ライフサイエンスコーパス: Ca2 sensitive

1 lphosphorylceramide, which renders the cells Ca2+-sensitive.

2 The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2)

3 Adenylyl cyclase (AC) 1 and AC8, the major Ca2+-sensitive AC isoforms, are not crucial for the base

4 We conclude that gelsolin is the primary Ca2+-sensitive actin filament recycling protein in the c

5 The Ca2+-sensitive actin-severing protein gelsolin concentra

6 uanylyl cyclase activating protein (GCAP), a Ca2+-sensitive activator, to resynthesize light-depleted

7 of Ca2+ can lower cAMP through its action on Ca2+-sensitive adenylate cyclases or phosphodiesterases,

8 biological properties of both aequorin and a Ca2+-sensitive adenylyl cyclase.

9 Ca2+-sensitive adenylyl cyclases are key integrators of

10 e findings not only extend the means whereby Ca2+-sensitive adenylyl cyclases may be regulated, they

11 -exist, cyclic nucleotide-gated channels and Ca2+-sensitive adenylyl cyclases may reciprocally modula

12 Previous studies have established that Ca2+-sensitive adenylyl cyclases, whether endogenously o

13 Ca2+-sensitive adenylyl cyclases, whether endogenously o

14 se [Ca2+] by laser photolysis of NP-EGTA was Ca2+ sensitive and biphasic: a rapid component approxima

15 4-aminopyridine (4-AP) which suppressed the Ca2+ sensitive and other K+ currents in rat carotid body

16 Ca2+-sensitive and H+-sensitive fluorescent probes were

17 This stimulation of cAMP was not Ca2+-sensitive and was unaffected by a range of protein

18 PKs with distinct Ca2+-sensitivities, highly Ca2+-sensitive Arabidopsis (Arabidopsis thaliana) AtCPK2

19 est degree of aggregation and being the most Ca2+ sensitive at a given protein concentration.

20 unctions as a Ca2+/K+ ion exchanger, and two Ca2+-sensitive channels, one to import K+ into the Ca2+-

21 with the recently described bovine tracheal, Ca2+-sensitive chloride channel protein (bCLCA1), bovine

22 cule-1 (Lu-ECAM-1), and the human intestinal Ca2+-sensitive chloride channel protein (hCLCA1).

23 investigating the possible contribution of a Ca2+-sensitive chloride conductance to the pathogenesis

24 rine role in regulating basolateral membrane Ca2+-sensitive Cl- conductance linked to Cl- and fluid t

25 th CLCA1 exhibited an increase in whole-cell Ca2+-sensitive Cl- currents that were outwardly rectifie

26 lations in action potential duration through Ca2+-sensitive conductances.

27 s of internal repeats, and the complex forms Ca2+-sensitive contractile fibers that function to reori

28 reviously identified by complementation of a Ca2+-sensitive (csg1) mutant.

29 n by whole-cell patch-clamp recording of the Ca2+-sensitive currents.

30 ular Ca2+ stores, but without increasing the Ca2+-sensitive currents.

31 ds using microscopic digital imaging and the Ca2+ sensitive dye fura-2.

32 e Ca2+ signal to AMPA was examined using the Ca2+ sensitive dye fura-2.

33 laser scanning confocal microscopy using the Ca2+-sensitive dye Fluo-4/AM, we determined that spontan

34 s was measured by microfluorimetry using the Ca2+-sensitive dye fura-2.

35 en they were monitored with the low-affinity Ca2+-sensitive dye fura-2FF, but not with the high-affin

36 oma cells and primary astrocytes loaded with Ca2+-sensitive dye reveals that XeC selectively blocks b

37 event of fusion (which was the diffusion of Ca2+-sensitive dyes from egg into sperm) and any change

38 we have adapted biolistic techniques to load Ca2+-sensitive dyes into guard cells of the flowering pl

39 urface because of the limited penetration of Ca2+-sensitive dyes.

40 the dynamics of [Ca2+]i that regulates this Ca2+-sensitive enzyme under a variety of physiological c

41 tic plasticity by differential activation of Ca2+ -sensitive enzymes such as calmodulin.

42 tricular cardiomyocytes were loaded with the Ca2+-sensitive fluorescent dye Fluo-3 and imaged by a di

43 entration ([Ca2+]i) were monitored using the Ca2+-sensitive fluorescent dye furaptra.

44 Intracellular Ca2+ was analyzed with the Ca2+-sensitive fluorescent dye INDO-1 and confirmed that

45 stores using confocal microscopic imaging of Ca2+-sensitive fluorescent dye loaded into the cells.

46 Using the Ca2+-sensitive fluorescent dye, Fluo-3, AM, and a trypan

47 2+ signals in strips of UBSM loaded with the Ca2+-sensitive fluorescent dye, fluo-4, using laser scan

48 an worm Cerebratulus lacteus were mixed with Ca2+-sensitive fluorescent dyes and injected into unfert

49 Although a wide range of Ca2+-sensitive fluorescent dyes is available, they are o

50 a2+ nanoscale resolution (SCCaNR), employing Ca2+-sensitive fluorescent dyes to localize stochastic o

51 n levator auris longus motor terminals using Ca2+-sensitive fluorescent indicator dyes (rhod-2, rhod-

52 The Ca2+-sensitive fluorescent indicator rhod-2 was used to

53 We used two-photon imaging with the Ca2+-sensitive fluorescent protein G-CaMP to map the pri

54 etry using membrane vesicles loaded with the Ca2+-sensitive fluorophore fura-2.

55 s could not be determined precisely with the Ca2+-sensitive fluorophore, fura-2, because of its high

56 ling was monitored using cells loaded with a Ca2+-sensitive fluorophore.

57 e 1, 3, 7, 11, 14 and 21 days old, using the Ca2+-sensitive fluoroprobe fura-2.

58 ession of putative Ca2+-insensitive, but not Ca2+-sensitive, forms of alpha-actinin reduced inactivat

59 Elevated [Ca2+](i) activates the Ca2+-sensitive Gardos channels, inducing KCl loss and ce

60 inside-out membrane patches were 2-fold less Ca2+ sensitive in high-frequency than in low-frequency c

61 Ca2+-sensitive inactivation only appeared when the membr

62 ase rate stimulated by the minifilaments was Ca2+-sensitive, indicating that single regulatory length

63 ped rat ventricular myocytes loaded with the Ca2+-sensitive indicator fluo-3, using confocal microsco

64 sured with fluorescent voltage-sensitive and Ca2+-sensitive indicators in rat brain slices.

65 Ca2+-sensitive involucrin AP-1 promotor activity was inc

66 rocytic endfeet exhibited large-conductance, Ca2+-sensitive K+ (BK) channel currents that could be ac

67 om the SR (sparks), stimulating plasmalemmal Ca2+-sensitive K+ (BK) channels, determines the refracto

68 um (Ca2+ sparks) activate large-conductance, Ca2+-sensitive K+ (BK) channels.

69 The activity of large conductance, Ca2+-sensitive K+ (BKCa) channels, known to control neur

70 e inhibited by the intermediate conductance, Ca2+-sensitive K+ (IKCa) channel inhibitors, TRAM-34, an

71 evented by clotrimazole, an inhibitor of the Ca2+-sensitive K+ (KCa) channel, suggesting that it was

72 muscle, Ca2+ release through RyRs activates Ca2+-sensitive K+ (KCa) channels to oppose vasoconstrict

73 Voltage- and Ca2+-sensitive K+ (MaxiK) channels play key roles in con

74 The Ca2+-sensitive K+ channel (K(Ca) channel) plays a key ro

75 the human pore-forming alpha-subunit of the Ca2+-sensitive K+ channel, Hslo, and the alpha-isoform o

76 Increased [Ca2+]i stimulates Ca2+-sensitive K+ channels (IK-Ca), and this, in turn, h

77 ve large conductance, voltage-dependent, and Ca2+-sensitive K+ channels are activated by cGMP-depende

78 that the alpha-subunit of large conductance Ca2+-sensitive K+ channels is substrate for G-Ialpha kin

79 rnal stores and the subsequent activation of Ca2+-sensitive K+ channels.

80 Intracellular Ca2+ was assessed by measuring Ca2+-sensitive K+ currents or imaging the fluorescence o

81 ype of K+ channel that dominates the IK: the Ca2+-sensitive (K(Ca)) channel, delayed rectifier (K(Dr)

82 e plasma membrane (PM) Ca2+ influx or of the Ca2+-sensitive leak coefficient of the ryanodine recepto

83 Here, we report that the Ca2+-sensitive luminescent protein aequorin does not rec

84 Synaptotagmin competes in a Ca2+-sensitive manner with binding of Gbetagamma to SNAP

85 -binding protein that activates RetGC-1 in a Ca2+-sensitive manner.

86 lyl cyclase-activating proteins (GCAPs) in a Ca2+-sensitive manner.

87 cetylases (HDAC4) regulate SRF activity in a Ca2+-sensitive manner.

88 ment membrane guanylate cyclase (RetGC) in a Ca2+-sensitive manner.

89 eptor membrane guanylyl cyclase, RetGC, in a Ca2+-sensitive manner.

90 ucocorticoid-treated thymocytes occurs via a Ca2+-sensitive mechanism and that exogenous Ca2+ promote

91 e surface membrane may explain how numerous (Ca2+)-sensitive membrane processes are activated at time

92 The Ca2+-sensitive microelectrodes were sensitive to intrace

93 rial matrix Ca2+ ([Ca2+]m) and activation of Ca2+-sensitive mitochondrial metabolism.

94 esis in order to understand the mechanism of Ca2+-sensitive modulation of GC1 activity.

95 ere we demonstrate that myosin Vb (MyoVb), a Ca2+-sensitive motor, conducts spine trafficking during

96 bservations indicated the lack of Ang II and Ca2+-sensitive NO production in pericytes of the vasa re

97 elium (47+/-8 U), indicating the presence of Ca2+-sensitive NO production.

98 We also find that MsNOS has a Ca2+-sensitive NO-producing activity similar to that of

99 to Ca2+, Sr2+, and Ba2+, the complex remains Ca2+- sensitive on fusion-incompetent CV, and disruption

100 2+]i due to Ca2+ release from IP3-sensitive, Ca2+-sensitive, or mitochondrial Ca2+ stores.

101 ly demonstrated that farnesol did not affect Ca2+-sensitive pathways implicated in smooth muscle cont

102 Deletion of either gene suppresses the Ca2+-sensitive phenotype of csg2Delta mutants, which ari

103 in a calcineurin mutant strain results in a Ca2+-sensitive phenotype.

104 TRP) proteins, can mediate activation of the Ca2+-sensitive phosphatase calcineurin in nonexcitable c

105 This may signal a role for Ca2+-sensitive PKC isoforms in cardiac mechanisms involv

106 pool." Upon activation of PKC, this "highly Ca2+-sensitive pool" is enhanced in size to a greater ex

107 l organelle-specific fluorescent markers and Ca2+-sensitive probes were used to identify the source o

108 (Ca2+)-sensitive processes at cell membranes involved in

109 We describe a Ca2+-sensitive protein complex involved in the regulatio

110 Increased expression of Ca2+-sensitive protein kinase C (PKC) isoforms may be im

111 endent mechanism involving the activation of Ca2+-sensitive protein phosphatase 2B (PP-2B, calcineuri

112 fferential regulation of Ras function by two Ca2+-sensitive Ras inhibitors: Ca2+-promoted Ras activat

113 ggest that although GCAP1 is involved in the Ca2+-sensitive regulation of GC in rod and cone outer se

114 l cyclase activating protein-2 (GCAP-2) is a Ca2+-sensitive regulator of phototransduction in retinal

115 t is important for the regulation of several Ca2+-sensitive responses.

116 The homogenate-activated channels were Ca2+ sensitive, selective for Ca2+ over Cs+, and driven

117 n is an adaptor that functions to localize a Ca2+ sensitive signal transduction machinery in sperm to

118 trations that should maximally activate most Ca2+-sensitive signaling kinases and phosphatases.

119 The manner in which Ca2+-sensitive signaling proteins are activated in contr

120 cts of luminal Ca2+ are mediated by distinct Ca2+-sensitive site(s) at the luminal face of the channe

121 esicles and by shifting vesicles to a highly Ca2+-sensitive state, enabling exocytosis at sites relat

122 pid deactivation of rhodopsin is therefore a Ca2+-sensitive step controlling the amplitude of the lig

123 We investigated the properties of Ca2+-sensitive steps in the cycling of synaptic vesicles

124 lved in PC2 oligomerization, and PC2-EF is a Ca2+-sensitive switch.

125 ular cues to the regulation of intracellular Ca2+-sensitive targets.

126 a2+]m) increase regulates intramitochondrial Ca2+-sensitive targets.

127 des activation of PI3-kinase, IGF1R and Akt, Ca2(+)-sensitive transcription factors and also TGFbeta1

128 t PCE1 is a component of a cell-specific and Ca2+-sensitive transcriptional regulatory mechanism that

129 Exon 6b encodes part of a putative Ca2+-sensitive troponin binding site in striated muscle