ライフサイエンスコーパス: COOH-terminal

1 COOH-terminal activating region 2 only activates p52/p65

2 COOH-terminal mutants are recognized for destruction by

3 COOH-terminal peptides of either Rpt2 or Rpt5 bind to th

4 plus end-binding proteins Kar3p, a class 14 COOH-terminal kinesin, and Bik1p, the CLIP-170 orthologu

5 acetate) are still dependent on the AR NH(2)/COOH-terminal interaction and are enhanced by steroid re

6 ganded AR did not undergo a detectable NH(2)/COOH-terminal interaction and was not coactivated by SRC

7 PKCtheta (but not with PKCalpha) via its 99 COOH-terminal residues.

8 A COOH terminal truncation mutant (FILIP1LDeltaC103) was m

9 ated to ribosome-inactivating proteins and a COOH-terminal domain, which displays similarity to eukar

10 l domain, two separate kinase domains, and a COOH-terminal domain.

11 l domain, two separate kinase domains, and a COOH-terminal domain.

12 al sequence, an immunoglobulin domain, and a COOH-terminal hydrophobic transmembrane domain.

13 ype SK, carboxypeptidase B-treated SK, and a COOH-terminal Lys414 deletion mutant (SKDeltaK414) demon

14 onents C1r/C1s, Uegf, and Bmp1) domain and a COOH-terminal PDGF/vascular endothelial growth factor do

15 DZ-binding motif) contains a WW domain and a COOH-terminal PDZ-binding motif that are proposed to med

16 f an NH(2)-terminal portion from PMCA4 and a COOH-terminal tail from PMCA2b was targeted to the basol

17 be overexpressed in HNSCC cells and to be a COOH-terminal IKK, but its relationship to NF-kappaB act

18 Biochemical interaction between a COOH-terminal Xorbit fragment and the kinetochore-associ

19 -A*0201 with a strong affinity and contain a COOH-terminal proteasomal cleavage site.

20 guanine nucleotide exchange factor domain, a COOH-terminal Src homology 3 domain, two spectrin-like r

21 ow that human Nup133 contains two domains: a COOH-terminal domain responsible for its interaction wit

22 charomyces cerevisiae Cks protein Cks1 has a COOH-terminal glutamine-rich sequence not present in oth

23 From 37K fragments, two peptides lacked a COOH-terminal lysine or arginine; instead they ended at

24 ization of Net1 as well as the presence of a COOH-terminal PDZ binding site.

25 e promoted efficient surface expression of a COOH-terminal Tir fragment.

26 ese proangiogenic effects are dependent on a COOH-terminal PDZ-binding motif of plexin-B1, which bind

27 nd endoplasmic reticulum of SMCs, but only a COOH-terminal PKGI fragment containing the catalytic reg

28 Here, we show that a COOH-terminal region in yeast Sac1p is crucial for ER ta

29 In the same model system, we show that a COOH-terminal truncation mutant of ING4 found in human c

30 d that Rud3p is localized to the Golgi via a COOH-terminal domain that is distantly related to the GR

31 ivity due to the presence of a 37 amino acid COOH-terminal region and that this region is capable of

32 to the structural contribution of the acidic COOH-terminal region of factor Va heavy chain to factor

33 P1 encompassing both the PI3K/Akt-activating COOH-terminal activation region (CTAR) 1 and the nonredu

34 The alpha COOH-terminal region was more important than that of bet

35 resulting in enhanced cleavage of the alpha-COOH-terminal fragment (alpha-CTF) of APP and correspond

36 protein (APP), beta-secretase, beta-amyloid, COOH-terminal fragment (CTF), insulin receptor, IGF-1 re

37 containing) were fused to NH(2) terminal and COOH terminal fragments of the firefly luciferase.

38 Intramolecular NH(2)- and COOH-terminal binding, which occurs when merlin transiti

39 teolytic cleavage to generate the NH(2)- and COOH-terminal cleavage fragments containing at least one

40 The NH(2)- and COOH-terminal domains both exhibited relatively high H-D

41 We further show that both the NH(2)- and COOH-terminal domains of E1B are required for the repres

42 The NH(2)- and COOH-terminal domains remain membrane bound owing to the

43 wn enzymatic activity to generate NH(2)- and COOH-terminal fragments, a process that is required for

44 oprotein (DSPP) is processed into NH(2)- and COOH-terminal fragments, but its key cleavage site has n

45 (a) [apo(a)] component of lipoprotein(a) and COOH-terminal Lys residues generated by partial degradat

46 he cysteine, proteolytic removal of aaX, and COOH-terminal methylation.

47 sequently losing its membrane attachment and COOH-terminal domains.

48 -binding protein EWS and the DNA-binding and COOH-terminal regions of the Ets transcription factor FL

49 The conserved central and COOH-terminal regions of troponin T (TnT) interact with

50 , whereas antibodies recognizing central and COOH-terminal regions recognized both LAP polypeptides.

51 ge conformational changes in the central and COOH-terminal regions to alter troponin I and tropomyosi

52 sphorylation of the juxtamembrane domain and COOH-terminal docking site of c-Met, and its downstream

53 its NH(2)-terminal actin-binding domain and COOH-terminal EF-hand-GAS2 domain.

54 ribosyltransferase active center (E112K) and COOH-terminal KDEL (E112K/KDEV or E112K/KDGL).

55 s representing the NH2-terminal (37 kDa) and COOH-terminal (57 kDa) portions of the cDNA-deduced amin

56 elical domain leads into the neck linker and COOH-terminal motor domain.

57 ed via both STAT NH2-terminal modulatory and COOH-terminal transactivation domains.

58 uction of IgG Abs that recognize both N- and COOH-terminal epitopes of the human Dsg3 ectodomain.

59 Thus, both NH2- and COOH-terminal CaM-binding sites in CNGB3 are functionall

60 potential CaM-binding sites in both NH2- and COOH-terminal cytoplasmic domains of CNGB3 using gel-ove

61 TKs are folded into two main lobes, NH2- and COOH-terminal lobes.

62 Both NH2- and COOH-terminal mutants are conformationally abnormal, as

63 Strikingly, NH2- and COOH-terminal Pma1 mutants are differentially recognized

64 aling motif) sequences found in the NH2- and COOH-terminal regions of PHAS-I, respectively, are requi

65 ations in their long, unstructured, NH2- and COOH-terminal tails.

66 of apoptosis repeat) domain of survivin and COOH-terminal alpha helix may be the key to separating i

67 eted in liver cancer 1 (DLC1) by tensin3 and COOH-terminal tensin-like protein (cten) controls EGF-dr

68 tated by co-expression of NH(2)-terminal and COOH-terminal CFTR half channels each containing one NBD

69 Serial NH(2)-terminal and COOH-terminal deletion mutants were constructed and func

70 nd FEN-1 mapped to the TRF2 NH2-terminal and COOH-terminal domains.

71 y exists as the processed NH(2)-terminal and COOH-terminal fragments in the extracellular matrix of t

72 on, is processed into the NH(2)-terminal and COOH-terminal fragments.

73 to the culture medium by SubA treatment, and COOH-terminal domain signal transduction is abrogated, w

74 p56lck is rapidly phosphorylated (Y505) and COOH-terminal Src kinase is recruited to the contact sit

75 Furthermore, APP COOH-terminal fragments generated by BACE1 are preferent

76 increased levels of T668-phosphorylated APP COOH-terminal fragments in hippocampal lysates from many

77 Pull-down assays showed that the AQP9 COOH-terminal SVIM motif is essential for interaction wi

78 tions, one at the activation loop and two at COOH-terminal sites, the turn motif and the hydrophobic

79 The actin-binding COOH-terminal region, the "tentacle," of the CP beta sub

80 The claudin-binding COOH-terminal domain is not toxic and is currently under

81 The PDZ protein-binding COOH-terminal tail of PMCA2b was not responsible for its

82 CP lacking both COOH-terminal regions did not bind actin.

83 Simultaneous binding of both COOH-terminal peptides had additive effects on peptide s

84 Microcephalin (MCPH1) is a BRCA1 COOH terminal (BRCT) domain containing protein involved

85 classify all missense variants in the BRCA1 COOH-terminal region.

86 is interaction is mediated through the BRCA1 COOH-terminal repeats of BRCA1.

87 Rad3-related (ATR), and proteins with BRCA1 COOH-terminal (BRCT) domains.

88 chanism in lung epithelial cells mediated by COOH-terminal Src kinase (Csk) that negatively regulates

89 , through the loss of negative regulation by COOH-terminal Src kinase (Csk) and the adaptor, Csk-bind

90 and intracellular distribution of Lyn, CD45, COOH-terminal Src kinase (Csk), and c-Cbl were studied b

91 terized by a long, highly positively charged COOH-terminal region, absent in most other chemokines.

92 rovide direct evidence orienting the charged COOH-terminal region of the amelogenin protein on the HA

93 ere primarily found in the highly conserved, COOH-terminal pore-region domain.

94 These proteins undergo three coordinated COOH-terminal events: isoprenylation of the cysteine, pr

95 The CXCR4 COOH-terminal domain (CTD) seems to play a major role in

96 placed as an extra stretch in the cytosolic COOH-terminal region, contributed per se to cold adaptat

97 mutant GFP::DAT-1 fusions identify a distal COOH terminal segment of the transporter as essential fo

98 ring mutations depriving NKCC2 of its distal COOH-terminal tail and interfering with the (1081)LLV(10

99 kL was strongly reduced by deletion of DOCK5 COOH-terminal amino acids 1832-1870.

100 Expression of the DOCK5 COOH-terminal region (Met1738-Gln1870), containing poten

101 , we solved the crystal structure of the EB1 COOH-terminal domain.

102 phosphorylating activity on a subset of EGFR COOH-terminal tyrosines and the consequent engagement of

103 sphorylation and is dependent on the extreme COOH-terminal tail of MCAK.

104 We generated COOH-terminal-truncated soluble forms of CR-1 based on t

105 Conversely, GRP78 COOH-terminal domain ligation is pro-apoptotic and anti-

106 The predicted 28-kDa GRP78 COOH-terminal fragment is released into the culture medi

107 ted phosphorylation of the RNA polymerase II COOH-terminal domain, specifically reduced RNA polymeras

108 a decrease in RNA polymerase II (RNA Pol II) COOH-terminal domain Ser(2) phosphorylation.

109 was dependent on a short peptide immediately COOH-terminal to the DNA-binding domain (the C-terminal

110 reduction of cleavage seen of transcripts in COOH-terminal domain-less polymerase elongation complexe

111 educed Csk phosphorylation of the inhibitory COOH-terminal tyrosine.

112 Moreover, an intact COOH-terminal PDZ recognition motif (EAKL) in SR-BI is n

113 Likewise, an intact COOH-terminal PDZ recognition motif in PTH1R is needed.

114 ate expression levels of the intramembranous COOH-terminal fragment of cleaved PC1 required an intact

115 However, deletion of the IP COOH-terminal region prevented internalization suggestin

116 f a conserved thrombin cleavage site that is COOH-terminal from a well-characterized RGD domain.

117 Ser-106, which is COOH-terminal to the ubiquitination sites, retards the d

118 s, liver, and peripheral leukocytes, and its COOH-terminal portion contains a putative PDZ binding mo

119 n also contains a regulatory element for its COOH-terminal RhoGAP domain.

120 ain another binding site for clathrin in its COOH-terminal region.

121 g during complex formation between SK or its COOH-terminal Lys(414) deletion mutant (SKDeltaK414) and

122 Wnt responsive reporter plasmid through its COOH-terminal domain.

123 Shot binds along the microtubule through its COOH-terminal GAS2 domain and binds to actin with its NH

124 NH2-terminal half and with Dnm1p through its COOH-terminal WD40 domain.

125 on on collagen alpha 3(VI) was mapped to its COOH-terminal C5 domain.

126 analysis showed that WOX1 bound Tau via its COOH-terminal short-chain alcohol dehydrogenase/reductas

127 ions, Fib-2, located at the disulfide-linked COOH-terminal ends of fibronectin, we prepared by limite

128 tracellular signal-regulated kinase-mediated COOH-terminal kinase domain (CTD).

129 In contrast, MSK1 COOH terminal or NH(2) terminal dead dominant negative m

130 The MUC1 COOH-terminal subunit (MUC1-C) cytoplasmic domain binds

131 The MUC1 COOH-terminal subunit (MUC1-C) is targeted to the nucleu

132 disease is not clear due to loss of multiple COOH-terminal AR protein domains, including the canonica

133 re prepared with substitution or deletion of COOH-terminal IP(3) receptor (IP(3)R) binding domains.

134 COOH terminus, suggesting the involvement of COOH-terminal residues in PfR4-PfR1 interaction.

135 n, we show that the stable overexpression of COOH-terminal Src kinase, the physiologic negative regul

136 unction for the thrombin-cleaved osteopontin COOH-terminal fragment.

137 etion analysis, we have identified the PELP1 COOH-terminal region as the histone 1 binding site.

138 main (the I domain) of meprin alpha prevents COOH-terminal proteolytic processing and results in the

139 Rab11-GTP associates with the Rabin8 COOH-terminal region and is required for Rabin8 precilia

140 MKII directly phosphorylated the recombinant COOH-terminal region of FAK at a residue equivalent to S

141 Interestingly, disease-related COOH-terminal menin mutants that do not interact with AS

142 he CH2 domain competes with the proline-rich COOH-terminal region of sos1 for the C-SH3 domain of grb

143 heavily O-glycosylated serine-threonine-rich COOH-terminal domain reduced binding.

144 Rpt2 and Rpt5 COOH-terminal peptides cross-linked to different but spe

145 ous polyposis coli (APC) that binds to EB1's COOH-terminal domain and identified a similar sequence i

146 essing in vivo, as a result of which JIP60's COOH-terminal eIF4E domain is released and functions in

147 n that p53R2 bound to hRRM1 through the same COOH-terminal heptapeptide as hRRM2.

148 f the COOH-terminal region of CXCL9, several COOH-terminal peptides were chemically synthesized.

149 in cleavage of osteopontin to generate short COOH-terminal osteopontin in the presence of cyclophilin

150 5 is modified with sulfenic acid on a single COOH-terminal cysteine (C581), and the level of sulfenic

151 The SK COOH-terminal Lys(414) residue and residues Arg253-Leu26

152 eractions between a Pg/Pm kringle and the SK COOH-terminal Lys(414).

153 ta-induced transcription downstream of Smad3 COOH-terminal phosphorylation and nuclear translocation.

154 AMPK did not reduce TGFbeta-stimulated Smad3 COOH-terminal phosphorylation and nuclear translocation,

155 at neither the Dsc1a- nor the Dsc1b-specific COOH-terminal cytoplasmic domain is required for establi

156 lesser contributions from the alpha subunit COOH-terminal region and the body of the protein.

157 fected by inflammatory cytokines that target COOH-terminal serine residues to activate ubiquitination

158 R-1 has a significantly higher activity than COOH-terminal-truncated soluble forms to induce Nodal si

159 We report that COOH-terminal binding protein (CtBP), a physiologically

160 In this report, we showed that COOH-terminal Src kinase (CSK) binds with and phosphoryl

161 through the NH(2) terminus of BRCA2 and the COOH terminal BRCT domains of MCPH1.

162 xon 3 and two truncated versions lacking the COOH terminal domain (CTD).

163 ch were truncated on either the NH(2) or the COOH terminal, as well as on both ends, were expressed f

164 The COOH-terminal domain of ZO-1 was required for its associ

165 The COOH-terminal end of TIMP-3 was involved in the interact

166 The COOH-terminal four-helix bundle domain has been shown to

167 The COOH-terminal fragment retained antibacterial activity w

168 The COOH-terminal half channel lacked all native cysteines.

169 The COOH-terminal lobe of vascular endothelial growth factor

170 The COOH-terminal NP domain comprises a conserved highly aci

171 The COOH-terminal peptide CXCL9(74-103) does not signal thro

172 The COOH-terminal polybasic region (PBR) of Rac1, a Rho fami

173 The COOH-terminal region of the heavy chain contains acidic

174 The COOH-terminal UCS domain of Rng3p alone restored motilit

175 ce CD44 receptors, little is known about the COOH-terminal osteopontin fragment.

176 ed that NH2-terminal modifications alter the COOH-terminal conformation of TnT and thin filament Ca2+

177 Although the COOH-terminal fragment may bind to cell surface CD44 rec

178 no acids direct CBF1 to target genes and the COOH-terminal 98 amino acids function in trans-activatio

179 the NH(2)-terminal ADAMTS-1 fragment and the COOH-terminal ADAMTS-1 fragment can inhibit pulmonary tu

180 rapidly as viral polysomes assembled and the COOH-terminal portion of eIF4GI cofractionated with vira

181 removal of the NH(2)-terminal domain and the COOH-terminal, putative leucine zipper tetramerization d

182 ydroxylation at an asparagine residue at the COOH-terminal activation domain of hypoxia-inducible fac

183 However, deletions and insertions at the COOH-terminal of sag were observed.

184 tatin intermediates requires cleavage at the COOH-terminal sides of paired basic residues, which is c

185 nant-negative Smad1, in which serines at the COOH-terminal SSVS motif are converted to alanines, supp

186 y a complete blockade of synergy between the COOH-terminal SAA1 fragments and CXCL8 or CCL3 in neutro

187 through the use of antagonists that bind the COOH-terminal ligand-binding domain.

188 0), is known to be on the cis-Golgi, but the COOH-terminal region that contains the GRAB domain has b

189 CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain, which initiates TLR2/6

190 crotubule lattice binding is mediated by the COOH-terminal region of the CLASP microtubule-binding do

191 and a dissociation mechanism mediated by the COOH-terminal region.

192 telomere elongation activity mediated by the COOH-terminal TPP1-interacting domain was telomere prote

193 -amidating monooxygenase (PAM) catalyzes the COOH-terminal amidation of peptide hormones.

194 f BCR/ABL genes with deletions of either the COOH-terminal actin binding or proline-rich domains resu

195 FGFR3 Delta8-10, lacking exons encoding the COOH-terminal half of immunoglobulin-like domain III and

196 Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan

197 This conformational change exposes the COOH-terminal tail of Syk, which has three conserved Tyr

198 the existing hypothesis, in fibrinogen, the COOH-terminal portions of two Aalpha chains are folded i

199 in the 450-nucleotide region coding for the COOH-terminal 150 amino acids of the nucleoprotein (N).

200 tudies suggest an essential function for the COOH-terminal leucine repeats/death domain of Par-4 in m

201 d the amino acid sequence homologous for the COOH-terminal portion of prostate-specific antigen (PSA)

202 he underlying mechanisms responsible for the COOH-terminal tail region in modulating PTEN biological

203 deletion of 26 amino acid residues from the COOH-terminal end (length 1010 aa) resulted in retargeti

204 deletion of 26 amino acid residues from the COOH-terminal end is functional.

205 the deletion of 3 or 20 amino acids from the COOH-terminal end of NBC1 (lengths 1032 and 1015 aa, res

206 Additional interactions from the COOH-terminal half of vWbp(1-474) strengthened the initi

207 region, and the 57K fragments were from the COOH-terminal part of DMP1.

208 s a result, MMP-26 proteolysis generates the COOH-terminal fragments of ERbeta.

209 he highest degree of identity resides in the COOH-terminal 20% of these proteins, the putative cataly

210 n the central domain (cp(C3)) and one in the COOH-terminal domain (cp(C2)).

211 ues and a tryptophan-containing motif in the COOH-terminal domain of NOD2.

212 ion induces an alpha-to-pi transition in the COOH-terminal end of the F-helix that shifts the beta-ca

213 mon interacts with the Cys-190 region in the COOH-terminal half of tropomyosin, resulting in the move

214 n the NH(2)-terminal NBD1 and another in the COOH-terminal NBD2.

215 N is acetylated on Lys(402), which is in the COOH-terminal PDZ domain-binding motif.

216 that CRS2 binds a 22 amino acid motif in the COOH-terminal region of CAF2 that is conserved in CAF1.

217 thermore, mutation of these tyrosines in the COOH-terminal region of Syk transforms it to an enzyme,

218 utant, in which Leu(499) and Leu(500) in the COOH-terminal sequence (DDISLLK) were replaced by alanin

219 required for high catalytic activity in the COOH-terminal Src kinase (Csk).

220 fragment in the E1a gene and interrupts the COOH-terminal region of both the E1A 12S and 13S protein

221 ctivation gate of K(v) channels involves the COOH-terminal section of the S6 segment (S6-b) and the S

222 f the p53-independent activity of ARF is the COOH-terminal binding protein (CtBP) family of metabolic

223 e truncated proteins, some of which lack the COOH-terminal catalytic domain.

224 Mutant BRCA1 that lacks the COOH-terminal BRCT domain also promotes ssDNA but fails

225 LXLX(6)LLX(5)LX(2)L) was identified near the COOH-terminal MYND domain at amino acids 454-476.

226 Nevertheless, the COOH-terminal peptide of Rpt2 greatly enhanced this effe

227 se results indicate that the FG helix of the COOH-terminal A1 cupredoxin-like subdomain of fVIII may

228 eraction between Q316 in the FG helix of the COOH-terminal A1 subdomain and M539 in the FG helix of t

229 Substitution of the COOH-terminal A1 subdomain of porcine fVIIIa, which deca

230 active by itself, although inclusion of the COOH-terminal domain speeds up the process approximately

231 d acts as transcriptional coactivator of the COOH-terminal fragment (CTF) of ErbB-4.

232 is terminated by transient expression of the COOH-terminal fragment of phospholipase C (PLC-beta1ct),

233 Elements of the COOH-terminal half of the core recognize a hydrophobic g

234 a2 analogue peptides by substitutions of the COOH-terminal isoleucine (I) for valine (V) and the NH(2

235 Partial deletions of the COOH-terminal region (114-250) of the human Gal-3 signif

236 To investigate the role of the COOH-terminal region of CXCL9, several COOH-terminal pep

237 ch could be rescued by overexpression of the COOH-terminal region of ELF.

238 Furthermore, deletion of the COOH-terminal RING finger domain of HdmX completely reve

239 Deletion of the COOH-terminal SkzL Lys(415) residue reduces affinity for

240 ion activity, stimulates the activity of the COOH-terminal TAD of p300 (p300C-TAD).

241 onserved residue Phe at position 1013 on the COOH-terminal end demonstrated retargeting to the apical

242 ant cluster of amino acids is located on the COOH-terminal portion of the heavy chain of factor Va, b

243 Deletion of only the COOH-terminal transcription activation domain dramatical

244 in binding sites, but we found that only the COOH-terminal USH-I/LWEQ module showed pH-dependent acti

245 lacking ankyrin binding activity and/or the COOH-terminal pleckstrin homology (PH) domain for their

246 vivo analyses show that calpain removes the COOH-terminal ligand binding domain generating a constit

247 its component lipoteichoic acid requires the COOH-terminal cytoplasmic portion of CD36, specifically

248 This binding requires the COOH-terminal thrombospondin type 1 repeats of the prote

249 rily related meprin beta subunit retains the COOH-terminal domains during biosynthesis and travels to

250 Interestingly, our data indicate that the COOH-terminal domain alone is sufficient to rescue JIL-1

251 face GRP78 topology and demonstrate that the COOH-terminal domain is necessary for pro-apoptotic sign

252 s of both STAT3 and HDAC1 and found that the COOH-terminal domain of HDAC1 is necessary for IL-6-indu

253 Our results demonstrate that the COOH-terminal domain of JIL-1 is necessary and sufficien

254 basis of these findings we propose that the COOH-terminal domain of Megator functions as a targeting

255 resonance energy transfer, we show that the COOH-terminal fragment of osteopontin binds with another

256 evel of regular structure, implying that the COOH-terminal half of the alphaC-domain adopts an ordere

257 ruct analysis in S2 cells indicates that the COOH-terminal part of Megator without the coiled-coil re

258 Our data demonstrate that the COOH-terminal region of factor Va heavy chain is indeed

259 The CP crystal structure suggests that the COOH-terminal regions of the CP alpha and beta subunits

260 Thus, our data suggest that the COOH-terminal tail can act as an autoinhibitory domain t

261 trates that arrestin-2 directly binds to the COOH-terminal domain of p105, whereas GRK5 binds to and

262 )-terminal domains of unrelated genes to the COOH-terminal fragment of RET.

263 helices 1-6, including Loop 1) binds to the COOH-terminal portion (containing TM helices 7-8 and Loo

264 This site was further localized to the COOH-terminal portion of the alphaC-domain including res

265 Furthermore, Pg binding to the COOH-terminal region of GRP78 stimulates cell proliferat

266 Using the COOH-terminal region of IP as bait we identified the del

267 The effect of TNF-alpha is mediated via the COOH-terminal domain of NKX3.1 where phosphorylation of

268 iates with full-length grb2 in vitro via the COOH-terminal src homology 3 (C-SH3) domain of grb2.

269 f bacterial response regulators, whereas the COOH-terminal four-helix bundle domain is novel and form

270 onucleotide-binding motifs, but not with the COOH-terminal domain.

271 Cell interactions with the COOH-terminal sequence are not through the elastin-bindi

272 ucleating sites via its interaction with the COOH-terminal sequence of CNN.

273 ted Y783 residue (pY783) associates with the COOH-terminal SH2 domain [SH2(C)] within the same molecu

274 that a small 53-amino acid region within the COOH-terminal domain can interact with the tail region o

275 an internal peptide motif located within the COOH-terminal regulatory domain of EGFR.

276 cysteines (Cys(227) and Cys(240)) within the COOH-terminal zinc finger of ERalpha DNA-binding domain

277 runcated JIL-1 protein which was without the COOH-terminal domain but retained histone H3S10 kinase a

278 tions of laminin alpha1 and alpha5 and their COOH-terminal LG domains, we have produced a collection

279 , and we identify binding proteins for their COOH-terminal SH3 domains.

280 CAM1(b)-4S, differing in the length of their COOH-terminal cytoplasmic tail.

281 sites by regulating interactions with their COOH-terminal guanylate kinase-like domains (GKs).

282 A third COOH-terminal serine at position 195 has a modulating ef

283 st, Rud3p binds to the GTPase Arf1p via this COOH-terminal "GRIP-related Arf-binding" (GRAB) domain.

284 Three COOH-terminal residues (aa 758-760) were essential for b

285 ng affinity and the ligand-induced NH(2)- to COOH-terminal intramolecular interaction is enhanced whe

286 ins NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl.

287 g-tagged TrkBT1 but not a Flag-tagged TrkBT1 COOH-terminal deletion mutant (Flag-TrkBT1DeltaC) in non

288 ding to the actin filament, in which the two COOH-terminal regions of CP bind independently to the ac

289 out by cystein proteases known as ubiquitin COOH-terminal hydrolases.

290 ue microarrays showed that reduced ubiquitin COOH-terminal esterase L1 in primary melanoma is associa

291 -associated RGMc frame-shift mutants undergo COOH-terminal cleavage only if this site is present.

292 cript variant of TrkB (TrkBT1) with a unique COOH-terminal 12-amino acid sequence and is mainly local

293 otyrosine binding domains linked to a unique COOH-terminal region.

294 of nuclear import can be augmented by unique COOH-terminal sequences that reconstitute classical AR N

295 apoptotic signal transduction occurring upon COOH-terminal antibody ligation.

296 1 new-onset type 1 diabetic Caucasians using COOH-terminal constructs incorporating the known human a

297 n of cysteine residues within the vulnerable COOH-terminal zinc finger of ERalpha DBD, resulting in f

298 ion 2 only activates p52/p65 dimers, whereas COOH-terminal activating region 1 activates p50/p50, p50

299 alphaDB1, whose COOH-terminal extension can be tyrosine phosphorylated,

300 Binding studies with COOH-terminal deletion mutants of TFIIIA and 5S nucleoso