1 demonstrate the existence in PC12 cells of a CaM kinase I cascade, the function of which may be to se

2           We find that constitutively active CaM kinase I and IV can activate both ATF1 and CREB.

3 report that intracellular infusion of active CaM-kinase I (CaMKI) into cultured hippocampal neurons e

4 s, termed here CaM kinase I kinase-alpha and CaM kinase I kinase-beta (CaMKIK alpha and CaMKIK beta,

5                                         Both CaM kinase I and CaM kinase IV are able to phosphorylate

6 horylation and activation of CaM kinase I by CaM kinase I kinase.

7                     The ability of PC12 cell CaM kinase I to be phosphorylated and activated by purif

8 y its phosphorylation in vitro by a distinct CaM kinase I kinase.

9 aM kinase I) activating kinases, termed here CaM kinase I kinase-alpha and CaM kinase I kinase-beta (

10 a(2+)-calmodulin-dependent protein kinase I (CaM kinase I) activating kinases, termed here CaM kinase

11 rylation of CaM kinase I and to increases in CaM kinase I activity of 5.1- and 7.3-fold, respectively

12 addition, expression vectors for full-length CaM kinase I and IV were able to augment the ability of

13                                Activation of CaM kinase I and CaM kinase IV occurs via phosphorylatio

14 racellular phosphorylation and activation of CaM kinase I by CaM kinase I kinase.

15 e here the phosphorylation and activation of CaM kinase I in PC12 pheochromocytoma cells in response

16         Depolarization-induced activation of CaM kinase I was reduced by approximately 80% by blockad

17 ection with constitutively active mutants of CaM kinase I or CaM kinase IV specifically blocks nuclea

18 l, led to rapid, biphasic phosphorylation of CaM kinase I and to increases in CaM kinase I activity o

19  kinase (STO-609), the upstream activator of CaM-kinase I (CaMKI), as well as by transfection with do

20  be phosphorylated and activated by purified CaM kinase I kinase in vitro was markedly reduced by pri