ライフサイエンスコーパス: CXC chemokine

1 mely, aminoacylation, and as a mimic of host CXC chemokine.

2 n the lung requires the production of ELR(+) CXC chemokines.

3 ighly potent inhibitors of a range of CC and CXC chemokines.

4 acid insertion (41VSRYR45) relative to other CXC chemokines.

5 growth factor 1 and 5 and of several CC and CXC chemokines.

6 d by a group of chemoattractants, especially CXC chemokines.

7 ch hepatic response is not restricted to the CXC chemokines.

8 phoma 2 (Bcl-2), but reduced serum levels of CXC chemokines.

9 CXC chemokine administration to the infection site resul

10 a CC chemokine, and interleukin-8 (IL-8), a CXC chemokine, along with their individual interactions

11 CXC chemokines also underwent cleavage by whole GBS cell

12 nfection was enhanced by administration of a CXC chemokine and abrogated by antibodies that blocked t

13 We hypothesized that neutrophil-related CXC chemokines and antimicrobial peptides are increased

14 induction of Th17 signature genes, including CXC chemokines and beta defensin-3.

15 y susceptible to OPC, with reduced levels of CXC chemokines and concomitantly impaired neutrophil rec

16 Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor

17 t IFN-gamma is a potent stimulator of CC and CXC chemokines and highlight the importance of CCR5 in t

18 s a means of both activating or inactivating CXC chemokines and inactivating CC chemokines.

19 actor-1alpha (SDF-1alpha) is a member of the CXC chemokines and interacts with the G protein, seven-t

20 nity binding to multiple inflammatory CC and CXC chemokines and is expressed by erythrocytes and endo

21 e objective of this study was to investigate CXC chemokines and its receptor in patients with Behcet'

22 D88/NF-kappaB/AP-1 pathway and production of CXC chemokines and neutrophil infiltration to infected t

23 eparan sulfate inhibited the accumulation of CXC chemokines and neutrophils in tissues and attenuated

24 acerbated disease by impeding the removal of CXC chemokines and neutrophils, whereas administration o

25 ted closely with the removal of tissue-bound CXC chemokines and resolution of accumulated neutrophils

26 the notion that increased expression of ELR+ CXC chemokines and their interaction with CXCR2 plays an

27 prosurvival and proangiogenic role of ELR(+)-CXC chemokines and their receptor CXCR2 during metanephr

28 CXC chemokines and their receptor, CXC chemokine recepto

29 The CXC chemokines and their receptor, CXCR2, are important

30 ression of CXCL2/MIP-2 and CXCL5/LPS-induced CXC chemokine, and activation of NF-kappaB and MAPKs in

31 keratinocyte-derived chemokine, LPS-induced CXC chemokine, and G-CSF were augmented in Adipo(-/-) ve

32 on, bronchoalveolar lavage concentrations of CXC chemokines, and airway hyperreactivity.

33 ities including beta-defensins, ELR-negative CXC chemokines, and the cathelicidin LL-37.

34 hion, vGPCR binds a broad spectrum of CC and CXC chemokines, and the roles of chemokines in vGPCR tum

35 These functions of CXC chemokines are important in the pathogenesis of pulm

36 Because ELR(+) CXC chemokines are important mediators of endothelial-le

37 amic acid-leucine-arginine-positive (ELR(+)) CXC chemokines associated with bronchiolitis obliterans

38 The ELR(+) CXC chemokines both mediate neutrophil recruitment and p

39 h then induce IL-1R1-dependent production of CXC chemokine by resident corneal fibroblasts.

40 epends at least in part on the production of CXC chemokines by intrinsic renal cells.

41 esangial cells with LPS caused production of CXC chemokines by wild-type cells only.

42 at PE results in increased expression of the CXC chemokines CINC-1 and CINC-2 between 6 and 18 h afte

43 that ET-1 additionally induces secretion of CXC chemokines critical for melanoma metastasis and tumo

44 tumor cells constitutively produced the ELC-CXC chemokine CXCL-8 (IL8), enabling them to recruit APR

45 M-1 and VCAM-1), and enhanced the release of CXC chemokine CXCL1 when incubated with primary cultures

46 ny-stimulating factor (G-CSF) and the ELR(+) CXC chemokine CXCL1.

47 The ELR(+) CXC chemokines CXCL1 and CXCL2 are up-regulated in the c

48 ontrast, cathepsins specifically process ELR CXC chemokines CXCL1, -2, -3, -5, and -8 N-terminally to

49 Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXC

50 Here, we show that the CXC chemokine CXCL4 (PF-4), the most abundant protein co

51 , as was recently reported, for example, for CXC chemokines CXCL4/PF4 and CXCL8/IL8 that interact to

52 We report a novel role for the CXC-chemokine, CXCL5, in the proliferation and invasion

53 tractant 1/CXCL1, lipopolysaccharide-induced CXC chemokine/CXCL5) and up-regulation of the angiogenes

54 and CCL4 are inactive, and the dimer of the CXC chemokine CXCL8 (which is closely related to CXCL1)

55 man monocytes and macrophages to release the CXC chemokine CXCL8 [(interleukin-8 (IL-8)].

56 e up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant

57 e role of non-glutamic acid-leucine-arginine CXC chemokine CXCL9 for T-cell recruitment to prevent re

58 The ELR(-)CXC chemokine CXCL9 is characterized by a long, highly p

59 he interferon-inducible Glu-Leu-Arg-negative CXC chemokines CXCL9, CXCL10, and CXCL11 exhibit antimic

60 inactivate and in some cases degrade non-ELR CXC chemokines CXCL9-12.

61 vaccine that is highly effective in blocking CXC chemokine degradation and permits opsonic Abs to kil

62 zation motifs represented by CC-chemokine or CXC-chemokine dimer interfaces.

63 d infection through enhancement of the local CXC chemokine-driven neutrophil response.

64 demonstrate that early, local treatment with CXC chemokines enhances neutrophil recruitment and clear

65 n vitro analysis demonstrated that all three CXC chemokines exerted direct antimicrobial effects agai

66 ages and epithelial cells, which facilitates CXC chemokine expression and aids neutrophil recruitment

67 onfirmed the importance of IL-1 signaling in CXC chemokine expression and neutrophil recruitment in v

68 L-1beta signaling or IL-17 signaling reduced CXC chemokine expression but did not alter the overall s

69 We also found that MIF induced angiogenic CXC chemokine expression in an autocrine manner in vitro

70 ed with the angiogenic activity and level of CXC chemokine expression in human specimens of non-small

71 itro and in vivo models indicate that ELR(+) CXC chemokine expression is higher in microvascular endo

72 eloid expression of CXCR2 directly regulated CXC chemokine expression levels after hepatic I/R, such

73 on reduces RSV-induced neutrophilia, mucosal CXC chemokine expression, activation of the IRF7-RIG-I a

74 The CXC chemokine family is a pleiotropic family of cytokine

75 In this study, ELR(+)-CXC chemokine family members CXCL2 and CXCL7, along with

76 In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates

77 mokine receptor that binds to members of the CXC chemokine family possessing angiogenic properties.

78 tivating peptide-78 (CXCL5), a member of the CXC chemokine family, has been shown to be involved in a

79 o be described and is the 17th member of the CXC chemokine family.

80 ment of CXCR2, the receptor for ELR-positive CXC chemokines, for RV-induced airway neutrophilia and h

81 that the DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation

82 revealed lower expression levels of several CXC chemokine genes (CXCL-1, -2, -3, -5, -6, -12) in CWF

83 As exemplified by the CXC chemokine genes clustered on chromosome 4, we demons

84 virulence by facilitating the generation of CXC chemokine gradients and stimulating chemokine-induce

85 and demonstrated that it readily cleaved the CXC chemokines GRO-alpha, GRO-beta, GRO-gamma, neutrophi

86 lished the abilities of three representative CXC chemokines, GRO-gamma, NAP-2, and GCP-2, to attract

87 detected by Sytox green staining, levels of CXC chemokines, histones, and cytokines also were measur

88 equivalently binds four different ELR-devoid CXC chemokines (ie, PF4/CXCL4, IP-10/CXCL10, MIG/CXCL9,

89 higher levels of tumor-associated angiogenic CXC chemokines (ie, the ELR score) and greater vasculari

90 ses (MMP-9, ADAM-8), CC chemokines (CCL-20), CXC chemokines (IL-8, CXCL-10, CXCL-11), oligoadenylate

91 ression of CXCL2/MIP-2 and CXCL5/LPS-induced CXC chemokine in Klebsiella-infected lungs, and 2) CXCL1

92 pression of a variety of inflammatory CC and CXC chemokines in all models.

93 We found elevated levels of multiple ELR+ CXC chemokines in human bronchoalveolar lavage fluid fro

94 re, we analyzed expression of genes encoding CXC chemokines in M. tuberculosis-infected murine lung t

95 A systemic derangement of CXC chemokines in maternal and fetal circulation disting

96 not TLR2-deficient mesangial cells produced CXC chemokines in response to stimulation with Pam(3)Cys

97 To prove the role of CXC chemokines in the augmented inflammation, CXC chemok

98 icantly lower concentrations of PMN-specific CXC chemokines in wound tissue than did WT mice.

99 l-derived chemokines, MIP-2, and LPS-induced CXC chemokines) in the lungs.

100 HPAF-II cells express ELR(+) CXC chemokines, including IL-8/CXCL8, which bind to CXCR

101 As a result, CXC chemokines increase in lung, setting the stage for n

102 When given immediately after CLP, CXC chemokines increased peritoneal neutrophil recruitme

103 Similarly, CXC chemokines induce biological responses through the m

104 potentiation of neutrophil mobilization via CXC chemokine induction is a putative mechanism underlyi

105 s would increase neutrophil migration toward CXC chemokines instilled into lungs of mice.

106 The Alu-Leu-Arg-negative CXC chemokine interferon-inducible protein 9 (IP-9; also

107 Production of the CXC chemokine interleukin (IL)-8/CXCL8 forms a common ep

108 s one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of

109 in kinases, and basolateral secretion of the CXC chemokine interleukin-8 (IL-8).

110 Local expression of CXC chemokines is critical for PMN recruitment.

111 Local lung production of CXC chemokines is intensified during experimental sepsis

112 triggered a more sustained production of the CXC chemokine KC compared to RSV.

113 lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response,

114 e susceptibility of C3H-HeN mice lacking the CXC chemokine KC or its receptor CXC receptor 2 (CXCR2)

115 dentium-stimulated induction of iNOS and the CXC chemokines KC and MIP-2 to the same degree as the NF

116 ed attenuation of expression of iNOS and the CXC chemokines KC and MIP-2.

117 However, high levels of CXC chemokines (KC and MIP-2), particularly at later tim

118 oid A and IL-6, and the neutrophil-selective CXC chemokines, KC and macrophage inflammatory protein-2

119 A comparison of the murine CXC chemokines, KC and MIP-2, revealed that KC was more

120 Levels of the CXC chemokines keratinocyte-derived chemokine and macrop

121 ere were no differences in the levels of the CXC chemokines keratinocyte-derived chemokine and MIP-2

122 hrough increased pulmonary expression of the CXC chemokines (keratinocyte-derived chemokine and macro

123 rived cells in the corneal stroma to produce CXC chemokines, leading to neutrophil recruitment to the

124 Increased CXC chemokine levels were associated with significantly

125 hagocytosis, and decreased IL-6 and MIP-2 (a CXC chemokine) levels after CLP in outbred (ICR/CD-1) mi

126 pon stimulation with CCL2, CCL19, CCL21, and CXC chemokine ligand (CXCL) 12 (DCs).

127 Microarray analysis of CXC chemokine ligand (CXCL) 12-treated T cells revealed

128 The urinary CXC chemokine ligand (CXCL)10 detects renal transplant i

129 Aberrant expression of the chemokine CXC chemokine ligand (CXCL)10 has been linked to the sev

130 em cells (MSCs) and their progeny, including CXC chemokine ligand (CXCL)12-abundant reticular (CAR) c

131 rophages and mesenchymal progenitors such as CXC chemokine ligand (CXCL)12-abundant reticular (CAR) c

132 ide evidence supporting functional roles for CXC chemokine ligand (CXCL)13 and interleukin (IL)-10 in

133 ligand (CCL)2, CCL3, CCL5, CCL19, CCL20, and CXC chemokine ligand (CXCL)8 were measured in gingival t

134 The CXC chemokine ligand (CXCL12, or stromal cell-derived fa

135 rum levels of interleukin-6, interleukin-10, CXC chemokine ligand 1, and interferon-gamma were signif

136 ed into murine lung, leading to induction of CXC chemokine ligand 1/2 and a neutrophilic response tha

137 [MHV]) expressing the T-cell chemoattractant CXC chemokine ligand 10 (CXCL10) resulted in increased s

138 The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor

139 uch as interferon-gamma-inducible protein 10/CXC chemokine ligand 10, interleukin 8, and monocyte che

140 nformations compared with the CXCR3 agonists CXC chemokine ligand 11 (CXCL11), VUF11418 [1-((1R,5S)-6

141 onse correlates with enhanced sensitivity to CXC chemokine ligand 12 (CXCL12) but not CXCL13 or CC ch

142 receptor 4 (CXCR4) in Cajal-Retzius cells by CXC chemokine ligand 12 (CXCL12) is important for contro

143 emokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed i

144 ling postnatal HSCs expressed high levels of CXC chemokine ligand 12 (CXCL12, also known as stromal c

145 stromal cell-derived factor-1 (SDF-1alpha or CXC chemokine ligand 12) are involved in the trafficking

146 A-1 molecules upon stimulation with CXCL-12 (CXC chemokine ligand 12).

147 CXC chemokine ligand 13 (CXCL13), CC chemokine ligand 21

148 lysis of chemokine transcripts revealed that CXC chemokine ligand 9 (CXCL9) and CXCL10, as well as CC

149 lowered rolling velocity further and induced CXC chemokine ligand-1 (CXCL1) and CXC chemokine recepto

150 CXC chemokine ligand-13 (CXCL13) has been implicated in

151 aortic wall and impaired local production of CXC-chemokine ligand (CXCL) 2.

152 vels of chemokines CC chemokine ligand 5 and CXC-chemokine ligand 4 were increased in the trJAM-A(-/-

153 ysaccharide-stimulated human MPhi identified CXC chemokine ligands (CXCLs), such as IP-10 (interferon

154 ize neutrophil chemoattractants CXCL1/CXCL2 (CXC chemokine ligands 1/2) in response to LPS.

155 TOF MS identified two differential proteins: CXC chemokine ligands 4 (CXCL4) and 7 (CXCL7), both of w

156 ne gene transcript levels of multiple CC and CXC chemokine ligands and receptors.

157 We found no effects of MMP-8 on LPS-induced CXC chemokine (LIX, or CXCL5)-induced neutrophil recruit

158 is associated with the local release of the CXC chemokines macrophage inflammatory protein 2 and KC.

159 In addition, mRNA levels of the CXC chemokines macrophage inflammatory protein 2 and ker

160 CXC chemokines, many of which can recruit neutrophils to

161 Pseudomonas and the ELR(+) CXC chemokines may interact to negatively influence lung

162 CXC chemokines mediate hepatic inflammation and injury f

163 oblasts and our previous studies showed that CXC chemokines mediate neutrophil recruitment, we examin

164 strating that IL-13 stimulates select CC and CXC chemokines (MIP-1alpha/CCL-3, MIP-1beta/CCL-4, MIP-2

165 matory cytokines (lipopolysaccharide-induced CXC chemokine, monocyte chemotactic protein-1, macrophag

166 Pulmonary levels of the CXC chemokines, monocyte inflammatory protein-2 and KC,

167 a may contribute to the higher production of CXC chemokines observed in lungs of aged mice vs. young

168 However, direct effects of CXC chemokines on hepatocytes during this response have

169 s in the production of MIP-2 and LPS-induced CXC chemokine or activation of NF-kappaB and MAPKs in th

170 CXC chemokines (particularly CXCL10/interferon-inducible

171 ly induced in the colon by infection encoded CXC chemokines, particularly CXCL1/2/5 and CXCL9/10, whi

172 Our findings reveal that a Th17-ELR(+) CXC chemokine pathway is critical for granulocyte mobili

173 cine-arginine (ELR) tripeptide motif (ELR(+) CXC chemokines) play an important role in leukocyte traf

174 CXC chemokines predominate within the RSV-infected lung.

175 lphabetaTCR+ cells and functions to regulate CXC chemokine production and neutrophil recruitment in v

176 ings indicate that IL-1R1 and MyD88 regulate CXC chemokine production and neutrophil recruitment to t

177 rTNF-alpha, rIL-1alpha, or rIL-1beta induced CXC chemokine production by corneal fibroblasts but not

178 We found no effect of rIFN-gamma on CXC chemokine production by macrophages or corneal fibro

179 TLR2 expression was also essential for CXC chemokine production by resident cells in the cornea

180 Eritoran tetrasodium significantly inhibited CXC chemokine production in the cornea and development o

181 Wild-type serotype Typhi induces less CXC chemokine production in tissue culture models than d

182 Low shear activated endothelial ELR(+) CXC chemokine production via cell surface heparan sulfat

183 alization, patterns of neutrophil influx and CXC chemokine production were assessed in C57Bl/6 mice a

184 The immunomodulatory effects of PEP35 on CXC chemokine production were TLR2 and NF-kappaB depende

185 naling in alveolar macrophages, resulting in CXC chemokine production, and C5a appears to play a pivo

186 in S. aureus infections in controlling local CXC chemokine production, neutrophil recruitment to the

187 s CCL5, they exhibit significantly increased CXC chemokine production, neutrophil recruitment to the

188 es, inflammatory cell recruitment, and local CXC chemokine production.

189 ance of the type I IFN inhibitory pathway on CXC chemokine production.

190 ced neutrophil recruitment or on LPS-induced CXC chemokine production.

191 a, IL-6, and LIX (lipopolysaccharide-induced CXC chemokine) production were attenuated in the lungs o

192 n transcript levels of genes encoding CC and CXC chemokines, proinflammatory cytokines, and TNF super

193 of the type IV collagen, thrombospondin, and CXC chemokine protein families, as well as somatotropin

194 eceptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CXCR) 3, and CXCR6 correlated wi

195 ein modifier inside the cell, functions as a CXC chemokine receptor (CXCR) 4 agonist outside the cell

196 ied extracellular ubiquitin as an endogenous CXC chemokine receptor (CXCR) 4 agonist.

197 r ubiquitin has recently been described as a CXC chemokine receptor (CXCR) 4 agonist.

198 G(+) plasma cells accompanied by defects in CXC chemokine receptor (CXCR) 4 expression, interleukin

199 CXC chemokine receptor (CXCR)4 is an HIV coreceptor and

200 ween stromal cell-derived factor (SDF)-1 and CXC chemokine receptor (CXCR)4.

201 We found that mice lacking the type 2 CXC chemokine receptor (CXCR2) were relatively resistant

202 de neutrophils to sites of liver necrosis by CXC chemokine receptor 2 (CXCR2) and formyl peptide rece

203 flammation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endot

204 emonstrate the dependence of this process on CXC chemokine receptor 2 (CXCR2) and vascular cell adhes

205 the alpha(1A)-adrenoceptor (alpha(1A)AR) and CXC chemokine receptor 2 (CXCR2) in live cells.

206 In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of p

207 We also found that neither CXC chemokine receptor 2 (CXCR2) nor interleukin-17 (IL-

208 ound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B

209 l receptor is the G-coupled protein receptor CXC chemokine receptor 2 (CXCR2).

210 oid cells was reduced using an antagonist of CXC chemokine receptor 2 (CXCR2).

211 ssue, Belperio et al. demonstrate a role for CXC chemokine receptor 2 in the regulation of angiogenes

212 The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor 3 (CXCR3) chemokine pathway promo

213 CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL1

214 gamma is required for efficient induction of CXC chemokine receptor 3 (CXCR3) on T cells upon activat

215 The interaction of the CXC chemokine receptor 3 (CXCR3) receptor with its ligan

216 CXC chemokine receptor 3 (CXCR3) signaling promotes kera

217 tosis of hepatocytes involving TLR4, but not CXC chemokine receptor 3 signaling.

218 mulated MPhi of chemoattractant activity for CXC chemokine receptor 3-transfected (receptor for IP-10

219 ow that extracellular ubiquitin is a natural CXC chemokine receptor 4 (CXCR4 and CD184) agonist.

220 The CXC chemokine receptor 4 (CXCR4) and its ligand, stromal

221 ll-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) are important regulator

222 We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by a

223 The CXC chemokine receptor 4 (CXCR4) contributes to the meta

224 romal cell-derived factor 1 and its receptor CXC chemokine receptor 4 (CXCR4) critically mediate the

225 The CXC chemokine receptor 4 (CXCR4) for the chemokine (C-X-

226 Activation of the CXC chemokine receptor 4 (CXCR4) in Cajal-Retzius cells

227 CXC chemokine receptor 4 (CXCR4) is a G protein-coupled

228 38+ cells in the blood, higher leukemic cell CXC chemokine receptor 4 (CXCR4) levels, and increased r

229 CXC chemokine receptor 4 (CXCR4) plays a role in the dev

230 The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signaling axis appears

231 CXC chemokine receptor 4 (CXCR4), initially linked with

232 The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC c

233 gous to the V3 loop of HIV-1, which binds to CXC chemokine receptor 4 (CXCR4), we hypothesized that B

234 ations covering all 352 residues of the GPCR CXC chemokine receptor 4 (CXCR4), we identified 41 amino

235 , indicating that PTEN was not requisite for CXC chemokine receptor 4 (CXCR4)-mediated chemotaxis of

236 erived factor-1 alpha (CXCL12/SDF-1) via the CXC chemokine receptor 4 (CXCR4).

237 cluding integrin beta1, integrin alpha4, and CXC chemokine receptor 4 (CXCR4).

238 hereas 26%-73% of cells coexpressed CCR5 and CXC chemokine receptor 4 (CXCR4).

239 or, either CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 (CXCR4).

240 a promising protein therapeutic and implies CXC chemokine receptor 4 as a drug target after polytrau

241 cell-derived factor 1alpha and its receptor CXC chemokine receptor 4 in beta-selection.

242 Disrupting homing dynamics with a CXC chemokine receptor 4 inhibitor reduced the formation

243 Plasma levels of the cognate CXC chemokine receptor 4 ligand stromal cell-derived fac

244 vels and corresponding surface expression of CXC chemokine receptor 4 on clonal PCs, suggesting that

245 The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degra

246 stem cell mobilizer or its receptor, CXCR4 (CXC chemokine receptor 4), would attenuate and reverse h

247 s, such as protease-activated receptor 1 and CXC chemokine receptor 4, RGS4 disrupted Rac1-dependent

248 growth factor receptor and G-protein-coupled CXC chemokine receptor 4.

249 bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis,

250 ided in the T cell areas, expressed CCR7 and CXC chemokine receptor 5 (CXCR5), and like follicular he

251 y modified unselected CD8 T cells to express CXC chemokine receptor 5 (CXCR5), the chemokine receptor

252 ssion of B-cell leukemia/lymphoma 6 (Bcl-6), CXC chemokine receptor 5, programmed death-1, and other

253 The CXC chemokine receptor CXCR2 and its specific ligands ha

254 We have determined previously that the CXC chemokine receptor CXCR2 is involved in advanced ath

255 CXC chemokine receptor CXCR3 and/or its main three ligan

256 m kinase ERK also in the presence of BCR and CXC chemokine receptor CXCR4 stimulation.

257 ion to formulate a basis for the function of CXC chemokine receptor signaling in hepatocytes.

258 derstanding of the pathways involved in both CXC chemokine receptor signaling in other cell types, mo

259 e evaluated their inhibitory activity on the CXC chemokine receptor type 4 (CXCR4), toxicity properti

260 We found that the CXC chemokine receptor type 4 accommodated the results b

261 CXC chemokine receptor-2 (CXCR2) has been shown to play

262 ed the significance of signaling through the CXC chemokine receptor-2 (CXCR2) receptor in the process

263 More recently, signaling through CXC chemokine receptor-2 (CXCR2) was shown to delay live

264 CXC chemokines and their receptor, CXC chemokine receptor-2 (CXCR2), are important componen

265 d induced CXC chemokine ligand-1 (CXCL1) and CXC chemokine receptor-2 (CXCR2)-dependent leukocyte arr

266 ated genes, interferon-gamma (IFNgamma), and CXC chemokine receptor-3 (CXCR3).

267 tic parental cells (686LN-Ps), we found that CXC chemokine receptor-4 (CXCR4) mRNA levels were signif

268 ral differentiation, we observed that CXCR4 (CXC chemokine receptor-4) expressing central nervous sys

269 ce markers of neutrophils (Ly6G, L-selectin, CXC chemokines receptor 2, and 7/4) and DCs (CD11c, MHC

270 ection within the liver was not dependent on CXC-chemokine receptor 2 (CXCR2) signaling as anti-CXCR2

271 CXC-chemokine receptor 4 (CXCR4) is a G protein-coupled

272 CXC-chemokine receptor 4 (CXCR4) regulates the retention

273 The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves c

274 iae lacking FimCDE fail to interact with the CXC-chemokine receptor 4 (CXCR4), and bacteria expressin

275 Recent crystal and NMR structures of the CXC chemokine receptors (CXCR) CXCR4 and CXCR1, combined

276 s known about the signaling pathways used by CXC chemokine receptors in hepatocytes.

277 "minor pocket," previously characterized in CXC chemokine receptors-1 and -2, is functionally conser

278 he nucleus, transcription of CXCL1 and other CXC chemokines, recruitment of neutrophils to the cornea

279 hereas T(H)17 transfer resulted in increased CXC chemokine secretion and neutrophil influx that was n

280 ne-cytokine receptor interaction (especially CXC-chemokine) signaling as well as cancer-related pathw

281 XC chemokines in the augmented inflammation, CXC chemokine-specific antibodies were delivered to the

282 ports indicate that interactions between the CXC chemokine stromal cell-derived factor 1 and its rece

283 protein 2) and CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cell

284 The CXC chemokine stromal cell-derived factor-1alpha (SDF-1)

285 We show that ovarian tumors strongly express CXC chemokine stromal-derived factor (SDF-1/CXCL12).

286 The human CXC chemokine, stromal cell-derived factor 1 (SDF-1alpha

287 Stromal Cell-derived factor 1 (SDF-1) is a CXC chemokine that binds to the CXCR4 receptor.

288 related with the strain's ability to degrade CXC chemokines, thereby preventing neutrophil chemotaxis

289 Intragraft production of CXC chemokines was measured by Luminex and enzyme-linked

290 Although the expression of CXC chemokines was modestly up-regulated in ECs, the exp

291 erferon-inducible Glu-Leu-Arg (ELR)-negative CXC chemokines was not affected by the BaPGN-induced ant

292 Expression of 11 of the 16 known human CXC-chemokines was increased in lung adenocarcinoma cell

293 neutrophil influx (along with expression of CXC chemokines) was significantly enhanced in infected t

294 aled that CXCR3, a receptor utilized by ELR- CXC chemokines, was expressed in vascular endothelial ce

295 TNF-alpha and CXC chemokines were detected in mast cell supernatants a

296 In addition, tracheal allograft ELR(+) CXC chemokines were persistently expressed even in the a

297 ents, plasma levels of CXCL5, another ELR(+) CXC chemokine, were elevated during acute lesion formati

298 GRO-alpha is a CXC chemokine with tumor-associated angiogenic as well a

299 CXC chemokines with a glutamate-leucine-arginine (ELR) t

300 the co-expression of MIF-CD74 and angiogenic CXC chemokines with tumor angiogenesis.