ライフサイエンスコーパス: CXC chemokine receptor

1 example of a CC chemokine, which binds to a CXC chemokine receptor.

2 unctioning as both a HIV-1 co-receptor and a CXC-chemokine receptor.

3 dependent on the level of the expression of CXC chemokine receptors.

4 vitro antagonistic activities against CC and CXC chemokine receptors.

5 Surprisingly, we found that CXC chemokine receptor 1 (CXCR1), the predominant neutro

6 "minor pocket," previously characterized in CXC chemokine receptors-1 and -2, is functionally conser

7 de neutrophils to sites of liver necrosis by CXC chemokine receptor 2 (CXCR2) and formyl peptide rece

8 flammation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endot

9 emonstrate the dependence of this process on CXC chemokine receptor 2 (CXCR2) and vascular cell adhes

10 the alpha(1A)-adrenoceptor (alpha(1A)AR) and CXC chemokine receptor 2 (CXCR2) in live cells.

11 In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of p

12 We also found that neither CXC chemokine receptor 2 (CXCR2) nor interleukin-17 (IL-

13 In contrast, the blockade of CXC chemokine receptor 2 (CXCR2), a receptor for CXC che

14 ound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B

15 Because all ELR(+) CXC chemokines bind to CXC chemokine receptor 2 (CXCR2), we hypothesized that C

16 oid cells was reduced using an antagonist of CXC chemokine receptor 2 (CXCR2).

17 l receptor is the G-coupled protein receptor CXC chemokine receptor 2 (CXCR2).

18 ivation by the C5a and C3a receptors, and by CXC chemokine receptor 2 and CCR8.

19 ssue, Belperio et al. demonstrate a role for CXC chemokine receptor 2 in the regulation of angiogenes

20 he receptor that binds these CXC chemokines, CXC chemokine receptor 2, significantly reduced the degr

21 ce markers of neutrophils (Ly6G, L-selectin, CXC chemokines receptor 2, and 7/4) and DCs (CD11c, MHC

22 ection within the liver was not dependent on CXC-chemokine receptor 2 (CXCR2) signaling as anti-CXCR2

23 CXC chemokine receptor-2 (CXCR2) has been shown to play

24 d the ligand-enhanced phosphorylation of the CXC chemokine receptor-2 (CXCR2) in a series of clonal 3

25 pulmonary nocardiosis is highly dependent on CXC chemokine receptor-2 (CXCR2) ligand-mediated neutrop

26 by activation of the murine homologue of the CXC chemokine receptor-2 (CXCR2) or IL-8R B.

27 ed the significance of signaling through the CXC chemokine receptor-2 (CXCR2) receptor in the process

28 More recently, signaling through CXC chemokine receptor-2 (CXCR2) was shown to delay live

29 CXC chemokines and their receptor, CXC chemokine receptor-2 (CXCR2), are important componen

30 sized that interaction of these ligands with CXC chemokine receptor-2 (CXCR2), their sole murine rece

31 d induced CXC chemokine ligand-1 (CXCL1) and CXC chemokine receptor-2 (CXCR2)-dependent leukocyte arr

32 or for MIP-2 and/or KC is unknown but is not CXC-chemokine receptor-2.

33 The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor 3 (CXCR3) chemokine pathway promo

34 CXC chemokine receptor 3 (CXCR3) is the receptor for the

35 CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL1

36 gamma is required for efficient induction of CXC chemokine receptor 3 (CXCR3) on T cells upon activat

37 The interaction of the CXC chemokine receptor 3 (CXCR3) receptor with its ligan

38 CXC chemokine receptor 3 (CXCR3) signaling promotes kera

39 amined the levels of chemokines that bind to CXC chemokine receptor 3 (CXCR3) to determine whether su

40 ited the release of chemotactic activity for CXC chemokine receptor 3 (CXCR3)-transfected lymphocytes

41 ARC and MDC, whereas Th1 lymphocytes express CXC chemokine receptor 3 and CCR5 (but not CCR4).

42 cytes coexpress the Th1-associated receptors CXC chemokine receptor 3 and CCR5, suggesting a potentia

43 tosis of hepatocytes involving TLR4, but not CXC chemokine receptor 3 signaling.

44 The presence of CXC chemokine receptor 3-expressing cells, specifically

45 mulated MPhi of chemoattractant activity for CXC chemokine receptor 3-transfected (receptor for IP-10

46 ated genes, interferon-gamma (IFNgamma), and CXC chemokine receptor-3 (CXCR3).

47 ow that extracellular ubiquitin is a natural CXC chemokine receptor 4 (CXCR4 and CD184) agonist.

48 demonstrates cell surface expression of both CXC chemokine receptor 4 (CXCR4) and CC chemokine recept

49 The CXC chemokine receptor 4 (CXCR4) and its ligand, stromal

50 CCR5 and CXC chemokine receptor 4 (CXCR4) are coreceptors for CD4

51 ll-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) are important regulator

52 We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by a

53 The CXC chemokine receptor 4 (CXCR4) contributes to the meta

54 romal cell-derived factor 1 and its receptor CXC chemokine receptor 4 (CXCR4) critically mediate the

55 The CXC chemokine receptor 4 (CXCR4) for the chemokine (C-X-

56 Activation of the CXC chemokine receptor 4 (CXCR4) in Cajal-Retzius cells

57 terferes with the expression and function of CXC chemokine receptor 4 (CXCR4) in CD4+ T lymphocytes.

58 have investigated the expression of surface CXC chemokine receptor 4 (CXCR4) in enriched populations

59 east cancer, GnRH in ovarian carcinomas, and CXC chemokine receptor 4 (CXCR4) in multiple malignancie

60 CXC chemokine receptor 4 (CXCR4) is a cell surface recep

61 CXC chemokine receptor 4 (CXCR4) is a co-receptor for hu

62 CXC chemokine receptor 4 (CXCR4) is a G protein-coupled

63 The human CXC chemokine receptor 4 (CXCR4) is a receptor for the c

64 38+ cells in the blood, higher leukemic cell CXC chemokine receptor 4 (CXCR4) levels, and increased r

65 al use of CC chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) may be intimately invol

66 Enhancement of CXC chemokine receptor 4 (CXCR4) mRNA expression was obs

67 CXC chemokine receptor 4 (CXCR4) plays a role in the dev

68 crophage-tropic coreceptor for HIV-1 whereas CXC chemokine receptor 4 (CXCR4) serves the counterpart

69 The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signaling axis appears

70 lls expressed elevated levels of CD95, CD25, CXC chemokine receptor 4 (CXCR4), and CC chemokine recep

71 CXC chemokine receptor 4 (CXCR4), initially linked with

72 The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC c

73 NSCs express CXC chemokine receptor 4 (CXCR4), the cognate receptor f

74 The receptor for SDF-1, CXC chemokine receptor 4 (CXCR4), was found to be expres

75 gous to the V3 loop of HIV-1, which binds to CXC chemokine receptor 4 (CXCR4), we hypothesized that B

76 ations covering all 352 residues of the GPCR CXC chemokine receptor 4 (CXCR4), we identified 41 amino

77 , indicating that PTEN was not requisite for CXC chemokine receptor 4 (CXCR4)-mediated chemotaxis of

78 al derived factor-1alpha, the ligand for the CXC chemokine receptor 4 (CXCR4).

79 gp120 with CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 (CXCR4).

80 erived factor-1 alpha (CXCL12/SDF-1) via the CXC chemokine receptor 4 (CXCR4).

81 cluding integrin beta1, integrin alpha4, and CXC chemokine receptor 4 (CXCR4).

82 hereas 26%-73% of cells coexpressed CCR5 and CXC chemokine receptor 4 (CXCR4).

83 or, either CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 (CXCR4).

84 1alpha (SDF-1alpha) binding to its receptor, CXC chemokine receptor 4 (CXCR4).

85 -derived factor (SDF)-1alpha (the ligand for CXC chemokine receptor 4 [CXCR4]) did not affect T(GFP)

86 a promising protein therapeutic and implies CXC chemokine receptor 4 as a drug target after polytrau

87 nfection, which was associated with CCR5 and CXC chemokine receptor 4 down-regulation.

88 cell-derived factor 1alpha and its receptor CXC chemokine receptor 4 in beta-selection.

89 Disrupting homing dynamics with a CXC chemokine receptor 4 inhibitor reduced the formation

90 Plasma levels of the cognate CXC chemokine receptor 4 ligand stromal cell-derived fac

91 vels and corresponding surface expression of CXC chemokine receptor 4 on clonal PCs, suggesting that

92 The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degra

93 gp120 coupled CXCR4 (CXC chemokine receptor 4) to induce NADPH oxidase-mediat

94 stem cell mobilizer or its receptor, CXCR4 (CXC chemokine receptor 4), would attenuate and reverse h

95 s, such as protease-activated receptor 1 and CXC chemokine receptor 4, RGS4 disrupted Rac1-dependent

96 We coinfected rhesus macaques with CXC chemokine receptor 4- and CC chemokine receptor 5-sp

97 upregulated in tissues infected ex vivo with CXC chemokine receptor 4-tropic but not CCR5-tropic HIV-

98 ceptor 5 (CCR5), whereas 84%-99% coexpressed CXC chemokine receptor 4.

99 growth factor receptor and G-protein-coupled CXC chemokine receptor 4.

100 bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis,

101 A chimeric protein consisting of CXC-chemokine receptor 4 (CXCR4) and the green fluoresce

102 CXC-chemokine receptor 4 (CXCR4) is a G protein-coupled

103 CXC-chemokine receptor 4 (CXCR4) regulates the retention

104 The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves c

105 iae lacking FimCDE fail to interact with the CXC-chemokine receptor 4 (CXCR4), and bacteria expressin

106 , up-regulates the surface expression of the CXC-chemokine receptor 4 (CXCR4), but not of the CC-chem

107 e the infectivity of HIV-1 isolates that use CXC-chemokine receptor 4 for entry.

108 eramide but not for CC-chemokine receptor 5, CXC-chemokine receptor 4, or CD4.

109 we reported that human RMS cells express the CXC chemokine receptor-4 (CXCR4) and postulated a role f

110 howed that inducible knockdown of endogenous CXC chemokine receptor-4 (CXCR4) gene expression in brea

111 romal cell-derived factor-1 and its receptor CXC chemokine receptor-4 (CXCR4) have received considera

112 tic parental cells (686LN-Ps), we found that CXC chemokine receptor-4 (CXCR4) mRNA levels were signif

113 the bone marrow via cross talk with the SDF-CXC chemokine receptor-4 (CXCR4) signaling axis.

114 Most importantly, BDNF reduced the levels of CXC chemokine receptor-4 (CXCR4), a receptor that mediat

115 d, these cells expressed substantial surface CXC chemokine receptor-4 (CXCR4), and CXCL12 stimulation

116 We hypothesized that the CXC chemokine receptor-4 (CXCR4)-stromal-derived factor-

117 oreceptor, whereas T cell-tropic strains use CXC chemokine receptor-4 for entry.

118 le describes the transient expression of the CXC chemokine receptor-4 in Xenopus laevis melanophores

119 These results indicate that SDF-1 and CXC chemokine receptor-4 interactions not only play a ro

120 a-mediated costimulation was blocked by anti-CXC chemokine receptor-4 mAb.

121 ral differentiation, we observed that CXCR4 (CXC chemokine receptor-4) expressing central nervous sys

122 ells with 12G5, an antibody specific for the CXC chemokine receptor-4, eliminates this response indic

123 nterleukin-10-induced apoptosis, all through CXC chemokine receptor-4.

124 Because the CXC chemokine receptor-4/stromal derived factor-1 (CXCR4

125 receptor LESTR, which we therefore designate CXC-chemokine receptor-4 (CXCR-4).

126 Deficiency in CXC chemokine receptor 5 (CXCR5), a receptor for B lymph

127 ided in the T cell areas, expressed CCR7 and CXC chemokine receptor 5 (CXCR5), and like follicular he

128 y modified unselected CD8 T cells to express CXC chemokine receptor 5 (CXCR5), the chemokine receptor

129 ssion of B-cell leukemia/lymphoma 6 (Bcl-6), CXC chemokine receptor 5, programmed death-1, and other

130 CXC chemokine receptor-5 (CXCR5) is required for B-cell

131 we hypothesized that the expression of CC or CXC chemokine receptor (CCR) molecules on activated CD8(

132 Interferon-gamma-inducible protein-10/CXC chemokine receptor (CXCR) 3 interactions were specif

133 cells in tissues and reduced percentages of CXC chemokine receptor (CXCR) 3(+)/CD3(+) and CXCR3(+)/C

134 eceptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CXCR) 3, and CXCR6 correlated wi

135 ein modifier inside the cell, functions as a CXC chemokine receptor (CXCR) 4 agonist outside the cell

136 r ubiquitin has recently been described as a CXC chemokine receptor (CXCR) 4 agonist.

137 ied extracellular ubiquitin as an endogenous CXC chemokine receptor (CXCR) 4 agonist.

138 G(+) plasma cells accompanied by defects in CXC chemokine receptor (CXCR) 4 expression, interleukin

139 receptors CC chemokine receptor (CCR) 7 and CXC chemokine receptor (CXCR) 4 have been implicated in

140 inding to this molecule, in conjunction with CXC chemokine receptor (CXCR) 4, is required for product

141 relative contribution of chemokine receptors CXC chemokine receptor (CXCR)-2 (IL-8R homologue) and CC

142 r expression and found that the frequency of CXC chemokine receptor (CXCR)4 expressing synovial tissu

143 CXC chemokine receptor (CXCR)4 is an HIV coreceptor and

144 ween stromal cell-derived factor (SDF)-1 and CXC chemokine receptor (CXCR)4.

145 chemokine 1 (BCA-1) responses correlate with CXC chemokine receptor (CXCR)5 expression, are first dis

146 CCR7 loss in activated CD4 cells accompanies CXC chemokine receptor (CXCR)5 gain, suggesting that the

147 Here we show that CXC chemokine receptor (CXCR)5, the receptor for B lymph

148 Recent crystal and NMR structures of the CXC chemokine receptors (CXCR) CXCR4 and CXCR1, combined

149 CXC-chemokine receptor (CXCR)-4/fusin, a newly discovere

150 The CXC chemokine receptor CXCR2 and its specific ligands ha

151 We have determined previously that the CXC chemokine receptor CXCR2 is involved in advanced ath

152 ine motif positive) CXC chemokines and their CXC chemokine receptor (CXCR2) in lung antibacterial hos

153 We found that mice lacking the type 2 CXC chemokine receptor (CXCR2) were relatively resistant

154 b-mediated neutralization of the common ELR+ CXC chemokine receptor, CXCR2, resulted in development o

155 CXC chemokine receptor CXCR3 and/or its main three ligan

156 Ckine is not a ligand for the human or mouse CXC chemokine receptor CXCR3.

157 nes in that it has been shown to bind to the CXC chemokine receptor CXCR4 as well as to a variety of

158 m kinase ERK also in the presence of BCR and CXC chemokine receptor CXCR4 stimulation.

159 functional role for tyrosine sulfate in the CXC-chemokine receptor family and underscore a general d

160 ines, CXCR1 functions as the single dominant CXC chemokine receptor in patients with sepsis.

161 s known about the signaling pathways used by CXC chemokine receptors in hepatocytes.

162 e simultaneous detection of mRNA for various CXC chemokine receptors in resting human umbilical vein

163 L-15 induces CC chemokine receptors, but not CXC chemokine receptors, in a dose-dependent manner.

164 broad spectrum interaction with both CC and CXC chemokine receptors including CCR5 and CXCR4, two pr

165 broad-spectrum interaction with both CC and CXC chemokine receptors including CCR5 and CXCR4, two pr

166 ively expressed mRNAs for an array of CC and CXC chemokine receptors, including CCR1-8 and CXCR4, but

167 R2, KFRHGL, which is conserved in all CC and CXC chemokine receptors, is required for the receptor bi

168 The simultaneous expression of different CXC chemokine receptors on oligodendrocytes, and their l

169 nction of the mouse chemokine receptor fusin/CXC chemokine receptor R-4 (CXCR-4) revealed a potential

170 ion to formulate a basis for the function of CXC chemokine receptor signaling in hepatocytes.

171 derstanding of the pathways involved in both CXC chemokine receptor signaling in other cell types, mo

172 e evaluated their inhibitory activity on the CXC chemokine receptor type 4 (CXCR4), toxicity properti

173 We found that the CXC chemokine receptor type 4 accommodated the results b

174 ant proteins and with other unrelated CC and CXC chemokine receptors under transient labeling conditi