ライフサイエンスコーパス: CYP11A1

1 CYP11A1 (rate-limiting enzyme) was expressed in cancerou

2 CYP11A1 expression was stable, CYP17A1 increased, and HS

3 CYP11A1, CYP17A1, HSD3beta, and HSD17beta3 were identifi

4 Mitochondrial cytochrome P450 11A1 (CYP11A1 or P450 11A1) is the only known enzyme that clea

5 two membrane proteins, cytochrome P450 11A1 (CYP11A1) and adrenodoxin reductase (AdR).

6 R), cytochrome P450 family 11, subfamily A1 (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase type 1

7 The ability of adipocyte CYP11A1 in producing pregnenolone is demonstrated for th

8 eurosteroids such as CYP46A1, 3alphaHSD, and CYP11A1.

9 reduced androgen biosynthesis and CYP17 and CYP11A1 mRNA when added to the medium of cultured PCOS t

10 in a PCOS phenotype of augmented CYP17A1 and CYP11A1 gene transcription, mRNA abundance, and androgen

11 educed androgen biosynthesis and CYP17A1 and CYP11A1 gene transcription.

12 xides induced spectral shifts in CYP27A1 and CYP11A1 but glycol metabolites were detected only with C

13 25-hydroperoxide to the enzymes CYP27A1 and CYP11A1 induced well-defined spectral changes while gene

14 ightly associated with the membrane, such as CYP11A1, can be quantified in the total tissue membrane

15 An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the pred

16 be the metabolism of 7-dehydrocholesterol by CYP11A1 to a single product identified as 7-dehydropregn

17 ined, the rate with which they are formed by CYP11A1 in vitro suggests an important role.

18 rocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in

19 novel pathways of D3 metabolism initiated by CYP11A1, with the product profile showing organ/cell typ

20 red for androgen synthesis from cholesterol (CYP11A1, CYP17A1, HSD3beta, HSD17beta3) were investigate

21 mRNA levels of CGA, CGB, PPARG, CYP19A1, CYP11A1, PTGS2, EREG, and the intracellular beta subunit

22 Additionally, CYP7A1, CYP11A1, CYP27A1, and CYP46A1 are parts of a broader cho

23 CPR and FdR) and tightly associated (CYP7B1, CYP11A1, CYP27A1, and CYP46A1) membrane proteins were qu

24 steroidogenesis pathway initiated by enzyme CYP11A1, and via the acidic bile acid pathway, which is

25 ntial actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as

26 In contrast, the steroidogenic enzymes CYP11A1 and CYP11B1 involved in glucocorticoid biosynthe

27 n in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3.

28 ween genotypes of the cytochrome P-450 genes CYP11A1 (-528[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta

29 In placenta and adrenal glands with high CYP11A1 expression, the predominant pathway was D3 --> 2

30 The active site cavity in CYP11A1 represents a long curved tube that extends from

31 controlling endogenous estrogen metabolism, CYP11A1 harbors common variants that may influence expre

32 Thus, we have detected novel CYP11A1-derived secosteroids in the skin, serum and adre

33 lt, protein levels and enzymatic activity of CYP11A1, a steroidogenic enzyme regulating CD8(+) T-cell

34 Products of CYP11A1 action on 7DHC, namely 22(OH)7DHC, 20,22(OH)27DH

35 We have compared quantifications of CYP11A1 using two different detergents, RapiGest SP and

36 n, we present the 2.5-A crystal structure of CYP11A1 in complex with the first reaction intermediate,

37 the steroidogenic enzyme cytochrome P450scc (CYP11A1) as well as CYP27B1 (1alpha-hydroxylase).

38 Cytochrome P450scc (CYP11A1) catalyzes conversion of cholesterol (CH) to pre

39 g purified mitochondrial cytochrome P450scc (CYP11A1) reconstituted with the iron-sulfer protein, adr

40 xpression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig

41 The CYP11A1 gene encodes the cholesterol side chain cleavage

42 The CYP11A1-22HC co-complex also provides insight into the s

43 In contrast, silencing of the CYP11A1 gene did not affect marinobufagenin production i

44 characterize the genetic architecture of the CYP11A1 gene in a Chinese study population.

45 tion of the role of genetic variation of the CYP11A1 gene in breast cancer risk in a study of 1193 br

46 mitochondrial P450, P450scc (product of the CYP11A1 gene).

47 Local androgen regulation in the skin of the CYP11A1 gene, which encodes a crucial enzyme that metabo

48 Overall, the CYP11A1 and AdR quantified in this work ranged from 110

49 l steroid dependent and mediated by upstream CYP11A1-dependent intraturmoral pregnenolone/progesteron

50 expression was significantly correlated with CYP11A1 (P = 0.0009), HSD3beta (P = 0.0297), and HSD17be

51 ced experimentally: MnBP with CGA, MBzP with CYP11A1, and MEHP with PTGS2.

52 t glycol metabolites were detected only with CYP11A1.