1 th unrepressed levels of cytochrome P450 7A (CYP7A), the rate-limiting enzyme in cholesterol disposal

2 ansfection of a CPF expression plasmid and a CYP7A reporter gene resulted in specific induction of CY

3            We designate this factor CPF, for CYP7A promoter binding factor.

4     The cholesterol 7alpha-hydroxylase gene (CYP7A) is transcriptionally regulated by a number of fac

5 suggest that CPF is a key regulator of human CYP7A gene expression in the liver.

6 ctor that binds to the promoter of the human CYP7A gene.

7 ene encoding cholesterol 7alpha-hydroxylase, CYP7A, is expressed exclusively in the liver.

8 orter gene resulted in specific induction of CYP7A-directed transcription.

9                            Overexpression of CYP7A in hamsters results in a reduction of serum choles

10 ates the transcriptional activity of the rat CYP7A promoter by binding to the sequences between nt -7

11  from nucleotides (nt) -74 to -55 of the rat CYP7A promoter that enhanced bile acid repression of the

12                                      The rat CYP7A promoter/reporter activity was strongly stimulated

13                            RXR may stimulate CYP7A gene transcription by binding to a direct repeat o

14  Mutation of the CPF binding site within the CYP7A promoter abolished hepatic-specific expression of