ライフサイエンスコーパス: CSF-1 receptor

1 ly EGF receptor and macrophages express only CSF-1 receptor.

2 KB) domain binds in vitro and in vivo to the CSF-1 receptor.

3 ls expressing this mutated form of the human CSF-1 receptor.

4 s of CSF-1 reduce the gene expression of the CSF-1 receptor.

5 tent with tissue-specific down-modulation of CSF-1 receptors.

6 ing through the colony-stimulating factor-1 (CSF-1) receptor.

7 where it is targeted to trophoblast bearing CSF-1-receptors.

8 ly, bone marrow M phi preincubated with anti-CSF-1 receptor Ab or anti-CSF-1 neutralizing Ab were res

9 r studies showed that the mRNA levels of the CSF-1 receptor also parallel this time course.

10 he autocrine effect is inhibited through the CSF-1 receptor, analysis of the CSF-1 receptor mRNA leve

11 Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control macrophage

12 ranulocyte/macrophage CSF (GM-CSF) or CD115 (CSF-1 receptor) and nearly completely (up to 90%) by bot

13 ssion of CD86, and lost expression of CD115 (CSF-1 receptor) and proliferative responsiveness to CSF-

14 eptor, CCR1, and regulatory receptors c-Fms (CSF-1 receptor) and RANK (receptor activator of nuclear

15 However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and r

16 ia depletion, via treatment of mice with the CSF-1 receptor antagonist PLX5622, and abrogated neurona

17 pletion of MR(hi) dermal macrophages by anti-CSF-1 receptor antibody reversed the nonhealing phenotyp

18 CSF-1 receptors are continuously subject to down-modulat

19 Analyses of CSF-1 receptor autophosphorylation mutants show that, al

20 In addition, there is evidence that the CSF-1 receptor carboxy-terminus is involved in down regu

21 the protein tyrosine phosphorylation of the CSF-1 receptor (CSF-1R) and many other, primarily cytoso

22 imulating factor-1 (CSF-1) activation of the CSF-1 receptor (CSF-1R) causes Cbl protooncoprotein tyro

23 The CSF-1 receptor (CSF-1R) is a tyrosine kinase that is tar

24 The CSF-1 receptor (CSF-1R) is expressed in >50% of human br

25 In the absence of SHPTP1, the CSF-1 receptor (CSF-1R) is hyperphosphorylated upon CSF-

26 The CSF-1 receptor (CSF-1R) regulates CNS microglial develop

27 We used an inhibitor of the CSF-1 receptor (CSF-1R) to target TAMs in a mouse proneu

28 Colony-stimulating factor-1 (CSF-1)-induced CSF-1 receptor (CSF-1R) tyrosine phosphorylation and ubi

29 lony-stimulating factor-1 (CSF-1)-stimulated CSF-1 receptor (CSF-1R) tyrosine phosphorylation initiat

30 myeloid progenitor 32D cell line expressing CSF-1 receptor (CSF-1R), CSF-1 activation of the extrace

31 roduction, are thought to be mediated by the CSF-1 receptor (CSF-1R), encoded by the c-fms proto-onco

32 ogenic factor, MIP-1alpha, were elevated and CSF-1 receptor (CSF-1R)-dependent production of MIP-1alp

33 One example is the CSF-1 receptor (CSF-1R, CD115, c-fms), which is used as

34 the JMD of the colony stimulating factor-1 (CSF-1) receptor (CSF-1R) binds to Src family kinases (SF

35 F) of the human colony-stimulating factor 1 (CSF-1) receptor (CSF-1R) impairs ligand-stimulated tyros

36 Colony-stimulating factor 1 (CSF-1) receptor (CSF-1R, or macrophage CSF receptor [M-C

37 H-3T3 cells expressing a partially defective CSF-1 receptor, CSF-1R (Y809F), exhibited impaired ERK1

38 CSF-1 receptor (CSF1R) signaling is important for the re

39 rrow chimeric mice, we have established that CSF-1 receptor-deficient hematopoietic precursors failed

40 imulating factor-1 (CSF-1) but are absent in CSF-1 receptor-deficient mice.

41 biquitin-protein ligase c-Cbl is involved in CSF-1 receptor degradation.

42 ain with lpr (C3H-lpr); and 3) modulation of CSF-1 receptor expression by CSF-1 is more rapid in MRL

43 wnregulating CSF-1 production and abrogating CSF-1 receptor expression.

44 F-1 signaling, PLCgamma1 is recruited to the CSF-1 receptor following exposure to the cytokine.

45 Instead, inflammatory DCs required Csf-1 receptor for their development.

46 the macrophage colony-stimulating factor-1 (CSF-1) receptor, has been observed in a variety of carci

47 in vivo and establish the importance of the CSF-1 receptor in this process.

48 on of the human colony-stimulating factor 1 (CSF-1) receptor in NIH 3T3 cells leads to activation of

49 Furthermore, blocking CSF-1 or the CSF-1 receptor induced less TEC apoptosis than the isoty

50 n the expression of the c-fms gene and CSF-1/CSF-1 receptor-induced invasion and anchorage-independen

51 eatment of Pten null mice with the selective CSF-1 receptor inhibitor GW2580 decreases MDSC infiltrat

52 Use of chimeric receptors indicates that the CSF-1 receptor is cleaved at least two times, once in th

53 o phorbol 12-myristate 13-acetate (PMA), the CSF-1 receptor is subject to proteolytic processing.

54 The colony-stimulating factor 1 (CSF-1) receptor is a protein-tyrosine kinase that regula

55 The colony-stimulating factor-1 (CSF-1) receptor is a protein-tyrosine kinase that regula

56 leukin-34 (IL-34), an alternative ligand for Csf-1 receptor, is produced by keratinocytes in the epid

57 by in vivo macrophage suppression using the CSF-1 receptor kinase inhibitor GW2580.

58 While alterations in the CSF-1 receptor-mediated clearance of CSF-1 appeared not

59 through the CSF-1 receptor, analysis of the CSF-1 receptor mRNA levels in cultured dental follicle c

60 nces CSF-1 gene expression, has no effect on CSF-1 receptor mRNA levels.

61 nd 2) WT bone marrow M phi blocked with anti-CSF-1 receptor or anti-CSF-1 Ab compared with the isotyp

62 beta1 is inhibited by blocking EGF receptor, CSF-1 receptor, or macrophage function, indicating that

63 Diabetes occurred in the anti-CSF-1 receptor protected mice after treatment with a blo

64 Immunostaining for the CSF-1 receptor protein shows that it is present in the d

65 eatment of NOD mice with an antibody against CSF-1 receptor reduced diabetes incidence and led to the

66 r NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident mac

67 We further provide evidence that the CSF-1 receptor's carboxy-terminus is a substrate for aut

68 s (LCs) and microglia is highly dependent on Csf-1 receptor signaling but independent of Csf-1.

69 s loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both m

70 Moreover, administration of a CSF-1 receptor-specific (CSF-1R-specific) antibody after

71 ence of diabetes, NOD mice treated with anti-CSF-1 receptor starting at 3 or 10 wk of age still conta

72 g a form of the colony-stimulating factor-1 (CSF-1) receptor that is partially defective in transduci

73 codes a soluble colony-stimulating factor 1 (CSF-1) receptor that neutralizes the effects of CSF-1 in

74 ansduction pathways that connect the surface CSF-1 receptor to these genes in the nucleus.

75 in of the human colony stimulating factor-1 (CSF-1) receptor to sequences encoding the transmembrane

76 g domain of the colony-stimulating factor-1 (CSF-1) receptor to the transmembrane and cytoplasmic dom

77 ononuclear cells and BARF1 encodes a soluble CSF-1 receptor, we examined whether recombinant BARF1 or

78 opolysaccharide, and PMA and may provide the CSF-1 receptor with an additional mechanism for signal t

79 S cells diminished the surface expression of CSF-1 receptors, with 50 J/m2 causing a significant redu

80 d Myc and cyclin D1 to complement the mutant CSF-1 receptor Y809F (containing a Y-to-F mutation at po