ライフサイエンスコーパス: CST

1 CST [for CTC1(Cdc13)/STN1/TEN1] is a trimeric chromosome

2 CST also improved peripheral leptin sensitivity in diet-

3 CST also simultaneously shortens the RNA and lengthens t

4 CST did not affect basal or isoproterenol-stimulated cAM

5 CST first aids in duplication of the telomeric dsDNA.

6 CST improved QoL in patients with HF.

7 CST labeling with crym-GFP is 10 times more efficient co

8 CST resembles Replication Protein A (RPA) in that the tw

9 CST resulted in greater improvements in QoL compared wit

10 CST treatment reduced fat depot size and increased lipol

11 CST was associated with changes in HPV status (P<.001).

12 CST was identified as a direct inhibitor of CaMKIIdelta

13 old was defined whereby no subject with >63% CST injury achieved clinically significant gains.

14 ontribute to the control of movement after a CST injury.

15 Participants were randomized to either a CST intervention or heart failure education, both delive

16 Inosine did not affect CST sprouting in the lumbar spinal cord but did restore

17 volitional control over spared fibers after CST injury, we hypothesized that a combination of physic

18 re-association of individual OB-folds allow CST to mediate loading and unloading of partner proteins

19 (OR, 3.59; 95% CI, 2.22-5.80; P < .001) and CST less than 300 microm (OR, 5.30; 95% CI, 2.40-11.67;

20 d CST variant peptides (viz. CST-Ser-364 and CST-Val-367) were significantly less potent than the wil

21 endent protein kinase IIdelta) activity, and CST reduced CaMKIIdelta-dependent phosphorylation of pho

22 k 24, the mean changes from week 12 BCVA and CST were +7.0 letters (P = .01) and -108.25 mum (P = .04

23 Changes is BCVA and CST were statistically significant (P < 0.0001), but the

24 Best-corrected visual acuity (BCVA) and CST were measured at baseline and every 4 weeks.

25 duration of diabetes, HbA1c, BMI, BCVA, and CST had no impact on the ability to achieve >/=2-step im

26 development of an appropriate curriculum and CST approach.

27 that dorsal root ganglion neurons (DRGs) and CST neurons fail to upregulate Sox11 after spinal axon i

28 , telomerase-mediated G-strand extension and CST-mediated C-strand fill-in are equally important for

29 ct (CST) developmental motor impairments and CST misprojections after M1 inactivation.

30 n was assessed for 10 weeks after injury and CST axons were traced by injecting biotin-conjugated dex

31 protection in Arabidopsis implicates KU and CST and their absence leads to chromosome fusions, sever

32 One-year VA and CST outcomes within prespecified subgroups based on both

33 fied subgroups based on both baseline VA and CST thresholds, defined as worse (20/50 or worse) or bet

34 oned blocks of spinal cord, we also assessed CST-YFP mice for 3D imaging and found that YFP fluoresce

35 th high proportions of the genera Atopobium (CST IV-B) had the slowest rate compared to L. crispatus-

36 utcome measure was mean change from baseline CST at week 12.

37 At week 12, mean change from baseline CST was significantly greater in the combination group (

38 eline VA (n = 305), irrespective of baseline CST, aflibercept showed greater improvement than bevaciz

39 ent in EphA4 knock-out mice with a bilateral CST.

40 ons of interest (ROI) included the bilateral CST in the cervical cord and brain.

41 ) and a decreased sprouting capacity of both CST and spinal serotoninergic fibers.

42 that best prediction was achieved using both CST injury and M1-M1 connectivity (r(2) = 0.44, p = 0.00

43 ); (3) simultaneous multimodal exercises (BS+CST); or (4) no training (NT).

44 Anatomically, multimodal BS+CST training neither increased corticobulbar fiber densi

45 Mice in the BS+CST training group showed a trend toward greater improve

46 ggesting inhibition of alpha-AR signaling by CST.

47 examine the mechanisms of PP stimulation by CST using purified complexes derived from Candida glabra

48 HF and whether the CgA fragment catestatin (CST) may directly influence cardiomyocyte function.

49 ed with the CHGA-derived peptide catestatin (CST) that is deficient in these mice.

50 m the Memorial Sloan-Kettering Cancer Center CST program are incorporated.

51 Lower FA in the cervical CST also correlated with impaired upper limb function, i

52 To clarify CST mechanism, we examined the capacity of CST to bind a

53 (crym-GFP), comprehensive and near complete CST labeling is achieved throughout the spinal cord.

54 The budding yeast G-tail binding complex CST (Cdc13-Stn1-Ten1) is crucial for both telomere prote

55 s identified as another RPA-related complex, CST (CTC1-STN1-TEN1).

56 otoneuronal connections from fast conducting CST fibers are indeed made exclusively from new M1 and i

57 onal connections over more slowly conducting CST axons, as well as exert disynaptic effects on motone

58 xcitatory transmission in the contralesional CST.

59 gaging the intrinsic mechanisms that control CST regrowth, it remains to be tested whether such metho

60 dorsal hemisection in the midthoracic cord, CST axons did not significantly regenerate in ngr1(+/+)

61 ea (p = 0.002) and a lower FA of the cranial CST at the internal capsule level (p = 0.001).

62 of 15 or more, change from baseline in CST, CST less than 300 microm, and resolution of ME.

63 atients receiving 15 mg or more twice daily, CST decreased by more than 100 mum in 5 patients and by

64 of inosine on motor and cognitive deficits, CST sprouting, and expression of synaptic proteins in an

65 s studies have evaluated caregiver-delivered CST.

66 ependently of EphA4 expression in descending CST axons and is linked to the distribution of Zic2+;Eph

67 in the forebrain that affects the developing CST but spares brainstem motor pathways and spinal motor

68 High-diversity CSTs and specific bacterial phyla (Gardnerella vaginalis

69 Within the non-Lactobacillus-dominant CST IV, GBS positive status was significantly more preva

70 west rate compared to L. crispatus-dominated CSTs (adjusted transition rate ratio [aTRR], 4.43, 95% c

71 Lactobacillus gasseri-dominated CSTs had the fastest HPV remission rate, and a low Lacto

72 eration, (2) whether interventions to enable CST regeneration enhance recovery of voluntary motor fun

73 adult rats by nongenetic techniques enables CST regeneration, (2) whether interventions to enable CS

74 fibrin into the injury site further enhances CST regeneration and motor recovery.

75 s, most YFP-labeled axons beyond established CST locations do not undergo Wallerian degeneration foll

76 x structures, thus providing a mechanism for CST to facilitate replication through telomeres and othe

77 ced adaptation, need to be demonstrated from CST.

78 f human CTC1 and demonstrate that functional CST is essential for telomere length maintenance due to

79 hat subsequently become refined with further CST development.

80 an be used as a standardized tool for future CST spinal cord injury studies.

81 es in PC12 cells was: CST-WT > CST-Ser-364 > CST-Val-367.

82 y these peptides in PC12 cells was: CST-WT > CST-Ser-364 > CST-Val-367.

83 Human CST (CTC1-STN1-TEN1) is a ssDNA-binding complex that hel

84 gain of 15 or more, change from baseline in CST, CST less than 300 microm, and resolution of ME.

85 ient of repeatability for relative change in CST (the degree of change that could be expected from me

86 At 12 months, the mean change in CST and MV were -133.9 (+/- 160.12) mum (P = .0001) and

87 n limits of agreement for relative change in CST between machines (the degree of change that could be

88 Therefore, a specific change in CST connectivity is associated with and explains a chang

89 virally expressed Channelrhodopsin (ChR2) in CST cell bodies and in axon terminals in cervical spinal

90 , aberrant CS terminations, and decreases in CST presynaptic sites and spinal cholinergic interneuron

91 D imaging and found that YFP fluorescence in CST-YFP mice is faint for clearing-based 3D imaging in c

92 -3-methanol, promotes further improvement in CST-dependent behavioral tasks.

93 l, the nonspecific and faint YFP labeling in CST-YFP mice limits their utility for assessments of CST

94 e status was significantly more prevalent in CST IV-A than CST IV-B.

95 significant correlation between reduction in CST and improvement in BCVA.

96 Reduction in CST from baseline correlated with degree of VA improveme

97 Reduction in CST from baseline correlated with degree of VA improveme

98 We show here that in CST-YFP mice, some YFP-labeled axons are not from the CS

99 Importantly, this model of increased CST regrowth enables the analysis of extrinsic regulator

100 dicators included increasing age, increasing CST, the presence of intraretinal fluid, pigment epithel

101 Indeed, CST mimicked the lipolytic effect of the alpha-AR blocke

102 In line with CaMKIIdelta inhibition, CST reduced Ca(2+) spark and wave frequency, reduced Ca(

103 (shRNA) promotes the regeneration of injured CST axons, and these axons form anatomical synapses in a

104 of motor cortex augments sprouting of intact CST axons and promotes functional recovery when applied

105 x that is driven by the aberrant ipsilateral CST misprojections.

106 l EphA4 mutations produce robust ipsilateral CST misprojections, resulting in bilateral corticospinal

107 ions beyond those with anterogradely labeled CST axons, most YFP-labeled axons beyond established CST

108 ere shortening accelerated in plants lacking CST and ATR.

109 ratio of incident HPV for low Lactobacillus CST IV-A was 1.86 (95% CI, .52-6.74).

110 d in the PC (-11.98%, p = 0.006) and lateral CST (-12.96%, p = 0.014).

111 unctional independence and FA in the lateral CST (z score 3.68, p = 0.020).

112 corticobulbar fiber density of the lesioned CST rostral to the lesion nor collateral sprouting of th

113 In liver, CST enhanced oxidation of fatty acids as well as their a

114 to <60% of the contralateral side, while M1 CST projections remained robust or expanded (>110%).

115 lescent cat development, RN on the active M1/CST side continued to show a substantial loss of spinal

116 However, the in vivo functions of mammalian CST remain unclear.

117 However, the function of mammalian CST remains poorly understood.

118 mere deprotection, suggesting that mammalian CST is not involved in capping telomeres.

119 Mean CST at week 12 and percentage of eyes with resolved edem

120 and a significant increase from week 24 mean CST at week 48 (+94.7 vs. +15.2 mum; P = 0.05) but not w

121 inimum angle of resolution (logMAR) and mean CST was 492+/-130 mum.

122 ants to have a substantial reduction in mean CST between 1 and 2 years were those with a baseline VA

123 k 144, and there were no differences in mean CST change from week 24 at weeks 48, 96, or 144.

124 hologic features was 0.24+/-0.2 logMAR, mean CST was 300+/-78 mum, and mean change in SER was -0.01+/

125 The mean VA, mean CST, and mean MV at baseline were 54.4 (+/- 15.26) lette

126 In ob/ob mice, CST enhanced leptin-induced signaling in adipose tissue.

127 Vaginal microbiota CST and alpha-diversity are not related to GBS status.

128 /=400 microm) or thinner (250 to 399 microm) CST.

129 ion and supporting our hypothesis of minimal CST involvement in the moment-to-moment control of stere

130 ot reliably visualize regenerating ngr1(-/-) CST axons, their regenerative course is clear with crym-

131 nly a few axons, the presence of labeled non-CST axons compromises interpretation.

132 fundus photographs have no DME based on OCT CST, while many eyes diagnosed as not having DME or CSME

133 photography, while treatment of DME uses OCT CST.

134 VA, OCT CST, and macular volume (MV) were recorded at baseline a

135 spinal fibers but spared approximately 3% of CST fibers that project via the dorsolateral funiculus.

136 nses resulted from optogenetic activation of CST terminals, demonstrating the ability of Sox11-stimul

137 mice limits their utility for assessments of CST axon regeneration.

138 y CST mechanism, we examined the capacity of CST to bind and resolve DNA structures found at sites of

139 caused by mutations in the CTC1 component of CST, which promotes polymerase alpha (polalpha)/primase-

140 ways to engineer target-specific control of CST connections to promote recovery.

141 deprive the left side of the spinal cord of CST input, and the right CST was treated with adeno-asso

142 treatment caused robust midline crossing of CST axons into previously denervated left spinal cord.

143 We show here that depletion of CST subunits leads to both telomeric and non-telomeric p

144 Mapping of the distribution of CST-evoked spinal activity revealed overall similarity b

145 hed nAChR desensitization-blocking effect of CST-Ser-364 as compared with CST-WT.

146 r, the overall architecture and functions of CST and RPA are distinct.

147 after SCI by enabling regenerative growth of CST axons.

148 brain neurons leading to genetic labeling of CST axons in the spinal cord, and it was suggested that

149 n of proprioceptive afferents to the loss of CST terminations and provide insight into mechanisms und

150 s to robust CST regrowth and the recovery of CST-dependent behavioral performance after both T10 late

151 Because regeneration of CST fibers can be extensive and can reestablish certain

152 ues, a recovery dependent on regeneration of CST fibers.

153 bles the analysis of extrinsic regulators of CST regeneration in vivo.

154 Here we examine the remodeling of CST axons directed by sensory fibers.

155 tion enables prediction of the remodeling of CST connections and spinal circuits after injury and inf

156 Increasing our knowledge of the role of CST plasticity in functional restoration after SCI may s

157 ts with acute HF, and the functional role of CST was explored in experimental models.

158 and resolve DNA structures found at sites of CST activity.

159 sgenic mouse is a useful tool for studies of CST anatomy in experimental studies of motor pathways.

160 CST-YFP mice would be useful for studies of CST regeneration.

161 Stn1, the most conserved subunit of CST, is alone capable of PP stimulation.

162 h Network eligibility criteria thresholds of CST for trials evaluating anti-vascular endothelial grow

163 The number and trajectory of CST axons in ngr1(-/-) mice without injury was indisting

164 The effects of CSTs on the rate of transition between HPV-negative and

165 red neurologically than either Caspr-null or CST-null mice.

166 ses preferentially stimulating CST pathways (CST); (3) simultaneous multimodal exercises (BS+CST); or

167 ntly less potent than the wild type peptide (CST-WT) to inhibit nicotine-stimulated catecholamine sec

168 amidotomy eliminated the 17,000 GFP-positive CST axons that were reproducibly labeled in brainstem fr

169 ropose that CP is caused by a defect in POT1/CST-dependent telomere fill-in.

170 netic resonance imaging with a probabilistic CST constructed from healthy control subjects.

171 es axonal dieback of DRG axons, and promotes CST sprouting and regenerative axon growth in both acute

172 indings identify a unique means of promoting CST axon regeneration in vivo by reengineering a develop

173 rently, NPC-treated mice displayed a reduced CST degeneration, increased axonal rewiring, and augment

174 50 or worse at baseline, bevacizumab reduced CST less than the other agents at 1 year, but at 2 years

175 In addition, stimulation of the regenerated CST at a variety of frequencies was at least as effectiv

176 ctivity was reduced in rats with regenerated CSTs.

177 Restraint alone only restored CST connectivity.

178 Early training restored CST connections and the M1 motor map, increased choliner

179 that following a cervical dorsal rhizotomy, CST projections originating from primary somatosensory (

180 the spinal cord of CST input, and the right CST was treated with adeno-associated virus (AAV)-Sox11

181 n (OPN), in cortical neurons leads to robust CST regrowth and the recovery of CST-dependent behaviora

182 hese data raise important questions about S1 CST involvement in recovery following spinal injury.

183 Extensive sprouting from the S1 CST has not been reported previously, and these data rai

184 ty afforded by crym-GFP revealed significant CST regeneration in NgR1 knock-out mice.

185 he compensatory circuitry mediated by spared CST axons.

186 Furthermore, by optogenetics-based specific CST stimulation, we show a direct limb motor control by

187 the major component of the telomere-specific CST complex, strongly protects the recessed strand from

188 how a direct limb motor control by sprouting CST axons, providing direct evidence for the reformation

189 r Response Analyzer (ORA) and the Corvis ST (CST) measured the corneal biomechanical changes before a

190 s, to assess the ability of Sox11-stimulated CST axons to functionally integrate in the circuitry of

191 n of functional synapses by Sox11-stimulated CST axons without significant behavioral benefit, sugges

192 mb-grip exercises preferentially stimulating CST pathways (CST); (3) simultaneous multimodal exercise

193 r telomerase has extended the G-rich strand, CST facilitates fill-in synthesis of the complementary C

194 the conversion equations predicted a Stratus CST within 10% of the observed thickness 86% and 89% of

195 For each cohort, the initial Stratus CST was within 10% of the replicate Stratus measurement

196 Synthesized CST variant peptides (viz. CST-Ser-364 and CST-Val-367)

197 STN1, a member of the human CTC1-STN1-TEN1 (CST) complex, thus linking this gene for the first time

198 cluding the newly identified CTC1-STN1-TEN1 (CST) complex.

199 ging evidence suggests that Cdc13-Stn1-Ten1 (CST), an RPA-like ssDNA-binding complex, may regulate pr

200 ignificantly more prevalent in CST IV-A than CST IV-B.

201 Finally, smFRET analysis indicates that CST binding to ssDNA is dynamic with CST complexes under

202 Tract tracing revealed that CST axons extended farther caudally in the group that re

203 Here we show that CST and ATR (ataxia telangiectasia mutated [ATM] and Rad

204 We show that CST binds preferentially to ss-dsDNA junctions, an activ

205 We show that CST tracing with crym-GFP is 10-fold more efficient than

206 We also show that CST unfolds G-quadruplex structures, thus providing a me

207 Our findings suggest that CST rescues stalled replication forks during conditions

208 The CST (CTC1-STN1-TEN1) complex mediates critical functions

209 t difference in the IOP with the ORA and the CST pre and postoperatively in either group.

210 In human cells, the CST complex (CTC1-STN1-TEN1) also functions in telomere

211 ice, some YFP-labeled axons are not from the CST.

212 ions between spinal FA and cranial FA in the CST and disability.

213 ging revealed significant differences in the CST of SCI subjects-compared with controls-in the pyrami

214 ging to assess white matter integrity in the CST, T1-weighted imaging to measure cross-sectional spin

215 on and ATM regulation, two components of the CST (CTC1-STN1-TEN1) complex involved in preventing telo

216 ave revealed a large plastic capacity of the CST after SCI.

217 A conserved biochemical function of the CST complex is its primase-Pol alpha (PP) stimulatory ac

218 and enhanced the sprouting potential of the CST in p53(-/-) mice, while, similarly, p53 expression i

219 ntact hemisphere after chronic lesion of the CST in the other hemisphere would restore function throu

220 (crym) gene as a high-fidelity marker of the CST.

221 ce, resulting in abnormal decussation of the CST.

222 Using crym-GFP, we reevaluated the CST in mice lacking nogo receptor 1 (NgR1), a protein im

223 We found that the CST projection is regulated dynamically in maturity by t

224 ple tracer injections and genetic tools, the CST is visualized to only a minor degree in experimental

225 aseline and month 12 (P = 0.79), whereas the CST significantly decreased at month 12 compared with ba

226 Thirty-six hours after the CSTs were crushed bilaterally, nocturnal NAT was decreas

227 Cognitive stimulation therapy (CST) is a well-established group psychosocial interventi

228 spinal cord, and it was suggested that these CST-YFP mice would be useful for studies of CST regenera

229 , in the subgroup with better VA and thicker CST at baseline (31-43 eyes), there was a suggestion of

230 for eyes with better initial VA and thicker CST, some VA outcomes may be worse in the bevacizumab gr

231 -treated patients with worse BCVA or thicker CST experienced >/=2-step DRSS score improvement compare

232 letters, central subfield macular thickness (CST) >/=350 mum on Topcon 3D OCT 2000, initiated on a lo

233 respectively, while mean retinal thickness (CST) on OCT decreased by -2.9%, -5.7%, -13.9, and -8.1%

234 Central subfield thickness (CST) and cube volume decreased in study eyes at 1 year b

235 d measurement of central subfield thickness (CST) by spectral-domain optical coherence tomography.

236 tomography (OCT) central subfield thickness (CST) can yield different prevalence rates for DME.

237 om baseline mean central subfield thickness (CST) in the 2.0-mg versus 0.5-mg group (396.1 vs. 253.5

238 dry or when the central subfield thickness (CST) measured by optical coherence tomography had reache

239 fined as Stratus central subfield thickness (CST) of 250 mum or greater, participated.

240 h 6-month VA and central subfield thickness (CST) outcomes in participants in the Study of Comparativ

241 ve and change in central subfield thickness (CST) within subgroups based on whether an eye received l

242 l acuity (BCVA), central subfield thickness (CST), and DRSS score.

243 ge from baseline central subfield thickness (CST, mum) at week 12 in Group 1 vs 2 was -100.8 vs -63.9

244 In the subgroup with better VA and thinner CST at baseline (61-73 eyes across 3 treatment groups),

245 pared with those with better BCVA or thinner CST, respectively, but these associations were not stati

246 ction of proprioceptive afferents after this CST injury, however, is not known.

247 average of 162 of the 6000 labeled thoracic CST axons (2.68%) regenerated >100 mum past the lesion s

248 lyses showed that participants randomized to CST experienced a reduction in the composite end point o

249 CgA-to-CST conversion in HF is impaired because of hyperglycosy

250 Low CgA-to-CST conversion was also associated with increased mortal

251 Optical coherence tomography CST and macular volume.

252 onounced dieback of the corticospinal tract (CST) and a decreased sprouting capacity of both CST and

253 ificant regeneration of corticospinal tract (CST) axons after SCI.

254 enables regeneration of corticospinal tract (CST) axons after spinal cord injury (SCI).

255 Partial injury to the corticospinal tract (CST) causes sprouting of intact axons at their targets,

256 ally ablated the dorsal corticospinal tract (CST) containing approximately 96% of corticospinal fiber

257 RN/RST compensates for corticospinal tract (CST) developmental motor impairments and CST misprojecti

258 ollateral growth in the corticospinal tract (CST) following stroke and focal TBI.

259 The corticospinal tract (CST) has dense contralateral and sparse ipsilateral spin

260 r an imaging measure of corticospinal tract (CST) injury in the acute phase can predict motor outcome

261 The corticospinal tract (CST) is a major descending pathway contributing to the c

262 that the anatomy of the corticospinal tract (CST) is abnormal in patients with NTN1-mutant CMM.

263 The corticospinal tract (CST) is the most important motor system in humans, yet r

264 escending pathways, the corticospinal tract (CST) is thought to be the most critical for voluntary fu

265 ncreases axon growth by corticospinal tract (CST) neurons after spinal injury.

266 nections come only from corticospinal tract (CST) neurons in the subdivision of primary motor cortex

267 mammalian CNS, notably corticospinal tract (CST) neurons, display a much lower regenerative capacity

268 limited rewiring of the corticospinal tract (CST) only partially compensates the lost functions after

269 wth of the axons in the corticospinal tract (CST) that originate in the motor cortex and innervate th

270 pinal projection of the corticospinal tract (CST) to investigate the effects of ipsilateral misprojec

271 within the ipsilesional corticospinal tract (CST), and an enhanced NMDA-mediated excitatory transmiss

272 ontext of injury to the corticospinal tract (CST), brainstem-origin circuits may provide an alternati

273 y for motor skills, the corticospinal tract (CST), sprout after brain or spinal cord injury.

274 The primate corticospinal tract (CST), the major descending pathway mediating voluntary h

275 ation as the descending corticospinal tract (CST), which develops postnatally.

276 ess regeneration of the corticospinal tract (CST).

277 ending motor tract, the corticospinal tract (CST).

278 ced regeneration of the corticospinal tract (CST).

279 f brain injury (smaller corticospinal tract [CST] injury), cortical function (greater ipsilesional mo

280 rity of PC and lateral corticospinal tracts (CST).

281 dependent competition between the CS tracts (CSTs) of the two hemispheres is imperative for normal de

282 of a telephone-based coping skills training (CST) intervention.

283 The cervical sympathetic trunks (CSTs) contain axons of preganglionic neurons that innerv

284 obacillus-poor vaginal community state type (CST 4) was inversely correlated with gestational age at

285 all vaginal microbiota community state type (CST).

286 of Lactobacillus spp. (community state type-CST IV) with increasing disease severity, irrespective o

287 ants were composed of community state types (CSTs) showing diversity (20/51; 39%) or predominated by

288 and clustered into 6 community state types (CSTs).

289 Currently, the mechanism underlying CST action at diverse replication issues remains unclear

290 stimulation in people with large unilateral CST lesions.

291 test this hypothesis in mice with unilateral CST lesions.

292 ted pathway, promotes sprouting of uninjured CST axons to the denervated spinal cord.

293 n nor collateral sprouting of the unlesioned CST caudal to the lesion.

294 Using CST, the deformation amplitude and HC peak distances inc

295 ree well with the numerical simulation using CST's Microwave Studio(R).

296 One year after vitrectomy, VA, CST, and MD improved in study eyes but not to the level

297 Synthesized CST variant peptides (viz. CST-Ser-364 and CST-Val-367) were significantly less pot

298 +) rise by these peptides in PC12 cells was: CST-WT > CST-Ser-364 > CST-Val-367.

299 A weighted CST lesion load (wCST-LL) was calculated by overlaying t

300 While CST does not enhance isolated DNA polymerase activity, i

301 cking effect of CST-Ser-364 as compared with CST-WT.

302 es that CST binding to ssDNA is dynamic with CST complexes undergoing concentration-dependent self-di

303 birth was more pronounced for subjects with CST 4 accompanied by elevated Gardnerella or Ureaplasma