ライフサイエンスコーパス: Cdc25 phosphatase

1 e structure of the catalytic domain of human Cdc25 phosphatase.

2 ologues of the catalytic domain of the human Cdc25 phosphatase.

3 ted by Wee1-related kinases and activated by Cdc25 phosphatase.

4 activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase.

5 ted by Wee1 tyrosine kinase and activated by Cdc25 phosphatase.

6 ical inhibitors of Wee1 and Myt1 kinases and Cdc25 phosphatases.

7 of MPF is regulated by Wee1/Myt1 kinases and Cdc25 phosphatases.

8 ved arginine, which is also present in human Cdc25 phosphatases.

9 idue Cys75 are unchanged with respect to the Cdc25 phosphatases.

10 s driven by downregulation of the activating Cdc25 phosphatases.

11 hat employ Chk1 and Chk2 Ser/Thr kinases and Cdc25 phosphatases.

12 p is not a phosphatase but is a homologue of CDC25 phosphatases.

13 tive, and partially competitive inhibitor of Cdc25 phosphatases.

14 PF through the activating phosphorylation on Cdc25 phosphatases.

15 eracting activities of Wee1/Myt1 kinases and Cdc25 phosphatases.

16 ternal mRNAs, string and twine, which encode Cdc25 phosphatases.

17 ate reductases form, together with the known Cdc25 phosphatases, a well-defined subfamily of the rhod

18 Cdc25 phosphatases activate cyclin-dependent kinases (Cd

19 Cdc25 phosphatases activate the cell division kinases th

20 string and twine; and (4) consequent loss of Cdc25 phosphatase activity allows inhibitory phosphoryla

21 We propose that direct inhibition of Cdc25 phosphatase activity by Chk1, as demonstrated in v

22 Although the regulation of CDC25 phosphatase activity has been elucidated both bioc

23 idues in the active site motif abolished the Cdc25 phosphatase activity.

24 ontrolled by Cdk1, which is activated by the Cdc25 phosphatase and inhibited by Wee1 tyrosine kinase,

25 At the MBT, down-regulation of Cdc25 phosphatase and the resulting inhibitory phosphory

26 Chk1 downregulates the Cdc25 phosphatases and concomitantly upregulates the Wee

27 e that triggers G2/M arrest and inhibits the Cdc25 phosphatase, and many compounds that synergize wit

28 f a key family of cell cycle regulators, the CDC25 phosphatases, and have identified four genes.

29 ) kinase dephosphorylation and activation by Cdc25 phosphatase are essential for mitotic entry.

30 with poor prognosis in many diverse cancers, Cdc25 phosphatases are attractive targets for anticancer

31 Cdc25 phosphatases are dual specificity phosphatases tha

32 Cdc25 phosphatases are key activators of the eukaryotic

33 dual specificity, low-molecular-weight, and Cdc25 phosphatases, are key mediators of a wide variety

34 Cdc25 phosphatases, as activators of the Cdk/cyclins, pl

35 Cdc25 phosphatases belong to the family of protein tyros

36 coding the Drosophila homologue of the yeast CDC25 phosphatase, contributes to the G2 cell cycle dela

37 be useful in further clarifying the role of Cdc25 phosphatase-dependent pathways in checkpoint contr

38 activates Wee1 and Myt1 kinases and inhibits Cdc25 phosphatase during the M to G1 transition.

39 t can be used to discover new members of the CDC25 phosphatase family.

40 st species, the G(2) checkpoint prevents the Cdc25 phosphatase from removing inhibitory phosphate gro

41 will focus on the role of Plk3 in regulating Cdc25 phosphatase function and its effect on the cell cy

42 s is accomplished in part by maintaining the Cdc25 phosphatase in a phosphorylated form that binds 14

43 s is accomplished in part by maintaining the Cdc25 phosphatase in a phosphorylated form that binds 14

44 Like DA3003-1, JUN1111 selectively inhibited Cdc25 phosphatases in vitro in an irreversible, time-dep

45 most potent reported synthetic inhibitor of Cdc25 phosphatases in vitro.

46 phila embryos, zygotic expression of the stg(cdc25) phosphatase in G2 activates cyclin/cdc2 kinases a

47 Cdc25 phosphatase induces mitosis by dephosphorylating t

48 Many of the more potent Cdc25 phosphatase inhibitors reported to date are quinon

49 Because selective Cdc25 phosphatase inhibitors would be valuable biologica

50 ng that protein substrate recognition by the Cdc25 phosphatases is an essential and evolutionarily co

51 ession levels, the intracellular activity of Cdc25 phosphatases is determined by their subcellular di

52 The Cdc25 phosphatases play key roles in cell-cycle progress

53 The Cdc25 phosphatase promotes entry into mitosis by removin

54 The Cdc25 phosphatase promotes entry into mitosis by removin

55 The Cdc25 phosphatase promotes entry into mitosis through th

56 CDC25 phosphatase promotes progression through the eukar

57 Cdc25 phosphatases propel cell cycle progression by acti

58 Active Cdc25 phosphatase released Cdc2-cyclin B from the deterg

59 Because Cdc25 phosphatases remove this phosphate, Cdc25 activity

60 Cdk1, a fraction of total cyclin B1, and the Cdc25 phosphatases reside predominantly in the cytoplasm

61 Dampening Cdc25 phosphatases simultaneously with Wee1 and Myt1 inh

62 A), regulator of cyclin A1 (rca1) and string/cdc25 phosphatase (stg), and the microtubule destabilizi

63 The cdc25 phosphatase string (stg) has been proposed to cont

64 ays and exerts its effect via suppression of CDC25 phosphatase String expression.

65 These genes include the G2/M regulator Cdc25 phosphatase, String; a regulator of the APC ubiqui

66 lated Cys-dependent hydrolases and rhodanese/Cdc25 phosphatases), suggesting that neither secondary s

67 d were abolished in cells overexpressing the Cdc25 phosphatase, suggesting a role for the Cdc2 cyclin

68 s, a well-defined subfamily of the rhodanese/Cdc25 phosphatase superfamily, characterized by a 7-amin

69 ses, which, in turn, belong to the rhodanese/Cdc25 phosphatase superfamily.

70 uch knowledge of the basic enzymology of the Cdc25 phosphatases that may aid in the development of sp

71 late times, we observed accumulation of the Cdc25 phosphatases that remove the inhibitory phosphates

72 ve-site motif CE[F/Y]SXXR that characterizes Cdc25 phosphatase, the novel CALSQ[Q/V]R motif is also c

73 hosphorylates and suppresses the activity of Cdc25 phosphatase: the resulting failure to remove inhib

74 Similar to Cdc25 phosphatase, these proteins are likely involved in

75 r gastrulation and require downregulation of Cdc25 phosphatase, which was previously attributed to th

76 rylating activity of Cpd 5, it might inhibit Cdc25 phosphatases, which contain a cysteine in the cata

77 The Cdc25 phosphatases, which control cell cycle progression

78 In particular, the Cdc25 phosphatases, which dephosphorylate cyclin-depende

79 ns are homologous to the catalytic domain of Cdc25 phosphatases, which, in turn, belong to the rhodan

80 structure, specificity, and mechanism of the Cdc25 phosphatases with a special focus on the activity

81 ases with a special focus on the activity of Cdc25 phosphatases with native protein substrates.

82 e a valuable reagent to probe the actions of Cdc25 phosphatases within cells and may also be useful s