ライフサイエンスコーパス: COP

1 COP binds to both RIP2 and the caspase-1 prodomain and i

2 COP capillaries (inner diameter of 19-28 mum) were succe

3 COP has been integrated with the microarray data normali

4 COP inhibits caspase- 1-induced IL-1beta secretion as we

5 COP is characterized by patchy peripheral or peribroncho

6 COP-5 consists of rigid, aromatic porphyrin and carbazol

7 COP-5 shows an unprecedented high selectivity in binding

8 COP-hfacac (2) provides rearranged allylic trichloroacet

9 performed to assess the efficacy of Bet v 1 COP immunotherapy during the 2013 birch pollen season.

10 Bet v 1 COP injections were well tolerated, with a higher freque

11 d medication scores improved in both Bet v 1 COP-treated groups, reaching statistical significance ov

12 Before the season, Bet v 1 COPs (50 and 100 mug in aluminum hydroxide) or placebo (

13 Bet v 1 COPs at 25 or 50 mug were administered on day 1, and 50

14 munotherapy using 2 dose regimens of Bet v 1 COPs versus placebo in subjects with birch pollen-induce

15 Copolymer-1 (COP-1) elicits neuroprotective activities in a wide rang

16 CO Probe 1 (COP-1) is capable of detecting CO both in aqueous buffer

17 ifetimes centered at 2.8 ns (representing (1)COP --> Cc ET).

18 o the conformational distributions in the (1)COP --> Cc ET whereas differences in overall porphyrin c

19 A genome scan was carried out on an F(2)(COP x DA) segregating population (n=224) to detect quant

20 We analyzed 21 COP and 39 TF patients.

21 were lost to follow-up, leaving 39 TF and 21 COP for analyses.

22 g with their 2D covalent organic polymer (2D COP) analogues, as energy materials.

23 o months of preseasonal immunotherapy with 3 COPs derived from Bet v 1 at a 50-mug dose showed promis

24 inating from triplet state were examined ((3)COP --> Cc ET).

25 ic cooling power of 2.8 watts per gram and a COP of 13.

26 he first single-crystal X-ray structure of a COP catalyst is also reported.

27 The assembly of such a COP is a thermodynamically controlled process, which inv

28 I, 2.9-4.6) vs. those treated for accidental COP (17 excess deaths; SMR, 1.3; 95% CI, 1.01-1.6).

29 alpha-COP binds to SMN, linking the COPI vesicular transport p

30 ly Golgi associated, in neuronal cells alpha-COP localizes to lamellipodia and growth cones and moves

31 rane proteins are captured by coatomer alpha-COP and beta'-COP subunits and packaged into COPI-coated

32 nding of KKxx motifs by the homologous alpha-COP domain.

33 ably, heterologous expression of human alpha-COP restored normal neurite length and morphology in SMN

34 We present crystal structures of alpha-COP and beta'-COP bound to a series of naturally occurri

35 between the C-terminal domain (CTD) of alpha-COP and full-length epsilon-COP, two components of the B

36 last approximately 170 amino acids of alpha-COP are also non-essential for cell viability, but requi

37 Reduced levels of alpha-COP restricted development of neuronal processes in NSC-

38 Depletion of alpha-COP resulted in mislocalization of SMN and actin at the

39 dentified single amino acid mutants of alpha-COP that selectively abrogate SMN binding, retain COPI-m

40 Through in vivo analysis of alpha-COP truncation mutants, we characterize distinct functio

41 cterize distinct functional domains on alpha-COP.

42 Binding experiments show that alpha-COP and beta'-COP have generally the same specificity fo

43 The alpha-COP CTD adopts a U-shaped architecture that complements

44 round a protruding beta-hairpin of the alpha-COP CTD, thus interlocking the two proteins.

45 The alpha-COP protein co-immunoprecipitates with SMN, small nuclea

46 The alpha-COP(CTD) x epsilon-COP complex forms heterodimers in sol

47 The alpha-COP(CTD) x epsilon-COP heterodimer forms a rod-shaped st

48 with the strength of interaction with alpha-COP.

49 Strikingly, the alphabeta'-COP core of coatomer crystallizes as a triskelion in whi

50 Clathrin adaptor and COP-I coatomer subunits, which function in vesicle coat

51 pathway negatively regulated by the DET1 and COP proteins.

52 ealed for producing tailor-made graphene and COP materials for efficient energy conversion and storag

53 amics that are dependent on microtubules and COP-II but not on COP-I vesicle machinery.

54 cally, BTZ and CFZ absorption in both PS and COP were all in the range of approximately 100-300 nm, w

55 an expansion of the number of SNARE, Rab and COP proteins.

56 oured both astaxanthin degradation (83%) and COPs formation (886.6 +/- 97.9 mug/g of lipids after 90

57 In both (ACI x COP)F(2) and (COP x ACI)F(2) populations, we find strong evidence for

58 hysin colocalized with the Golgi marker beta COP in elongated cytoplasmic compartments that extended

59 triskelion in which three copies of a beta'-COP beta-propeller domain converge through their axial e

60 ubiquitin from Snc1, or deletion of a beta'-COP subunit propeller domain that binds K63-linked polyu

61 nt crystal structures of alpha-COP and beta'-COP bound to a series of naturally occurring retrieval m

62 ng experiments show that alpha-COP and beta'-COP have generally the same specificity for KKxx and KxK

63 are captured by coatomer alpha-COP and beta'-COP subunits and packaged into COPI-coated vesicles for

64 ditionally reveals cargo bound beneath beta'-COP.

65 Flexibility between beta'-COP WD-repeat domains and the location of cargo binding

66 to the N-terminal WD-repeat domain of beta'-COP identifies electrostatic contacts between the motif

67 tif backbone with basic side chains of beta'-COP.

68 ecificity for KKxx and KxKxx, but only beta'-COP recognizes the RKxx signal.

69 Moreover, replacement of the beta'-COP propeller domain with unrelated ubiquitin-binding do

70 lementary patches at the center of the beta'-COP propeller.

71 beta-COP and several Galpha subunits (Galpha(i1-3), Galpha(s)

72 Beta-COP depletion did not affect CFTR synthesis but impaired

73 2) results in dispersion of giantin and beta-COP from their normal, condensed Golgi localization, and

74 ly interacts with at least zeta-COP and beta-COP of the COPI coatomer complex.

75 om both cerebellum and COS-7 cells, and beta-COP protein interacted directly with immobilized KA2 pep

76 -COP at a site common to the gamma- and beta-COP subunits.

77 ps with cellular Golgi proteins such as beta-COP and GS-28, G(C) expressed in the absence of G(N) loc

78 were recovered in the same fraction as beta-COP, a marker for Golgi membranes.

79 : an N-terminal dibasic site that binds beta-COP to hold channels in ER and a C-terminal "release" si

80 intermediate compartment that contains beta-COP, which is best known as a component of the COPI coat

81 d CFTR in epithelial cells, we depleted beta-COP from the human colonic epithelial cell HT-29Cl.19A u

82 ition, we demonstrate a requirement for beta-COP as a cellular cofactor for Nef that was necessary fo

83 ere observed and buds were labelled for beta-COP.

84 es that contained Rab2, PKCiota/lambda, beta-COP, and p53/p58.

85 and caused dispersion of Golgi markers beta-COP and GM130, whereas ER structure appeared intact.

86 and shows mutually exclusive binding of beta-COP and 14-3-3beta on adjacent N-terminal sites.

87 ssary for the downstream recruitment of beta-COP and release of Rab2-mediated retrograde-directed ves

88 compromised, as shown by the release of beta-COP into the cytosol.

89 tional consequence as cells depleted of beta-COP showed decreased cAMP-activated chloride currents.

90 branes contained a negligible amount of beta-COP that was reflected by the drastic reduction in Rab2-

91 anes were evaluated for the presence of beta-COP.

92 ntibodies against myocilin, tubulin, or beta-COP (a specific golgi protein) or vital stains for endop

93 n with the Golgi membrane markers p115, beta-COP, and the trans-Golgi network marker, syntaxin 6.

94 tream recruitment of beta-coat protein (beta-COP) to VTCs, the Rab2-PP2-treated membranes were evalua

95 tor, ArfGAP2/3, and the adaptor protein beta-COP-enable GIV to coordinately regulate Arf1 signaling.

96 omerase (PDI) and the COPI coat protein beta-COP.

97 ase alpha-subunit and the coat protein, beta-COP, a component of the COP-I complex.

98 Because Rab2, beta-COP, and p53/p58 are marker proteins for pre-Golgi inter

99 These vesicles contained Rab2, beta-COP, p53/gp58, and protein kinase Ciota/lambda but lacke

100 sed on numerous observations that show (beta-COP) GAPDH associates with cytoskeletal elements, we exa

101 Moreover, some beta-COP colocalizes with intracellular caveolin-1, which was

102 din A, except that the coatomer subunit beta-COP remained on Golgi-derived membrane tubules.

103 orylation-dependent fashion to suppress beta-COP binding and allow forward transport.

104 ectron microscopy, GIV colocalizes with beta-COP and Galpha(i3) on vesicles found in close proximity

105 he alpha-subunit does not interact with beta-COP and traffics to the plasma membrane.

106 nthesized alpha-subunit associates with beta-COP immediately after its synthesis but that this intera

107 The interaction with beta-COP was reduced by mutating a dibasic motif at Lys(54) i

108 sicles was based on colocalization with beta-COP, a marker for these vesicles.

109 a,K-ATPase alpha-subunit interacts with beta-COP, is retained in the endoplasmic reticulum, and is ta

110 A resolution crystal structure of betadelta-COP.

111 second Arf1-GTP molecule binds to betadelta-COP at a site common to the gamma- and beta-COP subunits

112 ctor 1 (Arf1):GTP-binding betagammadeltazeta-COP F-subcomplex, which is related to the adaptor protei

113 ellent enantiomeric purities (87-98% ee) by [COP-OAc](2)-catalyzed cyclization of phenolic (E)-allyli

114 vel 3-D rectangular prismatic molecular cage COP-5 in one step from a readily accessible porphyrin-ba

115 ast to previously reported Pd(II) catalysts, COP-OAc (4) promotes the asymmetric cyclization of (Z)-a

116 matographic behavior of the AEX latex-coated COP capillaries are greatly dependent on the degree of s

117 pholipase D1 (PLD1), (iii) recruit coatomer (COP-I) to Golgi-enriched membranes, and (iv) expand and

118 transport vesicles coated with coat complex (COP) II deliver secretory cargo to vesicular tubular clu

119 ER export and interacted with coat complex (COP)II, while an RxR motif also played an important role

120 sicle coats similar to coat protein complex (COP) I, COPII, and clathrin.

121 Quantification of coat protein complex (COP) II assembly revealed a dramatic up-regulation at ex

122 hat TRAPPIII binds the coat protein complex (COP) II coat subunit Sec23.

123 ates catalyzed by the palladium(II) complex [COP-OAc](2) is a broadly useful method for the asymmetri

124 Five WF.COP congenic lines containing COP RN02 segments were compared.

125 Copenhagen (COP) and DA inbred rat strains show a wide difference in

126 The genetically related ACI and Copenhagen (COP) rat strains display diametrically opposed susceptib

127 the genetically related ACI and Copenhagen (COP) rat strains.

128 rait in crosses to the resistant Copenhagen (COP) strain.

129 etically related, but resistant, Copenhagen (COP) rat strain.

130 s previously been shown that the Copenhagen (COP) rat contains several genetic loci that contribute t

131 rs decreased susceptibility when Copenhagen (COP)-resistant alleles are introgressed into a Wistar Fu

132 l system involving free-base coproporphyrin (COP) complexed with horse heart cytochrome c (Cc).

133 system can operate up to 84% of Carnot cycle COP at a temperature span of 41 K, which cannot be obtai

134 xpression of others (such as dergic53, dbeta'COP, and drab6).

135 ents, we show that COPI subunit delta (delta-COP) affects the biology of APP, including its subcellul

136 ode of binding and show that mammalian delta-COP binds related tryptophan-based motifs such as that f

137 ndings demonstrate the crucial role of delta-COP in APP metabolism and, consequently, the generation

138 By scanning the length of delta-COP via functional complementation in yeast, we dissect

139 monstrating that, by targeting subunit delta-COP function, the moderation of the COPI-dependent traff

140 We conclude that delta-COP subunits bind Wxn(1-6)[WF] motifs within unstructure

141 n yeast, we dissect the domains of the delta-COP subunit.

142 f at its extreme C terminus to bind to delta-COP at the same site in the same way.

143 rminal mu-homology domain of the yeast delta-COP subunit in complex with the WxW motif from its bindi

144 previously described chloride-bridged dimer COP-Cl (1).

145 ude attainment of complete response after DR-COP with highly active antiretroviral therapy.

146 mab plus pegylated liposomal doxorubicin (DR-COP) in an attempt to provide a more practical approach

147 ors, and the cargo-binding alphabeta'epsilon-COP B-subcomplex.

148 Clathrin, Sec13-Sec31, and alphabeta'epsilon-COP.

149 Glo3p, but not Gcs1p, and beta- and epsilon-COP interact with ARF-GTP.

150 ain structure of the alpha-, beta'-, epsilon-COP and beta-, gamma-, delta-, zeta-COP coatomer subcomp

151 s arose in mutants deficient in both epsilon-COP and either Cog1 or Cog2.

152 ly 10 min later by a COPI component (epsilon-COP) and a trans-Golgi network (TGN) marker (GRIP70).

153 for cell viability, but required for epsilon-COP incorporation into coatomer and maintainance of norm

154 n (CTD) of alpha-COP and full-length epsilon-COP, two components of the B-subcomplex, at a 2.9 A reso

155 coatomer and maintainance of normal epsilon-COP levels.

156 y small interfering RNA depletion of epsilon-COP in wild-type cells under conditions in which COG-ins

157 ure that complements the TPR fold of epsilon-COP.

158 epleted of the temperature-sensitive epsilon-COP subunit.

159 We show that epsilon-COP depletion for 12 h caused a primary block to virus i

160 SEC28 encodes the epsilon-COP subunit of COPI (coat protein complex I) coatomer pr

161 The epsilon-COP TPRs form a circular bracelet that wraps around a pr

162 rms a rod-shaped structure, in which epsilon-COP adopts a tetratricopeptide repeat (TPR) fold that de

163 The alpha-COP(CTD) x epsilon-COP complex forms heterodimers in solution, and we demon

164 The alpha-COP(CTD) x epsilon-COP heterodimer forms a rod-shaped structure, in which e

165 ting of a discrete lifetime at 15.0 ns (free COP) and a Gaussian distribution of lifetimes centered a

166 ein, an Arf GTPase, and a coat protein (e.g. COPs, APs, or GGAs) are minimal components required for

167 model is proposed in which ERManI and gamma-COP contribute to a Golgi-based quality control module t

168 s with regulatory proteins: beta'- and gamma-COP interact with the ARF-GTP-activating protein (GAP) G

169 by the requirement of both ERManI and gamma-COP to support efficient intracellular clearance of the

170 l interaction between NHK, ERManI, and gamma-COP was identified by co-IP and Western blotting.

171 direct interaction between ERManI and gamma-COP, the gamma subunit of coat protein complex I (COPI)

172 RNA interference-mediated knockdown of gamma-COP enhanced the association between ERManI and NHK, whi

173 site-directed mutagenesis of suspected gamma-COP-binding motifs in the cytoplasmic tail of ERManI was

174 iation of the K314Q alpha-subunit with gamma-COP, a component of COP I coats implicated in Golgi to E

175 the structure of Arf1 bound to the gammazeta-COP subcomplex of coatomer.

176 ting of the back ET reaction (reduced Cc --> COP(+)).

177 o older persons with no recent fall history (COP Displacement, Short Term Diffusion Coefficient, and

178 of Sac1 is required for coatomer complex-I (COP-I)-binding and continuous retrieval to the ER.

179 Importantly, COP-1 immunization reduced astro- and microgliosis while

180 on, including the role of PLD1 activation in COP-I recruitment, the role of COP-I in Golgi vesiculati

181 reased 10.6-fold in ACI rats and 4.5-fold in COP rats.

182 that acetate is a competent leaving group in COP-catalyzed enantioselective S(N)2' substitution react

183 uent carbonization of the metal-incorporated COPs led to the formation of COP-derived graphene analog

184 d colour values, TBARs, total and individual COPs, and the rancidity became pronounced.

185 tients (14%) had < a 20% response to initial COP (cyclophosphamide, vincristine, and prednisone) ther

186 the group treated initially for intentional COP (58 excess deaths; SMR, 3.7; 95% CI, 2.9-4.6) vs. th

187 Interestingly, COP-5 serves as an excellent receptor for fullerenes.

188 7-Ketocholesterol was the main COP in most cases during the whole heating treatment.

189 (COF) or an amorphous, microporous material (COP).

190 those taken from young adults (e.g., maximal COP velocity was 2.7x greater in fallers than young adul

191 ines were generated by transferring the Mcs1 COP allele onto a Wistar Furth (WF) genetic background.

192 on of these independent loci within the Mcs1 COP allele provide a model of the genetic complexity of

193 tly been elucidated, but the effects of most COPs and POPs on inflammasome assembly have not been inv

194 solvent bonding of PS or thermal bonding of COP, to alleviate the adverse effects of heterogeneous a

195 d IL-4-expressing lymphocytes into brains of COP-1-immunized animals was observed.

196 alpha-subunit with gamma-COP, a component of COP I coats implicated in Golgi to ER anterograde transp

197 Another interesting feature of COP capillaries lies in their flexibility.

198 performed using RNA extracted from femurs of COP, DA, F344 and LEW rats.

199 al-incorporated COPs led to the formation of COP-derived graphene analogues, which acted as efficient

200 t are particularly important at the level of COP.

201 Here, we discuss our model of COP- and POP-mediated inflammasome regulation.

202 Seventy-one percent of COP patients were off PPIs six months following TF.

203 The most common HRCT presentation of COP was ground-glass opacity (GGO) in 83.9% of cases, fo

204 The main presentations of COP on HRCT include bilateral GGOs and consolidations in

205 activation in COP-I recruitment, the role of COP-I in Golgi vesiculation caused by expression of the

206 shed as a routine method for the analysis of COPs in foods.

207 ation is a necessary step in the analysis of COPs in order to eliminate interferences and increase se

208 of astaxanthin and the elevated formation of COPs during sun drying and storage indicate the necessit

209 thods for the extraction and purification of COPs.

210 The main source of COPs is through diet, and particularly from the consumpt

211 systematic mapping of interaction domains on COP I subunits to gain novel insights into the architect

212 endent on microtubules and COP-II but not on COP-I vesicle machinery.

213 rphology without changes in PLD1 activity or COP-I binding is interpreted as evidence for at least on

214 larvae with IAP (inhibitor of apoptosis) or COP (COPI coatomer, beta subunit) dsRNA silenced their t

215 Cobalt oxazoline palladacycles (COP) containing acetylacetonate and hexafluoroacetylacet

216 Cobalt oxazoline palladacyclic (COP) complex 4 containing acetate as a bridging ligand i

217 comes 6-month post TF in crossover patients (COP), as compared to 6-month of HD PPI therapy, and 12-m

218 isting of 3 contiguous overlapping peptides (COPs) derived from Bet v 1, the major birch pollen aller

219 ower with a high coefficient of performance (COP) and the ability to be applied directly to surfaces.

220 This constitutive photomorphogenic (COP) phenotype was not observed for mutants of cct1 corr

221 bodies with CONSTITUTIVELY PHOTOMORPHOGENIC (COP) 1, a RING motif-containing E3 ligase.

222 roup of evolutionarily conserved pleiotropic COP/DET/FUS proteins was initially defined by their abil

223 the working hypothesis that the pleiotropic COP/DET/FUS group of proteins defined a protein ubiquiti

224 atterns of cryptogenic organizing pneumonia (COP) in X-rays have been reported for more than 20 years

225 (RB-ILD), cryptogenic organizing pneumonia (COP), acute interstitial pneumonia (AIP), and lymphoid i

226 sive natural seep field near Coal Oil Point (COP), California.

227 viving acute carbon monoxide (CO) poisoning (COP) may have increased risk for long-term mortality.

228 ape-persistent covalent organic polyhedrons (COPs) with ethynylene linkers are usually prepared throu

229 pe-persistent, covalent organic polyhedrons (COPs).

230 We describe novel cycloolefin polymer (COP)-based open tubular capillary ion exchange columns.

231 ted surface-sulfonated cyclo-olefin polymer (COP) capillary column with an inner diameter (i.d.) of 2

232 s polystyrene (PS) and cyclo-olefin polymer (COP) have become common materials for fabrication of mic

233 posable and single-use cyclo-olefin polymer (COP) microfluidic chip interfaced with a quantitative re

234 ctrodes deposited onto Cyclo Olefin Polymer (COP) substrates was fabricated for the detection of Camp

235 als (polystyrene (PS), cyclo-olefin polymer (COP), and PDMS).

236 A class of 2D covalent organic polymers (COPs) incorporating a metal (such as Fe, Co, Mn) with pr

237 (COF) and two new covalent organic polymers (COPs) made with fluoranthene-containing monomers and hex

238 Center of foot pressure (COP) and head displacements in the lateral plane were re

239 Center of pressure (COP) was measured during 4 minutes of quiet stance with

240 and displacements of the center of pressure (COP) were quantified within time intervals typical for A

241 ce plate to identify the center of pressure (COP), and its anteroposterior (AP) and mediolateral (ML)

242 Cholesterol oxidation products (COPs) and peroxides were formed during the heating treat

243 ecent years, cholesterol oxidation products (COPs) have drawn scientific interest, particularly due t

244 rmination of cholesterol oxidation products (COPs) in milk powder based foods is reported.

245 hrimp, while cholesterol oxidation products (COPs) showed a dramatic increase (8.6-fold), reaching a

246 (TBARs) and cholesterol oxidation products (COPs), and the rancidity was more pronounced.

247 describe the clash opportunity progressive (COP) computational method for designing a mutant aaRS to

248 p115 tethers coat protein (COP)I vesicles to Golgi membranes.

249 SCAP incorporation into common coat protein (COP)II-coated vesicles.

250 cided with a marked slowing of coat protein (COP)II-mediated protein export.

251 at the level of either the coatomer protein (COP)I or the COPII coat protein complex we examined the

252 We have identified a novel protein, COP (CARD only protein), which has a high degree of sequ

253 These CARD-only proteins (COPs) and PYD-only proteins (POPs) function as endogenou

254 s (POPs) and the related CARD-only proteins (COPs) in regulating inflammasome responses and their imp

255 4.3+/-11 years; 55% male) with biopsy-proven COP in a tertiary lung center between 2009 and 2012 were

256 decoy proteins encoding only a CARD or PYD, COPs and POPs, respectively, are assumed to inhibit infl

257 cyclobutadiene)cobalt]dipalladium, (R(p),S)-[COP-OAc](2), or its enantiomer.

258 Similarly, COPs are suggested to bind to the CARD of caspase-1 to p

259 idence of bacteremia and the admitting SMART-COP and PORT scores were similar in patients with and wi

260 isease at admission was assessed using SMART-COP and Pneumonia Outcomes Research Team (PORT) scoring

261 Variance of elderly subjects' COP measures from the young adult cohort were weighted t

262 Latex attachment on sulfonated COP surfaces are much stronger; several types show suffi

263 und to give significantly higher values than COP hearts for: (1) maximal developed tension (38.3 % gr

264 We conclude that COP-1 may warrant therapeutic consideration for HIV-1-as

265 he surface water refutes the hypothesis that COP seep methane appreciably influences carbon dioxide d

266 n regulate IL-1beta secretion, implying that COP may play a role in down-regulating inflammatory resp

267 Our data indicate that COP can regulate IL-1beta secretion, implying that COP m

268 a metabolic encephalopathy, we reasoned that COP-1 could be developed as an adjunctive therapy for di

269 10 generation was treated with DMBA, and the COP homozygous rats developed 1.5 +/- 0.3 carcinomas/rat

270 for which each locus was homozygous for the COP allele, tumor development was reduced by approximate

271 In the COP, TF further improved control of regurgitation and of

272 present and constitute resting states of the COP catalyst (however, monomeric palladium(II) complexes

273 catalyzed by palladium(II) complexes of the COP family is a powerful method for the preparation of e

274 realized with palladacyclic complexes of the COP family.

275 e coat protein, beta-COP, a component of the COP-I complex.

276 t targeting of REMORIN is independent of the COP-II-dependent secretory pathway and mediated by PI4P

277 of the congenic lines minimally retained the COP allele at D2Mit29 on the centromeric end of chromoso

278 Seeing that the COP seep field is one of the biggest natural seeps, a lo

279 of these sites is functionally linked to the COP I-dependent C-terminal dilysine ER retrieval pathway

280 With the COP design algorithm we then designed a mutant tyrosyl t

281 e thermodynamic stabilities of some of these COP structures.

282 To illustrate this COP procedure, we apply it to the design of mutant Metha

283 strating that DA inbred rats are superior to COP inbred rats in aerobic treadmill running capacity ha

284 Therefore, we develop an automated web tool-COP (COrrelations by Positional artifacts) to detect the

285 e range 10-36% in fresh samples with a total COPs amount from 212 to 645ngg(-1) and 6-14% for an oxid

286 Maximum total COPs concentrations were achieved at 20 min in neat chol

287 e Mcs1 congenic line that carried one or two COP alleles of the Mcs1 region had a significantly reduc

288 rnating cycles (total of six cycles) of VAMP/COP chemotherapy followed by response-based, involved-fi

289 -adapted combined-modality therapy with VAMP/COP and response-based, involved-field radiation therapy

290 A WF.COP-D2Mit29/D2Rat201 homozygous congenic strain derived

291 Five WF.COP congenic lines containing COP RN02 segments were com

292 still able to reach the plasma membrane when COP II-directed transport was disrupted by two different

293 by two different mutant forms of Sar1, when COP I-mediated vesicular traffic from the endoplasmic re

294 proliferative response to E2, compared with COP rats, as evidenced by quantification of S phase frac

295 on mechanism analogous to that observed with COP catalysts.

296 ted tomography (HRCT) scans in patients with COP.

297 In both (ACI x COP)F(2) and (COP x ACI)F(2) populations, we find strong

298 locus, Emca2, on chromosome 18 in the (ACI x COP)F(2) population.

299 (P < 0.001) compared with rats carrying zero COP alleles at this locus.

300 epsilon-COP and beta-, gamma-, delta-, zeta-COP coatomer subcomplexes and identify links between the

301 Fn specifically interacts with at least zeta-COP and beta-COP of the COPI coatomer complex.