ライフサイエンスコーパス: CRH receptor

1 ide (SRP) as specific ligands for the type 2 CRH receptor.

2 -glucocorticoid axis, mediated by the type 1 CRH receptor.

3 lays a role in regulating translation of the CRH receptor.

4 The addition of a CRH receptor 1 (CRHr1) antagonist to the antecedent CRH

5 Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience

6 le nucleotide polymorphism (rs110402) in the CRH receptor 1 (CRHR1) gene show behavioral and neuroend

7 ildhood trauma and sequence variation in the CRH receptor 1 gene (CRHR1) that increase risk for affec

8 the ontogeny of CRH, CRH binding protein and CRH receptor 1 in prefrontal cortex, amygdala, septum an

9 g hormone (CRH) acting primarily through the CRH receptor 1.

10 gnaling via corticotropin releasing hormone (Crh) receptor 1.

11 evels of both proopiomelanocortin (POMC) and CRH-receptor 1 (R1) mRNAs were significantly higher than

12 ffect was mediated through the activation of CRH receptor-1 and adenylate cyclase with increased intr

13 es modulates intestinal inflammation and the CRH receptor 2 (CRHR2) suppresses postnatal angiogenesis

14 We hypothesized that CRH receptor activity in the mPFC contributes to stress-

15 ts of caudal brainstem administration of the CRH receptor agonist, urocortin, on food intake and body

16 a decrease in the biological activity of the CRH receptor and in the generation of cyclic adenosine m

17 evidence that mast cells express functional CRH receptors and that CRH can induce VEGF secretion sel

18 We investigated the expression of CRH receptors and the effects of CRH in the human leukem

19 ion of anatomically disparate populations of CRH receptors, and that interactions between forebrain a

20 Bilateral infusions of the CRH receptor antagonist [9-41]-alpha-helical CRH (0.3, 1

21 etreatment of mice with 2.5 microg/kg of the CRH receptor antagonist alpha-helical CRH((9-41)) that b

22 matory pain test, we administered CRH or the CRH receptor antagonist alpha-helical CRH(9-41) (ahCRH)

23 onist HS014 (0.25-1.0 nmol) and nonselective CRH receptor antagonist alpha-helical-CRH9-41 (0.125-0.5

24 Intra-DRN microinjection of the nonselective CRH receptor antagonist d-Phe CRH (12-41) blocked the IS

25 Because the CRH receptor antagonist infusions did not impair retenti

26 ent with a neutralizing antibody to CRH or a CRH receptor antagonist.

27 Using subtype-selective CRH receptor antagonists, we provide evidence that the n

28 , only a fraction of skin mast cells express CRH receptors, as shown by FACS analysis of CRH receptor

29 using a rat corticotropin-releasing hormone (CRH) receptor assay led to the discovery that 2-anilinop

30 RH, an area containing NPY neurons, displays CRH receptor binding and CRH receptor mRNA.

31 eleasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels.

32 alyses have further revealed the presence of CRH receptors (CRH-Rs).

33 CRH receptors, as shown by FACS analysis of CRH receptor (CRHR) and c-kit double-positive disaggrega

34 er than CRH or urocortin, acting through the CRH receptors in brain regions believed to mediate stres

35 over, given the apparent absence of mRNA for CRH receptors in LC neurons, the exact location of actio

36 These findings indicate that activation of CRH receptors in the BLA, likely by training-induced rel

37 esent experiments, we found that blockade of CRH receptors in the mPFC with the non-selective recepto

38 emains enigmatic, the presence of functional CRH receptors in the myometrium suggests that CRH may mo

39 fects are mediated in part by stimulation of CRH receptors in this region of the caudal brainstem.

40 The other known mammalian ligand for CRH receptors is urocortin.

41 Indeed, in vivo, activation of CRH receptors--maximally expressed in hippocampus and am

42 In contrast, the type 2 CRH receptor mediates the stress-coping responses during

43 may be targets of the CRH system and express CRH receptors; most notable are tuberoinfundibular dopam

44 Y neurons, displays CRH receptor binding and CRH receptor mRNA.

45 sing hormone (CRH), leading to activation of CRH receptors on principal hippocampal neurons.

46 Research on the contribution of CRH receptor stimulation to energy homeostasis has focus

47 ry-adrenal (HPA) axis activity by preventing CRH receptor stimulation.

48 The present set of studies examined which CRH receptor subtype mediates the effects of IS.

49 rtin (UCN), also binds with high affinity to CRH receptor subtypes and decreases food intake in food-

50 bstantial increase in the expression of both CRH receptor subtypes in the ileal mucosa.

51 t alpha-helical CRH((9-41)) that blocks both CRH receptor subtypes reduced toxin A-mediated ileal sec

52 Moreover, administration of the CRH receptor type 1 (CRFR(1)) blocker NBI 30775 directly

53 we found that CRH, through activation of the CRH receptor type 1 (CRHR1), evokes a rapid induction of

54 release but were associated with changes in CRH receptor type 1 expression.

55 dent manner, and this action depended on the CRH receptor type 1.

56 he peptide, as well as the expression of the CRH receptor type that mediates them, are particularly p

57 Corticotropin-releasing hormone (CRH) receptor type 1 (CRF(1)) is a member of the recepto

58 the type 1 corticotropin-releasing hormone (CRH) receptor, which has a high affinity for naturally o

59 tivation of corticotropin-releasing hormone (CRH) receptors within the caudal dorsal raphe nucleus (D