ライフサイエンスコーパス: CPP

1 CPP FAP-310, a randomized, double-blind, Phase III trial

2 CPP-115 induced robust and significant increases in brai

3 CPP-115, a next-generation gamma-amino butyric acid (GAB

4 CPP-115-induced changes were exclusive to GABA and homoc

5 CPPs are known to be effective in promoting membrane tra

6 CPPs can also theoretically be used to modulate intracel

7 A bent 8H[12]CPP and a bent 12H[18]CPP, which were fused intramolecul

8 A molecule containing a bent 8H[12]CPP fused to a 4H[6]CPP was likewise constructed.

9 ptical, and electronic properties of [5]-[12]CPPs.

10 Functionalized [12]cycloparaphenylenes ([12]CPPs) containing four alternating biphenyl and naphthyl

11 benzoquinone produced the functionalized [12]CPPs.

12 A bent 8H[12]CPP and a bent 12H[18]CPP, which were fused intramolecularly with two and thre

13 tion of the TRPA1-V1 complex, and Tmem100-3Q CPP is a promising pain therapy.

14 (2,4-dichlorophenoxy)-propionic acid), and 4-CPP ((R,S)-2-(4-chlorophenoxy)-propionic acid); (b) comp

15 nantiomer fractionation in MCPP, DCPP, and 4-CPP was pronounced, with enantioselectivities (ES) of -0

16 nantiomer fractionation of MCPP, DCPP, and 4-CPP.

17 haracterization of [5]cycloparaphenylene ([5]CPP), a carbon nanohoop that can be envisaged as an open

18 f any para-polyphenylene synthesized make [5]CPP a desirable new material for organic electronics.

19 Inclusion of (Arg)9 or TAT(57-57) CPPs further modified the translation readouts, but vari

20 containing a bent 8H[12]CPP fused to a 4H[6]CPP was likewise constructed.

21 its of tetrahydro[6]cycloparaphenylene (4H[6]CPP) fused together through two 1,4-dimethoxybenzene uni

22 to synthesize a 2,2'-bipyridine-embedded [8]CPP, which we show can successfully coordinate to both P

23 fine-tuning of the binding properties of [8]CPP 1 toward pyridinium cations due to the presence of t

24 e been investigated and compared with the [8]CPP macrocycle.

25 Similarly, two 6H[9]CPPs were connected through three 1,4-dimethoxybenzene u

26 as blockade of beta-ARs immediately after a CPP test had little effect on subsequent CPP expression.

27 e that local dHipp beta-AR blockade before a CPP test prevents CPP expression shortly and long after

28 Aggressors develop a CPP, whereas non-aggressors develop a conditioned place

29 e and determine the secondary structure of a CPP within cells is critical for clarifying the mechanis

30 the delivery of a single SSO conjugated to a CPP, but here we describe the conjugation of two phospho

31 Treatment with systemic morphine abolished CPP to saphenous nerve block, demonstrating control of o

32 increases lHb neuronal firing and abolishes CPP to the intruder-paired context.

33 o-4-difluoromethylene-1-cyclopentanoic acid (CPP-115) showed 187 times greater potency than that of v

34 This activatable CPP conjugate platform could find applications in the se

35 orophiles as innovative concepts to activate CPPs.

36 Conversely, animals that received additional CPP conditioning, rather than extinction training, 1 h a

37 obal warming and climate change could affect CPP ranges and impact.

38 nicotine CPP reinstatement without affecting CPP acquisition.

39 e-induced cross-sensitization of amphetamine CPP, DeltaFosB in the NAc and medial prefrontal cortex,

40 P10W, a peptide derived from the amphipathic CPP transportan 10; the second was based on DL1a, a synt

41 data suggest that cell uptake of amphipathic CPPs correlates with their adopted alpha-helix content i

42 ere exclusive to GABA and homocarnosine, and CPP-115 afforded brain GABA+ concentration changes compa

43 nificantly reduced cocaine sensitization and CPP.

44 of AMPH-induced locomotor sensitization and CPP.

45 up-regulation, locomotor sensitization, and CPP, suggesting a role for Thr(30)-linked NET regulation

46 receiving injections of the NMDAr antagonist CPP immediately after four 45-min extinction sessions.

47 lace aversion to lithium chloride as well as CPP to palatable food.

48 We have reported that a modified Tat-based CPP (Tatm) with reduced positive charge is secreted effi

49 iginate from ionpair-pi interactions between CPP and activator implied that replacement of the pi-bas

50 d Iztli peptide 1 (IP-1) because it has both CPP and CAP activities.

51 Four candidate CPPs were discovered, and further study on one peptide (

52 ion between the anionic heparin and cationic CPP.

53 Observations of changing CPP distributions over the twentieth century suggest tha

54 tioning did not significantly affect cocaine CPP, suggesting that the CaMKII inhibitor blocks cocaine

55 Enhancement of LTP in the VTA and cocaine CPP in behaving rats both require glucocorticoid recepto

56 ing that the CaMKII inhibitor blocks cocaine CPP through selective disruption of cocaine-cue-associat

57 failed to condition to cocaine, but cocaine CPP in the alpha4 KO was preserved.

58 on of cocaine memory showed enhanced cocaine CPP compared with animals that did not reactivate the co

59 Cav1.2/CaMKII/S831 GluA1 pathway in cocaine CPP extinction, with data supporting contribution of hip

60 idation window), demonstrated normal cocaine CPP.

61 lace preference (CPP) and relapse of cocaine CPP (drug-free and cocaine-primed) following 30 days of

62 est did not affect the expression of cocaine CPP and cocaine-induced synaptic plasticity in the NAc s

63 This stress-induced reinstatement of cocaine CPP depends on type 1 orexin receptors (OX1Rs), type 1 c

64 ing cells resulted in attenuation of cocaine CPP extinction and lack of extinction-dependent changes

65 therapeutic target for disruption of cocaine CPP memories.

66 ditioning blocked the acquisition of cocaine CPP, whereas intra-VTA microinjections of tatCN21 before

67 c disinhibition and reinstatement of cocaine CPP.

68 gnificantly reduced reinstatement of cocaine CPP.

69 nd expression but not development of cocaine CPP.

70 hippocampus attenuated extinction of cocaine CPP.

71 of the hippocampus for extinction of cocaine CPP.

72 re cocaine significantly potentiated cocaine CPP and significantly increased the effects of cocaine o

73 day exhibited significantly reduced cocaine CPP.

74 In the cocaine CPP paradigm, mice receiving TAT-NET-Thr(30) but not TAT

75 and knockout mice alike all acquired cocaine-CPP and exhibited increased levels of silent synapses af

76 nsolidation of fear conditioning and cocaine-CPP, as well as extinction of CPP.

77 agnitude of a previously established cocaine-CPP after an additional cycle of cocaine place-condition

78 emonstrated a three-fold increase in cocaine-CPP over the response of either uninduced littermates or

79 or activation enhances extinction of cocaine-CPP via GluN2B-containing NMDARs.

80 quired for establishing or retaining cocaine-CPP.

81 the favoured candidate for high-conductance CPP single-molecule devices.

82 Changing the conjugated CPP resulted in a pronounced improvement in the antibact

83 a time-kill assay revealed three conjugated CPPs rapidly kill Listeria within 20 minutes without dis

84 A macrocyclic furan-containing CPP precursor was used for the Diels-Alder reaction with

85 rtion and enables more accurate controlling, CPP-based efficient virus-free delivery strategy has bee

86 Cycloparaphenylenes (CPP) can serve as both guest and host in a complex.

87 amolecular chemistries, cycloparaphenylenes (CPPs) have the potential to act as a new class of ligand

88 We selected the naturally derived CPP low-molecular-weight protamine (LMWP) to modify PLGA

89 cdA and TcsL, uncovered two new TcdA-derived CPPs.

90 To screen for TcdB-derived CPPs, a panel of synthetic peptides was tested for the a

91 ase (ODC) using low-dose eflornithine (DFMO, CPP-1X), combined with maximal PA export using low-dose

92 was covalently conjugated to five different CPPs.

93 lar" monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities

94 roduce the intermediate copalyl diphosphate (CPP), along with the more surprising finding of an atypi

95 de have been most important in disseminating CPPs, but there is some evidence for a latitudinal bias

96 Further, a distinct CPP can enter cells through many mechanisms, often leadi

97 pain and morphine conditioning that elicited CPP inhibited GABA synaptic transmission in CeA neurons.

98 id not affect withdrawal thresholds elicited CPP and NAc dopamine release, effects that were prevente

99 to overcome this selectivity issue, enabling CPP-mediated cellular drug delivery to be practically ap

100 iana benthamiana identified SdCPS1 as an ent-CPP synthase, which is prevalent in roots and, together

101 s (diTPSs), the ent-copalyl diphosphate (ent-CPP) synthase SdCPS1, and the clerodienyl diphosphate (C

102 ously acquired cocaine and alcohol (ethanol) CPP on subsequent days.

103 In this review, we summarize the existing CPP-based delivery system, emerging landscape of CPP app

104 Expressed CPPs, coupled to a secretory signal peptide (SP), can su

105 we report a novel inactivation mechanism for CPP-115, a mechanism-based inactivator that undergoes GA

106 npointed an asparagine residue necessary for CPP activity.

107 The partition ratio for CPP-115 with GABA-AT is about 2000, releasing cyclopenta

108 bolished transfection activity, and the free CPP-PNA was recovered after reduction of the azobenzene

109 The computed (1)H NMR shifts of the guest CPP are shifted by about 1 ppm upfield relative to their

110 The guest CPP is modestly inclined relative to the plane of the ho

111 hritic rats exhibited a significantly higher CPP score in response to morphine than ibuprofen.

112 y inclined relative to the plane of the host CPP except when the host and guest differ by four phenyl

113 e structures of these partially hydrogenated CPPs were established by X-ray structure analysis, NMR s

114 produce stereochemically novel ent-8-hydroxy-CPP.

115 tion, and displayed no reward or aversion in CPP/CPA assays, suggesting that analogs might represent

116 However, the mice differed in CPP retention and CP-AMPAR incorporation.

117 sub-threshold dose of morphine effective in CPP induction.

118 hydrolysis of the difluoromethylene group in CPP-115, resulting in a noncovalent, tightly bound compl

119 ellular uptake of converting the residues in CPPs from l- to d-stereochemistry, but conflicting resul

120 d anti-inflammatory drug ibuprofen increased CPP scores in arthritic rats, suggesting that analgesia

121 ing neurons (alpha4(D1-/-)) showed increased CPP.

122 pre-mRNA targets when compared to individual CPP-PMO conjugates both in cell culture and in vivo in t

123 cocaine (10 mg/kg, i.p.) was able to induce CPP in Wt but not in NOP (-/-).

124 ion and reconsolidation of a cocaine-induced CPP memory.

125 was decreased; but following cocaine-induced CPP, both frequency and amplitude of inhibitory currents

126 prevented the expression of morphine-induced CPP.

127 knock-out mice prevented foot-shock-induced CPP reinstatement.

128 -conditioning sessions required for inducing CPP behavior.

129 In addition, infusing CPP into the infralimbic medial prefrontal cortex (IL-mP

130 ignaling in the rostral ACC (rACC) inhibited CPP and NAc dopamine release resulting from non-opioid p

131 ating activity than several other well-known CPPs (TAT, penetratin, Pep-1, and TP10).

132 Many CPPs exhibit some sort of structural polymorphism, where

133 mized to: CPP-1X 750 mg and sulindac 150 mg, CPP-1X placebo and sulindac 150 mg, or CPP-1X 750 mg and

134 Thus, CCS will likely be a minor CPP compliance strategy but may play a larger role under

135 e we use dimeric fluorescence TAT as a model CPP to explore the broader consequences of l- to d-stere

136 oherent Raman microscopy to localize a model CPP-penetratin-and determine its secondary structure in

137 naptic NR1 and NR2b expression, and morphine CPP were absent when morphine was not paired with a spec

138 In contrast, morphine CPP extinguished mice that received a saline priming dos

139 lly, we found that reinstatement of morphine CPP was prevented by the selective blockade of the NR2b

140 After extinction of morphine CPP, a priming dose of morphine was sufficient to reinst

141 ortant role in the reinstatement of morphine CPP.

142 n, extinction, and reinstatement of morphine CPP.

143 orphine was sufficient to reinstate morphine CPP and was associated with LTP that was indistinguishab

144 Here we report that morphine CPP is associated with increased basal synaptic transmis

145 mice were trained using an unpaired morphine CPP design and was absent when morphine was administered

146 y correlate with the positive charge of most CPPs, has emerged as one of the main impediments for eff

147 The new CPP 2 exhibits peculiar optoelectronic properties: (i) f

148 -conotoxin MII [H9A; L15A], blocked nicotine CPP.

149 LA neurons was sufficient to induce nicotine CPP reinstatement, identifying an anatomically specific

150 the BLA prevented yohimbine-induced nicotine CPP reinstatement without affecting CPP acquisition.

151 ity is necessary for stress-induced nicotine CPP reinstatement.

152 g/kg, i.p.) induce reinstatement of nicotine CPP in a norbinaltorphimine (norBNI, a KOR antagonist)-s

153 naling cascades on reinstatement of nicotine CPP.

154 parison, alpha4(D2-/-) mice exhibited normal CPP, but no cocaine enhancement.

155 Notably, CPP thus extinguished cannot be reinstated by drug re-ex

156 Notably, CPPs and related structures were proposed as viable temp

157 hibition on the cell-penetrating activity of CPP to create the prodrug feature, and subsequently the

158 The pharmacodynamic characteristics of CPP-115 remain to be evaluated.

159 nd increase the local interfacial density of CPP on the surface of the cargo.

160 o receive either single daily 80 mg doses of CPP-115 (n=4) or placebo (n=2) for 6, 10, or 14 days.

161 althy subjects receiving oral daily doses of CPP-115 or placebo.

162 cterize the acute pharmacodynamic effects of CPP-115 with additional dose-descending measures.

163 (D1-/-) mice, blocked cocaine enhancement of CPP.

164 ction of Tat protein after the extinction of CPP also produced reinstatement without additional expos

165 ng and cocaine-CPP, as well as extinction of CPP.

166 based delivery system, emerging landscape of CPP application in stem cell manipulation and reprogramm

167 rating activity associated with secretion of CPP-fusion proteins.

168 uisition of FPPase activity for synthesis of CPP, LPP, and MPP.

169 t advancements in diagnosis and treatment of CPP.

170 d 2,2'-bipyridine units into the backbone of CPPs.

171 Through screening of a panel of CPPs, we identified a sequence (M918) capable of carryin

172 emphasis on both synthesis and properties of CPPs and related nanohoops.

173 s to understand the functional redundancy of CPPs and CAPs.

174 erived by-product can be used as a source of CPPs.

175 ess is known about the fate and structure of CPPs within cells largely due to measurement difficulty.

176 rally associated with an increased uptake of CPPs.

177 al class I (di)terpene synthase that acts on CPP to produce the abietane olefin miltiradiene, but als

178 distinct TF families: one TCP (OsPCF2), one CPP (OsCPP5) and three NIN-like (OsNIN-like2, OsNIN-like

179 distinct TF families: one TCP (OsPCF2), one CPP (OsCPP5) and three NIN-like (OsNIN-like2, OsNIN-like

180 l ionpair-pi interactions afford operational CPP activators in model membranes and cells.

181 0 mg, CPP-1X placebo and sulindac 150 mg, or CPP-1X 750 mg and sulindac placebo once daily for 24 mon

182 gnosis and treatment of chronic pelvic pain (CPP) have moved away from targeting a specific organ to

183 Crop pests and pathogens (CPPs) present a growing threat to food security and ecos

184 The mean difference between the patients' CPP and their CPPopt was related to outcome for both cal

185 peptide containing cell-penetrating peptide (CPP) and collagen (COLL) domains is designed to undergo

186 e have developed a cell-penetrating peptide (CPP) conjugate of the HIV TAT protein that is fused to a

187 was meditated by a cell penetrating peptide (CPP) developed in our lab-low molecular weight protamine

188 these approaches, cell penetrating peptide (CPP) is promising and affords widely used vector for eff

189 h heparin, and the cell penetrating peptide (CPP) modified drug component.

190 ort an activatable cell penetrating peptide (CPP) strategy ultimately aimed at delivering nucleic aci

191 ould function as a cell-penetrating peptide (CPP), also termed protein transduction domain (PTD), to

192 rotamine (LMWP), a cell penetrating peptide (CPP), insulin showed greatly improved permeability throu

193 effective system, cell-penetrating peptide (CPP)-assisted poly(lactic-co-glycolic acid nanoparticles

194 , enzyme-triggered cell penetrating peptide (CPP)-mediated systems seem to be a feasible approach.

195 Strikingly, a cell-permeable peptide (CPP) containing the C-terminal sequence of Tmem100-3Q mi

196 evious findings suggesting that, for peptide-CPP chimeras, distal hydrophobic residues upstream of th

197 Cell penetrating peptides (CPP) and cationic antibacterial peptides (CAP) have simi

198 be conjugated to cell penetrating peptides (CPP) to overcome challenging delivery barriers.

199 well-established cell-penetrating peptides (CPPs) and showing that the resulting polymers are not on

200 oes into cells by cell-penetrating peptides (CPPs) and the bactericidal activity of antimicrobial pep

201 Although cationic cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus promoting

202 conditions where cell-penetrating peptides (CPPs) are cytotoxic.

203 Cell-penetrating peptides (CPPs) are promising molecules as drug carriers.

204 Cell-penetrating peptides (CPPs) are short peptide sequences that can translocate a

205 Cell-penetrating peptides (CPPs) are well established as delivery agents for otherw

206 based delivery of cell penetrating peptides (CPPs) could represent a new platform for intracellular p

207 Many cell-penetrating peptides (CPPs) fold at cell surfaces, adopting alpha- or beta-str

208 antimicrobial and cell-penetrating peptides (CPPs) form amphipathic alpha-helices when bound to lipid

209 For cell penetrating peptides (CPPs) to fulfil their promise as effective delivery vect

210 TDs), also called cell-penetrating peptides (CPPs), can promote uptake of macromolecules via endocyto

211 ate arginine-rich cell-penetrating peptides (CPPs).

212 njugated cationic cell penetrating peptides (CPPs).

213 iii) inclusion of cell penetrating peptides (CPPs).

214 that function as cell-penetrating peptides (CPPs).

215 ify BBB-penetrant cell-penetrating peptides (CPPs).

216 , and normal CCS under the Clean Power Plan (CPP) and a hypothetical more stringent CO2 emission redu

217 ate that current-perpendicular-to-the-plane (CPP) junctions have three-orders-of-magnitude higher ele

218 f the broad-band centro-parietal positivity (CPP) and limb-selective beta-band (8-16 and 18-30 Hz) EE

219 that perfluorinated fatty acids are powerful CPP activators in HeLa cells but not in model membranes.

220 h-pull aromatics should afford more powerful CPP activators.

221 fected cocaine conditioned place preference (CPP) and cocaine-evoked synaptic plasticity in its targe

222 Conditioned place preference (CPP) and in vivo microdialysis were used to assess negat

223 instatement of conditioned place preference (CPP) and relapse of cocaine CPP (drug-free and cocaine-p

224 Conditioned place preference (CPP) and saccharin (0.2% w/v) self-administration were a

225 cues (ie, the conditioned place preference (CPP) apparatus) triggers a significant decrease in the n

226 In a conditioned place preference (CPP) assay, we observed that menthol plus nicotine produ

227 at paradigm of conditioned place preference (CPP) combined with ankle monoarthritis as a condition of

228 consume food (conditioned place preference (CPP) for an environment previously associated with a pal

229 on, of cocaine conditioned place preference (CPP) in male mice increased Cav1.2 L-type Ca(2+) channel

230 codone-induced conditioned place preference (CPP) in rats.

231 sing a cocaine conditioned place preference (CPP) model, we demonstrate that local dHipp beta-AR bloc

232 effects in the conditioned place preference (CPP) paradigm, using pharmacological antagonism of alpha

233 sessed using a conditioned place preference (CPP) paradigm.

234 sessed using a conditioned place preference (CPP) paradigm.

235 Using a conditioned place preference (CPP) procedure, we found that removal of PNNs primarily

236 Using a conditioned place preference (CPP) reinstatement procedure in mice, we show that both

237 ne blocked the conditioned place preference (CPP) to cocaine, but only significantly reduced the effe

238 ocaine-induced conditioned place preference (CPP), a task that requires behavioral flexibility.

239 sensitization, conditioned place preference (CPP), cue- and cocaine prime-induced reinstatement of co

240 ng and cocaine-conditioned place preference (CPP), during acquisition and extinction.

241 gm of unbiased conditioned place preference (CPP), focusing on GABAergic synaptic activity in neurons

242 sitization and conditioned place preference (CPP), mice receiving SB203580 on cocaine challenge day o

243 or amphetamine conditioned place preference (CPP).

244 uished cocaine-conditioned place preference (CPP).

245 ion in cocaine-conditioned place preference (CPP).

246 d AMPH-induced conditioned place preference (CPP).

247 locomotion and conditioned place preference (CPP).

248 ion of cocaine-conditioned place preference (CPP).

249 ion of cocaine conditioned place preference (CPP).

250 development of conditioned place preference (CPP).

251 relief (i.e., conditioned place preference, CPP), revealing the presence of ongoing pain.

252 determined the cerebral perfusion pressure (CPP) at which the pressure reactivity (PRx or wPRx) was

253 beta-AR blockade before a CPP test prevents CPP expression shortly and long after treatment, indicat

254 late dopamine release in the NAc and produce CPP.

255 ) decreases lHb neuronal firing and promotes CPP to the intruder-paired context.

256 By conjugating EEDs to a TAT-PTD/CPP spilt-GFP peptide complementation assay, we were abl

257 EAB-318 and (R)-CPP, GluN2A/B antagonists, blocked both monosynaptic and

258 Recently, CPP-115 was shown to have no adverse effects in a Phase

259 er hand, mNTS LepRb signaling did not reduce CPP expression for morphine reinforcement regardless of

260 e productive mode of action of arginine-rich CPPs.

261 ding (S)-alpha-cholorophenylproprionate ((S)-CPP).

262 h are significantly better than those of (S)-CPP.

263 although all groups displayed similar saline-CPP, Tat-induced GT-tg mice demonstrated a three-fold in

264 received a saline priming dose did not show CPP and had disrupted hippocampal LTP.

265 rent target sequences conjugated to a single CPP are biologically effective and potentially suitable

266 olino oligonucleotide (PMO) SSOs to a single CPP for simultaneous delivery and pre-mRNA targeting of

267 Conjugations of PMOs to a single CPP were carried out through an amide bond in one case a

268 In conclusion, we have identified six CPPs from large clostridial toxins and have demonstrated

269 The most active bi-specific CPP-PMOs demonstrated comparable exon skipping levels fo

270 han redispatching under the CPP and stronger CPP, respectively.

271 ent CO2 emission reduction target ("stronger CPP").

272 dging group, SGSGSGSG, to three well-studied CPPs: octaarginine, penetratin and TP10.

273 r a CPP test had little effect on subsequent CPP expression.

274 subsequent 90-min extinction retention test, CPP-treated rats lever pressed less than saline-treated

275 We show here that CPP binding to lipid bilayers, a simple model of the cel

276 TA microinjection of tatCN21 just before the CPP test did not affect the expression of cocaine CPP an

277 With foreknowledge, the CPP and beta-band signals exhibited a similar gradual bu

278 Without foreknowledge, the CPP exhibited identical dynamics, whereas choice-selecti

279 self-assembly the cargo-induced loss of the CPP affinity to bio-membranes.

280 distal hydrophobic residues upstream of the CPP sequence can have profound effects on the way they i

281 NA interference targeting either both of the CPP synthases, TwTPS7v2 and TwTPS9v2, or the subsequentl

282 disrupted consolidation of extinction of the CPP.

283 persisted up until the delayed response, the CPP dropped toward baseline after peaking.

284 Once accumulated at the targeting site, the CPP modified drug is released from the blockage by a sec

285 cost effective than redispatching under the CPP and stronger CPP, respectively.

286 ell transduction of the protein drug via the CPP function.

287 dicates that optimal binding occurs when the CPP nanohoops differ by five phenyl rings.

288 hould aid in experimental detection of these CPP planetary orbit complexes.

289 at response to current treatment approach to CPP syndrome is variable; organizations such as the Euro

290 dentified as another potential impediment to CPP-mediated intercellular transport.

291 improving and developing PNAs conjugated to CPPs to better target intracellular pathogens.

292 e pathways, attachment of cargo molecules to CPPs invariably reduces their cellular uptake.

293 gible adults with FAP will be randomized to: CPP-1X 750 mg and sulindac 150 mg, CPP-1X placebo and su

294 a randomized controlled single-blind trial (CPP 2009-A00346-51).

295 g loaded applications, i.e. enzyme-triggered CPP-mediated systems in drug delivery were reviewed.

296 nt types of applications of enzyme-triggered CPP-mediated systems in tumor imaging were illustrated.

297 The viral fusion mimic GALA, a pH-triggered CPP, takes advantage of the decreasing pH during endosom

298 An enzyme-triggered, CPP-mediated system would combine these advantages to yi

299 l manipulation and reprogramming, along with CPP contributions to gene editing techniques.

300 Our results suggested that conjugation with CPP followed by encapsulation in MNPs provides an effect