ライフサイエンスコーパス: Cepsilon

1 ma2) and epsilon-productive transcripts (VDJ-Cepsilon).

2 hese events was activation of protein kinase Cepsilon.

3 m involving increased direct CSR from Cmu to Cepsilon.

4 ely from Cmu to Cgamma1, and subsequently to Cepsilon.

5 g through beta2 integrins and protein kinase Cepsilon.

6 transcriptions and repress CSR to Cgamma and Cepsilon.

7 to Ras, mediates activation of phospholipase Cepsilon.

8 rference screen, we identified phospholipase Cepsilon 1 (PLCepsilon1) as a crucial regulator of strom

9 e-dependent effects of ATP on protein kinase Cepsilon activation and ER Ca(2+) release.

10 tely 80% reduction in hepatic protein kinase Cepsilon activation, and increased hepatic insulin sensi

11 ic diacylglycerol content and protein kinase Cepsilon activation.

12 tide-specific phospholipases (phospholipases Cepsilon and Cgamma1) in coordinating certain intracellu

13 oA and Rac1), phospholipases (phospholipases Cepsilon and Cgamma1), and phosphoinositide 3-kinase, in

14 AR2 was colocalized with protein kinase (PK) Cepsilon and PKA in a subset of dorsal root ganglia neur

15 he cooperative effects of protein kinase (PK)Cepsilon and PKCdelta and leads to AKT-FOXO3a phosphoryl

16 the TPA-induced activation of protein kinase Cepsilon and prevented subsequent activation of c-Jun NH

17 reased the phosphorylation of protein kinase Cepsilon and STAT-3.

18 delta, Cgamma3, Cgamma1, Cgamma2b, Cgamma2a, Cepsilon, and Calpha.

19 h agents inhibited S6 kinase, protein kinase Cepsilon, and glycogen synthase kinase 3 alpha and beta.

20 hanisms that influence CSR to Cgamma1 versus Cepsilon are incompletely understood.

21 This paper uses phospholipase Cepsilon as a model to demonstrate that lipids can act a

22 ed CSR activation pathways in the Cgamma and Cepsilon as opposed to the Calpha1/Calpha2 loci.

23 g(10) guanidinium Czeta atom and the Lys(13) Cepsilon atom are close to the lipid (31)P (4.0-4.2 A),

24 retion via stimulation of Rap2-phospholipase Cepsilon-[Ca(2+)]i signaling.

25 mponents phospholipase Cbeta, protein kinase Cepsilon, calcineurin, and phospholamban.

26 Although Cepsilon CSR can occur directly from Cmu, most mature pe

27 showed a significant effect on IL4-inducible Cepsilon DNA-binding and reporter gene expression.

28 n of antiapoptotic effectors (protein kinase Cepsilon, endothelial and inducible NO synthase isoforms

29 Moreover, replacement of the Cepsilon exons with a PGK-neor cassette in the opposite

30 transduce intracellular signals that lead to Cepsilon gene transcription independently of its associa

31 ipts encoded by multiple Cgamma, Calpha, and Cepsilon genes.

32 major effect on the downstream Cgamma2a and Cepsilon genes.

33 and gene expression of T-cell markers and of Cepsilon germline transcript, reflecting antibody isotyp

34 box protein 3 and a decreased expression of Cepsilon germline transcript.

35 if(-/-) B cells completely failed to express Cepsilon germline transcripts (GLT) and secrete IgE.

36 4 and IL-13 play a critical role in inducing Cepsilon germline transcripts and IgE isotype switching

37 IL-4 induces Cepsilon germline transcripts and IgE isotype switching

38 Induction of Cepsilon germline transcripts by IL-4 in B cells that la

39 e 1 (Jak1) activation, STAT6 activation, and Cepsilon germline transcripts in human B cell line BJAB.

40 ace as a homodimer, constitutively expressed Cepsilon germline transcripts.

41 Myd88(-/-) B cells had normal expression of Cepsilon GLT but reduced IgE secretion in response to LP

42 PS plus IL-4 stimulation selectively blocked Cepsilon GLT expression and IgE secretion but had little

43 epsilon-Cmu, Imu-Cgamma4, Igamma-Cmu, Igamma-Cepsilon, Iepsilon-Cgamma, and Igamma4-Calpha1 transcrip

44 es of chimeric Ig germ-line transcripts (Imu-Cepsilon, Iepsilon-Cmu, Imu-Cgamma4, Igamma-Cmu, Igamma-

45 4 induces CSR from Cmu to Cgamma1 (IgG1) and Cepsilon (IgE), the latter of which contributes to the p

46 presses constitutively active protein kinase Cepsilon in the heart and slowly develops a dilated card

47 diacylglycerol activation of protein kinase Cepsilon in triggering hepatic insulin resistance.

48 ost mature peripheral B cells undergo CSR to Cepsilon indirectly, namely from Cmu to Cgamma1, and sub

49 Protein kinase Cepsilon is a central player in the activation process.

50 l for LPS plus IL-4-driven activation of the Cepsilon locus and class switching to IgE.

51 , providing evidence that the productive VDJ-Cepsilon mRNA was derived from a transcriptionally activ

52 of products is initiated by cleavage of the Cepsilon-NdeltaH2+ bond, yielding urea and L-ornithine(H

53 rt halogen bond increases the flexibility of Cepsilon of MET146, whereas the rest of the residue fail

54 )Cdelta2 chemical shifts and (1)Hepsilon-(13)Cepsilon one-bond scalar couplings.

55 Cmu to a downstream Ch (for example, Cgamma, Cepsilon or Calpha), thereby switching expression from I

56 (cCSR) substitutes the Cmu gene with Cgamma, Cepsilon, or Calpha, thereby generating IgG, IgE, or IgA

57 for beta2-AR antagonism of the phospholipase Cepsilon pathway that may contribute to the known protec

58 ular epithelial cells express protein kinase Cepsilon (PKCepsilon ), an oncoprotein that coordinately

59 ing in a 3.6-fold increase in protein kinase Cepsilon (PKCepsilon) activation (P < 0.01) and a subseq

60 h functional coupling between protein kinase Cepsilon (PKCepsilon) and mitochondria has been implicat

61 Mice lacking protein kinase Cepsilon (PKCepsilon) are hypersensitive to both Gram-po

62 Mice lacking protein kinase Cepsilon (PKCepsilon) are supersensitive to positive all

63 Our recent work identified protein kinase Cepsilon (PKCepsilon) as a critical and causative player

64 protein complex of activated protein kinase Cepsilon (PKCepsilon) bound to RACK1, a receptor for act

65 usly shown that activation of protein kinase Cepsilon (PKCepsilon) in male rats induces a chronic, lo

66 The role of protein kinase Cepsilon (PKCepsilon) in the expression of TN-C was eval

67 ed by PD98059, rottlerin, and protein kinase Cepsilon (PKCepsilon) inhibitor peptide, suggesting that

68 Protein kinase Cepsilon (PKCepsilon) is a rational target for cancer th

69 activation and inhibition of protein kinase Cepsilon (PKCepsilon) mimicked and prevented, respective

70 IL-25 induces protein kinase Cepsilon (PKCepsilon) phosphorylation, and up-regulation

71 Protein kinase Cepsilon (PKCepsilon) plays a pivotal role in cardioprot

72 fic methylation occurs at the protein kinase Cepsilon (PKCepsilon) promoter of the babies born of mot

73 We have previously shown that protein kinase Cepsilon (PKCepsilon) protects breast cancer cells from

74 androgen receptor, c-Myc, and protein kinase Cepsilon (PKCepsilon) proteins are overrepresented in mo

75 Here, we show that protein kinase Cepsilon (PKCepsilon) regulates the N-ethylmaleimide-sen

76 ment induced translocation of protein kinase Cepsilon (PKCepsilon) to the plasma membrane of these ne

77 TP increased protein kinase Cepsilon (PKCepsilon) translocation to the particulate f

78 Furthermore, activation of protein kinase Cepsilon (PKCepsilon) was necessary for length recovery,

79 Protein kinase Cepsilon (PKCepsilon), a Ca(2+)-independent, phospholipi

80 Protein kinase Cepsilon (PKCepsilon), a diacyglycerol- and phorbol este

81 Protein kinase Cepsilon (PKCepsilon), a member of the novel PKC subfami

82 We previously observed that protein kinase Cepsilon (PKCepsilon), a member of the protein kinase C

83 A role for protein kinase Cepsilon (PKCepsilon), a second messenger implicated in

84 teroids were found to express protein kinase Cepsilon (PKCepsilon), an oncogenic protein capable of p

85 Here, we used protein kinase A (PKA) and Cepsilon (PKCepsilon), as well as ribosomal S6 kinase II

86 )P]orthophosphate in UGTs and protein kinase Cepsilon (PKCepsilon), following treatment of LS180 cell

87 e, induced activation of Akt, protein kinase Cepsilon (PKCepsilon), mitogen-activated protein kinase

88 ografts (a) the expression of protein kinase Cepsilon (PKCepsilon), phosphatidylinositol 3-kinase, ph

89 ptor) or direct activation of protein kinase Cepsilon (PKCepsilon), the pronociceptive effects of PGE

90 4 (a primary HA receptor) and protein kinase Cepsilon (PKCepsilon), which regulates a number of human

91 lyFn assembly is regulated by protein kinase Cepsilon (PKCepsilon), which translocates rapidly and in

92 gh constitutive expression of protein kinase Cepsilon (PKCepsilon), while phorbol 12-myristate 13-ace

93 nion channel (VDAC) through a protein kinase Cepsilon (PKCepsilon)-dependent pathway.

94 ften involves an outgrowth of protein kinase Cepsilon (PKCepsilon)-positive cells in recurrent prosta

95 re prevented by inhibition of protein kinase Cepsilon (PKCepsilon).

96 Phospholipase Cepsilon (PLCepsilon) has been characterized as a direct

97 Phospholipase Cepsilon (PLCepsilon) has been suggested to transduce si

98 , Epac2, and the Epac effector phospholipase-Cepsilon (PLCepsilon) in airway inflammation and remodel

99 Phospholipase Cepsilon (PLCepsilon) is a multifunctional enzyme implic

100 Phospholipase Cepsilon (PLCepsilon) is a novel member of phosphoinosit

101 Phospholipase Cepsilon (PLCepsilon) is activated downstream of G prote

102 Phospholipase Cepsilon (PLCepsilon) is one of the newest members of th

103 To define a role for phospholipase Cepsilon (PLCepsilon) signaling in cardiac myocyte hyper

104 gh the small GTPase responsive phospholipase Cepsilon (PLCepsilon).

105 (including Cgamma3, Cgamma2a, Cgamma2b, and Cepsilon) that lie as far as 120 kb upstream.

106 hase and the translocation of protein kinase Cepsilon to the plasma membrane, were observed with SWIP

107 n basal germ line Igamma-Cgamma and Iepsilon-Cepsilon transcriptions and repress CSR to Cgamma and Ce

108 nduced cytidine deaminase (AID) and Iepsilon-Cepsilon transcripts.

109 :1-diacylglycerol content and protein kinase Cepsilon translocation.

110 sulin resistance, and hepatic protein kinase Cepsilon was activated, providing a potential mechanism

111 hat IQGAP1 is a substrate for protein kinase Cepsilon, which catalyzes phosphorylation on Ser-1443.