ライフサイエンスコーパス: CXCR4 receptor

1 ly eliminates tumor cells overexpressing the CXCR4 receptor.

2 cally targeting the ligand binding pocket of CXCR4 receptor.

3 ds, confirming a direct interaction with the CXCR4 receptor.

4 CD39 and the multifunctional, mTOR-inducing CXCR4 receptor.

5 y, was also dependent on the presence of the CXCR4 receptor.

6 ive to TFF2 treatment upon expression of the CXCR4 receptor.

7 acts with the G protein, seven-transmembrane CXCR4 receptor.

8 (SDF-1) is a CXC chemokine that binds to the CXCR4 receptor.

9 ng of free SDF1 or the fusion protein to the CXCR4 receptor.

10 of CD45 and induced its association with the CXCR4 receptor.

11 y virus gp120-induced internalization of the CXCR4 receptor.

12 at least overlapping binding site(s) on the CXCR4 receptor.

13 F-1) is an alpha chemokine that binds to the CXCR4 receptor.

14 l line-adapted, strains (X4 strains) use the CXCR4 receptor.

15 ocytic leukemia cell lines all expressed the CXCR4 receptor.

16 dimeric beta1-adrenoreceptor, mu-opioid, and CXCR4 receptors.

17 ndocytosis and signaling of WT and WHIM-like CXCR4 receptors.

18 periphery: endocytosis of TCRs and chemokine CXCR4 receptors.

19 potentially capable of interacting with two CXCR4 receptors.

20 bodies (IgM-ALA) bind to CD3, CD4, CCR5, and CXCR4 receptors.

21 sis as well as for physical interaction with CXCR4 receptors.

22 tly evolve to T-tropic viruses (X4) that use CXCR4 receptors.

23 ulated the proportion of cells with CCR5 and CXCR4 receptors.

24 , HUT78, CEM, and Sup-T1 for the presence of CXCR4 receptors.

25 s T-cell-tropic and dual-tropic isolates use CXCR4 receptors.

26 CXCR4 receptor activation by SDF-1alpha is profibrogenic

27 se ligation of the CD4 receptor alone or the CXCR4 receptor alone causes p38 activation and apoptosis

28 ression is mediated by the G protein-coupled CXCR4 receptor and activation of the ERK pathway.

29 ngs suggest that in addition to CXCR4, a non-CXCR4 receptor and cell-surface heparans also play an im

30 antly up-regulated the CXCL12 ligand and its CXCR4 receptor and increased LCL migration.

31 tic structural motifs that interact with the CXCR4 receptor and induce apoptosis in CD4(+) lymphocyte

32 L12 is a human chemokine that recognizes the CXCR4 receptor and is involved in immune responses and m

33 ecules that will enable further study of the CXCR4 receptor and may contribute to the development of

34 SHP2 associated with the CXCR4 receptor and the signaling molecules SHIP, cbl, an

35 Here we have shown that a new CXCR4 receptor antagonist IgG1 antibody (PF-06747143) bi

36 in TFF2(-/-) mice was inhibited by AMD3100 (CXCR4 receptor antagonist).

37 The CXCR4 receptor binds with meaningful affinities only CXC

38 ther GPCRs such as beta2-adrenergic, FSH and CXCR4 receptors, but does not affect the beta-arrestin-i

39 We then evaluated the ability of CXCR4 receptors containing mutations of serines and thre

40 These studies indicate the mechanism of CXCR4 receptor desensitization induced by a natural liga

41 These results indicate that the CCR5 and CXCR4 receptor down-modulation mechanism and chemotaxis

42 tin polymerization may directly regulate the CXCR4 receptor during viral entry and is involved in vir

43 and in vitro and explored whether SDF-1alpha/CXCR4 receptor engagement promotes HSC activation, fibro

44 unit of NF-kappaB in PC-3 cells up-regulated CXCR4 receptor expression and increased the adhesion and

45 lpha-induced NF-kappaB reporter activity and CXCR4 receptor expression as shown by flow cytometry.

46 CXCR4 receptor expression is required for the retention

47 Because the CXCR4 receptor for the stromal cell-derived factor-1 (SD

48 We found that CLL B cells express functional CXCR4 receptors for the chemokine stromal cell-derived f

49 e cannabinoid system can negatively modulate CXCR4 receptor function and perhaps tumor progression.

50 Mouse embryos lacking the CXCR4 receptor have a reduced number of retinal ganglion

51 In this report, the expression of the CXCR4 receptor in cells of megakaryocytic lineage and th

52 The CXCR4 receptor in HT-29 cells was functionally coupled,

53 gp120 protein-induced down-modulation of the CXCR4 receptor in Jurkat cells.

54 Blockade of the CXCR4 receptor in normal thymocytes by AMD3100 led to th

55 HSCs express CXCR4 receptor in vivo and in vitro.

56 opulation of progenitor cells that expressed CXCR4 receptors in vitro and differentiated into neurons

57 clustering, increasing the incorporation of CXCR4 receptors into these microdomains.

58 kine expression in HPC progenies showed that CXCR4 receptor is detected on the majority of MKs from e

59 The CXCR4 receptor is expressed at the surface of inflammato

60 These results demonstrate that the CXCR4 receptor is functionally expressed in SCLC cells a

61 Fc to primary T cells, suggesting that a non-CXCR4 receptor is involved in the binding of FIV SU.

62 derived factor-1 (SDF-1), the ligand for the CXCR4 receptor, is a highly efficacious chemoattractant

63 tor 1 (SDF-1), the only known ligand for the CXCR4 receptor, is expressed close to these migration si

64 Blocking the CXCR4 receptor led to a reduction in apoptosis.

65 Signaling via the CXCR4 receptor may be one mechanism by which chemokines

66 r 1 (SDF-1) in a concentration-dependent and CXCR4 receptor-mediated manner.

67 ine CXCL12 via a concentration-dependent and CXCR4 receptor-mediated mechanism, termed chemorepulsion

68 We studied the effects of Lyn ablation on CXCR4 receptor-mediated migration and adhesion of hemato

69 se results suggest that JAK2 is required for CXCR4 receptor-mediated signaling that regulates cytoske

70 Down-regulation of the CCR5 and CXCR4 receptors occurred in cells treated with the cogna

71 f CXCR4 disrupts the interaction between the CXCR4 receptor on hematopoietic stem cells (HSCs) and th

72 To examine the expression of the CXCR4 receptor on megakaryocyte progenitors (colony-form

73 aqueous liposome chamber and then bound with CXCR4 receptors on the tumor cell surface to inhibit met

74 tor, site-specific mutagenesis, hybrid CXCR3/CXCR4 receptors, pharmacological reagents, peptide array

75 rove useful as a diagnostic tool to identify CXCR4 receptor-positive tumor cells in culture and tumor

76 Hippocampal neurons express CXCR4 receptor proteins and are stimulated by SDF1alpha

77 eceptor CCR7, and the down-regulation of the CXCR4 receptor provide a mechanistic basis of Ab-induced

78 or AMD3100, to delineate the role of CD4 and CXCR4 receptors, respectively, in gp120-induced p38 acti

79 This molecular characterization of CXCR4 receptors should prove useful in clarifying recept

80 The gp120SF2 isolate prefers binding to CXCR4 receptors, similar to the physiological alpha-chem

81 myces cerevisiae that expresses a functional CXCR4 receptor, site-specific mutagenesis, hybrid CXCR3/

82 In mice engineered to lack the CXCR4 receptor, the morphology of the hippocampal dentat

83 l role of signaling molecules connecting the CXCR4 receptor to the process of hematopoietic migration

84 , the role of signaling by SDF-1 through its CXCR4 receptor was analyzed in zebrafish.

85 To target tumor cells that overexpress the CXCR4 receptor, we linked the CXCR4 DV3 ligand to two tr

86 ometry and lipoparticles containing only the CXCR4 receptor, we quantified the binding affinity for t

87 rom the N-terminal extracellular tail of the CXCR4 receptor, we show that the principal determinants

88 We observed that CXCR4 receptors were expressed by dividing neural progen

89 Models of the adenosine A2AR and chemokine CXCR4 receptors were first ranked in GPCR-DOCK blind pre

90 Treatment of tumor cells expressing the CXCR4 receptor with either the DV3-TATp53C' or DV3-TAT-R

91 utgrowth of viruses capable of utilizing the CXCR4 receptor (X4 viruses), the existence of three dist