursor protein is
9 using antibodies specific for the NH(2) and COOH terminus of Sec61alpha was used to map the location
12 except in their third intracellular loop and COOH terminus, domains thought to be involved in signal
13 se mutations in the NH2 terminus (W236R) and COOH terminus (Y856H) of sMyBP-C have been causally link
15 tion also results in an unmasking of the ARF COOH terminus, suggesting that redistribution disrupts a
17 tein 1 (TopBP1) protein contains eight BRCA1 COOH terminus motifs and shares similarities with Cut5,
18 this single amino acid deletion in the BRCA1 COOH terminus (BRCT) domain affects the function of the
23 monstrate a novel role of the sodium channel COOH terminus structure in the control of channel inacti
26 logenin protein), which contains the charged COOH terminus of the full protein, on the HAP surface.
35 s abolished nucleotide binding to the entire COOH terminus or to the first 49 amino acid residues of
39 e, serine 1244 (Ser(1244)), near the extreme COOH terminus of NR2C, which is phosphorylated by both c
41 and Slo1(QEERL), which differ at the extreme COOH terminus, show markedly different steady-state expr
42 sease-causing mutation truncates the extreme COOH-terminus and induces a closed gating conformation.
43 ignal of synaptotagmin 1 lies at the extreme COOH-terminus of the protein and can function in the abs
44 med to assess the effect of loss of the FLI1 COOH terminus on transcriptional modulation of EWS/FLI1
45 se amyloid peptide Abeta has a heterogeneous COOH terminus, as variants 40 and 42 residues long are f
52 ecretion and to a cell-binding domain at its COOH terminus for receptor-mediated internalization.
54 5/Disc-large/ZO-1 (PDZ)-binding motif at its COOH terminus, the identity of the PDZ domain protein(s)
57 Because FAK function is regulated by its COOH terminus (FAK-CD), we used FAK-CD as a target to id
58 potentially novel interactions involving its COOH terminus as sites for early DNA damage and stress-m
64 d muscle myosin II motor domain fused on its COOH terminus to a thermal stable, fast folding variant
65 VCP is phosphorylated at Ser784 within its COOH terminus, a region previously shown to target VCP t
66 RF NH2-terminus that bound to SYK, or at its COOH-terminus motif that binds to MERLIN, the product of
67 gating enzyme Ubc13 and the ubiquitin ligase COOH terminus of Hsp70 interacting protein (CHIP) as bei
69 The intact RING finger domain at the Mdm2 COOH terminus (amino acids 399-489) was necessary and su
72 agment containing residues 194 to the native COOH terminus at position 319 was solved by x-ray diffra
73 several analyzed motifs present in the NKCC2 COOH terminus, only those required for ER exit and surfa
77 es virus fusion protein at either the NH2 or COOH terminus linked via a four-residue turn sequence (G
79 scent protein (YFP) were fused to the NH2 or COOH terminus of MRAP such that YFP fluorescence could o
80 assettes fused with either NH(2) terminus or COOH terminus of DNA polymerases broaden the salt concen
83 to activation, but whether the palmitoylated COOH terminus participates in signaling, especially when
84 trinsic affinity of PDK-1 for phosphorylated COOH terminus is over an order of magnitude greater than
86 on proteins, and its tyrosine-phosphorylated COOH terminus binds Nck, a host adaptor protein critical
88 G-protein signaling-GAIP-interacting protein COOH terminus (GIPC) is involved in protein trafficking,
90 cells the recombinant 393-amino acid residue COOH terminus of C19ORF5 (C19ORF5C) exhibited four types
93 aC) mice express a protein lacking the Runx2 COOH terminus, which integrates several cell proliferati
98 t activation potential appended to the Stat1 COOH terminus could substitute for the wild-type protein
100 cysteine to the long disordered beta-subunit COOH terminus (betaCT) enabled it to become cross-linked
110 Using a novel antibody directed against the COOH terminus of SUR1 (ABCC8), we show that this K(ATP)
111 inus is highly homologous to Poleta, and the COOH terminus is highly homologous to the S. cerevisiae
112 A direct interaction between F-actin and the COOH terminus of alpha-ENaC was further corroborated by
113 peptide identified by phage display, and the COOH terminus of FAK was detected by in vitro and in viv
115 bonds, which bring the sialylmotifs and the COOH terminus within close proximity, is critical for th
116 s, we conclude that the NH2 terminus and the COOH terminus, as well as the major portion of a large c
117 peptide binding groove is widened around the COOH terminus of the alpha 1 helix, which contains resid
119 evealed the juxtaposition of epitopes at the COOH terminus and near the proline-rich region, and of t
120 wever, extension of the kinase domain at the COOH terminus by inclusion of the 36 residue linker regi
125 n R205A exhibited altered specificity at the COOH terminus of fMLF, with R205A binding fMLF-O-butyl >
127 ingle-chain antibody against EGFRvIII at the COOH terminus of H and containing the marker green fluor
128 unctional nuclear localization signal at the COOH terminus of HIP1, which contributes to the nuclear
130 tion, the presence of the VEDEC motif at the COOH terminus of Slo1 channels is sufficient to confer a
131 ddition of green fluorescence protein at the COOH terminus of ST8Sia IV did not render the enzyme ina
134 other thin filament proteins is found at the COOH terminus of TnI, truncations of the last 19-23 amin
136 essive or individual EC domains fused at the COOH terminus to an Fc domain, were analyzed using a bea
137 pha (1-68) undergoes processing first at the COOH terminus to produce SDF-1alpha 1-67 and then at the
138 he His-tag plus two extra amino acids at the COOH terminus when expressed in Escherichia coli generat
139 ificantly when using a PfR4 truncated at the COOH terminus, suggesting the involvement of COOH-termin
148 Both of these residues are well beyond the COOH terminus predicted previously by two independent st
150 ve form is monomeric and is regulated by the COOH terminus of beta-catenin, which selectively compete
151 In turn, this allows SpoIVB to cleave the COOH terminus of SpoIVFA an event pivotal to activating
154 us mutation in the c-rel region encoding the COOH terminus of c-Rel (c-relDeltaCT/DeltaCT) display ma
157 pe, thus excluding an essential role for the COOH terminus domain of Par-4 in embryogenesis and devel
158 8 mutation truncated three residues from the COOH terminus and resulted in the loss of severing activ
159 -S) and a synthetic peptide derived from the COOH terminus of Galphaq abolished mechanically evoked 5
161 passing amino acid sequence 695-699 from the COOH terminus of the heavy chain of factor Va (Asp-Tyr-A
162 at amino acid region (695)DYDY(698) from the COOH terminus of the heavy chain of factor Va regulates
164 portion between 39 and 51 residues from the COOH terminus of the rat oxytocin receptor is required f
165 yeast two-hybrid screen that identified the COOH terminus of the Hsp70-interacting protein (CHIP) as
167 A, but MEN1 disease-derived mutations in the COOH terminus abolish the ability of menin to bind DNA.
169 VEGF-Ax has a 22-amino-acid extension in the COOH terminus and has been reported to function as a neg
170 deletion of the phosphorylation site in the COOH terminus domain of Rb abrogates phosphorylation of
171 ion, whereas tyrosine phosphorylation in the COOH terminus influences interaction with E-cadherin.
172 at there is an internalization signal in the COOH terminus of CFTR that consists of Tyr(1424)-X-X-Ile
173 n of the internalization motif SSXXIL in the COOH terminus of CXCR4 resulted in B cells that constitu
175 ce of the membrane interactive domain in the COOH terminus of gammaENaC was established with whole-ce
178 ified a nuclear localization sequence in the COOH terminus of NCoA62/SKIP and showed that NCoA62/SKIP
179 ephosphorylation of Ser/Thr-Pro sites in the COOH terminus of S6K, including Thr(412), a residue esse
180 ion of a predicted coiled-coil region in the COOH terminus of SNX1 also abolished vesicle localizatio
181 y a novel role for a structural motif in the COOH terminus of the heart NaV1.5 sodium channel in dete
182 ine 950 residue and serines 1280-1283 in the COOH terminus of the receptor are required for IGF-I-ind
183 2 to induce phosphorylation of Ser375 in the COOH terminus of the receptor, to induce association of
184 constructs containing point mutations in the COOH terminus that impair Rab5 but not PtdIns-3-P bindin
185 autophosphorylation at two positions in the COOH terminus, the turn motif, and the hydrophobic motif
191 (2)-terminal half, whereas residues near the COOH terminus are required for binding to claudins.
192 In contrast, the conserved tyrosine near the COOH terminus is dispensable and the pleckstrin homology
193 nd that a clearly delineated region near the COOH terminus of both proteins is necessary for both the
194 entified and characterized a region near the COOH terminus of PB1-F2 that is necessary and sufficient
197 ubulin that encompasses alpha379 is near the COOH terminus that has been proposed as a site of intera
200 residues from the NH(2)-terminal side of the COOH terminus abolished nucleotide binding to the entire
201 ata indicate that the central portion of the COOH terminus is not essential for lymphoid transformati
202 nd reveal that one important function of the COOH terminus is to stabilize the v-Abl protein in lymph
203 tate NMR to determine the orientation of the COOH terminus of an amelogenin splice variant, LRAP (leu
204 essential function of polyglycylation of the COOH terminus of beta-tubulin can be transferred to alph
205 t with earlier observations, deletion of the COOH terminus of BRCA1 did not affect significantly the
206 Deletion of the last six residues of the COOH terminus of either PMCA2b or PMCA4b did not alter t
207 We searched for binding partners of the COOH terminus of kinesin light chain, which contains tet
210 These cleavages result in the release of the COOH terminus of the molecule and the production of a M(
211 ery little effect on the conformation of the COOH terminus of TnI as indicated by the unaffected mAb
213 sing a v-Abl protein lacking portions of the COOH terminus were compared for their ability to transfo
214 of amino acids in the central region of the COOH terminus, including those implicated in JAK interac
218 gh affinity to integrin alpha(v)beta3 on the COOH terminus of the viral attachment (H) protein and re
219 opic expression of the PBS mutant and/or the COOH terminus of actopaxin in HeLa cells resulted in sub
220 linker attached to either the NH(2)- or the COOH terminus of an antigenic peptide that is tightly bo
221 (N0) epitope-tagged at either the NH2 or the COOH terminus showed their localization to the mitochond
225 inding and motility assays, we show that the COOH terminus mediates binding of sMyBP-C to thick filam
229 ing of this fusion protein revealed that the COOH terminus of Tir, by itself, is sufficient to initia
230 pic staining of myofibrils indicate that the COOH terminus of TnI forms an exposed structure in the m
231 f p18(INK4c) regulation mediated through the COOH terminus and suggest that functional differences mi
232 onstrated that TRP bound to INAD through the COOH terminus, and this interaction was required for loc
233 tivity and, notably, when transferred to the COOH terminus of a warm-adapted (rabbit) PEPT1, it confe
235 cking site for TSG101 has been mapped to the COOH terminus of Bcr, indicating that this interaction m
242 e docking of Cdc2-cyclin B1 complexes to the COOH terminus of Myt1 facilitates the phosphorylation of
243 have now produced a specific antibody to the COOH terminus of NGEP-L and showed that it detects an ap
244 se-binding region of p16(INK4a) fused to the COOH terminus of p18(INK4c) is active in all known bioch
245 es a series of plakin repeats similar to the COOH terminus of plakins such as plectin and BPAG1e.
246 equence (AAL) derived from DOC-2/DAB2 to the COOH terminus of R11, we showed that R11PPL but not R11
248 l three known K(ATP) channels but not to the COOH terminus of the ATP-insensitive channel, Kir2.1.
252 evealed interaction of MLCK-147 close to the COOH terminus of the first actin and near residues 228-2
254 Small espin is identical in sequence to the COOH terminus of the larger ( approximately 110-kD) espi
257 two PAM residues (Arg(126)-His(127)) to the COOH terminus of VEK30 (VEK32) maintained a monomeric pe
258 alytic domain (Deltacap, residues 433 to the COOH terminus) clamp tightly around the DNA helix to for
261 e in nascent lambda transcripts, whereas the COOH terminus binds RNA polymerase and contacts DNA temp
264 bstrate and that CaMKII interaction with the COOH terminus of alpha1C is essential for CDF of L-type
265 riched PDZ protein) that associates with the COOH terminus of GCC in biochemical assays and by co-imm
266 tion that CLNX physically interacts with the COOH terminus of SERCA2b and that after dephosphorylatio
268 ranslocation is indeed directional, with the COOH terminus of the substrate protein entering ClpP fir
270 t has been proposed that elements within the COOH terminus may determine substrate specificity of the
271 nsitive sites had been identified within the COOH terminus of aggrecan, demonstration that aggrecanas
272 To localize the ATP-binding site within the COOH terminus of Kir1.1, we produced and purified maltos
274 ugh all mutants lacking sequences within the COOH terminus were compromised for lymphoid transformati
275 dence that this 13-amino acid segment at the COOH-terminus of alpha-spectrin is crucial to the stabil
277 We report that the last 3 amino acids in the COOH-terminus of CFTR (T-R-L) comprise a PDZ-interacting
279 ng a monoclonal antibody that recognizes the COOH-terminus of hNIS revealed a band with a molecular w
283 sing synthetic peptides corresponding to the COOH-terminus of human complement C5a we demonstrated th
288 domain, triggering EZH2 degradation through COOH terminus of Hsp70-interacting protein (CHIP)-mediat
292 interacts electrostatically with the tubulin COOH terminus to permit diffusional translocation of MCA
294 Among >40 rab proteins, rab38 has a unique COOH terminus which would allow posttranslational farnes
296 cking or function of GCC, we used the unique COOH terminus of GCC as the "bait" to screen a human int
297 etal myofibers with antibodies to the unique COOH terminus of variant-1 demonstrated that, unlike oth
298 itude greater than that for unphosphorylated COOH terminus, contrasting with the finding that PDK-1 d
300 transformed with an alpha-tubulin gene whose COOH terminus was replaced by the wild-type COOH terminu
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