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1 CYP24A1 (hereafter referred to as CYP24) enzymatic activ
2 CYP24A1 expression is up-regulated by 1,25-dihydroxyvita
3 CYP24A1 may be a predictive marker of vitamin D3 clinica
4 CYP24A1 mRNA was elevated in malignant human prostate ti
5 CYP24A1 promoter DNA methylation was measured by means o
6 CYP24A1, the primary inactivating enzyme for vitamin D,
9 ing affinity and inhibitory activity against CYP24A1 identified the imidazole styrylbenzamides as pot
12 lorectal carcinoma cells express CYP27B1 and CYP24A1 that locally regulate 1,25D with potential impli
13 D-binding protein gene (Gc) and CYP27B1 and CYP24A1, which code for enzymes that, respectively, synt
14 (VDR), and the P450 cytochromes, CYP27B1 and CYP24A1; however, they have yet to be investigated in hu
15 rectal neoplasms, and CaR, VDR, CYP27B1, and CYP24A1 as modifiable, preneoplastic risk biomarkers for
18 fferentiation between SLC34A1 (NaPi-IIa) and CYP24A1 (24-hydroxylase) defects appears critical for ta
20 L13, and CYP24A1) and three SNPs (in IL4 and CYP24A1) were associated with total IgE and specific IgE
22 ckets, more work will need to be done before CYP24A1 inhibition can be integrated into the management
23 25(OH)2D3, on the other hand, increased both CYP24A1 and CYP27B1 protein expression in WT and VDR KO
26 with 1,25(OH)2D3 increased levels of Cyp24a1/CYP24A1 and Cyp7a1/CYP7A1 mRNA in mouse and human hepato
27 hway genes (VDR, GC, DHCR7, CYP2R1, CYP27B1, CYP24A1, and CASR) modify the effects of vitamin D3 or c
32 s work supports an important role for excess CYP24A1 activity in the pathogenesis of FGF23-mediated h
33 ly more 1,25-dihydroxyvitamin D(3) and fewer CYP24A1 transcripts, encoding the 1,25-dihydroxyvitamin
36 sed expression of the 1,25(OH)2D target gene CYP24A1 involved immunoprecipitation of hnRNPC1/C2 with
38 enografts of prostate cancer cells harboring CYP24A1 shRNA resulted in a drastic reduction in tumor v
41 duction and secretion of 25(OH)D3 and higher CYP24A1 gene transcript abundance in response to choleca
42 nic regions 50-69 kb downstream of the human CYP24A1 gene and 35-45 kb downstream of the mouse Cyp24a
45 enzyme 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1) were described that lead to increased sensitivi
46 CYP2R1) with 3-epi-25(OH)D3; 24-hydroxylase (CYP24A1) with 25(OH)D3, 3-epi-25(OH)D3, and 1,25-dihydro
48 tivation (CYP2R1, CYP27B1) and inactivation (CYP24A1, CYP3A4) and the newest physiological roles of v
49 ified several new UV target genes, including CYP24A1, GJA5, SLAMF7 and ETV1, which were frequently dy
53 epithelial cells (WT), 1,25(OH)2D3 increased CYP24A1 protein expression and decreased CYP27B1 express
56 ypothesize that an ovarian hormone inhibited CYP24A1 gene expression in the spinal cord, so the local
59 and potential VDREs located within mediated CYP24A1 induction, we constructed recombinant wild-type
60 YP3A4-dependent 4beta,25(OH)(2)D(3), but not CYP24A1-dependent 24R,25-dihydroxyvitamin D(3) formation
66 kdown of hnRNPC1/C2 suppressed expression of CYP24A1, but also increased expression of an exon 10-ski
67 roxyvitamin D(3) binding in the open form of CYP24A1 that clarifies the structural determinants of se
69 s demonstrate that deletion or inhibition of CYP24A1, which initiates degradation of the active form
70 ole styrylbenzamides as potent inhibitors of CYP24A1, having selectivity with respect to CYP27B1 comp
73 kinase CK2 is involved in the regulation of CYP24A1 expression by 1,25D(3) and CK2 inhibitor enhance
75 Our findings indicate that repression of CYP24A1 gene expression in human prostate cancer cells i
76 In this study, we investigated the role of CYP24A1 on malignant progression of a murine model of Br
77 on of vitamin D signaling via suppression of CYP24A1, a rate-limiting enzyme in the 1alpha,25-dihydro
79 ic clearance of CYP3A4 was less than that of CYP24A1, comparison of metabolite profiles and experimen
80 ngest association with rs6127099 upstream of CYP24A1 (P=4.2 x 10(-53)), a gene that encodes the prima
85 o increased expression of an exon 10-skipped CYP24A1 splice variant; in a minigene model the latter w
86 ex mechanism is responsible for the striking CYP24A1 up-regulation induced by the vitamin D hormone i
87 4A1, combination therapy with RNAi targeting CYP24A1 could be considered to improve clinical responsi
89 paired human prostate samples revealed that CYP24A1 expression is downregulated in prostate malignan
91 e absence of vitamin D(3), PXR activates the CYP24A1 gene by directly binding to and transactivating
99 Docking experiments on the inhibitors in the CYP24A1 enzyme active site suggest the compounds reach t
102 gly represses vitamin D(3) activation of the CYP24A1 gene, in which PXR indirectly binds to and preve
103 roperties, is degraded by the product of the CYP24A1 gene, which is downregulated in human prostate c
111 ctivity, regulate VDR downstream genes (VDR, CYP24A1, TRPV6 and CYP27B1), and inhibit the production
115 a stable prostate cancer cell line PC3 with CYP24A1 promoter driving luciferase expression to screen
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