ライフサイエンスコーパス: Ca channel

1 ed alpha(1C) and beta(2a) subunits of L-type Ca channel.

2 ical concentration of Ca ions permeating the Ca channel.

3 ration, mainly due to Ca flux through L-type Ca channels.

4 d structural studies of low-threshold T-type Ca channels.

5 selectivity and high flux that characterizes Ca channels.

6 ts in two closely related isoforms of T-type Ca channels.

7 ly with the pore-forming alpha(1)-subunit of Ca channels.

8 autoantibody-mediated disturbance of L-type Ca channels.

9 itant inhibitory influences on photoreceptor Ca channels.

10 , omega-Aga-IVA (1 microM) targeted multiple Ca channels.

11 DA and AMPA receptors but not sodium (Na) or Ca channels.

12 synaptic receptors as well as voltage-gated Ca channels.

13 inhibition of the native small conductance K(Ca) channel.

14 tant of Gbetagamma with reduced affinity for Ca-channels.

15 otein betagamma subunits (Gbetagamma) to the Ca-channels.

16 ffect is independent of the activation of BK(Ca) channels.

17 urface expression of a subset of podocyte BK(Ca) channels.

18 e-evoked outward current through podocyte BK(Ca) channels.

19 a source of Ca(2+) for the activation of BK(Ca) channels.

20 the Ca(2+)-dependent gating mechanism of BK(Ca) channels.

21 on of myocyte transient K(Ca) currents and K(Ca) channels.

22 an embryonic kidney 293T cells expressing BK(Ca) channels.

23 activation of iberiotoxin-sensitive, maxi-K(Ca) channels.

24 ) (maxi-K(Ca); K(Ca)1.1) channels, not int-K(Ca) channels.

25 negative for the entire family of SK(Ca)-IK(Ca) channels.

26 g the effective coupling of Ca2+ sparks to K(Ca) channels.

27 n, a specific blocker of small-conductance K(Ca) channels.

28 mutant abi1-1 disrupted ABA activation of I(Ca) channels.

29 assembly of hSlo1 monomers into functional K(Ca) channels.

30 ole of IbTX-sensitive large-conductance K(+)(Ca) channels.

31 eriotoxin implicating functional K(v) and BK(Ca) channels.

32 a and subsequent opening of smooth muscle BK(Ca) channels.

33 VSM in small mesenteric arteries requires BK(Ca) channels.

34 ther hyperpolarizing factor(s) activate K(+)(Ca) channels.

35 reases I(K(Ca)) due to a direct effect on K((Ca)) channels.

36 rge-conductance Ca2+-activated potassium (BK(Ca)) channels.

37 ough large-conductance Ca2+-activated K+ (BK(Ca)) channels.

38 IK1, and Slo1 calcium-activated potassium (K(Ca)) channels.

39 contribute to resting vascular tone by K(+)(Ca) channel activation and epoxyeicosatrienoic acid rele

40 nium chloride (TEA) was used to inhibit K(+)(Ca) channel activation and fluconazole was used to inhib

41 The contribution of K(+)(Ca) channel activation compared with nitric oxide is gre

42 ose to Ca(2+) sensors for exocytosis and I(K(Ca)) channel activation, like the P/Q-type channels they

43 This inhibition was rescued by a Ca channel activator, Bay K8644.

44 The L-type Ca+ channel activator FPL-64176 induced a slowly activat

45 low state were examined in the presence of K(Ca) channel activators/blockers and several other vasodi

46 ast, endogenous protein kinases inhibited BK(Ca) channel activity at two functionally distinct sites.

47 of the N-terminal isoforms can fine-tune BK(Ca) channel activity in cells, highlighting a novel mech

48 ontact with astrocytes, but did not affect K(Ca) channel activity in myocytes that were alone.

49 The EGFR-mediated increase in maxi-K(Ca) channel activity was blocked by inhibiting cAMP-depe

50 bbit ventricular myocytes exposed to 1), the Ca channel agonist BayK8644 (100 nM) to increase SR Ca l

51 The L-type Ca channel agonist BayK8644 reduced the rate of Ca trans

52 ng agent halothane or the ryanodine receptor Ca channels agonist 4-chloro-m-cresol was compared in bl

53 experiments were to determine whether the BK(Ca) channel agonist NS1619 is able to induce immediate p

54 sin was coadministered with the K(ATP) and K(ca) channel agonists cromakalim and NS1619 in a concentr

55 pg/ml) coadministered with the K(ATP) and K(ca) channel agonists, cromakalim and NS1619 (10(-8), 10(

56 we report the discovery of an endogenous BK(Ca) channel alpha-subunit intron-containing mRNA in the

57 ould demonstrate that changes in a unique BK(Ca) channel alpha-subunit intron-containing splice varia

58 comprises approximately 10% of the total BK(Ca) channel alpha-subunit mRNAs, is distributed in a gra

59 mulation of plasma membrane expression of BK(Ca) channels also occurs when M2 cells are transfected w

60 appeared abruptly when a voltage step opened Ca channels and disappeared or dimmed abruptly when Ca c

61 ted by calcium (Ca) signaling between L-type Ca channels and Ryanodine receptors that occurs mainly a

62 cycling incorporating stochastic openings of Ca channels and ryanodine receptors to investigate the e

63 enhanced functional coupling between L-type Ca channels and RyR2 in T3+Dex-treated cells.

64 strate that mAChR activation inhibits L-type Ca channels and thus may contribute to the suppression o

65 y glutamate to stimulate arteriole myocyte K(Ca) channels and dilate cerebral arterioles.

66 indings, in abi1-1, H(2)O(2) activation of I(Ca) channels and H(2)O(2)-induced stomatal closing were

67 portant repolarizing roles for both Kv and K(Ca) channels and identify distinct roles for SK channel

68 anisms involving the activation of SK(Ca)/IK(Ca) channels and NOS.

69 guard cells that activates plasma membrane I(Ca) channels and support a requirement for extracellular

70 d Kv2.1(-/-) islets to characterize Kv and K(Ca) channels and their respective roles in modulating th

71 sures the consequence is activation of EC IK(Ca) channels and vasodilation, reducing the myogenic ton

72 large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel and subsequent smooth muscle hyperpolarizat

73 or of large-conductance Ca2+-activated K+ (K(Ca)) channels and Ca2+ spark-induced transient K(Ca) cur

74 activation of calcium-activated potassium (K(Ca)) channels and was reversed by pharmacologically incr

75 ransient dissociation of Gbetagamma from the Ca-channels and can occur during high-frequency bursts o

76 blocker with selectivity versus hERG, Na and Ca channels, and an acceptable preclinical PK profile.

77 ine receptors (Ca(2+) sparks) to activate BK(Ca) channels, and (2) endothelial-dependent mechanisms i

78 egulation of lipoxygenase/cyclooxygenase, BK(Ca) channels, and ATP receptor activation within astrocy

79 ge-conductance Ca(2+)-activated potassium (K(Ca)) channels, and decreased transient K(Ca) current fre

80 neither of these effects was inhibited by BK(Ca) channel antagonists.

81 Ca channels are heteromeric proteins consisting of a por

82 BK(Ca) channels are activated by voltage and by micromolar

83 The gating properties of BK(Ca) channels are Ca(2+)-, voltage- and stretch-sensitive

84 t that apamin- and iberiotoxin-insensitive K(Ca) channels are subject to diurnal modulation by the ci

85 Small- and intermediate-conductance K(+)(Ca) channels are the dominant species involved in modula

86 neuronal transcriptome using a subunit of BK(Ca) channels as bait, and the interaction was confirmed

87 evoked a robust stimulation of functional K(Ca) channels at stages before the normal appearance of t

88 mall-conductance or Slo1 large-conductance K(Ca) channels at up to 1 microM in physiologically releva

89 lar to multivesicular release (MVR) when two Ca channels/AZ open at potentials above the threshold fo

90 lo1 channels with the neuronally abundant BK(Ca) channel beta(4) subunit.

91 e high-conductance Ca(2+)-activated K(+) (BK(Ca)) channel between freshly isolated ECs and SMCs from

92 Blockade of the K(Ca) channel BK with slotoxin increased beta-cell AP ampl

93 nses to the activator of large conductance K(Ca) channels (BK(Ca)), NS1619 (10(-5) M), and to the end

94 n, a specific blocker of large-conductance K(Ca) channels (BK), but not by apamin, a specific blocker

95 nel blocker -conotoxin GVIA and the P/Q-type Ca channel blocker -agatoxin IVA increased Ca(2+) signal

96 ontal cells, and showed that both the N-type Ca channel blocker -conotoxin GVIA and the P/Q-type Ca c

97 in Ca(i) were blocked by the addition of the Ca channel blocker La(3+) to the basolateral but not to

98 irm that omega-Aga-IVA is a selective P-type Ca channel blocker.

99 s increased, by either RN1734 or TRAM-34 (IK(Ca) channel blocker), but not by apamin (SK(Ca) channel

100 (Ca) channel blocker), but not by apamin (SK(Ca) channel blocker).

101 rs SKF525A or clotrimazole, but not by the K(Ca) channel blocker, charybdotoxin, or the cyclooxygenas

102 elective astrocyte toxin, and paxilline, a K(Ca) channel blocker.

103 n was largely abolished by iberiotoxin, a BK(Ca) channel blocker.

104 -conductance calcium-activated potassium (SK(Ca)) channel blocker.

105 e 5-HT3 antagonist tropisetron or the N-type Ca-channel blocker omega-Conotoxin GVIA.

106 I(mAHP) is blocked by the SK(Ca) channel blockers apamin and bicuculline, whereas I(s

107 In contrast, the BK(Ca) channel blockers iberiotoxin and paxilline, the phos

108 NMA1 encodes the pore-forming subunits of BK(Ca) channel but is expressed in a potentially very large

109 e and potent pharmacological inhibitors of K(Ca) channels but not K(V) channels reduce Ca(2+) entry i

110 e tested the hypothesis that CO activates BK(Ca) channels by binding to channel-bound heme, a BK(Ca)

111 conductance, calcium-sensitive potassium (BK(Ca)) channels by local Ca(2+) signals (Ca(2+) sparks) th

112 the major pore-forming subunit of the L-type Ca channel (Ca(v)1.2).

113 ecipitation and GST pull-down assays that BK(Ca) channels can associate with endogenous TRPC3 and TRP

114 transporters, including voltage-gated Na and Ca channels, cardiac ryanodine receptors, Na/Ca-exchange

115 ch-clamp electrophysiology on recombinant BK(Ca) channels cloned from mouse brain and expressed in Xe

116 nels and disappeared or dimmed abruptly when Ca channels closed.

117 Here, we show that the Slo1 subunits of BK(Ca) channels contain a novel cytoplasmic actin-binding d

118 e (Ca(V)2.2) voltage-gated calcium channels (Ca-channels) controls many cellular functions including

119 BK-type K(Ca) channels could not be detected in inside-out patches

120 -conductance calcium-activated potassium (BK(Ca)) channels create a connection between calcium signal

121 it also reduced the composite high-threshold Ca channel current recorded in these cells (46.1 +/- 6.9

122 It similarly reduced the high-threshold Ca channel current that remains after a blockade of P-ty

123 ml(-1)) all caused a 20% increase in maxi-K(Ca) channel current that was blocked by AG-1478 or by kn

124 mic neurons 500 nm kurtoxin inhibited T-type Ca channel currents almost completely (90.2 +/- 2.5% at

125 Here we report its effects on Ca channel currents, carried by 5 mm Ba(2+) ions, in rat

126 rtoxin partially inhibited N-type and L-type Ca channel currents, respectively.

127 action, nor did it affect voltage-activated Ca channel currents.

128 of inactivation, and because facilitation of Ca-channel currents (I(Ca)) masks the extent and kinetic

129 te that the ATP secreted in the ASDN in a BK(Ca) channel-dependent manner is physiologically availabl

130 BK(Ca) channels do not traffic to the plasma membrane in M2

131 First, by activating TEA-inhibitable K(+)(Ca) channels, endothelium-derived hyperpolarizing factor

132 Studies of Ca channels expressed in oocytes have identified kurtoxi

133 , inhibits low-threshold alpha1G and alpha1H Ca channels expressed in oocytes with relatively high po

134 Thus, the actions of GDNF on LMN K(Ca) channel expression appear to use a transduction path

135 The effects of GDNF on K(Ca) channel expression in LMNs require 24 hr of continuo

136 IK(Ca) channels focused within EC projections toward the sm

137 sitive K (K(ATP)) and calcium sensitive K (K(ca)) channel following fluid percussion brain injury (FP

138 K(+) (K(ATP)) and calcium sensitive K(+) (K(ca)) channels following fluid percussion brain injury (F

139 CO dilates cerebral arterioles by priming K(Ca) channels for activation by Ca2+ sparks.

140 This shifts the Ca-channels from "willing" to "reluctant" gating states

141 ntrations maximally effective to modulate BK(Ca) channel function (100 mM), fails to gate the channel

142 pressin contributes to impaired K(ATP) and K(ca) channel function after brain injury.

143 ory subunit, which is required for normal BK(Ca) channel function and flow-sensitive ATP secretion in

144 O2(-) generation contributes to K(ATP) and K(ca) channel function impairment after FPI.

145 Normal BK(Ca) channel function is required for flow-sensitive ATP

146 Similar to the positive K(Ca) channel-gating modulators 1-ethyl-2-benzimidazolinon

147 so examined expression and localization of K(Ca) channel gene products in the coronary microvasculatu

148 tery appear to lack the expression of the BK(Ca) channel gene.

149 ) Ca(2+)-activated K channels (SK(Ca) and IK(Ca) channels) generate hyperpolarization that passes to

150 ar mechanism of calcium activation of the BK(Ca) channel have focused on the large intracellular carb

151 flux is mediated by Ca(2+)-activated K(+) (K(Ca)) channels, hSKCa2 in the human leukemic T cell line

152 location of a second RCK domain in human BK(Ca) channels (hSloRCK2).

153 a channel antagonists (tetrodotoxin), L-type Ca channel (I(Ca,L)) antagonists (nifedipine, cadmium, v

154 ator of intermediate and small conductance K(Ca) channels (IK(Ca)/SK(Ca)), NS309 (10(-5) M), and to t

155 ession of Rem2 with CaV 1.2 or CaV1.3 L-type Ca + channels in a heterologous expression system comple

156 to demonstrate (1) expression of the alpha1D Ca channel in human fetal heart, (2) inhibition of alpha

157 ngly, knockout of the neuroendocrine alpha1D Ca channel in mice results in significant sinus bradycar

158 ta established the expression of the alpha1D Ca channel in the human fetal heart.

159 he consequence of chronic exposure of L-type Ca channels in newborn pups to maternal autoantibodies d

160 e presence of low-voltage-activated (T-type) Ca channels in nuclear neurons has fostered the inferenc

161 We localized L-, N- and P/Q-type Ca channels in rat horizontal cells, and showed that bot

162 ter a blockade of P-type, N-type, and L-type Ca channels in thalamic neurons.

163 the endoplasmic reticulum and activation of Ca channels in the basolateral membranes of epithelial c

164 ntraction coupling, the couplon where L-type Ca channels in the sarcolemmal membrane adjoin ryanodine

165 ominant-negative suppression of the native K(Ca) channel in Jurkat T cells by overexpression of a tru

166 onsistently, expression of both K(ATP) and K(Ca) channels in 9L tumors was increased to a significant

167 -neuregulin-1 inhibited the development of K(Ca) channels in CG neurons.

168 oproterenol, forskolin, or dopamine opens BK(Ca) channels in coronary myocytes and that this effect i

169 e for functional K(v), BK(Ca,) IK(Ca) and SK(Ca) channels in CPASMCs.

170 , are the first to implicate AC-5 and maxi-K(Ca) channels in gene activation related to EGFR signalli

171 ad no effect on the surface expression of BK(Ca) channels in HEK293T cells or on the amplitudes of cu

172 we show that the functional expression of K(Ca) channels in LMNs developing in vitro can be stimulat

173 e strategies to assess the involvement of SK(Ca) channels in mediating the current underlying the sAH

174 and increased current through endogenous BK(Ca) channels in mouse podocytes.

175 ivated transient K(Ca) currents and single K(Ca) channels in myocytes that were in contact with astro

176 The activation of BK(Ca) channels in smooth muscle contributes to the endothe

177 Although it is possible to open BK(Ca) channels in the absence of calcium, calcium binding

178 rt due to impaired function of SK(Ca) and IK(Ca) channels in the coronary microcirculation.

179 ical neurons and to elucidate the role of BK(Ca) channels in the initiation of immediate precondition

180 s) and to elucidate the roles of RyRs and BK(Ca) channels in this response.

181 A similar stimulation of K(Ca) channels in vitro can be produced by the trophic fac

182 dlimb reduced the functional expression of K(Ca) channels in vivo to levels seen in LMNs deprived of

183 regulation of Ca(2+)-dependent chloride (Cl(Ca)) channels in a human pancreatoma epithelial cell lin

184 l conductance Ca(2+)-activated K(+) (SK or K(Ca)) channels in human and mouse cardiac myocytes that c

185 on of large-conductance Ca2+-activated K+ (K(Ca)) channels in lumbar motoneurons (LMNs) of the develo

186 large conductance Ca(2+)-activated K(+) (BK(Ca)) channels in smooth muscle cells downstream from the

187 d the role of calcium-activated potassium (K(Ca)) channels in this dysfunction in the human coronary

188 f the NOS/NO/sGC/cGMP/PKG pathway and the BK(Ca)-channel in mediating NO-induced reductions in SC cel

189 se (NOS) and NO signaling pathway and the BK(Ca)-channel in mediating SC cell volume decreases.

190 ctivation of voltage-gated calcium channels (Ca channels) in photoreceptors.

191 8 implicates other K(+) channels, possibly K(Ca) channels, in regulating AP repolarization.

192 ptation to mean potential resulted from both Ca channel inactivation and vesicle depletion, whereas a

193 ount for the major characteristics of T-type Ca channel inactivation.

194 is supported by at least three subtypes of K(Ca) channels, including apamin-sensitive channels, iberi

195 In vitro studies support K(+)(Ca) channel-induced smooth muscle hyperpolarization as u

196 cle BK(Ca) channels show that CO reverses BK(Ca) channel inhibition by heme but not by hemin.

197 ) secretion was blocked by the voltage-gated Ca channel inhibitor, nifedipine, or by hyperpolarizatio

198 toxin-sensitive, and is inhibited by the BK(Ca) channel inhibitor charybdotoxin, but not by the nitr

199 G inhibitor (RP)-8-Br-PET-cGMP-S, and the BK(Ca) channel inhibitor IBTX.

200 nnels by binding to channel-bound heme, a BK(Ca) channel inhibitor, and altering the interaction betw

201 as abolished by the PKG inhibitor and the BK(Ca) channel inhibitor.

202 large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel inhibitor, iberiotoxin, produced identical

203 The BK(Ca++) channel inhibitor greatly reduced the majority of

204 or without rottlerin (CP) (n=9), and the BK(Ca++) channel inhibitor paxilline 100 nmol/L was supplie

205 ance calcium-activated potassium channel (BK(Ca) channel) inhibitor iberiotoxin (50 nM).

206 effects of H(2)S, as selective IK(Ca) and SK(Ca) channel inhibitors, charybdotoxin and apamin, inhibi

207 uced heme is a functional CO receptor for BK(Ca) channels, introduce a unique mechanism by which CO r

208 e, we tested the hypothesis that the alpha1D Ca channel is a novel target for positive IgG.

209 because we estimate that the same number of Ca channels is present at cell surface and T-tubule junc

210 Recovery from inactivation of T-type Ca channels is slow and saturates at moderate hyperpolar

211 rming alpha subunit of the homotetrameric BK(Ca) channel is expected to contain two intracellular RCK

212 Second, activation of K(+)(Ca) channels is only partly through epoxyeicosatrienoic

213 a coupled manner with K(+) efflux through BK(Ca) channels is required for inhibitory purinergic regul

214 large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel is essential for maintaining the membrane i

215 y to be due to a difference in the number of Ca channels/junction at each site because we estimate th

216 reduced by nearly 60% in arterioles from BK(Ca) channel knockout mice.

217 ctures (dyads) along t-tubules, where L-type Ca channels (LCCs) appose sarcoplasmic reticulum (SR) Ca

218 arge-conductance Ca(2)(+)-activated K(+) (BK(Ca)) channels, leading to ASM membrane hyperpolarization

219 f voltage-sensitive sodium (Na) and calcium (Ca) channels located on dendrites and spines in regulati

220 al for motor coordination and suggest that K(Ca) channels may constitute a potential therapeutic targ

221 s are inconsistent with the proposal that SK(Ca) channels mediate I(sAHP) in pyramidal cells and indi

222 o show that vasopressin blunted K(ATP) and K(ca) channel mediated cerebrovasodilation in a cyclooxyge

223 ta show that vasopressin blunts K(ATP) and K(ca) channel mediated cerebrovasodilation.

224 jects, whereas in hypercholesterolemia, K(+)(Ca) channel-mediated vasodilation compensates for the re

225 inin, but not acetylcholine, stimulates K(+)(Ca) channel-mediated vasodilation in healthy subjects, w

226 sts that this subunit participates widely in Ca-channel-mediated signaling in the retina.

227 levels of the mature splice forms of the BK(Ca) channel mRNAs.

228 Since lymphocytes express the same Ca channel mutation found in malignant hyperthermia-susc

229 alpha(2)/delta) and T-type (I(Ba)-alpha(1H)) Ca channels, Na channels (I(Na)-hH1), and K channels (I(

230 N cells showing that it is similar to the BK(Ca) channel of other preparations.

231 behavior, Ca(2+) entry through voltage-gated Ca channels often supports bursting activity and mediate

232 f MOR mRNA and measured opioid inhibition of Ca channels on identified nociceptors and low-threshold

233 acts as the transferrable EDHF activating BK(Ca) channels on the smooth muscle cells.

234 nst the pore-forming alpha-subunit of the BK(Ca) channel only detected its expression in the SMCs, wh

235 bited an attenuated stimulatory effect on BK(Ca) channel open probability in inside-out membrane patc

236 In the presence of intracellular calcium, BK(Ca) channels open at more negative membrane potentials.

237 t in SMCs that was absent in ECs, and the BK(Ca) channel opener NS 1619 only enhanced K(+) current in

238 the phagocytic vacuole, whereas NS1619, a BK(Ca) channel opener, enhanced both.

239 rise to apparent one-to-one coupling between Ca channel opening and vesicle release, allowing presyna

240 rs explain the much lower efficacy of L-type Ca channel opening to trigger local SR Ca release at low

241 Ca(2+)-sensitive, large-conductance K(+) (BK(Ca)) channel opening as iberiotoxin (100 nM) significant

242 waves" because they are initiated by L-type Ca channel openings during the action potential.

243 ation while inhibition of Ca(2+) channel, BK(Ca) channel or phosphodiesterase-5 did not.

244 f PAs which was inhibited by about 60% by BK(Ca) channel or RyR blockers, in a nonadditive manner.

245 hile blocking GABA and glycine receptors, K((Ca)) channels, or mGluRs.

246 High-voltage activated Ca channels participate in multiple cellular functions,

247 Thus, K(Ca) channels play a vital role in T cell Ca(2+) signalin

248 Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels play an important role in the regulation o

249 BK(Ca) channels possess a voltage sensor mainly represented

250 -reactivity of positive IgG with the alpha1D Ca channel protein.

251 that positive IgG binds directly to alpha1D Ca channel protein.

252 an greatly impact the distribution of the BK(Ca) channel protein to dendritic spines and intrinsic fi

253 rect interaction of positive IgG with L-type Ca channel proteins and the possible inhibition of T-typ

254 of firing decreases Ca influx through L-type Ca channels, providing a necessary signal for LTP.

255 The first RCK domain in BK(Ca) channels (RCK1) has been shown to contain residues c

256 structure of the second RCK domain in the BK(Ca) channel (RCK2) is still being examined, and the pres

257 erlying the sAHP could be carried through SK(Ca) channels, recent work has uncovered anomalies that a

258 support a deactivation-first path for T-type Ca channel recovery from inactivation.

259 tance voltage- and Ca(2+)-activated K(+) (BK(Ca)) channels regulate important physiological processes

260 Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels regulate the physiological properties of m

261 Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels regulate the physiology of many cell types

262 cells, highlighting a novel mechanism of BK(Ca) channel regulation.

263 Ca channels rely on four glutamate residues (the EEEE lo

264 ever, the mechanism by which CO activates BK(Ca) channels remains unclear.

265 intermediate-conductance K(+) (SK(Ca) and IK(Ca)) channels, respectively, and N(G)-nitro-L-arginine m

266 leak through the sarcoplasmic reticulum (SR) Ca channel (ryanodine receptor, RyR) and/or decreased ac

267 loned (cbv) cerebral artery smooth muscle BK(Ca) channels show that CO reverses BK(Ca) channel inhibi

268 channels and gap junctions or that activate Ca(++) channels significantly improve movement of NALCN-

269 Interestingly, the K(Ca) channel SK significantly contributes to Kv2.1(-/-) m

270 inhibitory effect of Ins(3,4,5,6)P(4) on Cl(Ca) channel stimulation by CaMKII was reduced by raising

271 The latter K(Ca) channel subtype is involved in rate-dependent regula

272 ovide a tentative image of the structures in Ca channels that make them exceptionally selective.

273 ns in the C terminus of alpha(1B-1) produced Ca channels that were inhibited after activation of both

274 transcript and express two novel types of K(Ca) channels that are gated by activation of a G-protein

275 Here we show that BK(Ca) channels that lack the whole intracellular C terminu

276 inhibitor for calcium-dependent potassium (K(Ca)) channels, that are effectors in cGMP signaling.

277 This review summarizes iBK(Ca) channels, their possible functions, and efforts to i

278 ves to sparks, leads to the activation of BK(Ca) channels to induce dilation of cerebral PAs.

279 s are necessary for normal trafficking of BK(Ca) channels to the plasma membrane and that the mechani

280 have previously shown that trafficking of BK(Ca) channels to the plasma membrane is associated with p

281 A is necessary for normal trafficking of BK(Ca) channels to the plasma membrane, but this effect doe

282 our molecularly defined subclasses of L-type Ca channels, two are expressed ubiquitously in the mamma

283 n/localization of Na/Ca exchanger and L-type Ca channel type 1.2 with a parallel reduction in Na/Ca e

284 ating-modifier that interacts with different Ca channel types with high affinity.

285 ancing the inactivation of voltage-dependent Ca(++) channels (VDCCs), but not by affecting secretory

286 e uncaging, to examine how voltage-sensitive Ca channels (VSCCs) and ionotropic glutamate receptors c

287 ppocampal slices, CaV(2.3) voltage-sensitive Ca channels (VSCCs) are found selectively on spines and

288 ing and digestion were abolished when the BK(Ca) channel was blocked, revealing an essential and unex

289 The open probability (P(o)) of the BK(Ca) channel was finely tuned by bilayer thickness, first

290 e-conductance (BK-type) Ca2+-activated K+ (K(Ca)) channels was examined in developing chick lumbar mo

291 To test for a role for SK(Ca) channels, we overexpressed K(Ca)2.1 (SK1) and K(Ca)2

292 e (cGMP), protein kinase G (PKG), and the BK(Ca) channel were used to characterize their involvement

293 Corresponding currents through BK(Ca) channels were also increased with TRPC6 coexpression

294 -conductance calcium-activated potassium (BK(Ca)) channels were studied in inside-out patches of huma

295 hus, bovine coronary SMCs densely express BK(Ca) channels whereas adjacent ECs in the same artery app

296 Inactivation of Ca-channels will also limit Ca2+ entry, but it remains u

297 na, we provide evidence that the location of Ca channels with low open probability within nanometers

298 Targeting AF caused by leaky RyR2 Ca channels with R-propafenone may be a more mechanism-b

299 In current clamp, blocking L-type Ca channels with the specific blocker nifedipine greatly

300 exon splicing in rSlo interact to produce BK(Ca) channels with a physiologically relevant phenotype.