ライフサイエンスコーパス: CQA

1 (CGA) measured as 5-O-caffeoylquinic acid (5-CQA).

2 ce for defining critical quality attributes (CQA).

3 ug products is a critical quality attribute (CQA).

4 e classified as critical quality attributes (CQAs).

5 olic compounds such as caffeoylquinic acids (CQAs).

6 hods to monitor critical quality attributes (CQAs).

7 measurements of critical quality attributes (CQAs).

8 e and also demonstrated no impact on product CQAs.

9 vely by the quinic or caffeic acid moiety of CQAs.

10 fety and efficacy and thus are considered as CQAs.

11 and pulp, namely 3-O-caffeoylquinic acid (3-CQA), 4-p-coumaroylquinic acid (HC1), 4-O-caffeoylquinic

12 the content of chlorogenic acid derivates (3-CQA, 4-CQA and 5-CQA) and caffeine using the high perfor

13 oncentrations in unfermented coffee, while 3-CQA, 4-CQA, and nicotinic acid increased with fermentati

14 uinic acid (HC1), 4-O-caffeoylquinic acid (4-CQA), 5-O-caffeoylquinic acid (5-CQA), derivative of p-c

15 designation as a critical quality attribute (CQA) affecting potency and stability.

16 y (UPLC) separations are coupled with MS for CQA analyses; however, these measurements often take ove

17 ant variability from 89 to 571 mg/100g for 5-CQA and 48 to 486 mg/100g for 1,5-DCQA in dry material.

18 tent of chlorogenic acid derivates (3-CQA, 4-CQA and 5-CQA) and caffeine using the high performance l

19 noside, Ficus capensis (Cape fig) the most 3-CQA and 5-CQA, and Parinari curatellifolia (Mobola plum)

20 ffeine, trigonelline, caffeoylquinic acids 5-CQA and diCQA presented the highest concentrations in un

21 on and quantification of chlorogenic acid (5-CQA) and 1,5-dicaffeoylquinic acid (1,5-DCQA) as main co

22 the synthesis of mainly chlorogenic acid (5-CQA) and 3,5-dicaffeoylquinic acid.

23 c acid (CA), 4 kinds of caffeoylquinic acid (CQA) and 6 kinds of dicaffeoylquinic acid (DCQA), were s

24 lorogenic acid derivates (3-CQA, 4-CQA and 5-CQA) and caffeine using the high performance liquid chro

25 be an important critical quality attribute (CQA), and several analytical approaches have been propos

26 ations in unfermented coffee, while 3-CQA, 4-CQA, and nicotinic acid increased with fermentation.

27 cus capensis (Cape fig) the most 3-CQA and 5-CQA, and Parinari curatellifolia (Mobola plum) had the h

28 landscape of mRNA research, emphasizing that CQAs are a marker of the quality of the LNP production p

29 CQAs are considered beneficial for human health, mainly

30 wenty potential critical quality attributes (CQAs) are identified for the dosage form, and a prioriti

31 Caffeoylquinic acids (CQAs) are nutraceutical polyphenols highly represented i

32 Caffeoylquinic acids (CQAs) are specialized plant metabolites we encounter in

33 red an important critical quality attribute (CQA), as it is known to impact efficacy, stability, half

34 The current CQA assessment strategy requires the integration of stru

35 r assisting the critical quality attributes (CQAs) assessment of antibodies.

36 ions, evidencing that CA at 10 mumol/l and 5-CQA at 25 mumol/l can be qualified as potent anti-inflam

37 Furthermore, for studies on CQA bioactivity, plant-based laboratory animal diets con

38 for the simultaneous monitoring of multiple CQAs, but conventional methods often suffer from low thr

39 Biotransformation of CQAs by gut microbiota, the discovery of new enzymatic b

40 d for the quantitation of three selected PTM CQAs (CDR isomerization, Fc Met oxidation, and CDR Met o

41 tration, on two critical quality attributes (CQAs): content uniformity and 60-minute permeation acros

42 timized HPLC-UV method was used to monitor 5-CQA conversion to its main isomers, while LC-HRMS/MS was

43 Compounds composed by one or two CQAs covalently linked with pentose (Pent) residues (1-1

44 Consequently, CQA dehydrodimers (MW 706 Da) are among the main product

45 decided to decipher the interactions between CQA dehydrodimers and SP (gPRPs, aPRPs, statherins/P-B p

46 s showed that contrary to what was expected, CQA dehydrodimers presented a low interaction with PRPs,

47 d mass spectrometry, the structures of seven CQA dehydrodimers were elucidated using (1)H and (13)C o

48 CQA dehydrodimers were previously synthesized in a biomi

49 aled different degrees of isomerization in 5-CQA depending on the water sample, and the formation of

50 is regarded as a critical quality attribute (CQA) depending on its impact on the safety and efficacy

51 nic acid (4-CQA), 5-O-caffeoylquinic acid (5-CQA), derivative of p-coumaroylquinic acid (HC2) and 3,5

52 has been used for many years to monitor PTM CQAs during product development.

53 nsidered to be a critical quality attribute (CQA) during development.

54 of samples ranged from 3.93 to 14.13 g of 5-CQA equivalent/100g dry weight (DW).

55 ss spectrometry (AR-SEC-MS) method for rapid CQA evaluation in therapeutic mAbs.

56 Lineweaver-Burk plots indicated that 5-CQA exerts a mixed type inhibition as km increased and V

57 The results showed that CA and all selected CQAs exhibited lower cytotoxicity (IC(50): >50 mumol/l).

58 icated the presence of caffeoylquinic acids (CQA), feruloylquinic acids (FQA) and dicaffeoylquinic ac

59 3-CQA fitted well as a decreasing TTI as expected.

60 ILIS is a valuable methodology in addressing CQAs for the QbD paradigm.

61 e esterase hydrolyzed all chlorogenic acids (CQAs, FQAs) and their corresponding lactones (CQALs, FQA

62 CGA; subsequent relative quantities were: 4-CQA>3-CQA>5-FQA>4-FQA>diCQA (sum of 3,4, 3,5 and 4,5-diC

63 subsequent relative quantities were: 4-CQA>3-CQA>5-FQA>4-FQA>diCQA (sum of 3,4, 3,5 and 4,5-diCQA).

64 er caffeic acid, CFA, >caffeoylquinic acids, CQAs, >dicaffeoylquinic acids, diCQAs, exhibiting the re

65 umption of foods rich in chlorogenic acid (5-CQA) have been reported.

66 validated using an established workflow for CQA identification based on thoroughly characterized ion

67 fits compared to conventional approaches for CQA identification, owing to its faster turn-around and

68 sor response was linear (R(2) = 0.998) for 5-CQA in the concentration range 0.56-7.3 umol L(-1), with

69 A higher proportion of 5-CQA in the phenolic mixture was responsible for an incre

70 The method offers an approach to assessing CQAs in high-throughput analysis applications such as st

71 Humans consume CQAs in mg-to-gram quantities through dietary consumptio

72 he first report showing that microstructural CQAs in PLGA microspheres derived from imaging can be qu

73 hibited similar critical quality attributes (CQAs), including particle size <100 nm, low PDI (<0.2),

74 ty of mRNAs are critical quality attributes (CQAs), influencing the translation efficiency and protei

75 etric assay was exploited for detection of 5-CQA into leaf extract from artichoke, obtaining a value

76 Therefore, a synthetic diet free of CQAs is advised to avoid interferences since some CQAs m

77 5-O-caffeoylquinic acid (CQA) is one of the major hydroxycinnamic acid derivative

78 Since 5'-O-Caffeoylquinic acid (CQA) is one of the major phenolic compounds and the pref

79 Assessment of critical quality attributes (CQAs) is an important aspect during the development of t

80 d for rapid and sustainable detection of a 5-CQA isomer (Chlorogenic acid) in AW extract was develope

81 erate a yellow color associated with 5- to 3-CQA isomerization reaction, as suggested by NMR and MS a

82 nd the formation of oxidation derivatives of CQA isomers.

83 he designation and nomenclature of different CQA isomers.

84 With the exception of Desiree, TPC and 5-CQA levels decreased after cooking.

85 Significant increases in TSP, AC and 5-CQA levels were observed for each sample following UV-B

86 CQA levels were reduced through processing but to a grea

87 is advised to avoid interferences since some CQAs may produce bioactivity even at nanomolar levels.

88 aining nanomaterials, where multiple complex CQAs must be identified and monitored.

89 The most abundant hydroxycinnamic acid was 5-CQA (neochlorogenic acid) with 259.12-481.4mg/kgf.w. in

90 k, and DSPE-PEG2k), which did not impact LNP CQAs, nor their clearance from the injection site.

91 strengthen the use of on-line LC to monitor CQAs of a mAb continuously with various PAT IEX analytic

92 n be an important tool to identify potential CQAs of a therapeutic mAb such as tryptophan oxidation l

93 n be a potential critical quality attribute (CQA) of the product.

94 ed cell impacts critical quality attributes (CQAs) of retrovirally engineered T cell products.

95 ely measure the critical quality attributes (CQAs) of the drug product.

96 thods to assess critical quality attributes (CQAs) of the mRNA component is crucial for ensuring the

97 genic acid isomer 5-O-caffeoylquinic acid (5-CQA) on digestion of potato starch by porcine pancreatic

98 ) are among the main products resulting from CQA oxidation.

99 egree of ambiguities for defining meaningful CQAs, particularly for complex bispecific antibody forma

100 (ID) testing, sequence variant control, and CQA quantitation in commercial QC labs.

101 Total chlorogenic acids (CQAs) ranged from 43 to 953mg/100g dw and were more conc

102 This work describes the evaluation of 5-CQA reactivity in commercial waters after microwave trea

103 the application of this method in assessing CQAs related to antibody target binding, which included

104 CQA results obtained with the ID-MAM method were similar

105 Co- and pre-incubation of PPAA with 5-CQA significantly reduced PPAA activity in a dose depend

106 antification of critical quality attributes (CQAs) such as sequence variants and post-translational m

107 ssessment of key quality control attributes (CQAs), such as of molecular weight and content ratio of

108 Currently, evaluating key CQAs, such as mRNA integrity and encapsulation efficienc

109 DoE establishes clear links between CPPs and CQAs, supports the development of control strategies, an

110 d a prioritisation exercise identifies those CQAs that are most pertinent to the dosage form and that

111 as an important critical quality attribute (CQA) that can affect immunogenicity, solubility, and sta

112 omerization is a critical quality attribute (CQA) that requires careful control, monitoring, and quan

113 herapeutics are critical quality attributes (CQAs) that need to be controlled to ensure product quali

114 Chlorogenic acid (CQA), the ester of caffeic acid with quinic acid supplie

115 sis, a mixture of 5-O-caffeoylquinic acid (5-CQA), the most abundant chlorogenic acid in green coffee

116 inking these to critical quality attributes (CQA) to ensure quality and consistency of phage drug sub

117 phenolics (TSP), 5-O-caffeoylquinic acid (5-CQA), total carotenoids, AC, and phenylalanine ammonia-l

118 In the case of 5-CQA, understanding of the degradation process would allo

119 5-CQA was present at the highest levels, between 25 and 30

120 acid (FA), and for 3-caffeoylquinic acid (3-CQA) was developed and validated.

121 Both CA and 5-CQA were found to have the most significant contribution

122 Levels of CQA were significantly (p<0.05) lower in some industrial

123 nt microsphere formulations, microstructural CQAs were identified including the abundance, domain siz

124 CQAs were recently linked to memory improvement; they se

125 Critical quality attributes (CQAs) were examined for mAbs purified with different Pro

126 plant-based laboratory animal diets contain CQAs, which makes it difficult to include proper control

127 herapeutics is a critical quality attribute (CQA) with direct impact on biological activity.