ライフサイエンスコーパス: CYP2B1

1 vities of the genes for cytochrome P450 2B1 (CYP2B1) and cytochrome P450 2C1 (CYP2C1) have been assay

2 ide (CPA)-sensitive rat cytochrome P450 2B1 (CYP2B1) and the ganciclovir (GCV)-sensitive herpes simpl

3 We examined the role of cytochrome P450 2B1 (CYP2B1) in this complement-mediated sublytic injury.

4 and diOH-PCBs) via rat cytochrome P450 2B1 (CYP2B1) mediated biotransformation were investigated in

5 formational dynamics of cytochrome P450 2B1 (CYP2B1) were investigated through the introduction of a

6 CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22

7 CYP+33/1A1 and CYP2B1 did not require peripheral TOM70, TOM20, or TOM22

8 17- to 32-fold more potent toward CYP2B4 and CYP2B1 than CYP2B5.

9 to be critical for inhibition of CYP2B4 and CYP2B1.

10 f AMPK mimics the PB induction of CYP2B6 and CYP2B1 gene expression.

11 tivities of minimal promoters for CYP2C1 and CYP2B1 were detectable in untreated animals but were not

12 of glucokinase, cytochrome P450s CYP3A1 and CYP2B1/2, testosterone/4-nitrophenol uridine diphosphate

13 ethylbiphenyl were determined for CYP4B1 and CYP2B1 to further map their active site dimensions.

14 ntisera showed NADPH-P450 oxidoreductase and CYP2B1/2 in various hypothalamic nuclei and CYP1A1 in th

15 arious rat liver microsomal preparations and CYP2B1 were determined.

16 Squalestatin 1 treatment induced both CYP2B1 and CYP2B2 and activated reporter gene expression

17 ire direct cell-cell contact was mediated by CYP2B1-expressing MCF-7 cells on non-CYP2B1 cells.

18 phenobarbital pretreated rats (which contain CYP2B1 as the predominant isozyme) oxidize [1'-(13)C, 1'

19 suggesting that interactions between the CPA/CYP2B1 and GCV/HSV-TK gene therapies occurred at the lev

20 by rRp450 viral oncolysis combined with CPA/CYP2B1 and GCV/HSV-TK gene therapies, whereas all other

21 e by P450(cam) (CYP101), P450(BM3) (CYP102), CYP2B1, and CYP2E1.

22 ed to be involved in the turnover of CYP1A1, CYP2B1/2, or NADPH reductase.

23 In contrast, levels of CYP1A1, CYP1A2, CYP2B1, CYP2J3, CYP4A1, and CYP4A3 were unchanged with f

24 estigate the effects of plumbagin on CYP1A2, CYP2B1/6, CYP2C9/11, CYP2D1/6, CYP2E1 and CYP3A2/4 activ

25 Reaction of CYP4B1, CYP2B1, and CYP102 with phenyldiazene produced spectrosc

26 Unlike use of the 10 mg/kg dose, CYP2B1 and CYP2B2 induction by phenobarbital at 1 mg/kg

27 ymes including four cytochrome P450 enzymes, CYP2B1, CYPDelta2B4, CYPDelta2E1, and CYPDelta2E1 T303A,

28 this work were four cytochrome P450 enzymes, CYP2B1, CYPDelta2E1, CYPDelta2E1 T303A, and CYPDelta2B4,

29 tivity, monitored by tumor growth delay, for CYP2B1-e xpressing MCF-7 tumors as compared to CYP2B1-ne

30 ression of the deuterium isotope effects for CYP2B1 occurred only with the biphenyl substrate.

31 2 and CYP2D1, and competitive inhibition for CYP2B1, CYP2C11 and CYP2E1 with Ki values less than 9.93

32 ithin the active site of CYP4B1, whereas for CYP2B1, equilibration is facile for methyl groups distan

33 Thus, GEC CYP2B1 contributes to complement C5b-9-mediated injury a

34 Transfer of a liver cytochrome P450 gene, CYP2B1, into human breast MCF-7 cancer cells is presentl

35 sertion of the two prodrug activating genes, CYP2B1 and secreted human intestinal carboxylesterase.

36 course of phenobarbital induction of hepatic CYP2B1 and CYP2B2.

37 The differential expression rates of hepatic CYP2B1 mRNA in the young and mature male and female rats

38 t C5b-9-mediated injury but was preserved in CYP2B1-silenced cells.

39 as little as 1 mg/kg phenobarbital increased CYP2B1 mRNA concentrations by 100%, there was no transla

40 orthern blot analysis showed that PB induced CYP2B1 mRNA in male WKY rats but not female rats.

41 subdomain inhibited squalestatin 1-inducible CYP2B1-reporter expression.

42 or rat CAR restored squalestatin 1-inducible CYP2B1-reporter expression.

43 Intratumoral CYP2B1 expression conferred a distinct therapeutic advan

44 and S-nitroso-N-acetylpenicillamine mimicked CYP2B1 protein suppression.

45 ated by CYP2B1-expressing MCF-7 cells on non-CYP2B1 cells.

46 rochiral substrate cumene by CYP4B1, but not CYP2B1 or CYP102, resulted in the formation of the therm

47 rrested the CYP2B1-expressing cells, but not CYP2B1-negative cells, at G(2)-M phase.

48 The blockade of CYP2B1 down-regulation by NO synthase inhibitors was rev

49 gnal antagonizing phenobarbital induction of CYP2B1 and CYP2B2.

50 t leads to the sexual dimorphic induction of CYP2B1 gene in WKY rats.

51 ion, so that both the rate and initiation of CYP2B1 and CYP2B2 induction were suppressed most in the

52 a plasmid containing approximately 2.4 kb of CYP2B1 gene 5'-flanking region or containing a previousl

53 tion were accompanied by decreased levels of CYP2B1/2 and CYP3A2.

54 induction, ascertained though the measure of CYP2B1, CYP2B2, and CYP3A1 mRNA levels.

55 ts demonstrate two independent mechanisms of CYP2B1 down-regulation by LPS: a rapid, NO-dependent sup

56 Overexpression of CYP2B1 in GECs significantly increased the formation of

57 articipation of NO in the down-regulation of CYP2B1 by bacterial endotoxin (LPS) in rat hepatocytes c

58 nitude more potent in the down-regulation of CYP2B1 mRNA than in induction of NO production.

59 LPS caused the down-regulation of CYP2B1 mRNA to 20% of control values within 12 h of trea

60 tion and produced a rapid down-regulation of CYP2B1 protein to 30% and <5% of control at 6 and 24 h,

61 In contrast, silencing of CYP2B1 markedly attenuated anti-Fx1A-induced reactive ox

62 hat gender- and age-dependent suppression of CYP2B1 occurs at a pretranscriptional or transcriptional

63 MCF-7 cells following stable transfection of CYP2B1 but exhibited no toxicity to parental tumor cells

64 Rat CYP2B1 could stereoselectively biotransform chiral PCBs

65 hibition of rabbit CYP2B4 and CYP2B5 and rat CYP2B1 by phenylimidazoles was assessed with active-site

66 y knock-out of Hsrr and insertion of the rat CYP2B1 transgene responsible for the bioactivation of th

67 d a phenobarbital-responsive unit in the rat CYP2B1/2 and mouse Cyp2b10 genes about -2.3 kilobase pai

68 The induction of human CYP2B6 and the rat (CYP2B1) and mouse (Cyp2b10) homologues by PB is mediated

69 Incubation of 2a with purified reconstituted CYP2B1 also afforded 4, 6a, and M1 in a 2:5:2 mole ratio

70 expression from a squalestatin 1-responsive CYP2B1 reporter plasmid.

71 atment of HeLa cells expressing c-Myc-tagged CYP2B1 with NOC-18 down-regulated its expression and enh

72 of the CYP2C1 promoter by 5-15-fold and the CYP2B1 promoter by 2.5-5-fold.

73 ycle analysis revealed that CPA arrested the CYP2B1-expressing cells, but not CYP2B1-negative cells,

74 toxicity could be appreciably blocked by the CYP2B1 inhibitor metyrapone.

75 efective recombinant adenovirus carrying the CYP2B1 gene driven by the cytomegalovirus (CMV) promotor

76 ferase reporter construct that contained the CYP2B1/2 NF-kappaB element.

77 an oncolytic herpesvirus that expresses the CYP2B1 cDNA, responsible for bioconverting cyclophospham

78 tive phenobarbital-responsive element in the CYP2B1 proximal promoter did not reduce the relative res

79 CAAT/enhancer binding protein element in the CYP2B1 proximal promoter region reduced expression, but

80 CBF1 binds an atypical NF-kappaB site in the CYP2B1/2 promoters and may help to maintain a low level

81 Subsequent oxidation of the CYP2B1 and CYP102 complexes followed by LC/ESI--MS analy

82 gulates the dimorphic induction by PB of the CYP2B1 gene in Wistar Kyoto (WKY) rats.

83 s GRIP1 alone induced transactivation of the CYP2B1 PB-dependent enhancer 15-fold, whereas CAR expres

84 C-terminal (CT) CYP3A4 heptapeptide onto the CYP2B1 C terminus switched its proteolytic susceptibilit

85 We also show that the CYP2B1/2 NF-kappaB element, but not the Igkappa NF-kappa

86 e examined in liver and kidney, in which the CYP2B1/2 genes are expressed and not expressed, respecti

87 P2B1-e xpressing MCF-7 tumors as compared to CYP2B1-negative control tumors.

88 f rabbit CYP4B1 has been studied relative to CYP2B1 and CYP102 using a variety of aromatic probe subs

89 YP4B1 is considerably restricted relative to CYP2B1.

90 Thus, unlike CYP2B1, CYP3A4 harbors additional/multiple structural de

91 not observed with Fisher 344 rats, in which CYP2B1 mRNA was induced in both sexes.

92 used a decrease in each CYP apoprotein, with CYP2B1/2 exhibiting the greatest decrease, to 33 +/- 8%

93 ulted in a decrease in each CYP enzyme, with CYP2B1/2 exhibiting the greatest loss, to 33 +/- 9% of u