ライフサイエンスコーパス: CPM

1 CPM also enhanced the DAKD-induced B1R conformational ch

2 CPM and B1R are also co-localized in lipid raft/caveolin

3 CPM increased B1R affinity for DAKD by approximately 5-f

4 CPM is associated with decreased MCBC incidence but not

5 CPM is cost-effective compared with surveillance for pat

6 CPM is no longer cost-effective for patients older than

7 CPM positive allosteric action was independent of enzyme

8 CPM provides 21.22 mean QALYs compared with 20.93 for su

9 CPM treatment lowered the extraction of seed tannins, ex

10 CPM was induced using a cold water bath, and the pain th

11 CPM-99Fe-derived material, denoted CPM-99Fe/C, exhibits

12 CPM-E264Q-mediated activation of B1Rs by bradykinin resu

13 cted to identify factors associated with (1) CPM vs all other treatments combined, (2) CPM vs unilate

14 r patients with coronary artery disease, 168 CPMs for population samples, and 79 models for patients

15 conformational activation of the B1R, and 2) CPM-generated des-Arg-kinin agonist is efficiently deliv

16 1) CPM vs all other treatments combined, (2) CPM vs unilateral mastectomy (UM), and (3) CPM vs breast

17 CPMs for 31 index conditions, including 215 CPMs for patients with coronary artery disease, 168 CPMs

18 ) CPM vs unilateral mastectomy (UM), and (3) CPM vs breast-conserving surgery (BCS).

19 -7 mins, 95%CI-9,-5), and had lower CPM (-32 CPM, 95%CI-44,-19) and steps per day (-813 steps, 95%CI,

20 ith early-stage breast cancer and received a CPM increased in many states; however, it did not correl

21 with the proportion of women who received a CPM.

22 population are likely not attributable to a CPM-derived decrease in MCBC incidence.

23 vasive early-stage breast cancer underwent a CPM from 2010 to 2012.

24 with surgery, the proportion who underwent a CPM nationally increased between 2004 and 2012 from 3.6%

25 iates CPM from B1R, and was not found with a CPM-E264Q-B1R fusion protein.

26 Key observations include (a) CPM results exhibited low temporal variability, (b) fals

27 ective physician-patient communication about CPM is needed to reduce potential overtreatment.

28 n recommendations, level of discussion about CPM, satisfaction with surgical decision making, receipt

29 43) reported no substantial discussion about CPM.

30 toperative complications were observed after CPM and reconstruction, these procedures were associated

31 ho received no recommendation for or against CPM from a surgeon, 148 (19.0%) underwent CPM.

32 that their surgeon did not recommend against CPM but discussed it.

33 port of first-surgeon recommendation against CPM and the extent of discussion about it with 3 outcome

34 First-surgeon recommendation against CPM does not appear to substantively increase patient di

35 % among patients with recommendation against CPM vs 15.1% of others; P = .52) nor to receive surgery

36 % among patients with recommendation against CPM vs 8.3% of others; P = .88).

37 Women who received a recommendation against CPM were not more likely to seek a second opinion (17.1%

38 %) reported a surgeon recommendation against CPM, of whom only 12 (1.9%) underwent CPM, but among the

39 that their first surgeon recommended against CPM and 30.1% (n = 343) reported no substantial discussi

40 for those whose surgeon recommended against CPM with no substantive discussion (14.5%; n = 37).

41 Although CPMs hold promise for supporting sex-specific decision m

42 s of MCBC were significantly decreased among CPM recipients [RR = 0.04 (95% CI: 0.02, 0.09); RD = -24

43 s response required co-expression of B1R and CPM-E264Q in the same cell, was disrupted by antibody th

44 Thus, a close relationship of B1Rs and CPM on the membrane is required for efficiently generati

45 t of total phenols, but higher than in C and CPM wines.

46 rward translational studies between DNIC and CPM, gauged between bench and bedside, are key for the d

47 nserving surgery, unilateral mastectomy, and CPM.

48 nserving surgery, unilateral mastectomy, and CPM.

49 Data collected during periods of natural and CPM conditions show that the alternative pathway was sig

50 eventeen (90%) are de novo CPMs, 21 (3%) are CPM recalibrations, and 58 (7%) are CPM adaptations.

51 (3%) are CPM recalibrations, and 58 (7%) are CPM adaptations.

52 As CPM focuses on linear modeling and a purely data-driven

53 ved from patient self-report, categorized as CPM, unilateral mastectomy, or breast conservation surge

54 quantitative sensory testing (QST) to assess CPM levels, pressure-pain thresholds, and pressure-pain

55 re CPM, one was EPM, and six were associated CPM and EPM.

56 te the association between RA and attenuated CPM.

57 ascular endothelial cells, disruption of B1R-CPM heterodimers inhibited B1R-dependent NO production s

58 e synergistic effects of heterometals bestow CPM-200s with the highest CO2 uptake capacity among know

59 Associations between CPM receipt and surgeon recommendations were also evalua

60 and immunosuppression were compared between CPM/EPM patients and control group of transplanted patie

61 s and assumptions of QOL differences between CPM and surveillance patients.

62 k 20% Pt/C in alkaline and acidic media, but CPM-99Fe/C is more durable and methanol-tolerant.

63 g the most porous crystalline chalcogenides, CPM-120-ZnGeS (exchanged with Cs(+) ions) also shows rev

64 e created a novel database and characterized CPMs based on the stage of development, population under

65 M were younger than those who did not choose CPM.

66 030 patients with DCIS; 2,072 patients chose CPM.

67 Postoperatively, women who chose CPM with implant reconstructions were more satisfied wit

68 he superior outcomes observed when comparing CPM recipients with nonrecipients in the general populat

69 Many patients consider CPM, but knowledge about the procedure is low and discus

70 Overall, 1301 (43.9%) patients considered CPM (601 [24.8%] considered it very strongly or strongly

71 e analytic sample, 18.9% strongly considered CPM and 7.6% received it.

72 Of those who strongly considered CPM, 32.2% received CPM, while 45.8% received unilateral

73 with unilateral breast cancer who considered CPM (n = 1140).

74 Many women considered CPM and a substantial number received it, although few h

75 a systematic review for articles containing CPMs for cardiovascular disease published between Januar

76 This database contains CPMs for 31 index conditions, including 215 CPMs for pat

77 consider when counseling women contemplating CPM as part of their breast cancer treatment.

78 ell size in the CPM so that in the corrected CPM, cell size is independent of the cell motility.

79 PM Registry, a comprehensive database of CVD CPMs published from January 1990 to May 2012.

80 Despite conflicting data, CPM rates continue to increase.

81 CPM-99Fe-derived material, denoted CPM-99Fe/C, exhibits the best ORR activity, comparable t

82 shown by a series of new materials (denoted CPM-200s) with superior CO2 uptake capacity (up to 207.6

83 There were 10 subjects that developed CPM, with an overall incidence of 0.5%.

84 wn about the impact of surgeons discouraging CPM on patient care satisfaction or decisions to seek tr

85 , was disrupted by antibody that dissociates CPM from B1R, and was not found with a CPM-E264Q-B1R fus

86 tive Analytics and Comparative Effectiveness CPM Registry, a comprehensive database of CVD CPMs publi

87 ly embedded (metallo)porphyrin centers endow CPM-99 with highly desirable properties as precursors fo

88 Treatment of cells co-expressing CPM and B1R with methyl-beta-cyclodextrin to disrupt lip

89 otomy-induced decrease in polymodal C-fiber (CPM) heat threshold, but transiently prevented the recru

90 Choice for CPM was associated with an improvement in breast satisfa

91 t recurrence appeared to drive decisions for CPM although the procedure has not been shown to reduce

92 eness ratio (ICER) of $4,869/QALY gained for CPM.

93 variables included clinical indications for CPM (genetic mutation and/or strong family history), dia

94 tion can also be tuned from -16.4 kJ/mol for CPM-200-Sc/Mg to -79.6 kJ/mol for CPM-200-V/Mg.

95 kJ/mol for CPM-200-Sc/Mg to -79.6 kJ/mol for CPM-200-V/Mg.

96 y dependent on assumptions regarding QOL for CPM versus surveillance strategy.

97 Four cubic zirconium-porphyrin frameworks, CPM-99(H2, Zn, Co, Fe), were synthesized by a molecular-

98 lecting patients most likely to benefit from CPM.

99 In this age group, CPM proportions for the period from 2010 to 2012 were ov

100 Greater cancer worry predicted who had CPM (P = 0.02).

101 interested in CPM and 12 (10%) of women had CPM at the time of their primary breast cancer surgery.

102 pects of CPM may affect the decision to have CPM and should be addressed when discussing surgical opt

103 important factors in their decision to have CPM.

104 bout how women approach the decision to have CPM.

105 surgical visit and the likelihood of having CPM after the visit differed (P </= 0.001).

106 n rated their perceived likelihood of having CPM and the surgeons rated the appropriateness of CPM.

107 the patient's reported likelihood of having CPM were not significantly different (P = 0.49).

108 n (n = 52) accounted for 13% of those having CPM.

109 tu were significantly associated with higher CPM rates among all surgically treated patients and all

110 However, after regeneration, some identified CPMs and CHs stained positively for both markers, which

111 We identified CPMs in the Tufts Predictive Analytics and Comparative E

112 RA patients have impaired CPM when compared to pain-free control subjects.

113 d not affect the axotomy-induced decrease in CPM threshold, but transiently prevented the recruitment

114 aires assessing knowledge of and interest in CPM and associated psychosocial factors.

115 Interest in CPM before surgical visit and the likelihood of having C

116 Interest in CPM is common among women with sporadic breast cancer.

117 ancer worry (P = 0.03) predicted interest in CPM.

118 chosocial factors that influence interest in CPM.

119 n were moderately to extremely interested in CPM and 12 (10%) of women had CPM at the time of their p

120 conducted a field synopsis of sex effects in CPMs for CVD.

121 Here, we found that a catalytically inactive CPM mutant that still binds substrate (CPM-E264Q) also f

122 ent that various surgical options (including CPM) were discussed; also, the women rated their perceiv

123 Among sex-including CPMs, women with heart failure were at lower mortality r

124 were significantly associated with increased CPM rates among all surgically treated patients but lowe

125 response to B2R agonists without inhibiting CPM.

126 lts of mediation analyses suggested that low CPM levels might be attributed, in part, to sleep distur

127 ng all surgically treated patients but lower CPM rates among patients undergoing mastectomy.

128 ctivity (-7 mins, 95%CI-9,-5), and had lower CPM (-32 CPM, 95%CI-44,-19) and steps per day (-813 step

129 n-protein interaction of carboxypeptidase M (CPM) and kinin B1 receptor (B1R) enhances B1R signaling

130 Carboxypeptidase M (CPM) is a membrane protein potentially well suited for t

131 odimerizes with membrane carboxypeptidase M (CPM), facilitating receptor signaling via CPM-mediated c

132 ontrol C), cold pre-fermentation maceration (CPM), saignee (S), pre-fermentation heating with extende

133 of contralateral prophylactic mastectomies (CPMs) among patients with invasive unilateral breast can

134 of contralateral prophylactic mastectomies (CPMs) continues to rise, although there is little eviden

135 te of contralateral prophylactic mastectomy (CPM) among women diagnosed as having breast cancer has r

136 rding contralateral prophylactic mastectomy (CPM) among women with sporadic breast cancer.

137 dergo contralateral prophylactic mastectomy (CPM) and breast reconstruction.

138 ds in contralateral prophylactic mastectomy (CPM) and determine whether survival differed for invasiv

139 es of contralateral prophylactic mastectomy (CPM) have increased dramatically, particularly among you

140 Contralateral prophylactic mastectomy (CPM) rates in women with unilateral breast cancer are in

141 that contralateral prophylactic mastectomy (CPM) should be discouraged in patients without an elevat

142 dergo contralateral prophylactic mastectomy (CPM) to prevent cancer in the opposite breast.

143 Contralateral prophylactic mastectomy (CPM) use is increasing among women with unilateral breas

144 Specifically, a new material, CPM-33b-Ni without any open metal sites, exhibits the CO

145 we can create crystalline porous materials (CPMs) with superior CO(2) uptake capacity.

146 ), the Raven's Colored Progressive Matrices (CPM), and school performance tests.

147 redox activity of coarse particulate matter (CPM), three sampling sites were set up up in the Los Ang

148 The median CPM level was 0.5 kg/cm2 (interquartile range [IQR] -0.1

149 Controlled pressure methods (CPM) have been proposed as an alternative, but temporal

150 copy (AFM)-based colloidal probe microscopy (CPM) method.

151 vel of physical activity (counts per minute [CPM], steps, time spent in light, moderate or vigorous a

152 ell clusters using the Cellular Potts Model (CPM) in a monolayer geometry.

153 oped a connectome-based predictive modeling (CPM) approach.

154 resent connectome-based predictive modeling (CPM), a data-driven protocol for developing predictive m

155 Clinical prediction models (CPMs) estimate the probability of clinical outcomes and

156 e role of sex in clinical prediction models (CPMs).

157 Conditioned pain modulation (CPM) is the human counterpart of DNIC and requires a des

158 h as diminished conditioned pain modulation (CPM), may play a role in enhancing pain perception among

159 Moreover, CPM-120-ZnGeS could also function as a robust photocatal

160 s of identified afferents revealed that most CPMs were isolectin B4 (IB4) positive and transient rece

161 ntral pontine and extrapontine myelinolysis (CPM/EPM) are severe neurologic complications after liver

162 occurrence of central pontine myelinolysis (CPM).

163 7), but no difference was reported in the no-CPM group in the other QOL domains.

164 generation, whereas C-polymodal nociceptors (CPMs) had lower heat thresholds.

165 generation, cutaneous polymodal nociceptors (CPMs) lacking transient receptor potential vanilloid 1 (

166 Compared with nonrecipients, CPM recipients had higher rates of overall survival [OS;

167 Seven hundred seventeen (90%) are de novo CPMs, 21 (3%) are CPM recalibrations, and 58 (7%) are CP

168 h cardiovascular disease, there are numerous CPMs available although the extent of this literature is

169 nstructive surgery was performed in 48.3% of CPM patients compared with only 16.0% of unilateral mast

170 nstructive surgery was performed in 48.3% of CPM patients compared with only 16.0% of unilateral mast

171 are important to the biological activity of CPM, and that a more targeted control strategy may be ne

172 tional mutation that reduced the affinity of CPM for C-terminal Arg and increased the affinity for C-

173 Surgeons' rating of the appropriateness of CPM and the patient's reported likelihood of having CPM

174 nd the surgeons rated the appropriateness of CPM.

175 The informational and emotional aspects of CPM may affect the decision to have CPM and should be ad

176 sis were used to evaluate the association of CPM with four BREAST-Q QOL domains.

177 Crustal materials, the major component of CPM, demonstrated very low water-solubility, in contrast

178 ibody to the C-terminal beta-sheet domain of CPM reduced the B1R response to B2R agonists without inh

179 In non-BRCA patients, cost-effectiveness of CPM is highly dependent on assumptions regarding QOL for

180 led us to evaluate the cost-effectiveness of CPM versus routine surveillance as an alternative contra

181 ells inhibited the allosteric enhancement of CPM on B1R DAKD binding or ERK1/2 activation.

182 tably transfected with B1R, co-expression of CPM enhanced DAKD-stimulated increases in intracellular

183 The incidence of CPM correlates with hyponatremia, although its overall i

184 Although infrequent, the incidence of CPM did correlate with serum sodium levels (P < 0.01).

185 n of the CPM/B1R interaction or knockdown of CPM in cytokine-treated primary human endothelial cells

186 study was undertaken to examine the level of CPM, pressure-pain threshold, and pressure-pain toleranc

187 mpared to identify independent predictors of CPM.

188 n (OR = 1.7) to be independent predictors of CPM.

189 tively evaluated single-center prevalence of CPM/EPM and associated risk factors: cause of liver dise

190 results present distinct diurnal profiles of CPM-induced ROS formation in the two seasons, with much

191 The rate of CPM by surgeon varied from 1% to 26%.

192 The rate of CPM was 13.8% (n = 407), increasing from 6.7% in 1997 to

193 tion, are associated with increased rates of CPM.

194 ltivariate regression showed that receipt of CPM (vs either unilateral mastectomy or breast conservat

195 Receipt of CPM was the primary dependent variable for analysis and

196 ically, QOL differed according to receipt of CPM.

197 aging at diagnosis contributed to receipt of CPM.

198 d a mastectomy and 1,598 reported receipt of CPM.

199 The use and trends of CPM for DCIS in the United States have not previously be

200 The use of CPM for DCIS in the United States markedly increased fro

201 ates of occult CBC do not support the use of CPM in average-risk women with newly diagnosed breast ca

202 These data suggest that increasing use of CPM is not associated with increased recognition of pati

203 The use of CPM more than tripled during the study period despite ev

204 The use of CPM more than tripled during the study period despite ev

205 ut the underlying factors driving the use of CPM.

206 an alternative, but temporal variability of CPM results and whether they are indicative of impacts u

207 There is an abundance of CPMs available for a wide assortment of cardiovascular d

208 The number of CPMs published each year is increasing steadily over tim

209 the temporal trend and in the proportion of CPMs among women with early-stage unilateral breast canc

210 Temporal changes in the proportion of CPMs among women with early-stage unilateral breast canc

211 The increase in the proportion of CPMs among women with early-stage unilateral breast canc

212 variation and increasing trend in the use of CPMs.

213 rves for the adsorption of carbon dioxide on CPM-5 (crystalline porous materials) were obtained exper

214 In many respects, the GGH or CPM methodology and the approach of the centre-based mod

215 nserving therapy), unilateral mastectomy, or CPM, with subsequent subgroup analysis stratifying by ag

216 nserving therapy), unilateral mastectomy, or CPM, with subsequent subgroup analysis stratifying by ag

217 of the lattice-based Cellular Potts Model or CPM (also known as the Glazier-Graner-Hogeweg or GGH mod

218 tain the microcubic morphology of the parent CPM-99 but also possess porphyrinic active sites, hierar

219 For BRCA-positive patients, CPM is clearly cost-effective, providing more QALYs whil

220 esent the first meta-analysis to assess post-CPM outcomes in women with UBC.

221 are included in only one third of published CPMs.

222 who strongly considered CPM, 32.2% received CPM, while 45.8% received unilateral mastectomy and 22.8

223 1.2%) underwent UM, and 428 (17.3%) received CPM.

224 he majority of patients (68.9%) who received CPM had no major genetic or familial risk factors for co

225 Soluble, recombinant CPM bound to HEK cells expressing B1Rs without stimulati

226 re chief determinants in decisions regarding CPM.

227 Of 592 CVD-related CPMs, 193 (33%) included sex as a predictor or presented

228 The Raven's CPM score ranged from 21.4 to 22.4.

229 bers of women with breast cancer are seeking CPM.

230 Here, we show CPM is also a positive allosteric modulator of B1R signa

231 To prevent one CBC, six CPMs would be needed.

232 Among them, highly stable CPM-120-ZnGeS allows for ion exchange with diverse metal

233 ctive CPM mutant that still binds substrate (CPM-E264Q) also facilitates efficient B1R signaling by B

234 his study is the first involving a long-term CPM test at a house having a multiyear high temporal res

235 The tested CPM-5 showed an outstanding adsorption equilibrium capac

236 ates how controlled-pressure-method testing (CPM), soil gas sampling, and screening-level emissions c

237 trongly); only 395 (38.1%) of them knew that CPM does not improve survival for all women with breast

238 Despite knowing that CPM does not clearly improve survival, women who have th

239 Here we show that CPM expression is required to generate a B1R-dependent i

240 The CPM rate was 4.1% for all surgically treated patients an

241 On multivariable analysis, the CPM group continued to report higher breast satisfaction

242 We determined the CPM rate as a proportion of all surgically treated patie

243 age 45 years are comparable: $36,594 for the CPM and $35,182 for surveillance.

244 tor associated with occult malignancy in the CPM (OR 2.88, P = 0.04).

245 , mean breast satisfaction was higher in the CPM group (60.4 v 57.9, P < .001) and mean physical well

246 nd mean physical well-being was lower in the CPM group (74.6 v 76.6, P < .001).

247 were not significantly more frequent in the CPM group than in the group of women who did not undergo

248 motility-induced changes in cell size in the CPM so that in the corrected CPM, cell size is independe

249 This is an artifact in the CPM.

250 th finding either malignancy or a HRL in the CPM.

251 was associated with occult malignancy in the CPM; however, lack of standardized definitions and diffe

252 An analysis of the CPM reveals an explicit inverse-relationship between the

253 ure regardless of day or time of year of the CPM test.

254 Some members of the CPM-200s family consist of combinations of metal ions (e

255 Disruption of the CPM/B1R interaction or knockdown of CPM in cytokine-trea

256 s (including breast-conserving surgery), the CPM rate increased by 148% from 1998 (2.1%) to 2005 (5.2

257 s undergoing breast-conserving surgery), the CPM rate increased by 188% from 1998 (6.4%) to 2005 (18.

258 ressibility within the CPM and find that the CPM predicts that increased cell motility leads to small

259 It has been demonstrated that the CPM protocol performs as well as or better than many of

260 It was found that the CPM-5 has a dynamic CO2 adsorption capacity of 11.9 wt %

261 Thus, the CPM results were a reliable indicator of VI occurrence a

262 cell motility and compressibility within the CPM and find that the CPM predicts that increased cell m

263 Thus, CPM and B1Rs on cell membranes form a critical complex t

264 Thus, CPM binding to extracellular loop 2 of the B1R results i

265 R signaling in two ways; 1) kinin binding to CPM causes a conformational activation of the B1R, and 2

266 Kinin peptide binding to CPM causes a conformational change in the B1R leading to

267 ctivities, despite their low contribution to CPM mass, are important to the biological activity of CP

268 o protect the public health from these toxic CPM sources.

269 Among 997 transplants, CPM/EPM were diagnosed in 11 patients (1.1%), of whom fo

270 natural conditions; it was identified under CPM conditions when measured emission rates were 2 order

271 an in the group of women who did not undergo CPM (14 of 86 [16.3%] vs 113 of 848 [13.3%], P = .43).

272 Patients who did and did not undergo CPM within 1 year of treatment for their index cancer we

273 8%], P = .01) than those who did not undergo CPM.

274 wing number of women are choosing to undergo CPM, yet the benefit of this procedure for the average w

275 t known FGR should not be advised to undergo CPM.

276 ed that women with breast cancer who undergo CPM live longer than those who do not.

277 provement in BCSS or OS for women undergoing CPM (BCSS: HR 1.08, 95% confidence interval 1.01-1.16; O

278 provement in BCSS or OS for women undergoing CPM (BCSS: HR 1.08, 95% confidence interval 1.01-1.16; O

279 Overall, the proportion of women undergoing CPM increased from 3.9% in 2002 to 12.7% in 2012 (P < 0.

280 Overall, the proportion of women undergoing CPM increased from 3.9% in 2002 to 12.7% in 2012 (P < 0.

281 Women undergoing CPM were younger than those who did not choose CPM.

282 nt unilateral mastectomy, and 7.0% underwent CPM.

283 nt unilateral mastectomy, and 7.0% underwent CPM.

284 st CPM from a surgeon, 148 (19.0%) underwent CPM.

285 Among 2965 patients, 407 (13%) underwent CPM.

286 gainst CPM, of whom only 12 (1.9%) underwent CPM, but among the 746 (46.8%) of these women who receiv

287 Eighty-six of the 934 (9.2%) women underwent CPM and were more likely to be younger (mean age, 48 yea

288 Previously using CPM, we defined a high-attention network, comprising con

289 M (CPM), facilitating receptor signaling via CPM-mediated conversion of bradykinin or kallidin to des

290 VM CPM was lower in children with PAH (n = 29) than in cont

291 In post hoc analyses, VM CPM and time spent in moderate/vigorous combined and vig

292 Vector magnitude counts per minute (VM CPM) and time per day spent in different PA intensity le

293 sed in 11 patients (1.1%), of whom four were CPM, one was EPM, and six were associated CPM and EPM.

294 sis can be found isolated or associated with CPM in up to two of three liver transplanted patients wi

295 tivariable analysis, factors associated with CPM included younger age (per 5-year increase: odds rati

296 r of MR imaging lesions for association with CPM by using the Fisher exact test, exact chi(2) test, a

297 Patients undergoing mastectomy with CPM for their first diagnosis of unilateral stage 0 to I

298 rt improvement in quality of life (QOL) with CPM.

299 patients, with rates of reconstruction with CPM rising from 35.3% in 2002 to 55.4% in 2012 (P < 0.00

300 patients, with rates of reconstruction with CPM rising from 35.3% in 2002 to 55.4% in 2012 (P < 0.00