ライフサイエンスコーパス: CTZ

10 ](2) (7), and [Ru(II)(eta(6)-p-cymene)(acac)(CTZ)][BF(4)] (8) (bipy = bipyridine; en = ethlylenediami

11 The long-lasting epileptiform activity after CTZ washout may also make it a very useful model in scre

12 hange of the neural network properties after CTZ treatment.

13 combined L497Y-S750Q mutations abolished all CTZ and TCM actions without disrupting CX614 activity.

14 rent rebound when co-application of GABA and CTZ was terminated suggests that the binding site for CT

15 Intermediate structures between CTZ and IDRA-21 show reduced potency, suggesting that th

16 2)(CTZ)] (5), [Ru(II)(eta(6)-p-cymene)(bipy)(CTZ)][BF(4)](2) (6), [Ru(II)(eta(6)-p-cymene)(en)(CTZ)][

17 d facilitation (CIF) was dependent upon both CTZ dose and exposure time and was accompanied by a long

18 inding to rifampicin (Rif) and clotrimazole (CTZ) by recruiting transcriptional coactivators.

19 armaceuticals ibuprofen (IBU), clotrimazole (CTZ), clofibric acid (CFA) and propranolol (PRP), found

20 ght new ruthenium complexes of clotrimazole (CTZ) with high antiparasitic activity have been synthesi

21 nificant cell death in hippocampal cultures, CTZ treatment does not result in any apparent neuronal d

22 Cyclothiazide (CTZ) is a potent blocker of AMPA receptor desensitizatio

23 Cyclothiazide (CTZ) is well known for its effect of enhancing glutamate

24 Cyclothiazide (CTZ), a potentiator of AMPAR, revealed slowly rising AMP

25 Cyclothiazide (CTZ), a selective antagonist at mGluR1, markedly reduced

26 Cyclothiazide (CTZ), the allosteric modulator of AMPARs, potentiates re

27 ia AMPA receptors produced by cyclothiazide (CTZ) to estimate the concentration of glutamate reached

28 in the presence of 100 microM cyclothiazide (CTZ) causes an increase in [Ca(2+)](i) in cultured cereb

29 sive, AMPA receptor modulator cyclothiazide (CTZ) induces a profound and long-lasting increase in the

30 The application of cyclothiazide (CTZ) revealed that desensitization of postsynaptic recep

31 We tested the effects of cyclothiazide (CTZ), an agent used to block desensitization of AMPA-typ

32 Effects of cyclothiazide (CTZ), trichlormethiazide (TCM), and CX614 were compared

33 on is commonly achieved using cyclothiazide (CTZ), the most potent modulator of the benzothiadiazide

34 that chronic stimulation with cyclothiazide (CTZ) or kainic acid (KA) induces robust epileptiform act

35 DMSO)(2)(CTZ)(2)] (2), Na[Ru(III)Cl(4)(DMSO)(CTZ)] (3), Na[trans-Ru(III)Cl(4)(CTZ)(2)] (4), [Ru(II)(e

36 ne to proline on the rho2 subunit eliminated CTZ sensitivity, whereas switching proline to serine on

37 [BF(4)](2) (6), [Ru(II)(eta(6)-p-cymene)(en)(CTZ)][BF(4)](2) (7), and [Ru(II)(eta(6)-p-cymene)(acac)(

38 erminated suggests that the binding site for CTZ on the GABA(C) receptor is distinct from that for GA

39 C50, 1810 microM in control vs 304 microM in CTZ), we estimate that the extrasynaptic transmitter con

40 -known epileptogenic agent kainic acid (KA), CTZ affects neuronal activity mainly through modulating

41 ver, the effect of the allosteric modulator, CTZ on agonist activation of AMPAR can also be modified

42 RP), found responses to IBU and CFA, but not CTZ or PRP.

43 The ability of CTZ to interact with various types of neurotransmitter r

44 notably, complex 5 increases the activity of CTZ by factors of 110 and 58 against L. major and T. cru

45 The amount of CTZ-induced facilitation (CIF) was dependent upon both C

46 Cs along with mass spectrometric analysis of CTZ-treated slices indicates that the cause is prolonged

47 at the cause is prolonged bioavailability of CTZ.

48 The epileptogenic effect of CTZ is probably due to its enhancing glutamatergic neuro

49 ated in in vivo recordings that injection of CTZ (5 micromol in 5 microl) into the lateral ventricles

50 Additionally, AMPA in the presence of CTZ causes a depletion of thapsigargin-sensitive intrace

51 The inhibitory properties of CTZ were consistent with its action as a channel blocker

52 ivity lasts more than 48 h after washing off CTZ, suggesting a permanent change of the neural network

53 serine on the rho1 subunit made the receptor CTZ sensitive.

54 in addition to its action on AMPA receptors, CTZ also exerts a powerful but opposite effect on GABAA

55 tor is distinct from that for GABA, and that CTZ acts as a non-competitive antagonist on the GABA(C)

56 These results demonstrate that CTZ interacts with both glutamate and GABAA receptors an

57 We have recently demonstrated that CTZ also inhibits GABA(A) receptors.

58 We found that CTZ reversibly inhibited both evoked and spontaneous inh

59 ingle-channel analyses revealed further that CTZ greatly reduced the open probability of GABAA recept

60 Results indicate that CTZ and TCM target deactivation and agonist potency inde

61 Here we report that CTZ induces robust epileptiform activity in hippocampal

62 Therefore, the CTZ-induced epilepsy model may provide a novel research

63 hermore, GluR1L3T was totally insensitive to CTZ potentiation of KA and glutamate-activated currents

64 ant receptor currents were more sensitive to CTZ potentiation than the wild-type receptor current.

65 This is in contrast with mammals, where CTZ is a potent PXR-agonist.

66 ronic treatment of hippocampal cultures with CTZ (5 microM, 48 h) results in epileptiform activity in

67 nic pretreatment of hippocampal neurons with CTZ or KA resulted in a marked reduction in GABAergic in

68 Treatment of the slice with CTZ (90 muM) for 1 h increased the integrated XII ( XII)